glmmSeq

Myles Lewis, Katriona Goldmann, Cankut Cubuk, Elisabetta Sciacca, Anna Surace

2021-02-09

Help from code review

For the purposes of the code review I think we can ignore the mathematical part and focus on some other aspects:

Outstanding tasks for developers

Purpose

The aim of this package is to model gene expression with a general linear mixed model (glmm). This allows us to include random effects as well as mixed effects. For the purpose of the package we use the glmer function in lme4 package which fits glmm via REML or maximum likelihood.

Differences between other packages

Package Differences/Limitations Reference
Limma Inflexible cannot return interactions Limma
DESeq No possibility for time/longitudinal analysis DESeq2
Dream
MCMseq
rmRNA-seq voom-like, shrinkage estimate

Installing

To load the package as a library you can run the code in ./package_creator then:

library(glmmSeq)

Else you can source the functions individually:

functions = list.files(paste0(path_package, "/R"), full.names = TRUE)
invisible(lapply(functions, source))

But you will need to load in the additional libraries then:

library(MASS)
library(car)
library(ggplot2)
library(ggpubr)
library(lme4)
library(methods)
library(parallel)
library(plotly)
library(qvalue)
library(stats)
library(gghalves)

Overview

To get started first we load in the package

library(glmmSeq)

Then we can load in the example data set:

data(PEAC_minimal_load)
data(PEAC_dispersions)

metadata$EULAR_bin  = NA
metadata$EULAR_bin[metadata$EULAR_6m %in% c("Good responder", "Moderate responder" )] = "responder"
metadata$EULAR_bin[metadata$EULAR_6m %in% c("Non responder")] = "non_responder"
metadata = metadata[! is.na(metadata$EULAR_bin), ]

tpm = tpm[, metadata$SAMID]

The metadata contains the following, where EULAR is a rheumatoid arthritis response metric:

kable(head(metadata), row.names = F) %>% kable_styling()
SAMID PATID Timepoint EULAR_6m EULAR_bin
SAM20389187 PAT359 6 Good responder responder
SAM20389185 PAT232 6 Good responder responder
SAM20389181 PAT242 6 Moderate responder responder
SAM20389179 PAT234 6 Good responder responder
SAM20389177 PAT239 6 Good responder responder
SAM20389176 PAT235 6 Good responder responder

Individual Genes

To model one gene over time using the model:

gene expression ~ fixed effects + random effects

In R the formula is defined by both the fixed-effects and random-effects part of the model, with the response on the left of a ~ operator and the terms, separated by + operators, on the right. Random-effects terms are distinguished by vertical bars (“|”) separating expressions for design matrices from grouping factors.

We want to use time and response as fixed effects and the patients as random effects:

gene expression ~ time + response + (1 | patient)

To achieve this we use a negative binomial model with gene dispersions passed in. These dispersions were previously created using DESeq2

Modelling a gene

For a specific gene, say MS4A1, we view the lmer fit using glmmGene:

metadata$Dummy = factor(sample(c("a", "b", "c", "d"), nrow(metadata), replace=T))

MS4A1fit <- glmmGene(~ Timepoint * EULAR_6m + Dummy + (1 | PATID),
                     gene = "MS4A1",
                     id = "PATID",
                     countdata = tpm,
                     metadata = metadata,
                     dispersion = disp["MS4A1"], 
                     pairedOnly=TRUE)

MS4A1fit
## Generalized linear mixed model fit by maximum likelihood (Laplace
##   Approximation) [glmerMod]
##  Family: Negative Binomial(0.5589)  ( log )
## Formula: 
## count ~ Timepoint + EULAR_6m + Dummy + (1 | PATID) + Timepoint:EULAR_6m
##    Data: data
##  Offset: offset
##       AIC       BIC    logLik  deviance  df.resid 
##  619.0965  646.0944 -298.5483  597.0965        75 
## Random effects:
##  Groups Name        Std.Dev.
##  PATID  (Intercept) 0.6433  
## Number of obs: 86, groups:  PATID, 43
## Fixed Effects:
##                           (Intercept)                             Timepoint6  
##                               2.79223                                0.04196  
##            EULAR_6mModerate responder                  EULAR_6mNon responder  
##                               0.43192                               -0.97788  
##                                Dummyb                                 Dummyc  
##                              -1.04272                                0.23035  
##                                Dummyd  Timepoint6:EULAR_6mModerate responder  
##                              -0.48935                               -1.28024  
##      Timepoint6:EULAR_6mNon responder  
##                               0.05075  
## optimizer (bobyqa) convergence code: 0 (OK) ; 0 optimizer warnings; 1 lme4 warnings

Or to create a GlmmSeq object, we can use glmmSeq, which contains the following slots:

metadata$EULAR_bin = metadata$EULAR_6m

MS4A1glmm <- glmmSeq(~ Timepoint * EULAR_bin + (1 | PATID),
                     id = "PATID",
                     countdata = tpm["MS4A1", ],
                     metadata = metadata,
                     dispersion = disp["MS4A1"],
                     verbose=FALSE)

names(attributes(MS4A1glmm))
##  [1] "formula"        "stats"          "predict"        "reducedFormula"
##  [5] "countdata"      "metadata"       "modelData"      "optInfo"       
##  [9] "errors"         "variables"      "class"

Overall Model

To fit for all genes we can use the glmmSeq function. This creates an object of class GlmmSeq.

Note that this analysis can take some time:

Therefore I will only run it for 1000 genes here.

genes = rownames(tpm)

resultTable <- glmmSeq(~ Timepoint * EULAR_bin + (1 | PATID),
                       id = "PATID",
                       countdata = tpm[genes, ],
                       metadata = metadata,
                       pairedOnly=TRUE,
                       dispersion = disp[genes])
## 
## n=86 samples, 43 individuals
## Time difference of 1.006739 mins
## Errors in 6 gene(s):IGHV1-58, IGHV1-67, IGHV3OR16-10, IL20RB, MMP7, THRIL

The variables used by the model are in the @modeldata slot

kable(resultTable@modelData) %>% kable_styling()
Timepoint EULAR_bin
0 Good responder
6 Good responder
0 Moderate responder
6 Moderate responder
0 Non responder
6 Non responder

The model fit statistics can be viewed in the @stats slot:

stats = data.frame(resultTable@stats)
kable(stats[order(stats$P_Timepoint.EULAR_bin), ]) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")
Dispersion AIC logLik X.Intercept. Timepoint6 EULAR_binModerate.responder EULAR_binNon.responder Timepoint6.EULAR_binModerate.responder Timepoint6.EULAR_binNon.responder Chisq_Timepoint Chisq_EULAR_bin Chisq_Timepoint.EULAR_bin P_Timepoint P_EULAR_bin P_Timepoint.EULAR_bin
CILP2 1.4411270 482.92532 -233.46266 1.2885943 0.6167530 -1.7375263 -0.3560534 1.5214677 -0.1827549 3.097892e+03 2.402378e+04 1.851556e+04 0.0000000 0.0000000 0.0000000
FGFR3 1.3106020 330.77960 -157.38980 0.7554035 -0.8167682 -0.5428591 -0.0714576 -0.5076933 -0.3984177 1.384412e+04 6.085041e+03 5.326355e+03 0.0000000 0.0000000 0.0000000
IGHV1-69-2 3.9214968 582.35011 -283.17506 1.7492908 -0.2351499 0.8465027 -0.3483394 -1.2134510 -0.8904520 1.489443e+03 2.241260e+04 6.058835e+04 0.0000000 0.0000000 0.0000000
IGHV5-78 2.9921665 380.79639 -182.39819 0.8469865 -0.1485160 0.0225659 0.8423153 -0.8849723 -0.9759983 4.069807e+01 6.491509e+02 1.618085e+03 0.0000000 0.0000000 0.0000000
RGS4 0.6829379 348.05870 -166.02935 0.5750804 -0.2071724 -0.2459392 0.0788603 -0.2760689 0.8788462 6.047874e+02 9.294062e+02 1.176238e+04 0.0000000 0.0000000 0.0000000
FGFRL1 0.2438707 495.99805 -239.99902 1.7059370 0.0475056 -0.0007756 0.1998243 -0.0327591 -0.1896873 8.325402e+01 8.598530e+02 1.288341e+03 0.0000000 0.0000000 0.0000000
CD109 0.2595885 531.68749 -257.84374 1.7302086 0.4305650 -0.0839433 0.1046032 0.1425346 -0.1279601 5.845855e+03 5.673686e+02 1.159563e+03 0.0000000 0.0000000 0.0000000
CXCL13 3.0430032 678.65852 -331.32926 3.4712702 -0.4797138 0.3589819 -1.4843860 -1.3792856 0.6504407 1.190692e+02 1.141089e+03 1.142492e+03 0.0000000 0.0000000 0.0000000
IL2RG 0.6209438 758.37047 -371.18524 3.4293268 -0.4390963 0.2093960 -0.4598898 -0.2695497 0.2611503 1.340777e+03 1.775791e+03 9.817679e+02 0.0000000 0.0000000 0.0000000
CXCL6 2.8545998 393.56693 -188.78347 0.8355028 -0.1390280 -0.0485956 0.6850474 -0.2745304 -0.5060130 5.345025e+01 1.275103e+03 8.982257e+02 0.0000000 0.0000000 0.0000000
CXCL9 2.3744785 708.71899 -346.35949 3.3234160 -0.7379555 0.1213946 -1.3053692 0.2943391 0.6132494 9.220811e+02 3.034296e+03 7.462908e+02 0.0000000 0.0000000 0.0000000
PFKFB1 1.7018059 261.30839 -122.65420 -0.3507725 -0.7258154 0.5968370 0.7552377 -0.2363562 0.5984363 7.135278e+03 1.073649e+04 6.073131e+02 0.0000000 0.0000000 0.0000000
S100B 0.9590636 687.25596 -335.62798 2.4447110 -0.0381928 0.5195408 0.4010798 -0.5426512 0.4531701 4.989205e+01 4.114379e+02 4.525652e+02 0.0000000 0.0000000 0.0000000
IGHD 2.3226913 483.90728 -233.95364 2.0112496 -0.9457765 -0.2758959 0.3055079 -0.2303206 -0.4210911 1.558221e+03 1.496587e+00 3.082843e+02 0.0000000 0.4731735 0.0000000
CXCL1 1.7535172 697.44496 -340.72248 2.6523817 -0.5583380 0.3619117 0.4440293 -0.3368270 -0.2362412 5.043091e+02 4.594248e+02 2.489196e+02 0.0000000 0.0000000 0.0000000
IGHA2 2.8563652 838.82913 -411.41456 3.9142383 -0.6554242 0.5478273 -0.2162295 -0.4527288 1.1992418 3.537865e+01 2.585064e+01 1.525620e+02 0.0000000 0.0000024 0.0000000
IGHM 2.9121674 1229.54657 -606.77329 6.2604297 -0.7770905 0.6835071 -0.3082630 -0.5896470 -0.9103001 7.820583e+01 4.953413e+01 1.128145e+02 0.0000000 0.0000000 0.0000000
MS4A1 1.7891158 618.92016 -301.46008 2.1974932 0.0879270 0.5825285 -0.7230743 -1.0580361 -0.1806808 2.373247e+01 1.643254e+03 1.062194e+02 0.0000011 0.0000000 0.0000000
IGHG4 3.5445281 1294.32152 -639.16076 6.2481295 -0.6119740 1.0211899 -0.2890794 -1.0042152 -0.2995753 1.762922e+02 4.260411e+02 3.329386e+01 0.0000000 0.0000000 0.0000001
IGHV3-6 5.5318804 504.82497 -244.41248 2.1567633 -0.2805404 1.0471157 -1.2925343 -2.0045538 3.1459442 5.086919e-01 2.419250e-01 1.329986e+01 0.4757056 0.8860672 0.0012941
ADAM12 1.1835027 444.32998 -214.16499 1.9894865 -1.1509420 -0.4409071 -0.5803316 0.1466447 1.9263961 6.328959e+00 4.773444e+00 8.886023e+00 0.0118782 0.0919305 0.0117605
IGHV3-22 4.6800429 335.97354 -159.98677 0.1147006 0.7333562 1.5325665 1.4615052 -3.1901210 -1.6973333 2.218791e+00 8.758038e-01 7.699474e+00 0.1363398 0.6453891 0.0212853
IGHV3-63 5.0137038 527.35278 -255.67639 2.4027591 0.3857720 1.0559461 -0.6905488 -2.7291652 -2.2048254 4.661773e+00 7.106920e+00 6.691286e+00 0.0308413 0.0286254 0.0352376
IGHV3-23 3.6261089 1122.54094 -553.27047 6.8739172 -0.1230068 0.3019696 -0.5703320 -1.8065561 -2.2319972 9.425698e+00 9.383919e+00 5.682533e+00 0.0021397 0.0091687 0.0583517
USP9Y 7.8919766 317.86150 -150.93075 -1.0184547 1.3837211 2.1678654 2.4180948 -0.9728379 -4.0878753 9.025870e-02 5.141694e+00 5.203867e+00 0.7638486 0.0764707 0.0741301
IGHV3-38 5.6480925 389.71875 -186.85938 1.0427845 -0.4731288 2.2091507 -0.0570427 -2.6588017 -0.6893595 9.039556e+00 4.093196e+00 5.077355e+00 0.0026420 0.1291736 0.0789708
FGF1 0.5690355 289.48497 -136.74248 0.0321119 0.3871638 0.5989142 0.4518460 -1.0850177 0.1485961 3.163410e-02 3.164987e+00 5.010509e+00 0.8588330 0.2054622 0.0816548
IGHV3-62 6.2203919 492.70969 -238.35485 1.6744587 0.8530747 0.9229385 0.2268159 -2.6528298 -1.4058648 5.847652e-01 5.980906e-01 4.657388e+00 0.4444506 0.7415258 0.0974229
IGHV3-74 4.0954404 759.62327 -371.81164 3.7971253 0.4266690 0.9240223 0.2291054 -1.8807762 -1.5209145 1.820967e+00 9.460558e-01 3.988482e+00 0.1771982 0.6231127 0.1361169
IGHV3-49 5.1180623 849.52989 -416.76494 4.9905272 -0.4434283 0.2625095 1.5029531 -1.8323920 -2.1357556 1.033749e+01 2.931138e+00 3.897518e+00 0.0013036 0.2309466 0.1424507
IGHV1OR15-9 6.1805309 432.57658 -208.28829 1.3461300 -0.0745026 0.6359060 0.1846313 0.6405569 -2.3947480 2.226957e-01 5.778416e+00 3.818624e+00 0.6369935 0.0556202 0.1481823
CILP 1.3221469 769.18803 -376.59402 2.2335037 1.2648596 -0.4001068 0.7848699 0.2477525 -1.2070644 1.424820e+01 5.233349e-01 3.789438e+00 0.0001602 0.7697670 0.1503606
IGHV3OR16-12 7.8753152 337.42746 -160.71373 0.9438135 0.6696589 0.1253670 -0.1558517 -2.7709936 -1.5969402 9.390085e-01 2.961565e+00 3.738790e+00 0.3325330 0.2274596 0.1542170
FGF23 0.8956050 223.57820 -103.78910 -0.3298898 0.2100079 -0.2501233 -0.4945870 -0.0778325 1.4885275 2.370653e+00 3.399454e+00 3.651907e+00 0.1236353 0.1827334 0.1610640
IGHV7-27 6.2003274 263.14385 -123.57193 1.4537065 -2.9491822 -0.8277109 -1.9629138 0.9217863 3.1072421 9.405880e+00 6.456797e-01 3.635641e+00 0.0021629 0.7240898 0.1623793
IL1B 1.0478707 401.70222 -192.85111 1.3740769 -0.6789238 -0.1555105 -0.4436456 -0.3037805 1.2409838 4.552215e+00 8.289140e-01 3.585914e+00 0.0328762 0.6606990 0.1664672
IGHV1OR15-2 5.4222427 422.77278 -203.38639 1.4087907 0.3326940 1.1407250 -0.5956683 -2.1335873 -0.9365555 1.597284e+00 2.966236e+00 3.404559e+00 0.2062885 0.2269291 0.1822675
IGHV3-69-1 4.8504900 728.71536 -356.35768 3.6331381 0.2076780 0.5773100 0.6037990 -1.5666299 -2.0506954 2.835452e+00 4.459185e-01 3.384899e+00 0.0922049 0.8001474 0.1840681
IGHV3-21 4.1333989 1012.03252 -498.01626 6.1171856 -0.5001746 0.4234043 -0.4806345 -1.4536223 -1.8661366 1.062653e+01 5.897808e+00 3.362419e+00 0.0011148 0.0523971 0.1861487
IGHV1-17 4.0566639 265.72849 -124.86424 -0.1793647 -0.8260531 2.3112843 0.5418265 -2.0735076 -1.0525363 1.308625e+01 7.510451e+00 3.261540e+00 0.0002975 0.0233952 0.1957788
RAB3IL1 0.1185099 669.48757 -326.74378 2.8799007 0.1576318 0.0319388 0.3053523 0.2092953 -0.2109951 4.643721e+00 1.662551e+00 3.190662e+00 0.0311674 0.4354936 0.2028414
IGHV3-7 3.9610364 987.64501 -485.82250 5.7888871 -0.4293143 0.6472207 -0.3811185 -1.7028595 -0.6268721 7.724116e+00 1.462392e+00 3.123618e+00 0.0054488 0.4813330 0.2097563
IGHA1 3.1078425 1307.50098 -645.75049 7.2817510 -0.3514026 0.4826388 -0.2934548 -1.1113049 0.6608198 2.813025e+00 2.152750e-02 3.104980e+00 0.0935019 0.9892940 0.2117202
IGHV3-41 5.5282437 424.16701 -204.08350 1.4750686 -0.1014696 0.8468584 0.1659012 -2.0468839 -1.0957735 4.230656e+00 2.936902e-01 3.026554e+00 0.0397001 0.8634277 0.2201872
IGHG3 3.4055290 1217.72177 -600.86088 7.3800803 -1.4326492 0.0326085 -0.8306498 -0.7173448 1.3447050 1.223220e+01 3.053774e-01 2.989718e+00 0.0004697 0.8583969 0.2242802
IL24 0.9105298 280.89840 -132.44920 0.5495696 -0.4464317 0.0635065 -0.8008211 -0.3709541 1.0042449 1.858327e+00 3.639499e-01 2.935616e+00 0.1728180 0.8336222 0.2304301
IL1RAP 0.1744432 325.77654 -154.88827 0.9904554 -0.1939306 -0.1126976 -0.2069255 0.2494767 0.7337603 1.431556e-01 9.813829e-01 2.924274e+00 0.7051639 0.6122030 0.2317405
IGHV3-60 5.4771794 367.31709 -175.65854 0.9696813 -0.2746268 0.4730220 0.8873514 -1.6482163 -2.1148903 5.826566e+00 2.727155e-01 2.917796e+00 0.0157859 0.8725304 0.2324924
CARMIL2 0.9443373 442.31812 -213.15906 1.5332155 -0.4499192 0.3199380 -0.2515739 -0.5478312 0.5585103 5.048509e+00 8.119930e-02 2.892451e+00 0.0246471 0.9602135 0.2354574
IGHV1-69 5.4329672 814.59539 -399.29770 4.4162108 0.2600999 0.7642761 0.5861487 -0.6598959 -2.2862440 8.456826e-01 2.086572e+00 2.883806e+00 0.3577766 0.3522951 0.2364773
IGHV3-47 5.9314716 402.79650 -193.39825 0.9975866 0.4039019 0.7441095 0.0117277 -1.8271393 -1.9139246 1.421645e+00 1.541137e+00 2.831362e+00 0.2331328 0.4627499 0.2427602
EMILIN3 1.7437861 331.36784 -157.68392 0.2935695 1.0085827 -1.5698200 -0.9008988 1.3939911 0.6329607 1.824874e+01 2.554883e+00 2.748804e+00 0.0000194 0.2787496 0.2529909
IGHV7-56 7.3352622 369.50063 -176.75031 1.4800824 0.0448606 0.5623886 -1.2957158 -1.9994719 -2.1959690 2.989392e+00 6.389843e+00 2.741300e+00 0.0838116 0.0409697 0.2539419
IGHV1-45 6.5262502 427.53604 -205.76802 3.7234764 -1.6974738 -2.1094400 -4.5118167 0.8948972 3.1154101 1.310547e+00 7.714505e+00 2.708753e+00 0.2522956 0.0211260 0.2581082
SAA1 2.7550934 509.14265 -246.57133 1.8985313 -0.7917104 -0.7873416 0.5312670 -0.6915477 1.0251778 4.014912e+00 9.493480e+00 2.697353e+00 0.0450996 0.0086799 0.2595836
COLGALT2 0.6515204 463.83102 -223.91551 1.0174207 0.6158436 -0.2499688 0.2696535 0.4880521 -0.4077493 1.137135e+01 3.171240e-02 2.627624e+00 0.0007459 0.9842689 0.2687935
CXCR1 1.1823573 461.97248 -222.98624 1.1508817 0.2917865 0.5977859 0.4545711 -0.9722748 -0.4159209 3.154192e-01 3.491200e-01 2.624103e+00 0.5743736 0.8398264 0.2692671
HILPDA 0.3336806 526.35726 -255.17863 2.1813298 -0.2030473 0.0420321 0.0381714 -0.0230094 0.5482300 3.886169e-01 3.078300e+00 2.573699e+00 0.5330273 0.2145634 0.2761393
IGHJ3 4.5828262 1096.33595 -540.16798 6.7199044 -0.8578507 0.3504850 -0.2019400 -1.2057383 0.6664868 6.384704e+00 4.283947e-01 2.524530e+00 0.0115108 0.8071891 0.2830123
CLEC17A 1.7161799 209.69152 -96.84576 -0.2433997 -0.2447279 0.3004883 -0.7767356 -0.9180404 0.8353068 1.032727e+00 2.574878e-01 2.466864e+00 0.3095191 0.8791991 0.2912911
PADI4 1.1925883 294.08413 -139.04207 -0.0232832 0.3010949 0.6896938 0.8255479 -1.0247606 -0.8275468 7.972631e-01 1.057711e+00 2.405939e+00 0.3719129 0.5892789 0.3003012
BLK 1.0940018 385.49525 -184.74762 0.9776621 0.1366645 0.2935813 -0.3179190 -0.8307705 0.0561788 3.607897e-01 6.163545e-01 2.397389e+00 0.5480680 0.7347851 0.3015876
FGFBP2 1.1321851 983.30787 -483.65393 3.5430098 1.2077227 0.3662783 0.9114524 -0.2146277 -1.0092331 1.236011e+01 9.675659e-01 2.356731e+00 0.0004386 0.6164470 0.3077814
IGHV3-71 5.0763883 438.80131 -211.40066 2.0531426 -0.4671179 0.2438695 -0.6720273 -1.6881414 -0.3692058 5.295689e+00 1.937207e+00 2.334900e+00 0.0213783 0.3796127 0.3111594
CXCR2 1.0879657 488.73706 -236.36853 1.2934094 0.2892210 0.5082808 0.2969800 -0.8736023 -0.4845694 2.758665e-01 3.435820e-02 2.332327e+00 0.5994233 0.9829676 0.3115599
PILRB 0.2039455 710.76593 -347.38296 3.0599094 0.1014714 0.2199776 0.4965024 -0.2354488 -0.4241344 5.171360e-01 2.052458e+00 2.319997e+00 0.4720660 0.3583557 0.3134866
IGHV1-18 4.1610769 1017.86794 -500.93397 6.0838039 -0.4801420 0.6496744 -0.0175466 -1.3159204 -1.4253939 8.297033e+00 1.798471e+00 2.317220e+00 0.0039710 0.4068806 0.3139223
IGHV2-26 5.7395474 733.34272 -358.67136 4.5991159 -0.5324022 0.4962482 -1.4798203 -1.7642001 -0.7228647 6.672854e+00 7.178250e+00 2.294102e+00 0.0097892 0.0276225 0.3175718
IGHGP 2.9509749 766.91573 -375.45787 3.1368873 -0.6384069 0.6917343 0.2149604 -1.0506791 0.2971985 6.611823e+00 2.677664e-01 2.277638e+00 0.0101304 0.8746922 0.3201970
IGLV4-3 3.4400643 323.87649 -153.93825 1.2561948 -1.2868808 0.6401132 -1.0739818 -1.4962490 0.3805190 9.725807e+00 1.764352e+00 2.262901e+00 0.0018170 0.4138813 0.3225650
IGHV5-51 3.9223263 1011.31620 -497.65810 5.8663505 -0.2516110 0.6444579 -0.1705353 -1.4431107 -0.7054314 4.797726e+00 8.851163e-01 2.247735e+00 0.0284973 0.6423910 0.3250204
IGHV1-12 6.1679293 529.67646 -256.83823 3.1501380 -0.8540126 -0.3416657 -2.2730497 0.5646531 2.1691040 1.361227e-01 2.922638e+00 2.233077e+00 0.7121664 0.2319302 0.3274112
IGHV3OR16-8 6.1207754 513.76958 -248.88479 2.9677966 -0.6980120 -0.2491531 -0.5103878 -1.0206819 1.1366854 2.383925e+00 1.896047e+00 2.192012e+00 0.1225892 0.3875063 0.3342033
IL20RA 1.1995780 205.79494 -94.89747 0.4485148 -1.3781255 -1.3232823 -0.9496444 1.2689732 0.9662118 3.095314e+00 2.595948e+00 2.150360e+00 0.0785180 0.2730846 0.3412364
IGHV3-15 3.9887966 908.01143 -446.00572 5.6129625 -0.5086199 0.0278748 -0.4365632 -0.8733728 -1.6194471 7.375979e+00 4.630893e+00 2.104870e+00 0.0066101 0.0987221 0.3490867
LILRA5 0.6373128 549.14768 -266.57384 2.2656022 -0.3778815 0.1131676 -0.3244438 -0.0626535 0.7052435 1.952824e+00 2.548447e-01 2.062708e+00 0.1622828 0.8803618 0.3565239
SVIL 0.1553703 585.03527 -284.51764 2.3189297 0.1788285 -0.2382911 0.0817165 0.2625475 -0.1260486 5.248961e+00 3.634554e-01 2.037427e+00 0.0219599 0.8338283 0.3610591
IGHV3OR16-15 4.6772884 254.10977 -119.05489 0.5034365 -0.7907149 -0.0022401 -2.0487177 -0.8787121 1.4040025 2.605313e+00 2.547587e+00 1.979617e+00 0.1065061 0.2797682 0.3716479
IL1RN 0.7888388 519.50152 -251.75076 2.3111797 -0.6612931 -0.4992137 -0.7657782 0.2460911 0.8951327 3.317251e+00 2.284100e+00 1.969016e+00 0.0685564 0.3191640 0.3736230
IGHV4-34 3.5615779 890.96849 -437.48425 4.7947364 -0.5162039 1.1132983 -0.3770085 -1.3113325 -0.7955251 7.250318e+00 3.956565e+00 1.956500e+00 0.0070888 0.1383066 0.3759685
SAA2 1.6899371 325.15842 -154.57921 0.6473300 -0.6996460 -0.8129330 -0.2850470 -0.6151155 0.8039186 3.069007e+00 3.772731e+00 1.928413e+00 0.0797982 0.1516219 0.3812857
FGF14 0.8081567 285.49968 -134.74984 -0.2043500 0.8129736 -0.0246494 0.8667644 -0.0040735 -0.8762681 4.654659e+00 1.807642e+00 1.920091e+00 0.0309694 0.4050191 0.3828755
IGHJ3P 4.5329147 773.09670 -378.54835 4.7285148 -0.2318137 0.2419155 -1.0611902 -1.4254706 -0.4903421 3.527071e+00 4.495381e+00 1.916993e+00 0.0603744 0.1056429 0.3834691
PIGH 0.0617623 601.35547 -292.67774 2.8788051 0.1608922 -0.0074943 0.1156364 0.1700511 -0.0754871 8.416875e+00 7.700424e-01 1.893619e+00 0.0037175 0.6804362 0.3879769
IGHV3-72 4.7494022 591.66600 -287.83300 3.1320079 -1.3002576 0.7025219 -1.1319959 -0.3627797 1.3837656 5.853720e+00 2.337975e+00 1.882240e+00 0.0155442 0.3106813 0.3901905
IFI44L 0.4803384 591.33008 -287.66504 2.4700102 -0.0953480 -0.0949526 -0.7113016 0.4945113 0.3257848 9.081971e-01 7.208960e+00 1.845546e+00 0.3405932 0.0272016 0.3974154
IGHV3-64 6.3489795 514.39127 -249.19564 3.1608778 -0.8713987 -0.0316254 -1.1239615 -1.5491233 -0.0145153 6.859512e+00 2.896281e+00 1.825815e+00 0.0088171 0.2350068 0.4013556
IL11RA 0.1749202 745.37809 -364.68904 3.2301700 0.3332186 0.0300043 0.2645817 0.0445919 -0.3025251 8.127414e+00 3.226086e-01 1.806638e+00 0.0043601 0.8510330 0.4052225
IL17D 0.5110845 624.97599 -304.48800 2.1017195 0.6366629 -0.1968985 0.4305658 0.2863507 -0.3222526 1.518117e+01 1.233514e+00 1.782587e+00 0.0000977 0.5396917 0.4101248
IGHV1-69D 4.2784356 1021.79786 -502.89893 5.9616654 -0.4478735 0.7473324 -0.0735905 -0.9530180 -1.4786667 6.203013e+00 3.221151e+00 1.780130e+00 0.0127533 0.1997726 0.4106290
IGHV5-10-1 6.0333580 814.84755 -399.42377 5.0701558 -0.2403186 0.2757988 0.1867337 -1.4182028 0.0960463 1.987686e+00 9.765778e-01 1.752308e+00 0.1585830 0.6136756 0.4163813
IL32 0.5488618 984.19822 -484.09911 4.9878791 -0.2928202 -0.1134586 -0.4548681 0.0833045 0.5519362 8.280575e-01 6.918068e-01 1.728926e+00 0.3628348 0.7075808 0.4212777
IGHV3-35 6.4000443 443.99049 -213.99524 1.4631532 0.0445084 0.7448214 -1.0052740 -0.9448412 1.0373667 3.149060e-02 9.517741e-01 1.727096e+00 0.8591504 0.6213337 0.4216633
IGHV3-11 4.3828316 902.12061 -443.06031 5.4194833 -0.6856472 0.3698290 -0.1673849 -0.9770951 -1.4561728 8.959479e+00 2.322812e+00 1.723274e+00 0.0027603 0.3130457 0.4224699
NFKBIL1 0.1895656 544.11362 -264.05681 2.5065871 0.2190723 -0.1154484 0.2490120 0.1543474 -0.2347139 4.137774e+00 1.292417e+00 1.689044e+00 0.0419363 0.5240288 0.4297628
IL1R2 0.5338219 410.71830 -197.35915 1.2375002 -0.0788107 -0.1805904 0.0416776 0.1148654 0.7491646 2.286716e-01 2.790890e+00 1.652858e+00 0.6325106 0.2477227 0.4376093
LILRA4 1.6473777 301.71318 -142.85659 0.7327773 -0.8910053 0.0300121 -0.6390106 -0.4200249 0.7962296 6.351074e+00 2.628978e-01 1.644912e+00 0.0117310 0.8768241 0.4393512
IGHV3-53 5.2617476 711.88556 -347.94278 4.4172513 -0.6716714 0.4779408 -0.5864928 -1.0278519 -1.5724604 7.721876e+00 4.837276e+00 1.634949e+00 0.0054556 0.0890428 0.4415455
LILRA2 0.4296738 542.38042 -263.19021 1.9837630 0.3477269 0.1381031 0.4610630 -0.1134522 -0.5284261 1.470705e+00 8.802293e-01 1.616218e+00 0.2252345 0.6439626 0.4457001
IGHV1OR21-1 9.9142574 270.62657 -127.31329 -1.3115011 1.3897802 1.7377530 -0.2726319 -1.9645603 -1.8850887 1.215816e-01 3.102418e+00 1.611415e+00 0.7273254 0.2119915 0.4467718
HHIP 1.5362580 358.40351 -171.20175 0.1328932 0.3345041 0.3952143 1.2560058 0.3786608 -0.6467127 1.131261e+00 5.921484e+00 1.608036e+00 0.2875065 0.0517805 0.4475273
LTA 0.9249689 247.65422 -115.82711 0.2355334 -0.4768142 0.1227363 -0.7427583 -0.1894211 0.8882514 1.592338e+00 5.123197e-01 1.600496e+00 0.2069925 0.7740182 0.4492176
IGHV1-46 4.2459510 765.72865 -374.86433 3.9467926 -0.4620421 1.1583400 0.2317182 -1.2564923 -0.6769072 5.780494e+00 1.544808e+00 1.572660e+00 0.0162050 0.4619013 0.4555134
NEIL1 0.1770385 653.56976 -318.78488 2.8031210 0.2021667 0.1631807 0.3570077 -0.2464690 -0.2907475 2.024944e-01 1.845626e+00 1.572652e+00 0.6527149 0.3973995 0.4555153
SKIL 0.1136944 478.74083 -231.37041 1.7873814 0.1052905 0.0807877 0.1661918 0.2687992 -0.0258706 3.532298e+00 3.095061e+00 1.552980e+00 0.0601843 0.2127728 0.4600179
PPIL6 0.3948141 313.17608 -148.58804 0.1349914 0.7063593 0.2069363 0.7461138 0.0311301 -0.5835023 7.554952e+00 2.691394e+00 1.549428e+00 0.0059845 0.2603581 0.4608355
IGHV6-1 4.2954588 805.40528 -394.70264 4.9776875 -0.7060587 0.4454137 -0.6322524 -1.1823534 -1.0114982 9.173463e+00 3.832960e+00 1.544530e+00 0.0024555 0.1471239 0.4619656
IGHV3-43 4.6255201 835.41161 -409.70581 5.2809693 -0.8655013 -0.1697740 -0.9863137 -0.5431405 1.0281163 3.368142e+00 9.251360e-01 1.533453e+00 0.0664687 0.6296646 0.4645312
CXCL12 0.3448525 1193.42111 -588.71055 5.7661373 0.0625487 0.1860995 0.1433931 0.1484293 -0.2886310 2.035939e-01 2.511673e+00 1.524424e+00 0.6518355 0.2848375 0.4666330
PIWIL4 0.2058325 430.16015 -207.08008 1.2948353 0.2155826 0.0324278 0.2701021 0.2493748 -0.2003071 3.604071e+00 9.840342e-01 1.518917e+00 0.0576383 0.6113919 0.4679198
IL4I1 1.3620275 528.00406 -256.00203 1.8786334 -0.5816736 0.1110627 -0.2524904 -0.0114181 0.8856581 2.099652e+00 1.174757e-01 1.518260e+00 0.1473327 0.9429539 0.4680735
IL1RL2 0.2869679 201.30063 -92.65032 -0.0764845 -0.1989275 -0.4172909 0.0599226 0.5680635 -0.2857566 4.531560e-02 1.222256e-01 1.498484e+00 0.8314248 0.9407171 0.4727248
FGF14-AS2 0.3313764 403.12419 -193.56209 0.9507309 0.6346271 0.3081078 0.4996256 -0.2921382 -0.5139398 6.064395e+00 1.177912e+00 1.469271e+00 0.0137934 0.5549062 0.4796802
LGALSL 0.2482274 560.81209 -272.40605 2.1874928 0.0314576 -0.2276721 -0.0439360 0.3339869 0.0174188 1.480725e+00 7.153210e-02 1.450659e+00 0.2236610 0.9648660 0.4841650
IFNLR1 1.0229762 184.62266 -84.31133 -0.4393335 -0.0734795 0.1237486 -0.8281954 -0.6959707 0.5730202 3.620931e-01 8.042210e-01 1.431597e+00 0.5473461 0.6689068 0.4888016
CXCR6 1.0002408 286.82303 -135.41151 0.8283213 -1.0969310 -0.0428494 -0.9243985 0.3334078 0.9888635 7.099988e+00 1.909220e+00 1.422710e+00 0.0077084 0.3849623 0.4909784
IGHJ1 4.8593009 880.38397 -432.19198 5.4033337 -0.7448368 0.8620154 -1.1135829 -1.4281191 -0.6476466 7.103022e+00 4.738630e+00 1.399711e+00 0.0076954 0.0935448 0.4966569
FGF11 0.3177769 344.41584 -164.20792 1.0943614 -0.3727706 -0.1886793 -0.0549540 0.1361854 0.5521568 1.129714e+00 2.035875e+00 1.390291e+00 0.2878363 0.3613395 0.4990019
SVIL-AS1 0.0569996 641.07262 -312.53631 2.9171692 0.1161941 0.1283254 0.0578126 0.0016574 0.1996717 5.277121e+00 1.695259e+00 1.382119e+00 0.0216075 0.4284293 0.5010450
DUSP4 0.6229931 314.48258 -149.24129 0.6350515 -0.9309107 0.2931255 0.0196910 0.1771041 0.7591560 7.205898e+00 1.604691e+00 1.375592e+00 0.0072664 0.4482764 0.5026828
FGF18 0.5512359 447.34906 -215.67453 1.0427626 0.4477057 0.1167212 0.1644230 0.2795650 -0.3369492 6.107531e+00 1.366360e+00 1.375362e+00 0.0134607 0.5050086 0.5027405
IGHV3-66 4.6401528 758.59791 -371.29896 5.3181190 -1.4823603 -0.9149140 -1.0191590 -0.5231714 0.9641892 1.000346e+01 4.999169e+00 1.364479e+00 0.0015625 0.0821191 0.5054836
IL10 0.8107031 450.08345 -217.04172 1.4566865 -0.1921039 0.1326389 -0.4298377 0.2674464 0.7010656 5.563780e-02 1.637940e+00 1.362542e+00 0.8135284 0.4408855 0.5059735
IL10RB 0.0588211 636.75546 -310.37773 3.2773222 -0.1099203 0.0025650 -0.0867889 0.1664421 0.1451550 6.089740e-02 1.458868e+00 1.356633e+00 0.8050831 0.4821819 0.5074705
IGHV3OR15-7 5.4030956 372.25237 -178.12619 0.6463981 0.1724349 0.6297945 0.3349415 -0.1868876 -1.6150854 1.643455e-01 1.759776e+00 1.348222e+00 0.6851868 0.4148293 0.5096093
FGFR1 0.1784490 876.02828 -430.01414 3.6583528 0.1934197 0.1432198 0.3384047 0.1339267 -0.1689350 4.623031e+00 1.323256e+00 1.345068e+00 0.0315455 0.5160105 0.5104135
IL12RB2 0.4869271 191.29516 -87.64758 0.0967225 -0.8850147 -0.4086487 -0.7350302 0.7679047 0.5895136 2.332573e+00 1.343253e+00 1.323697e+00 0.1266923 0.5108769 0.5158969
IGHV4-80 6.0288770 447.65319 -215.82660 1.8552711 -0.1625738 0.8511690 -0.2915145 -1.3878615 -0.5644640 2.186919e+00 1.030450e+00 1.317995e+00 0.1391875 0.5973660 0.5173698
IGHV3-19 5.6504384 627.17293 -305.58647 3.2086006 0.0856310 0.4237892 -0.4094945 -1.2942500 -0.9420310 1.318650e+00 1.637090e+00 1.314059e+00 0.2508346 0.4410729 0.5183890
XBP1 0.4853172 1034.41376 -509.20688 5.1616562 -0.3282259 0.2845946 -0.1965975 -0.3913744 -0.1061421 1.020996e+01 1.954595e+00 1.300609e+00 0.0013968 0.3763268 0.5218868
ILF3-AS1 0.1509798 524.96388 -254.48194 2.3121530 0.4022699 0.0311340 0.3195922 -0.1259312 -0.3100407 7.710784e+00 2.075767e+00 1.292434e+00 0.0054892 0.3542036 0.5240244
IGHV3OR16-9 5.2911942 647.54801 -315.77400 3.5924760 -0.9425704 0.5715768 -0.6488834 -0.2060325 -1.4744219 6.914494e+00 7.106421e+00 1.248964e+00 0.0085500 0.0286326 0.5355388
FGFR2 1.2147242 282.38613 -133.19307 0.8205801 -0.8372991 -0.9113778 -1.1082279 0.2277330 0.9762693 2.784819e+00 3.637824e+00 1.243607e+00 0.0951615 0.1622021 0.5369750
FRZB 0.6480875 508.00298 -246.00149 1.6992693 0.5090009 -0.6018768 -0.1303816 0.1829540 -0.4236336 5.670899e+00 3.442249e+00 1.230113e+00 0.0172486 0.1788649 0.5406104
LILRB5 0.2315324 829.47672 -406.73836 3.3690342 0.2537090 0.4483112 0.5174154 0.0123111 -0.2974254 2.986222e+00 6.780831e+00 1.226453e+00 0.0839759 0.0336947 0.5416006
PAX5 1.5557622 187.64812 -85.82406 -0.2626672 -0.3717196 -0.1079792 -0.8013917 -0.7103589 0.5920012 1.348380e+00 1.002282e+00 1.219423e+00 0.2455615 0.6058391 0.5435077
IGHJ4 3.7319498 1387.46185 -685.73093 8.6095091 -0.6628248 -0.0772725 -0.5403273 -0.7804213 -1.1082984 8.091805e+00 3.903968e+00 1.216027e+00 0.0044466 0.1419921 0.5444313
IGHV4-39 3.9754180 1058.78813 -521.39406 6.4498721 -0.5371045 0.3155041 -0.1919211 -1.0446428 -0.3809378 5.463874e+00 4.724183e-01 1.173488e+00 0.0194136 0.7896155 0.5561352
IGHV3-75 5.8079757 299.00235 -141.50117 0.2004681 0.4180237 0.8864706 -1.1103903 -1.3265418 -0.7134985 1.593679e-01 4.465186e+00 1.160746e+00 0.6897391 0.1072500 0.5596895
A1BG 0.7315062 659.24245 -321.62123 2.5750839 0.1589435 0.2041418 0.3195477 -0.1876172 0.3732159 7.752708e-01 4.062941e+00 1.159966e+00 0.3785914 0.1311425 0.5599078
IL2RA 0.8172636 383.82561 -183.91280 1.3778415 -0.9252582 -0.0644002 -0.7371289 0.2600296 0.7209681 7.886036e+00 1.543227e+00 1.143131e+00 0.0049818 0.4622665 0.5646407
ILF2 0.0567107 796.59232 -390.29616 4.2326316 -0.0883269 -0.0240809 -0.0254403 0.1284804 0.1191407 6.807190e-02 2.364437e-01 1.134719e+00 0.7941651 0.8884989 0.5670207
IGHV3-73 5.5748075 622.52588 -303.26294 3.2677890 0.0258433 0.0097916 0.0408851 -1.0668258 -1.1599586 1.430406e+00 1.036315e+00 1.130299e+00 0.2316982 0.5956170 0.5682751
IGHV3-20 5.0532969 752.29260 -368.14630 4.2400766 -0.4093831 0.6716454 -0.2041699 -0.7856899 -1.3075785 4.017931e+00 2.973567e+00 1.128805e+00 0.0450189 0.2260988 0.5686997
LILRB2 0.3688626 720.04140 -352.02070 3.3138241 -0.4485540 0.1439515 -0.2042463 0.0553091 0.4023511 6.034736e+00 1.239931e+00 1.128667e+00 0.0140271 0.5379629 0.5687390
IL1R1 0.1506835 759.63388 -371.81694 3.2914650 0.0343785 0.0546949 0.1182757 0.1130738 -0.1607552 2.318468e-01 4.432693e-01 1.117071e+00 0.6301578 0.8012080 0.5720461
IGHV3OR16-7 7.6010564 262.63683 -123.31841 0.4331590 -0.5729409 -1.2754148 0.4335564 -0.0861267 -1.7851055 2.056197e+00 3.134214e+00 1.101136e+00 0.1515881 0.2086479 0.5766221
IGHV1-3 4.9109382 821.42033 -402.71017 5.1200880 -0.8752466 0.3279901 -0.1428809 0.0521006 -1.2084592 5.358915e+00 2.825650e+00 1.097854e+00 0.0206166 0.2434545 0.5775692
IL5RA 0.8578468 253.64362 -118.82181 0.0504819 0.0800551 0.2657266 -0.3010222 -0.6170539 0.0546611 2.282164e-01 4.923693e-01 1.093758e+00 0.6328495 0.7817778 0.5787532
IGHG2 2.9568575 1231.30910 -607.65455 6.9509736 -0.7929588 0.4323255 -0.3730065 -0.5142149 0.5759276 5.137912e+00 2.844710e-01 1.087005e+00 0.0234088 0.8674170 0.5807107
IGHV3-30 3.7607324 1119.75224 -551.87612 6.9289606 -0.6114027 0.2442451 -0.8450346 -0.9524191 -0.6462363 6.925764e+00 4.481132e+00 1.058646e+00 0.0084963 0.1063983 0.5890035
CD27 1.2304771 689.70332 -336.85166 2.7373035 -0.1598486 0.5031703 -0.3994594 -0.4567183 0.1738945 1.393549e+00 2.110340e+00 1.009589e+00 0.2378067 0.3481333 0.6036295
IL7R 0.7740563 569.29512 -276.64756 1.9773962 -0.2265893 0.2511303 -0.3789873 -0.2350837 0.3743340 1.159026e+00 6.553051e-01 9.953304e-01 0.2816676 0.7206134 0.6079484
UBFD1 0.0873723 501.35866 -242.67933 2.1289503 -0.1940922 -0.0485517 -0.0153496 0.1416840 0.2525556 7.472853e-01 4.599354e-01 9.880261e-01 0.3873371 0.7945593 0.6101728
IGHV3-64D 5.5198810 769.34542 -376.67271 4.8970506 -0.7133577 -0.3703652 0.0107832 -0.3665819 -1.3409468 4.953697e+00 1.342254e+00 9.786097e-01 0.0260349 0.5111322 0.6130524
IL21R 0.9134103 398.34952 -191.17476 1.5213549 -0.8934772 0.2088124 -0.6065805 -0.2304301 0.4468168 1.309745e+01 2.146682e+00 9.618040e-01 0.0002957 0.3418645 0.6182255
RALA 0.0897153 589.80242 -286.90121 2.7007652 0.0104430 0.0813353 -0.0361392 0.0417318 0.2184599 7.339002e-01 1.059109e+00 9.599155e-01 0.3916219 0.5888671 0.6188095
IL1RL1 0.5025456 167.99839 -75.99920 -0.6280073 -0.2110235 -0.1960041 -0.2183785 0.7335873 0.2182680 1.379293e-01 5.251253e-01 9.588389e-01 0.7103483 0.7690782 0.6191427
LILRB1 0.4202910 599.44431 -291.72215 2.4473229 -0.4822116 0.1623151 -0.2440362 0.0255586 0.4043087 5.734222e+00 8.001336e-01 9.571815e-01 0.0166374 0.6702753 0.6196560
IGHV2-5 4.7185316 907.76953 -445.88476 5.4872531 -0.5233417 0.4094835 -0.3802705 -1.0321743 -0.4564391 4.575220e+00 9.789643e-01 9.559675e-01 0.0324376 0.6129437 0.6200323
ZWILCH 0.0900126 394.19571 -189.09786 1.3412829 -0.0722834 0.0772149 -0.0010805 0.1963727 0.3068517 3.281703e-01 1.675502e+00 9.552656e-01 0.5667385 0.4326826 0.6202499
C1GALT1 0.4006421 623.14677 -303.57339 2.6524425 -0.4214557 0.0110845 -0.1528614 0.2133810 0.3839864 2.833930e+00 3.359477e-01 9.286080e-01 0.0922923 0.8453759 0.6285724
IL17B 0.8823973 240.63478 -112.31739 -0.1653491 0.3223773 0.0695275 0.0431675 -0.6438616 -0.0947409 7.423460e-02 5.572682e-01 9.183091e-01 0.7852681 0.7568168 0.6318176
IL7 0.3356518 291.06203 -137.53101 0.6925051 -0.4048981 -0.0142284 -0.1207384 0.3326767 -0.1839628 2.051368e+00 1.306889e+00 9.177841e-01 0.1520695 0.5202506 0.6319835
IL18 0.3726359 650.65968 -317.32984 3.0960978 -0.3954662 -0.0727600 -0.2719333 0.2106991 0.3335364 3.072336e+00 5.244720e-01 8.905126e-01 0.0796350 0.7693294 0.6406600
IL13RA1 0.0801684 783.57956 -383.78978 3.5101484 0.0780218 0.1617373 0.0500070 0.1446072 0.0247028 3.818839e+00 3.568132e+00 8.849723e-01 0.0506794 0.1679539 0.6424373
ISG15 0.7635947 962.78711 -473.39356 4.3546988 0.1189553 -0.0205703 -0.3120895 0.3937507 0.0977166 2.268733e+00 1.984494e+00 8.823427e-01 0.1320078 0.3707427 0.6432825
IGHJ5 3.8397040 1324.09044 -654.04522 8.2436155 -0.6728095 0.1525815 -1.0626642 -0.8549612 -0.1291306 5.803515e+00 4.025226e+00 8.762228e-01 0.0159942 0.1336390 0.6452539
RILPL2 0.0916242 391.62388 -187.81194 1.5439327 0.3251196 0.0802266 0.1718770 -0.0940749 -0.2782589 4.220832e+00 5.851100e-02 8.601253e-01 0.0399306 0.9711683 0.6504684
IGHE 3.1391557 398.44729 -191.22365 1.0428698 -0.1749112 0.3240153 0.1665488 -0.8256708 -0.6085286 2.098311e+00 5.015100e-02 8.510176e-01 0.1474619 0.9752363 0.6534372
CXCR4 0.5232822 789.09586 -386.54793 3.4755226 -0.2194088 0.0729468 -0.1454852 -0.2049316 0.2145784 2.251049e+00 2.187850e-02 8.420746e-01 0.1335239 0.9891203 0.6563656
HP 2.2796151 454.81656 -219.40828 1.9300346 -1.0250095 -1.3033898 -0.2166393 0.6670524 0.7437288 2.557942e+00 4.951229e+00 8.381203e-01 0.1097414 0.0841113 0.6576646
IFNAR2 0.1371482 601.21373 -292.60687 2.9662056 -0.0631647 0.1929372 -0.0892558 -0.1606412 0.0385769 1.541031e+00 2.328515e+00 8.284147e-01 0.2144644 0.3121543 0.6608639
CXCL5 1.8931942 213.06715 -98.53357 -0.6464177 0.0774972 -0.3849540 0.5539001 -1.0106829 -0.4125022 3.953205e-01 2.881171e+00 8.276328e-01 0.5295159 0.2367891 0.6611223
IGHV3-52 5.4873958 275.89718 -129.94859 0.1496761 -1.1413114 0.7693762 -0.3189468 -0.9412742 0.3584229 5.922919e+00 5.624326e-01 8.258003e-01 0.0149452 0.7548650 0.6617283
LAMP5 1.1306199 338.93732 -161.46866 0.8214996 -0.6149346 0.1701641 -0.4711498 -0.5150147 0.0701669 7.499833e+00 9.104360e-01 8.087949e-01 0.0061705 0.6343097 0.6673788
IL36G 13.0972755 250.37590 -117.18795 1.5873949 -2.8553044 -2.5167642 -2.2506782 1.6945845 1.3602836 5.224139e+00 3.938268e+00 8.076322e-01 0.0222755 0.1395777 0.6677669
NEIL3 0.7218268 104.48231 -44.24115 -1.2812819 -0.7551232 -0.2333040 -0.3897848 0.3113608 1.2029242 4.192494e-01 2.626793e-01 8.069621e-01 0.5173118 0.8769199 0.6679907
IGHV4-55 5.0546902 776.43992 -380.21996 4.2645812 -0.2072914 0.4884851 -0.3532144 0.2066248 -0.9412292 4.514171e-01 4.559299e+00 7.896188e-01 0.5016628 0.1023200 0.6738085
GATA1 0.7087481 185.27709 -84.63854 -0.9293877 0.5128685 0.4877094 0.4383256 -0.5316869 -0.7426346 1.731065e-01 2.558783e-01 7.871709e-01 0.6773656 0.8799069 0.6746337
FGF10 0.6728256 609.03451 -296.51725 2.0476560 0.0776409 0.1823735 0.2079691 0.3245756 -0.0795877 8.673627e-01 1.592526e+00 7.755291e-01 0.3516865 0.4510112 0.6785721
IGHV2-70D 5.7476866 588.52127 -286.26064 3.5361891 -0.5498974 -0.1318975 -0.8716215 -0.8347660 -1.0674966 4.171722e+00 2.950136e+00 7.707126e-01 0.0411040 0.2287632 0.6802082
IGHJ2 4.5078685 961.62234 -472.81117 6.4301014 -1.1206941 -0.3619729 -1.4798569 -0.5416608 0.5334334 6.982680e+00 4.145301e+00 7.648530e-01 0.0082302 0.1258518 0.6822040
EAF2 0.5317739 504.98658 -244.49329 2.0968998 -0.4622582 0.1802003 -0.3622584 -0.1706221 0.2631477 6.903139e+00 1.670895e+00 7.613361e-01 0.0086045 0.4336804 0.6834047
ILVBL 0.0968703 584.42863 -284.21432 2.9129848 -0.0722184 -0.0149202 0.2322071 0.1345410 -0.0365253 1.325419e-01 3.844234e+00 7.541905e-01 0.7158109 0.1462969 0.6858508
IGHV4-31 4.5025298 839.42936 -411.71468 5.0730935 -0.6207908 0.4423085 -0.7330294 -0.8306194 -0.7121596 5.537747e+00 3.814508e+00 7.287134e-01 0.0186105 0.1484876 0.6946434
IGHMBP2 0.1623800 553.21979 -268.60989 2.2164673 0.2152612 0.0878573 0.2619122 -0.1257593 -0.2418370 1.115331e+00 5.825060e-01 7.282167e-01 0.2909261 0.7473266 0.6948159
FGF12 0.6138578 153.01277 -68.50639 -0.9073266 -0.0275109 0.1230625 -0.0005961 -0.3827590 0.4714259 1.308560e-02 4.549671e-01 7.246263e-01 0.9089268 0.7965355 0.6960644
OASL 0.4851495 420.61489 -202.30745 1.4552966 -0.1293267 -0.0890858 -0.6921828 0.3140775 0.3431409 9.095810e-02 4.396695e+00 7.160696e-01 0.7629626 0.1109864 0.6990488
IGHV7-34-1 6.4794561 347.17338 -165.58669 0.6717124 -0.8429642 1.0865939 -1.0715000 -0.4461881 0.9183842 2.097911e+00 3.773823e+00 7.109777e-01 0.1475006 0.1515391 0.7008308
MMP10 2.8949821 144.27037 -64.13518 -1.7328498 0.4273943 0.1153113 1.1210261 -0.5415113 -1.2307174 1.621210e-02 9.851887e-01 7.079137e-01 0.8986817 0.6110391 0.7019053
FGFR1OP2 0.0617269 598.74936 -291.37468 2.8632482 0.0065042 0.0814856 -0.0622989 0.1196130 0.1350071 1.206632e+00 2.372019e+00 7.065082e-01 0.2720001 0.3054377 0.7023987
IGHV4-61 4.2715546 822.56169 -403.28085 4.3527726 -0.3897712 0.8312234 -0.6765639 -0.9592656 -0.7040025 2.386299e+00 2.829213e+00 7.054062e-01 0.1224031 0.2430213 0.7027858
IGHJ6 7.8492731 845.16912 -414.58456 5.5695540 -0.1118225 -0.5436253 0.6847799 -0.6917488 -1.4672772 9.148758e-01 8.579877e-01 7.051772e-01 0.3388240 0.6511639 0.7028663
CD38 0.7257801 467.59925 -225.79962 1.8662532 -0.6743817 0.2347239 -0.3693754 -0.2250468 0.2541107 1.123567e+01 1.468163e+00 6.883003e-01 0.0008024 0.4799462 0.7088225
PHOSPHO1 0.7415235 452.46491 -218.23246 1.5126435 -0.0546034 0.1030844 0.2253072 -0.3919313 -0.1941337 1.150360e+00 5.603647e-01 6.590700e-01 0.2834739 0.7556459 0.7192581
IL17RC 0.0716512 604.09741 -294.04871 2.9248925 0.0166850 -0.0588301 0.1562546 0.0841883 -0.0786741 1.614139e-01 1.128165e+00 6.531159e-01 0.6878581 0.5688820 0.7214026
IGHV3-48 4.4702133 918.49438 -451.24719 5.6756797 -0.5869577 -0.3211707 -0.9555437 -0.1318878 0.8277601 1.028905e+00 9.777582e-01 6.455050e-01 0.3104160 0.6133135 0.7241530
RSAD2 0.4760226 474.49566 -229.24783 1.6154121 0.1992986 0.0204843 -0.4761773 0.3121229 0.1222856 3.671734e+00 5.316481e+00 6.366080e-01 0.0553426 0.0700714 0.7273816
TIGIT 1.1108144 405.91026 -194.95513 1.3674899 -0.2637062 0.1108858 -0.8601870 -0.4022617 0.0977692 2.160186e+00 4.618969e+00 6.315203e-01 0.1416275 0.0993124 0.7292343
CXCL10 2.0447383 726.57736 -355.28868 3.2165568 -0.5254700 0.1299150 -1.0690666 -0.1239497 0.6076779 1.462720e+00 2.225669e+00 6.294470e-01 0.2264978 0.3286262 0.7299907
CARMIL1 0.1028348 442.96319 -213.48160 1.4705383 0.2716922 0.1618838 0.3546988 -0.0254269 -0.2232918 3.430854e+00 1.845207e+00 6.098819e-01 0.0639890 0.3974828 0.7371669
VIL1 1.7371784 165.35256 -74.67628 -1.2457883 0.5407374 -0.0038141 0.3781710 -0.2338293 -0.9686868 3.082558e-01 7.520300e-02 6.097192e-01 0.5787525 0.9630967 0.7372269
IL11 1.2359912 185.35393 -84.67697 -0.8405012 0.2691142 0.0718713 0.2071962 -0.4698923 0.3089184 2.392190e-01 1.164908e+00 6.038425e-01 0.6247708 0.5585260 0.7393963
STIL 0.1350939 180.36947 -82.18473 -0.2446167 -0.2513391 -0.0044314 -0.1113825 0.0467554 0.5115106 1.897534e-01 2.305244e-01 5.986259e-01 0.6631220 0.8911325 0.7413274
IFNG-AS1 0.7898257 203.07394 -93.53697 -0.2695855 -0.2931844 0.3458390 -0.4074723 -0.3878166 0.2945886 1.445584e+00 9.173885e-01 5.984400e-01 0.2292379 0.6321085 0.7413963
ODC1 0.1071104 651.75450 -317.87725 3.2227289 -0.0934069 0.0160838 -0.1026194 -0.0435622 0.1311395 9.731222e-01 8.868390e-02 5.979078e-01 0.3239027 0.9566268 0.7415936
IGHV7-81 5.5504870 375.07333 -179.53666 1.0100528 -0.2880539 0.6231212 -0.4235900 -0.7321743 -0.9537986 1.973229e+00 2.356260e+00 5.803820e-01 0.1601055 0.3078539 0.7481206
IL16 0.1837841 678.68234 -331.34117 3.1713932 -0.0569805 -0.0269019 -0.2932704 0.1016969 0.2092840 5.552200e-02 1.622432e+00 5.783028e-01 0.8137190 0.4443174 0.7488988
FGF5 1.1820533 89.11771 -36.55885 -2.0196140 -0.1909579 -0.0824378 -0.1871443 0.1729210 1.1952056 7.187250e-02 6.236293e-01 5.770793e-01 0.7886296 0.7321172 0.7493571
IGHG1 4.7130203 1612.98282 -798.49141 9.3727395 -0.7650183 0.3052766 -0.1083078 -0.7522207 -0.0496045 5.087473e+00 4.715710e-02 5.765223e-01 0.0240993 0.9766972 0.7495658
FGF16 1.4281904 186.24654 -85.12327 -1.1537274 0.4091612 0.4562552 -0.1667826 -0.0291260 0.7659686 1.771694e+00 9.784339e-01 5.712466e-01 0.1831726 0.6131063 0.7515457
IGHV1OR16-4 9.0994974 428.85833 -206.42917 2.2244313 -0.6763371 -0.1615795 -1.0187440 0.7690499 -0.5386195 5.622984e-01 2.904866e+00 5.707478e-01 0.4533357 0.2340003 0.7517331
IGHV1OR16-3 31.8328345 355.05770 -169.52885 0.9134714 2.1962056 -2.9929130 -2.9929130 -2.1962056 -1.0429171 9.492821e-01 9.128012e+00 5.661972e-01 0.3299021 0.0104202 0.7534455
IGHV3-42 8.4017375 274.32550 -129.16275 0.0228469 0.5795276 -0.3068978 -1.7159310 -1.0105787 0.1678855 1.162027e-01 3.029758e+00 5.636080e-01 0.7331901 0.2198347 0.7544215
IL23A 0.2621430 236.86579 -110.43289 0.1334847 -0.1690630 0.1450965 0.0289176 -0.0480551 0.3826365 1.865310e-01 6.103215e-01 5.634099e-01 0.6658196 0.7370049 0.7544963
IL17RE 0.3869151 398.68640 -191.34320 1.1600298 -0.1234049 0.1054213 0.3666515 -0.2902773 -0.0238639 1.603465e+00 2.436382e+00 5.577856e-01 0.2054129 0.2957647 0.7566210
IL34 0.3022231 523.93937 -253.96969 2.0603261 0.0855798 -0.1052474 -0.2146705 0.1265642 -0.1674320 4.905531e-01 1.568111e+00 5.469453e-01 0.4836807 0.4565506 0.7607331
IGHV1OR15-1 1.9851716 569.17261 -276.58630 2.4750781 -0.8464268 0.3484549 -1.0666950 -0.4872879 0.1177892 8.427608e+00 4.531914e+00 5.457324e-01 0.0036957 0.1037307 0.7611946
IL21R-AS1 0.7340196 114.51307 -49.25653 -1.5094977 -0.1281104 0.3166125 -0.1135932 -0.2813499 0.6665638 3.254040e-02 2.396852e-01 5.445186e-01 0.8568467 0.8870600 0.7616567
PPIL4 0.1227801 561.00798 -272.50399 2.2052055 -0.0044885 0.0574514 -0.0173857 0.1322839 0.1812214 6.767741e-01 5.783453e-01 5.444995e-01 0.4106998 0.7488829 0.7616640
FTCDNL1 0.5041412 258.30312 -121.15156 0.2199378 -0.1372520 0.1417741 -0.2117290 0.0340093 0.4664227 1.405920e-02 3.418699e-01 5.382792e-01 0.9056148 0.8428764 0.7640366
IL27RA 0.2036813 446.84024 -215.42012 1.7102894 -0.1785276 0.1513903 -0.1931274 -0.0355409 0.2279208 1.186576e+00 1.185725e+00 5.362452e-01 0.2760214 0.5527427 0.7648140
CXCL11 2.3669596 367.35717 -175.67859 1.3327075 -0.4474993 -0.2847792 -1.6257457 0.0452374 0.7334161 5.358692e-01 4.988457e+00 5.256637e-01 0.4641497 0.0825601 0.7688712
IMPAD1 0.0612541 537.68592 -260.84296 2.1849938 0.0614114 0.2079468 0.0885599 0.0274183 0.1606260 1.564225e+00 3.719340e+00 5.188564e-01 0.2110476 0.1557240 0.7714926
IL26 1.1769603 192.97014 -88.48507 -0.5320617 -0.1497382 0.3773432 0.0413561 -0.4810704 -0.6513274 1.432385e+00 5.511574e-01 5.058414e-01 0.2313756 0.7591327 0.7765295
IL12RB1 0.3537914 409.97698 -196.98849 1.4359069 -0.3163418 0.2573398 -0.2816855 0.0666026 0.3271704 1.800330e+00 3.890074e+00 5.016685e-01 0.1796726 0.1429820 0.7781513
IGLL5 3.1663664 1054.45397 -519.22698 6.0530861 -0.6179434 0.1360618 -0.5808466 -0.5172405 0.1114836 4.201341e+00 1.061057e+00 4.988475e-01 0.0403920 0.5882941 0.7792497
FGFR1OP 0.0690095 432.06088 -208.03044 1.7512256 -0.1975644 0.0804926 -0.0025490 0.0944423 0.2002521 1.208402e+00 1.072490e+00 4.964954e-01 0.2716489 0.5849407 0.7801667
CXCL8 1.5200815 426.79517 -205.39759 1.0984717 -0.5694004 -0.3104100 0.1881102 0.0855506 0.7358033 1.526139e+00 1.500179e+00 4.915820e-01 0.2166928 0.4723243 0.7820857
IL31RA 0.9998531 104.09403 -44.04702 -1.5324347 -0.1762438 -0.2583872 -0.7871957 0.3309227 1.0907490 5.788040e-02 3.575930e-02 4.805492e-01 0.8098780 0.9822793 0.7864119
HYAL3 0.1288294 257.09937 -120.54968 0.5455092 -0.0525411 -0.2072548 -0.1740612 0.2887051 0.1668928 2.130145e-01 1.526625e-01 4.784604e-01 0.6444148 0.9265092 0.7872336
FGF2 0.3792747 362.90064 -173.45032 0.4762895 0.5319026 0.4403356 0.2558395 -0.2505106 -0.3087428 3.616090e+00 1.623161e+00 4.762900e-01 0.0572232 0.4441555 0.7880884
FGF7P3 0.7650171 220.21285 -102.10642 -0.4845040 0.1175023 0.1551021 0.7234411 0.0639219 -0.4553387 7.649300e-03 1.650271e+00 4.757265e-01 0.9303057 0.4381757 0.7883105
PI16 1.8354171 622.89736 -303.44868 2.6935450 -1.1831491 0.1765288 0.7527440 0.3973588 0.5032503 9.056431e+00 5.407174e+00 4.740141e-01 0.0026177 0.0669649 0.7889857
FGFBP1 3.1844309 300.68243 -142.34122 1.8797046 -1.7817149 -1.4702584 -1.2045930 0.3728966 0.8605560 7.663651e+00 2.857138e+00 4.721976e-01 0.0056344 0.2396516 0.7897026
STAG3L5P-PVRIG2P-PILRB 0.1965810 517.08168 -250.54084 1.8868572 0.0148123 0.1953153 0.2506258 -0.1303705 -0.2163778 4.270272e-01 5.787994e-01 4.670850e-01 0.5134513 0.7487129 0.7917240
FGFBP3 0.1364815 232.37947 -108.18973 -0.0037964 0.3400642 0.0791045 0.3773624 0.0151099 -0.3257293 1.671356e+00 5.995794e-01 4.658205e-01 0.1960770 0.7409740 0.7922247
PDCD1 1.0394244 375.95438 -179.97719 1.3384284 -0.7301784 0.0395046 -0.6279106 -0.0120242 0.4425558 6.183987e+00 1.735498e+00 4.540735e-01 0.0128912 0.4198958 0.7968915
IGHV1OR15-4 4.2143279 511.95438 -247.97719 2.2540360 -0.2053635 0.6197109 -0.7095592 -0.6162249 0.0132092 9.320032e-01 2.717435e+00 4.468094e-01 0.3343429 0.2569902 0.7997911
IGHV3-33 4.1705169 1033.79046 -508.89523 6.1563693 -0.6124224 0.0794686 -0.1628623 -0.5650635 0.1122094 3.290072e+00 1.675962e-01 4.459135e-01 0.0697000 0.9196169 0.8001495
MILR1 0.2303157 613.66713 -298.83356 2.6349849 -0.2531382 0.1173176 -0.0155932 0.1386273 0.1939895 1.758717e+00 1.124530e+00 4.452726e-01 0.1847846 0.5699167 0.8004059
XCR1 0.9625341 223.37687 -103.68844 -0.1556596 -0.6625253 0.4185931 -0.4366387 0.3909869 0.5602890 1.369375e+00 3.993616e+00 4.397415e-01 0.2419193 0.1357680 0.8026225
IL15 0.1854734 461.67742 -222.83871 1.8157712 0.0504169 0.2224258 0.1117720 -0.1020974 -0.2198225 7.464100e-02 1.761291e+00 4.337339e-01 0.7846956 0.4145152 0.8050371
IGHV7-4-1 5.5413997 726.28453 -355.14226 4.9464079 -1.6348527 0.8667185 -2.0852260 -0.7118372 -0.6593898 1.439987e+01 1.536405e+01 4.239237e-01 0.0001478 0.0004610 0.8089955
CXCL2 0.5853667 527.11356 -255.55678 2.0078174 -0.3973195 -0.1346121 -0.1696973 0.1254617 0.3355780 2.131684e+00 7.990670e-02 4.214858e-01 0.1442822 0.9608343 0.8099823
FGFR4 0.5799627 165.13249 -74.56625 -0.6828577 -0.1900089 -0.3323093 0.2502846 0.5176440 0.1319809 2.747800e-03 7.242737e-01 4.123747e-01 0.9581942 0.6961871 0.8136806
CXCL14 1.0392313 944.27380 -464.13690 4.9085575 -0.9752076 -0.2840320 -0.6578199 0.3354798 0.2618381 1.102271e+01 2.211101e+00 4.101956e-01 0.0009000 0.3310287 0.8145676
VILL 0.1258849 431.92818 -207.96409 1.8265553 0.0769352 0.0849171 0.2433713 -0.1249958 -0.1714025 4.100100e-03 1.208061e+00 4.076200e-01 0.9489448 0.5466040 0.8156173
IGHV4-28 4.9646684 668.07077 -326.03539 3.8530319 -0.5631419 0.0373668 -0.6496586 0.5032995 -0.2839508 8.116606e-01 2.716447e+00 4.072836e-01 0.3676297 0.2571172 0.8157545
COIL 0.0171416 374.95826 -179.47913 1.5111783 0.0562886 0.0361560 0.1245671 0.1140593 -0.0414524 8.092169e-01 9.290124e-01 4.069429e-01 0.3683519 0.6284454 0.8158935
FGF20 1.5540806 138.32441 -61.16221 -1.7627536 0.2949364 0.3121851 0.8652911 0.2478575 -0.5436782 2.614053e-01 1.035904e+00 3.989397e-01 0.6091564 0.5957393 0.8191649
IGHV1-2 3.8667624 965.48702 -474.74351 5.6602683 -0.6034698 0.0482776 -0.1332682 0.0703626 -0.6166938 2.769550e+00 8.787422e-01 3.931980e-01 0.0960731 0.6444416 0.8215200
RILPL1 0.1145048 526.17188 -255.08594 2.2411685 0.0207750 -0.0836560 0.1867887 0.0402634 -0.1261545 5.610200e-03 1.265372e+00 3.847288e-01 0.9402933 0.5311632 0.8250062
IL6 1.7518860 516.59632 -250.29816 2.0992472 -1.3250283 -0.4098507 0.1779651 0.3301030 -0.1030650 7.893237e+02 5.396863e-01 3.794731e-01 0.0000000 0.7634992 0.8271770
CXCR5 2.8048181 447.22158 -215.61079 1.1096194 -0.0035314 0.1067084 0.3301688 -0.3377401 -0.6035082 4.447966e-01 3.806070e-02 3.779376e-01 0.5048164 0.9811496 0.8278123
IGHV1OR16-1 6.2737699 448.06447 -216.03224 2.1609085 -0.9202375 0.1385083 -0.7879471 0.1506479 -0.7546508 3.333162e+00 3.280969e+00 3.641875e-01 0.0678962 0.1938861 0.8335232
IL2RB 0.6578507 401.62465 -192.81233 1.4152525 -0.6766291 0.0512408 -0.3695113 0.0485149 0.3507614 7.199433e+00 7.567891e-01 3.606767e-01 0.0072927 0.6849602 0.8349877
EMILIN2 0.2099529 724.12953 -354.06477 3.3685866 -0.1563030 0.2751906 0.2831379 0.1301881 -0.0023829 1.027734e+00 8.936038e+00 3.602829e-01 0.3106915 0.0114700 0.8351521
LILRB4 0.5771483 880.90978 -432.45489 3.9579631 -0.3393928 0.2028156 -0.1049390 0.1851578 0.2397312 1.549199e+00 1.648888e+00 3.431994e-01 0.2132538 0.4384787 0.8423163
SIL1 0.3509430 745.83151 -364.91576 3.5815283 -0.0202192 0.1251435 0.2319395 -0.1225643 0.0764270 1.402141e-01 2.378407e+00 3.398429e-01 0.7080683 0.3044637 0.8437311
CXCR3 0.9621586 420.19236 -202.09618 1.5795176 -0.7533636 0.1902980 -0.4824692 -0.0021414 0.3578279 7.866802e+00 2.227993e+00 3.389410e-01 0.0050351 0.3282444 0.8441117
IL18BP 0.4037688 630.39579 -307.19789 2.9254876 -0.3846910 0.0717069 -0.1624949 -0.0720922 0.1631207 6.525910e+00 3.475811e-01 3.388928e-01 0.0106314 0.8404729 0.8441320
IGHV3-13 4.3335421 604.92102 -294.46051 3.8261268 -1.7571501 0.0752347 -0.7266719 -0.6153906 -0.2889143 1.775105e+01 1.624753e+00 3.251277e-01 0.0000252 0.4438021 0.8499618
IL12A 0.3067847 160.70623 -72.35311 -0.5272648 -0.0319105 -0.1703801 -0.4267201 -0.0962169 0.4133806 1.768900e-03 4.059892e-01 3.191501e-01 0.9664522 0.8162827 0.8525060
FGF9 1.1886771 151.84508 -67.92254 -0.9926468 0.5491007 -0.8216629 -0.2521326 0.2514642 -0.4842403 1.413438e+00 1.955093e+00 3.186990e-01 0.2344864 0.3762330 0.8526983
RADIL 0.4588615 342.96514 -163.48257 0.5452758 0.3222814 0.1129023 0.4064493 0.0357462 -0.2557050 1.813233e+00 1.038172e+00 3.170191e-01 0.1781209 0.5950641 0.8534148
LY6E 0.3515667 1038.90552 -511.45276 5.2056655 0.0174271 0.0624345 -0.0759116 0.1026287 -0.0899762 7.672610e-02 1.545187e+00 3.109108e-01 0.7817842 0.4618139 0.8560253
ILK 0.0598387 898.76387 -441.38193 4.4572478 0.1944982 0.0894017 0.2697250 -0.0152733 -0.0839609 8.804341e+00 2.470614e+00 3.101507e-01 0.0030051 0.2907456 0.8563506
PPIL2 0.0863844 581.04649 -282.52324 2.6550205 0.0313032 0.1469112 0.2780844 -0.0995643 -0.0842632 8.821390e-02 3.579401e+00 3.084355e-01 0.7664602 0.1670102 0.8570854
IGHV1-14 5.9704622 307.45234 -145.72617 0.8415873 -0.0519792 -0.7603251 -0.9012406 -0.2608297 -0.8624963 2.920129e-01 3.529256e+00 3.035130e-01 0.5889335 0.1712505 0.8591975
IFNGR1 0.0896459 842.22713 -413.11356 3.7689703 0.0018582 0.0828696 -0.0293806 0.0856279 0.0109413 2.510632e-01 1.199598e+00 2.957383e-01 0.6163275 0.5489218 0.8625440
NFIL3 0.1758007 583.42483 -283.71242 2.5602439 -0.3321835 -0.0427128 0.0477579 0.0807963 0.1579587 5.727681e+00 4.513974e-01 2.905580e-01 0.0166995 0.7979585 0.8647810
FGF7P6 0.7079634 167.04922 -75.52461 -0.3947204 -0.3037851 -0.8189977 -0.0933151 0.4652084 0.1348022 1.545600e-01 2.001304e+00 2.899070e-01 0.6942152 0.3676396 0.8650625
IL17RD 0.3281740 312.07710 -148.03855 0.2193467 0.4520956 0.0949993 0.2761579 0.1617941 -0.1169531 5.712008e+00 7.759953e-01 2.852014e-01 0.0168493 0.6784139 0.8671002
FILIP1 0.2056906 286.50128 -135.25064 0.4755125 0.1632489 -0.0469531 0.0958986 0.1501351 -0.1119867 1.063720e+00 3.773330e-02 2.802529e-01 0.3023682 0.9813102 0.8692483
PILRA 0.3305271 682.92297 -333.46149 3.1063427 -0.2132186 0.0968656 0.0126248 0.0123243 0.1821180 1.647871e+00 5.332772e-01 2.788111e-01 0.1992489 0.7659498 0.8698752
IGHV7-40 10.1273807 302.89795 -143.44897 1.5321191 -2.5802560 -0.7584716 -1.6733151 0.5537552 1.0315883 8.383313e+00 1.478465e+00 2.729301e-01 0.0037868 0.4774801 0.8724368
IL9R 1.3943970 192.95215 -88.47607 -0.4573984 -0.3557234 0.2111375 -0.2413711 -0.3478284 0.1767977 1.303714e+00 1.649708e-01 2.705038e-01 0.2535359 0.9208249 0.8734958
IGHV2-70 5.4446515 730.92775 -357.46387 4.5933277 -1.0754113 0.6029011 -0.8501381 -0.1702742 -0.6916518 6.458830e+00 6.165761e+00 2.638390e-01 0.0110402 0.0458271 0.8764115
EMILIN1 0.4067200 771.87037 -377.93519 3.5887758 -0.3551333 0.0082157 0.3757877 0.0769673 -0.1249557 5.611555e+00 2.388827e+00 2.622821e-01 0.0178424 0.3028815 0.8770940
IL4R 0.1139512 728.84092 -356.42046 3.2340008 -0.0643989 0.2119544 0.0580025 -0.0918541 -0.0066135 1.404714e+00 1.034229e+00 2.614293e-01 0.2359359 0.5962386 0.8774681
IFNG 1.8887340 175.81194 -79.90597 -0.3291726 -0.9412817 -0.1829109 -1.0242451 0.2354921 0.6965298 2.511750e+00 1.160698e+00 2.609617e-01 0.1130004 0.5597031 0.8776733
IL10RB-AS1 0.9984176 433.63013 -208.81506 1.2444396 -0.0540258 0.0649436 0.2727779 0.1341338 -0.1975684 3.528760e-02 3.788010e-01 2.538552e-01 0.8509943 0.8274551 0.8807974
CXCL3 0.8644953 460.23847 -222.11923 1.3956229 -0.4361336 -0.1303082 0.1632599 0.0992228 0.3350210 1.882036e+00 9.149163e-01 2.537097e-01 0.1701029 0.6328903 0.8808615
ILDR1 0.7637869 87.25219 -35.62609 -1.7330402 -0.2631261 -0.0666995 -0.4684799 -0.1974347 0.6465778 1.111708e-01 4.675820e-02 2.513788e-01 0.7388152 0.9768921 0.8818887
PADI1 10.3670246 177.16407 -80.58203 -1.7923927 0.4435987 -0.3990174 0.3136718 -0.6796462 -1.0393680 3.750000e-05 5.349791e-01 2.340410e-01 0.9951160 0.7652983 0.8895669
IFNGR2 0.1417711 823.70418 -403.85209 4.1638047 0.0531543 0.0956479 0.0724840 0.0904032 0.0503509 1.312666e+00 2.249569e+00 2.233509e-01 0.2519125 0.3247225 0.8943345
FGF7 0.7236335 596.78414 -290.39207 2.4445507 -0.4701105 -0.3070267 -0.0421748 0.2199497 0.0969517 3.084252e+00 5.117830e-01 2.224588e-01 0.0790536 0.7742260 0.8947335
TRIL 0.3773539 311.01172 -147.50586 0.3384053 0.2608191 0.1101203 0.4143410 -0.0493074 -0.2463348 7.804348e-01 9.752062e-01 2.177320e-01 0.3770082 0.6140966 0.8968506
IL10RA 0.1815313 778.10738 -381.05369 3.4772089 -0.1273802 0.2544776 0.0189644 0.0795878 0.1147855 5.180717e-01 3.477724e+00 2.152413e-01 0.4716654 0.1757202 0.8979682
IL3RA 0.2278045 623.88790 -303.94395 2.9192369 0.0167550 -0.0390552 0.1487953 0.0380615 -0.1048366 5.569300e-03 5.896715e-01 2.138196e-01 0.9405107 0.7446539 0.8986067
PPIL1 0.1337270 508.32109 -246.16054 2.4670481 -0.1721822 0.0369424 -0.0161521 0.0047970 0.1178856 2.029119e+00 1.506525e-01 2.138176e-01 0.1543100 0.9274408 0.8986076
CXCL16 0.2304216 805.66471 -394.83236 3.7284736 -0.1833163 0.1197400 0.0399015 0.1064988 0.0885273 1.249024e+00 1.226670e+00 1.984975e-01 0.2637391 0.5415417 0.9055175
NEIL2 0.0914181 432.55777 -208.27888 2.0115262 -0.0206489 -0.0195390 0.0616411 0.0598909 0.1168323 7.116360e-02 9.009791e-01 1.973649e-01 0.7896501 0.6373161 0.9060304
IL18RAP 0.5748740 276.80783 -130.40391 0.0652429 -0.0205913 0.5735076 0.1904431 -0.2176965 0.0165226 1.927077e-01 2.816428e+00 1.968272e-01 0.6606725 0.2445797 0.9062740
IL13RA2 0.5422414 454.87162 -219.43581 1.2851583 0.2072706 -0.1461028 0.0571981 0.0519137 0.2244101 1.997664e+00 8.313245e-01 1.911084e-01 0.1575418 0.6599031 0.9088691
AVIL 0.2307442 487.36206 -235.68103 1.9260852 -0.3565907 0.1704880 0.1961734 0.0987273 -0.0445950 5.960846e+00 1.833049e+00 1.877980e-01 0.0146270 0.3999065 0.9103747
IGHV3OR16-13 5.8254344 396.54358 -190.27179 1.9811997 -1.2915883 -0.1318277 -1.3814710 -0.4471699 0.0728775 7.026048e+00 3.297699e+00 1.759446e-01 0.0080332 0.1922710 0.9157862
IL33 0.3454783 674.04423 -329.02212 2.6710312 -0.0510368 0.0600236 0.0535397 0.1011619 -0.0484743 2.412610e-02 2.033907e-01 1.745251e-01 0.8765646 0.9033047 0.9164365
LILRA6 0.3247321 610.30991 -297.15495 2.2112534 0.0772776 0.3331260 0.4026142 0.0322190 -0.1223800 2.078075e-01 3.826830e+00 1.715544e-01 0.6484913 0.1475756 0.9177987
CARMIL3 0.6885289 178.42051 -81.21026 -0.3184232 -0.6095959 -0.3631838 0.0753417 0.3059944 0.2564815 1.599784e+00 8.315403e-01 1.623703e-01 0.2059339 0.6598319 0.9220230
CXCR2P1 1.0977879 185.02870 -84.51435 -0.5902085 -0.0698627 0.1913614 -0.4778839 0.0467542 -0.4204691 7.606420e-02 2.165846e+00 1.599058e-01 0.7827036 0.3386043 0.9231598
SDK2 0.6493056 242.90227 -113.45114 -0.0752330 0.3192844 -0.3623568 -0.1555088 0.2370088 0.0140592 2.041892e+00 5.322530e-01 1.531832e-01 0.1530192 0.7663422 0.9262681
LILRP1 1.9654449 84.33710 -34.16855 -2.0701129 -0.2385485 -0.3260609 -0.5583284 0.3275105 0.7787249 1.334900e-03 4.630710e-02 1.520479e-01 0.9708550 0.9771124 0.9267940
IL17RA 0.1165206 438.61650 -211.30825 1.6219450 -0.0088598 0.2940470 0.1477453 -0.0928958 -0.0900067 3.108295e-01 3.205373e+00 1.479440e-01 0.5771716 0.2013549 0.9286977
IGHV1-24 4.2421426 820.93135 -402.46567 4.5850704 0.0539701 0.1041951 -0.5776505 -0.2663842 -0.4195415 8.914400e-02 2.002321e+00 1.429375e-01 0.7652682 0.3674528 0.9310254
IL6ST 0.1632442 693.65057 -338.82528 2.7298922 0.2237663 0.3070552 0.1937496 -0.0384958 -0.1033885 3.358500e+00 2.790825e+00 1.419701e-01 0.0668590 0.2477308 0.9314758
LILRA1 0.3367641 314.25762 -149.12881 0.8514207 -0.3087270 0.0514880 -0.1520792 0.0194710 0.1832385 1.800941e+00 2.221048e-01 1.273006e-01 0.1795988 0.8948919 0.9383331
IL36RN 19.4325345 296.08369 -140.04184 1.4681399 -2.5155077 -2.0578324 -1.3288273 0.8261137 0.3887552 4.361784e+00 2.229550e+00 1.247028e-01 0.0367538 0.3279891 0.9395527
IL27 0.8439578 175.81549 -79.90775 -0.6536505 -0.0569313 0.0211854 -0.2510657 -0.0584625 0.2873973 3.757900e-03 4.228830e-02 1.221553e-01 0.9511191 0.9790778 0.9407502
IL22RA1 1.5096769 147.90593 -65.95296 -0.4584790 -1.0020745 -0.6416982 -0.4148671 0.0858790 -0.4280920 4.001124e+00 1.229769e+00 1.165993e-01 0.0454699 0.5407035 0.9433672
NKILA 0.1821951 173.78531 -78.89265 -0.4425051 0.0611145 -0.1200179 0.1165499 0.0935140 -0.1580821 4.404580e-02 9.260750e-02 1.072320e-01 0.8337685 0.9547519 0.9477960
EDIL3 0.7388625 553.95041 -268.97521 1.6810405 0.3729077 -0.1631396 0.1990618 0.0458290 0.1833911 4.211646e+00 1.349177e+00 1.068181e-01 0.0401474 0.5093660 0.9479921
IGHV4-59 3.9423711 1006.43490 -495.21745 6.1742830 -0.8556174 -0.1375892 -0.5046838 -0.3106751 -0.1976579 5.585105e+00 1.149838e+00 1.060279e-01 0.0181138 0.5627505 0.9483668
FILIP1L 0.2714560 825.29943 -404.64971 3.3919372 0.1883811 0.2616398 0.1522384 0.0635989 -0.0338102 2.841369e+00 1.874185e+00 9.823720e-02 0.0918659 0.3917652 0.9520682
PPIL3 0.1086377 708.84448 -346.42224 3.1199801 0.1242206 0.1004742 0.2319891 -0.0475003 -0.0604047 1.248966e+00 1.281002e+00 9.743050e-02 0.2637501 0.5270284 0.9524523
SVILP1 0.4449481 108.74436 -46.37218 -1.4485948 -0.0293806 -0.1420410 -0.0937396 0.1856124 0.3639567 6.302940e-02 5.876700e-02 9.073230e-02 0.8017703 0.9710440 0.9556475
DBIL5P 0.7122845 139.33581 -61.66791 -1.2527909 0.1637047 0.1945332 0.2438806 -0.2417144 0.0152856 3.541510e-02 2.237035e-01 8.342860e-02 0.8507285 0.8941768 0.9591438
ILKAP 0.0892046 658.45695 -321.22848 3.2236644 0.1312096 0.0700191 0.2293183 0.0222581 -0.0367687 2.994959e+00 3.668773e+00 8.285460e-02 0.0835240 0.1597114 0.9594191
USP18 0.2836978 390.87054 -187.43527 1.2533858 0.2157307 0.1180230 -0.2524189 -0.0898634 -0.0925170 1.045899e+00 2.782888e+00 7.861910e-02 0.3064536 0.2487159 0.9614531
FGF10-AS1 0.4620062 148.22106 -66.11053 -1.2065188 0.3485410 0.1302423 0.2192506 0.2018073 0.0161896 1.355377e+00 4.138021e-01 6.674860e-02 0.2443403 0.8131001 0.9671765
LILRB3 0.3186235 661.27696 -322.63848 2.7765132 -0.2364748 0.3025602 0.0657595 -0.0132292 0.0776738 2.712545e+00 2.487071e+00 6.256260e-02 0.0995620 0.2883629 0.9692029
IL9RP3 1.5399351 96.89330 -40.44665 -1.9984678 -0.0989243 0.4152088 0.0144230 -0.2938250 -0.0335794 1.315345e-01 1.999710e-01 4.915500e-02 0.7168462 0.9048505 0.9757220
IFI27 0.4806181 1334.71061 -659.35531 6.7493379 0.1915578 0.1924554 -0.2301413 0.0305536 -0.0594235 1.620016e+00 5.295594e+00 4.842940e-02 0.2030896 0.0708070 0.9760761
IFNAR1 0.0677559 528.34170 -256.17085 2.4641090 0.0299623 0.1928424 0.0660823 -0.0113381 0.0356009 1.615075e-01 4.127820e+00 4.552850e-02 0.6877723 0.1269566 0.9774929
IL15RA 0.2142398 543.91649 -263.95824 2.4558890 -0.1989596 0.1448958 -0.1048902 -0.0524882 -0.0043828 3.380282e+00 2.010988e+00 4.322810e-02 0.0659808 0.3658638 0.9786179
PIWIL2 0.2456914 148.04245 -66.02123 -1.1609633 0.3421433 0.1491316 0.4118402 0.0271803 0.1704348 1.346317e+00 1.472241e+00 4.248930e-02 0.2459230 0.4789684 0.9789794
FGF22 1.7704760 144.15292 -64.07646 -0.6345037 -0.9807215 -0.5725046 0.1218545 0.2363705 0.0530904 3.073783e+00 1.052258e+00 3.973890e-02 0.0795641 0.5908878 0.9803266
IL12B 0.3434760 78.71428 -31.35714 -2.1717064 0.0463511 0.2248875 0.1107223 -0.0473762 0.2484901 1.944340e-02 1.265064e-01 3.709980e-02 0.8891027 0.9387058 0.9816211
FGF13 0.4019804 305.66985 -144.83493 0.5760937 -0.0321708 0.0774785 0.1015108 -0.0870693 -0.0696459 1.421141e-01 6.013680e-02 3.633390e-02 0.7061882 0.9703792 0.9819971
ILF3 0.0523578 818.43229 -401.21615 3.7182880 -0.0284730 0.0858392 0.0947299 0.0234323 0.0101815 8.271530e-02 6.581165e-01 2.980510e-02 0.7736509 0.7196011 0.9852080
IGHV4-4 5.1731053 843.04654 -413.52327 4.8432616 -0.7571471 0.1079372 -0.1259593 -0.1987467 -0.1507834 2.185205e+00 7.152720e-02 2.976700e-02 0.1393425 0.9648684 0.9852267
RILP 0.2004065 592.59134 -288.29567 2.8914214 0.0798216 0.0138905 0.0668859 0.0247016 -0.0243904 5.987112e-01 1.473093e-01 2.860480e-02 0.4390702 0.9289925 0.9857994
IL37 8.0979107 222.18704 -103.09352 0.9766282 -2.4119149 -0.9530405 -0.8436230 0.2544044 0.0623393 9.816607e+00 1.378841e+00 2.403460e-02 0.0017294 0.5018669 0.9880546
PADI2 0.6567632 286.25720 -135.12860 0.4008216 -0.7071289 -0.2046819 0.1935694 -0.0259778 -0.0851058 6.419281e+03 7.663396e-01 2.401140e-02 0.0000000 0.6816971 0.9880661
FGF17 0.6366124 110.10344 -47.05172 -1.7107698 0.2358667 0.1266420 0.3675500 -0.0921985 -0.1436032 1.160264e-01 2.209599e-01 1.432140e-02 0.7333848 0.8954043 0.9928649
BCL2L12 0.1661472 534.54728 -259.27364 2.6422769 -0.0288726 -0.0059884 0.0671048 0.0153657 -0.0167846 6.471280e-02 2.037043e-01 1.292520e-02 0.7991965 0.9031631 0.9935582
IL18R1 0.2900986 271.14232 -127.57116 0.4267697 -0.1218438 0.1117918 -0.1728590 0.0088336 0.0594292 2.536368e-01 7.835873e-01 1.053080e-02 0.6145258 0.6758435 0.9947485
IL6R 0.1064792 502.91740 -243.45870 1.9751130 0.0329182 0.1643320 -0.0115767 0.0048683 0.0137561 1.308856e-01 1.512278e+00 2.358700e-03 0.7175155 0.4694755 0.9988214
ILDR2 1.0211017 54.19758 -19.09879 -2.9239006 0.1915436 -0.1753325 0.1620144 -0.0799469 -0.0194411 3.001070e-02 9.147460e-02 1.387700e-03 0.8624660 0.9552929 0.9993064
IL17RB 0.1069132 190.17334 -87.08667 -0.0457732 -0.1113093 -0.0747753 -0.2118919 0.0154167 -0.0082807 1.907085e-01 4.024344e-01 1.382400e-03 0.6623276 0.8177348 0.9993090

And the final model output in the @predict slot:

predict = data.frame(resultTable@predict)
kable(predict) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")
y_0_Good.responder y_6_Good.responder y_0_Moderate.responder y_6_Moderate.responder y_0_Non.responder y_6_Non.responder LCI_0_Good.responder LCI_6_Good.responder LCI_0_Moderate.responder LCI_6_Moderate.responder LCI_0_Non.responder LCI_6_Non.responder UCI_0_Good.responder UCI_6_Good.responder UCI_0_Moderate.responder UCI_6_Moderate.responder UCI_0_Non.responder UCI_6_Non.responder
A1BG 1.313242e+01 15.3947641 1.610655e+01 15.6512711 1.807684e+01 30.7777198 8.6703465 10.1933737 10.4094593 10.1102021 10.1259795 17.3871686 1.989083e+01 2.325028e+01 2.492164e+01 2.422922e+01 3.227067e+01 5.448087e+01
ADAM12 7.311778e+00 2.3129980 4.704782e+00 1.7233707 4.092495e+00 8.8871726 4.3002032 1.2856949 2.6369463 0.8990015 1.8747357 4.2242156 1.243246e+01 4.161142e+00 8.394169e+00 3.303673e+00 8.933802e+00 1.869740e+01
AVIL 6.862592e+00 4.8042190 8.138234e+00 6.2884195 8.349975e+00 5.5905230 5.0666769 3.4682404 5.9258491 4.5305643 5.4971080 3.5860270 9.295080e+00 6.654821e+00 1.117660e+01 8.728321e+00 1.268341e+01 8.715480e+00
BCL2L12 1.404515e+01 13.6454249 1.396129e+01 13.7739842 1.501999e+01 14.3496340 11.2145304 10.8846226 10.9940534 10.8412541 10.9594617 10.4483792 1.759023e+01 1.710648e+01 1.772937e+01 1.750006e+01 2.058495e+01 1.970755e+01
BLK 2.658234e+00 3.0475152 3.565283e+00 1.7809329 1.934295e+00 2.3457058 1.4131620 1.6524364 1.9641134 0.9277103 0.8333840 0.9650958 5.000283e+00 5.620397e+00 6.471745e+00 3.418871e+00 4.489525e+00 5.701336e+00
C1GALT1 1.418865e+01 9.3090470 1.434680e+01 11.6517008 1.217739e+01 11.7295557 9.6383440 6.4080140 9.8267920 7.9339723 7.2942700 7.0046930 2.088718e+01 1.352343e+01 2.094587e+01 1.711150e+01 2.032950e+01 1.964147e+01
CARMIL1 4.351577e+00 5.7100655 5.116252e+00 6.5449083 6.204266e+00 6.5119410 3.2402068 4.3419906 3.7951662 4.9423116 4.2514062 4.4745598 5.844140e+00 7.509194e+00 6.897204e+00 8.667164e+00 9.054162e+00 9.476994e+00
CARMIL2 4.633051e+00 2.9544021 6.379907e+00 2.3523223 3.602549e+00 4.0157843 2.6337905 1.6740391 3.6801633 1.2785792 1.7185708 1.7652352 8.149911e+00 5.214031e+00 1.106016e+01 4.327789e+00 7.551832e+00 9.135623e+00
CARMIL3 7.272950e-01 0.3953361 5.058035e-01 0.3733614 7.842076e-01 0.5509034 0.3745445 0.1726048 0.2272714 0.1519331 0.3139216 0.1959341 1.412270e+00 9.054826e-01 1.125690e+00 9.175005e-01 1.959029e+00 1.548963e+00
CD109 5.641830e+00 8.6778475 5.187570e+00 9.2014847 6.263955e+00 8.4775088 5.5798926 8.5433726 5.1072480 9.0005658 6.1669618 8.2923481 5.704456e+00 8.814439e+00 5.269154e+00 9.406889e+00 6.362474e+00 8.666804e+00
CD27 1.544528e+01 13.1635935 2.554582e+01 13.7894931 1.035888e+01 10.5054068 8.0092712 6.7666875 13.2575364 6.8409903 4.2909395 3.5251511 2.978507e+01 2.560783e+01 4.922401e+01 2.779570e+01 2.500767e+01 3.130747e+01
CD38 6.464032e+00 3.2932388 8.174153e+00 3.3252624 4.467718e+00 2.9347045 3.9428305 1.9400334 5.0727005 1.9727307 2.2099327 1.4426568 1.059739e+01 5.590327e+00 1.317183e+01 5.605109e+00 9.032177e+00 5.969882e+00
CILP 9.332507e+00 33.0612951 6.255099e+00 28.3892069 2.045799e+01 21.6751989 3.9027127 14.2695061 2.5715358 11.9706220 6.2762690 6.8178909 2.231671e+01 7.660035e+01 1.521513e+01 6.732708e+01 6.668443e+01 6.890903e+01
CILP2 3.627684e+00 6.7217420 6.383095e-01 5.4156273 2.540957e+00 3.9217541 3.5490285 6.5169190 0.6188398 5.1841267 0.8396780 1.2973571 3.708082e+00 6.933002e+00 6.583918e-01 5.657466e+00 7.689215e+00 1.185499e+01
CLEC17A 7.839581e-01 0.6137746 1.058750e+00 0.3309858 3.605461e-01 0.6507977 0.3525846 0.2636568 0.4760750 0.1139269 0.0903119 0.2003139 1.743100e+00 1.428824e+00 2.354568e+00 9.615955e-01 1.439383e+00 2.114370e+00
COIL 4.532068e+00 4.7944879 4.698928e+00 5.5715998 5.133283e+00 5.2100092 3.6179243 3.8496589 3.7149330 4.4835055 3.7998629 3.8645434 5.677189e+00 5.971208e+00 5.943558e+00 6.923762e+00 6.934618e+00 7.023908e+00
COLGALT2 2.766051e+00 5.1205630 2.154270e+00 6.4970467 3.622173e+00 4.4600883 1.6234900 3.1111653 1.1997396 3.8700004 1.7490074 2.1870009 4.712711e+00 8.427763e+00 3.868239e+00 1.090739e+01 7.501478e+00 9.095738e+00
CXCL1 1.418779e+01 8.1176746 2.037469e+01 8.3238791 2.211843e+01 9.9924706 13.4937646 7.5704301 18.9661790 7.5682514 20.5862810 9.0977495 1.491751e+01 8.704478e+00 2.188780e+01 9.154950e+00 2.376460e+01 1.097518e+01
CXCL10 2.494209e+01 14.7476955 2.840235e+01 14.8359335 8.563339e+00 9.2970586 10.2392124 5.4003390 11.5600667 5.8124142 2.5043913 2.5539000 6.075741e+01 4.027423e+01 6.978277e+01 3.786807e+01 2.928088e+01 3.384443e+01
CXCL11 3.791295e+00 2.4234891 2.851737e+00 1.9072576 7.459937e-01 0.9929039 1.5589996 0.7970634 1.2312606 0.7682953 0.2080571 0.2890835 9.219961e+00 7.368672e+00 6.604942e+00 4.734679e+00 2.674779e+00 3.410289e+00
CXCL12 3.193020e+02 339.9117231 3.846127e+02 474.9524798 3.685331e+02 293.9612953 231.8665785 249.0086484 276.8996099 341.8993477 235.9709324 186.4961275 4.397087e+02 4.639999e+02 5.342258e+02 6.597844e+02 5.755650e+02 4.633514e+02
CXCL13 3.217759e+01 19.9166568 4.607415e+01 7.1796651 7.292775e+00 8.6504474 29.4894149 17.6185573 40.7318754 6.0384831 6.4434142 7.2680675 3.511081e+01 2.251451e+01 5.211711e+01 8.536513e+00 8.254098e+00 1.029575e+01
CXCL14 1.354439e+02 51.0777954 1.019544e+02 53.7744053 7.015714e+01 34.3763246 68.4028570 29.5468780 57.6822921 30.1125224 33.0098585 16.1751871 2.681912e+02 8.829837e+01 1.802060e+02 9.602937e+01 1.491077e+02 7.305830e+01
CXCL16 4.161554e+01 34.6451339 4.690919e+01 43.4406712 4.330964e+01 39.3929196 31.5603246 26.3581657 35.3192461 32.6415371 29.6285152 26.7645915 5.487437e+01 4.553751e+01 6.230235e+01 5.781259e+01 6.330808e+01 5.797967e+01
CXCL2 7.447045e+00 5.0053028 6.509127e+00 4.9597113 6.284712e+00 5.9084208 4.5909574 3.0434139 3.9436093 2.9624854 3.2031238 2.9977108 1.207994e+01 8.231892e+00 1.074364e+01 8.303412e+00 1.233097e+01 1.164537e+01
CXCL3 4.037489e+00 2.6103631 3.544208e+00 2.5304672 4.753507e+00 4.2963685 2.2056672 1.3908075 1.8908105 1.3138687 2.0622319 1.7040244 7.390650e+00 4.899309e+00 6.643399e+00 4.873595e+00 1.095698e+01 1.083246e+01
CXCL5 5.239192e-01 0.5661362 3.565176e-01 0.1402179 9.116332e-01 0.6521226 0.1966190 0.2156827 0.1155061 0.0312542 0.2606754 0.1738786 1.396057e+00 1.486027e+00 1.100416e+00 6.290693e-01 3.188160e+00 2.445752e+00
CXCL6 2.305973e+00 2.0066662 2.196592e+00 1.4525907 4.574741e+00 2.4000968 2.2210233 1.9030737 2.0830611 1.3477308 4.3380634 2.2266291 2.394172e+00 2.115898e+00 2.316311e+00 1.565609e+00 4.824332e+00 2.587079e+00
CXCL8 2.999578e+00 1.6973552 2.199130e+00 1.3555563 3.620391e+00 4.2758582 1.2868654 0.7335989 0.9434111 0.5259256 1.1630419 0.8721107 6.991773e+00 3.927234e+00 5.126262e+00 3.493902e+00 1.126978e+01 2.096404e+01
CXCL9 2.775500e+01 13.2693976 3.133735e+01 20.1095367 7.523615e+00 6.6415183 26.4687183 12.4064506 29.2752711 18.2753594 7.0353162 6.0343045 2.910379e+01 1.419237e+01 3.354467e+01 2.212780e+01 8.045805e+00 7.309834e+00
CXCR1 3.160979e+00 4.2319726 5.746940e+00 2.9100761 4.980114e+00 4.3987409 1.7105183 2.3372398 2.6888572 1.4931844 2.1357176 1.7883458 5.841379e+00 7.662711e+00 1.228303e+01 5.671465e+00 1.161274e+01 1.081945e+01
CXCR2 3.645193e+00 4.8677434 6.059882e+00 3.3780851 4.905659e+00 4.0351399 1.9542107 2.6531698 2.9359259 1.7074533 2.0581593 1.6177634 6.799387e+00 8.930799e+00 1.250786e+01 6.683321e+00 1.169272e+01 1.006473e+01
CXCR2P1 5.542117e-01 0.5168145 6.710933e-01 0.6557631 3.436634e-01 0.2104674 0.2522791 0.2311727 0.3051026 0.2965608 0.0929212 0.0433474 1.217503e+00 1.155401e+00 1.476114e+00 1.450041e+00 1.271019e+00 1.021897e+00
CXCR3 4.852614e+00 2.2845156 5.869771e+00 2.7574618 2.995312e+00 2.0168013 2.9452414 1.3225444 3.4846132 1.5688112 1.4237247 0.9163375 7.995224e+00 3.946190e+00 9.887527e+00 4.846724e+00 6.301705e+00 4.438853e+00
CXCR4 3.231471e+01 25.9484981 3.476007e+01 22.7400778 2.793939e+01 27.8047521 20.6479851 16.5809016 21.9572271 14.1728739 15.1935266 14.5513698 5.057348e+01 4.060844e+01 5.502801e+01 3.648598e+01 5.137776e+01 5.312931e+01
CXCR5 3.033204e+00 3.0225112 3.374772e+00 2.3990105 4.219802e+00 2.2996307 1.3387217 1.3337973 1.4239551 0.9955678 1.3502982 0.7095012 6.872471e+00 6.849297e+00 7.998207e+00 5.780873e+00 1.318726e+01 7.453549e+00
CXCR6 2.289472e+00 0.7644416 2.193442e+00 1.0221914 9.083939e-01 0.8153444 1.3159038 0.3788908 1.2143208 0.5130989 0.3523643 0.3075678 3.983333e+00 1.542320e+00 3.962040e+00 2.036401e+00 2.341837e+00 2.161431e+00
DBIL5P 2.857063e-01 0.3365238 3.470599e-01 0.3210150 3.646161e-01 0.4360841 0.1106975 0.1386541 0.1370864 0.1230837 0.1082531 0.1404999 7.373977e-01 8.167684e-01 8.786473e-01 8.372405e-01 1.228093e+00 1.353519e+00
DUSP4 1.887119e+00 0.7438921 2.529893e+00 1.1904963 1.924647e+00 1.6209100 1.0512008 0.3796650 1.4459142 0.6353943 0.9092888 0.7447012 3.387763e+00 1.457536e+00 4.426513e+00 2.230554e+00 4.073805e+00 3.528058e+00
EAF2 8.140892e+00 5.1276197 9.748370e+00 5.1769689 5.666895e+00 4.6437898 5.3428306 3.3450348 6.4192159 3.3568599 3.1911859 2.5668941 1.240431e+01 7.860153e+00 1.480410e+01 7.983952e+00 1.006325e+01 8.401120e+00
EDIL3 5.371142e+00 7.7986310 4.562638e+00 6.9353926 6.554176e+00 11.4318245 3.0225777 4.6329414 2.5755185 3.9839409 3.1393434 5.4283320 9.544557e+00 1.312744e+01 8.082903e+00 1.207339e+01 1.368350e+01 2.407491e+01
EMILIN1 3.618974e+01 25.3719066 3.648829e+01 27.6278829 5.269726e+01 32.6052898 25.3471275 18.3268570 25.7906502 19.5169818 33.3594319 20.7060554 5.167045e+01 3.512515e+01 5.162319e+01 3.910953e+01 8.324486e+01 5.134271e+01
EMILIN2 2.903746e+01 24.8357362 3.823599e+01 37.2503841 3.854107e+01 32.8857246 23.1085786 19.7113537 30.1348505 29.3478356 28.0616466 23.8725927 3.648748e+01 3.129231e+01 4.851495e+01 4.728087e+01 5.293397e+01 4.530178e+01
EMILIN3 1.341206e+00 3.6772022 2.790818e-01 3.0842955 5.448039e-01 2.8128948 0.5211719 1.5265409 0.0868342 1.3536048 0.1524217 0.9201170 3.451519e+00 8.857814e+00 8.969579e-01 7.027811e+00 1.947304e+00 8.599317e+00
FGF1 1.032633e+00 1.5208595 1.879538e+00 0.9353562 1.622483e+00 2.7724122 0.5823358 0.9117735 1.1239588 0.4995840 0.7966354 1.4766214 1.831127e+00 2.536829e+00 3.143054e+00 1.751239e+00 3.304462e+00 5.205308e+00
FGF10 7.749714e+00 8.3753836 9.300140e+00 13.9049649 9.541256e+00 9.5226990 4.7048459 5.1873158 5.5453286 8.3901684 4.8536864 4.7705908 1.276515e+01 1.352280e+01 1.559738e+01 2.304460e+01 1.875596e+01 1.900850e+01
FGF10-AS1 2.992372e-01 0.4240187 3.408624e-01 0.5910066 3.725932e-01 0.5365811 0.1215375 0.1951821 0.1381762 0.2879170 0.1169434 0.1981209 7.367510e-01 9.211493e-01 8.408625e-01 1.213158e+00 1.187118e+00 1.453251e+00
FGF11 2.987274e+00 2.0577039 2.473619e+00 1.9524733 2.827541e+00 3.3831034 2.0568582 1.3599088 1.6311964 1.2494452 1.6554224 2.0281399 4.338563e+00 3.113551e+00 3.751105e+00 3.051076e+00 4.829575e+00 5.643294e+00
FGF12 4.036018e-01 0.3926497 4.564555e-01 0.3028451 4.033613e-01 0.6287587 0.1791358 0.1727084 0.2009153 0.1148448 0.1278444 0.2383529 9.093349e-01 8.926826e-01 1.037012e+00 7.986010e-01 1.272643e+00 1.658623e+00
FGF13 1.779075e+00 1.7227518 1.922396e+00 1.7063082 1.969155e+00 1.7785311 1.1303101 1.0898267 1.2008481 1.0484059 1.0559364 0.9363569 2.800213e+00 2.723253e+00 3.077496e+00 2.777061e+00 3.672164e+00 3.378170e+00
FGF14 8.151770e-01 1.8378999 7.953290e-01 1.7858609 1.939469e+00 1.8205156 0.4217436 1.0740181 0.3932854 1.0067888 0.9145913 0.8503753 1.575634e+00 3.145083e+00 1.608369e+00 3.167794e+00 4.112811e+00 3.897429e+00
FGF14-AS2 2.587600e+00 4.8810383 3.521330e+00 4.9596125 4.264634e+00 4.8116674 1.7494845 3.4800849 2.3975776 3.4680499 2.6088096 2.9781355 3.827228e+00 6.845964e+00 5.171788e+00 7.092676e+00 6.971420e+00 7.774040e+00
FGF16 3.154588e-01 0.4749403 4.978422e-01 0.7280126 2.669991e-01 0.8646936 0.1171429 0.1992892 0.2007145 0.3205791 0.0604136 0.3024805 8.495111e-01 1.131864e+00 1.234823e+00 1.653265e+00 1.180009e+00 2.471878e+00
FGF17 1.807266e-01 0.2288009 2.051266e-01 0.2368189 2.610039e-01 0.2862309 0.0573673 0.0813772 0.0649267 0.0804112 0.0655981 0.0758700 5.693508e-01 6.432987e-01 6.480686e-01 6.974545e-01 1.038490e+00 1.079849e+00
FGF18 2.837044e+00 4.4391737 3.188287e+00 6.5979197 3.344060e+00 3.7357252 1.7535426 2.7480779 1.9325387 4.1243016 1.7244260 1.9560536 4.590032e+00 7.170926e+00 5.260010e+00 1.055513e+01 6.484902e+00 7.134591e+00
FGF2 1.610089e+00 2.7406417 2.500836e+00 3.3135398 2.079503e+00 2.5994213 0.9910134 1.7795637 1.5247150 2.1367179 1.0981916 1.4181294 2.615895e+00 4.220763e+00 4.101869e+00 5.138510e+00 3.937686e+00 4.764721e+00
FGF20 1.715718e-01 0.2304279 2.344370e-01 0.4034210 4.076026e-01 0.3178409 0.0489000 0.0750676 0.0718886 0.1508010 0.1102126 0.0771007 6.019811e-01 7.073224e-01 7.645262e-01 1.079227e+00 1.507449e+00 1.310272e+00
FGF22 5.301986e-01 0.1988459 2.990907e-01 0.1420808 5.989069e-01 0.2368614 0.2191715 0.0596138 0.0987567 0.0331851 0.1782738 0.0478543 1.282605e+00 6.632642e-01 9.058147e-01 6.083145e-01 2.012014e+00 1.172377e+00
FGF23 7.190029e-01 0.8870252 5.598910e-01 0.6390084 4.384643e-01 2.3966181 0.3575640 0.4598035 0.2509686 0.2962785 0.1368516 1.1336796 1.445798e+00 1.711196e+00 1.249072e+00 1.378202e+00 1.404813e+00 5.066492e+00
FGF5 1.327067e-01 0.1096379 1.222054e-01 0.1200210 1.100568e-01 0.3004390 0.0339245 0.0248863 0.0272810 0.0264770 0.0135644 0.0750157 5.191253e-01 4.830150e-01 5.474199e-01 5.440577e-01 8.929626e-01 1.203263e+00
FGF7 1.152537e+01 7.2025867 8.478419e+00 6.6019381 1.104940e+01 7.6081274 6.6225372 4.1986721 4.9785426 3.8498342 5.3770798 3.6042561 2.005789e+01 1.235563e+01 1.443868e+01 1.132142e+01 2.270548e+01 1.605979e+01
FGF7P3 6.160027e-01 0.6928085 7.193539e-01 0.8624504 1.269899e+00 0.9058339 0.3016582 0.3487036 0.3503777 0.4370370 0.5626446 0.3708070 1.257912e+00 1.376480e+00 1.476892e+00 1.701963e+00 2.866184e+00 2.212836e+00
FGF7P6 6.738684e-01 0.4973280 2.970906e-01 0.3491357 6.138311e-01 0.5183947 0.3400425 0.2321816 0.1105006 0.1382897 0.2260908 0.1794327 1.335417e+00 1.065266e+00 7.987546e-01 8.814521e-01 1.666536e+00 1.497682e+00
FGF9 3.705945e-01 0.6417566 1.629504e-01 0.3628576 2.880044e-01 0.3073036 0.1490518 0.2984312 0.0432599 0.1371154 0.0702806 0.0775363 9.214266e-01 1.380055e+00 6.137982e-01 9.602543e-01 1.180219e+00 1.217953e+00
FGFBP1 6.551570e+00 1.1029514 1.505984e+00 0.3681105 1.964252e+00 0.7818853 0.9049733 0.2914602 0.4934511 0.1091642 0.5213588 0.1861546 4.743020e+01 4.173818e+00 4.596173e+00 1.241299e+00 7.400445e+00 3.284069e+00
FGFBP2 3.457081e+01 115.6689800 4.986344e+01 134.6101908 8.600988e+01 104.8941593 17.9713862 61.5745232 23.4758170 70.3223645 35.1051348 43.8221977 6.650244e+01 2.172865e+02 1.059117e+02 2.576691e+02 2.107298e+02 2.510779e+02
FGFBP3 9.962108e-01 1.3997139 1.078216e+00 1.5379991 1.452907e+00 1.4738838 0.6082842 0.9140392 0.6504349 0.9958863 0.8027068 0.8171792 1.631533e+00 2.143452e+00 1.787343e+00 2.375212e+00 2.629774e+00 2.658332e+00
FGFR1 3.879738e+01 47.0764323 4.477153e+01 62.1107471 5.442140e+01 55.7703390 27.8041471 33.7910468 31.4955140 43.7927157 34.1023079 34.9554221 5.413713e+01 6.558514e+01 6.364368e+01 8.809102e+01 8.684716e+01 8.897992e+01
FGFR1OP 5.761660e+00 4.7287519 6.244607e+00 5.6327410 5.746992e+00 5.7624597 4.5661704 3.6865477 4.9146213 4.3912692 4.1377628 4.1525917 7.270146e+00 6.065592e+00 7.934512e+00 7.225194e+00 7.982072e+00 7.996438e+00
FGFR1OP2 1.751834e+01 17.6326522 1.900560e+01 21.5602433 1.646026e+01 18.9624481 14.6750912 14.7858739 15.8123208 18.0094631 12.7841214 14.8262777 2.091245e+01 2.102753e+01 2.284376e+01 2.581110e+01 2.119350e+01 2.425251e+01
FGFR2 2.271817e+00 0.9834200 9.132025e-01 0.4964047 7.500257e-01 0.8618469 0.9790152 0.4484346 0.4020954 0.1974703 0.2493475 0.2935326 5.271782e+00 2.156646e+00 2.073982e+00 1.247872e+00 2.256043e+00 2.530486e+00
FGFR3 2.128470e+00 0.9404802 1.236821e+00 0.3289278 1.981682e+00 0.5878755 2.0996851 0.9225307 1.2132316 0.3200826 0.6229696 0.1581285 2.157650e+00 9.587789e-01 1.260869e+00 3.380174e-01 6.303778e+00 2.185549e+00
FGFR4 5.051713e-01 0.4177523 3.623419e-01 0.5028155 6.488374e-01 0.6122582 0.2412442 0.1883372 0.1479848 0.2292659 0.2505478 0.2316409 1.057841e+00 9.266197e-01 8.871970e-01 1.102752e+00 1.680278e+00 1.618281e+00
FGFRL1 5.506543e+00 5.7744476 5.502274e+00 5.5840144 6.724525e+00 5.8332812 5.4506805 5.6917827 5.4235386 5.4713572 6.6267321 5.7215753 5.562978e+00 5.858313e+00 5.582152e+00 5.698991e+00 6.823762e+00 5.947168e+00
FILIP1 1.608839e+00 1.8941334 1.535045e+00 2.1000128 1.770764e+00 1.8639043 1.0568870 1.2751535 0.9752212 1.4011895 0.9979595 1.0616457 2.449043e+00 2.813576e+00 2.416233e+00 3.147364e+00 3.142017e+00 3.272409e+00
FILIP1L 2.972348e+01 35.8849612 3.861254e+01 49.6777431 3.461114e+01 40.3966349 20.9198275 25.5185664 26.8738970 34.6040574 21.1583964 24.6568187 4.223195e+01 5.046249e+01 5.547867e+01 7.131760e+01 5.661729e+01 6.618405e+01
FRZB 5.469949e+00 9.0999618 2.996343e+00 5.9855457 4.801304e+00 5.2291825 3.1778253 5.6511683 1.7519107 3.6164640 2.4269171 2.6186998 9.415351e+00 1.465348e+01 5.124731e+00 9.906571e+00 9.498687e+00 1.044196e+01
FTCDNL1 1.245999e+00 1.0862004 1.435785e+00 1.2949462 1.008243e+00 1.4012707 0.7348023 0.6257848 0.8392929 0.7444447 0.4534449 0.6814081 2.112832e+00 1.885363e+00 2.456209e+00 2.252532e+00 2.241845e+00 2.881621e+00
GATA1 3.947954e-01 0.6593378 6.429564e-01 0.6309702 6.119761e-01 0.4863493 0.1718444 0.3309828 0.3075947 0.3004164 0.2251322 0.1641152 9.070028e-01 1.313441e+00 1.343954e+00 1.325238e+00 1.663532e+00 1.441278e+00
HHIP 1.142128e+00 1.5958353 1.695720e+00 3.4600132 4.010432e+00 2.9349500 0.5573519 0.8089476 0.8299842 1.7847333 1.6750959 1.1991397 2.340454e+00 3.148153e+00 3.464484e+00 6.707832e+00 9.601578e+00 7.183426e+00
HILPDA 8.858078e+00 7.2303144 9.238337e+00 7.3691710 9.202739e+00 12.9965494 6.5052495 5.2640397 6.6700178 5.2677297 5.9594366 8.5508279 1.206188e+01 9.931051e+00 1.279560e+01 1.030893e+01 1.421114e+01 1.975368e+01
HP 6.889749e+00 2.4719940 1.871321e+00 1.3082465 5.547766e+00 4.1875449 2.7101167 0.8922296 0.7234478 0.4798256 1.6797132 1.2153951 1.751535e+01 6.848859e+00 4.840493e+00 3.566940e+00 1.832319e+01 1.442784e+01
HYAL3 1.725487e+00 1.6371683 1.402497e+00 1.7760973 1.449832e+00 1.6254744 1.1696290 1.1003824 0.8946433 1.1815714 0.8027981 0.9251969 2.545512e+00 2.435808e+00 2.198640e+00 2.669768e+00 2.618359e+00 2.855789e+00
IFI27 8.534934e+02 1033.6956677 1.034624e+03 1291.9457252 6.780334e+02 773.8135210 619.3761718 750.1801922 736.3882178 919.5939276 430.7684054 491.6631644 1.176104e+03 1.424360e+03 1.453645e+03 1.815066e+03 1.067231e+03 1.217881e+03
IFI44L 1.182257e+01 10.7473824 1.075163e+01 16.0261378 5.804936e+00 7.3092848 8.0327478 7.2319148 7.1836798 10.7249419 3.2525067 4.1699582 1.740041e+01 1.597174e+01 1.609170e+01 2.394764e+01 1.036040e+01 1.281203e+01
IFNAR1 1.175300e+01 12.1104805 1.425277e+01 14.5207048 1.255591e+01 13.4066979 9.8109597 10.1244411 11.8814544 12.1151776 9.7704160 10.4778156 1.407947e+01 1.448611e+01 1.709736e+01 1.740386e+01 1.613553e+01 1.715430e+01
IFNAR2 1.941810e+01 18.2294962 2.355040e+01 18.8278446 1.776002e+01 17.3286651 15.8878280 14.8888222 19.1342233 15.2046934 13.3243251 12.9872017 2.373280e+01 2.231973e+01 2.898583e+01 2.331436e+01 2.367237e+01 2.312143e+01
IFNG 7.195188e-01 0.2807041 5.992458e-01 0.2958588 2.583558e-01 0.2022664 0.3117161 0.0954581 0.2378086 0.0960771 0.0538619 0.0366645 1.660830e+00 8.254388e-01 1.510019e+00 9.110645e-01 1.239238e+00 1.115841e+00
IFNG-AS1 7.636960e-01 0.5696290 1.079236e+00 0.5462123 5.081098e-01 0.5088237 0.3910448 0.2725822 0.5679602 0.2470968 0.1716933 0.1720281 1.491470e+00 1.190383e+00 2.050761e+00 1.207413e+00 1.503701e+00 1.504996e+00
IFNGR1 4.333542e+01 43.4160164 4.707960e+01 51.3839506 4.208072e+01 42.6227885 34.9851794 35.0908874 37.6218036 41.0796975 31.0974205 31.4466076 5.367868e+01 5.371624e+01 5.891501e+01 6.427288e+01 5.694320e+01 5.777100e+01
IFNGR2 6.431576e+01 67.8269074 7.077123e+01 81.6964152 6.915074e+01 76.6917368 53.5474616 56.4972638 58.3220011 67.4045850 53.4128218 59.3073884 7.724954e+01 8.142853e+01 8.587784e+01 9.901855e+01 8.952578e+01 9.917183e+01
IFNLR1 6.444658e-01 0.5988088 7.293622e-01 0.3378899 2.815265e-01 0.4639455 0.3070925 0.2805715 0.3417261 0.1270860 0.0696019 0.1447489 1.352479e+00 1.278006e+00 1.556712e+00 8.983647e-01 1.138720e+00 1.487027e+00
IGHA1 1.453531e+03 1022.8502600 2.355221e+03 545.4888342 1.083873e+03 1476.9187819 520.9876784 342.3585368 881.2114786 200.5951416 320.6572552 347.4346698 4.055283e+03 3.055927e+03 6.294818e+03 1.483376e+03 3.663666e+03 6.278271e+03
IGHA2 5.011089e+01 26.0186644 8.666635e+01 28.6144737 4.036685e+01 69.5347388 40.0357895 19.0896160 63.9277996 18.7354880 29.9541792 45.9184395 6.272141e+01 3.546278e+01 1.174928e+02 4.370252e+01 5.439917e+01 1.052971e+02
IGHD 7.472649e+00 2.9022117 5.670933e+00 1.7493716 1.014273e+01 2.5854250 7.1291761 2.7154106 2.4142463 0.7077185 4.0551741 1.0316011 7.832671e+00 3.101863e+00 1.332071e+01 4.324178e+00 2.536883e+01 6.479658e+00
IGHE 2.837348e+00 2.3820432 3.923112e+00 1.4423923 3.351535e+00 1.5310883 0.8307487 0.6701824 1.3681754 0.4320646 0.6473407 0.3216117 9.690708e+00 8.466545e+00 1.124915e+01 4.815242e+00 1.735221e+01 7.289012e+00
IGHG1 1.176330e+04 5473.7609107 1.596280e+04 3500.9062311 1.055581e+04 4674.1796137 4329.3050198 2003.3890728 5520.5108822 1206.9668114 2551.9638752 1132.6906648 3.196244e+04 1.495569e+04 4.615712e+04 1.015467e+04 4.366250e+04 1.928855e+04
IGHG2 1.044166e+03 472.4891374 1.608889e+03 435.3391387 7.190760e+02 578.7877746 353.9269905 161.2297019 576.1165157 162.1965246 192.7156313 142.2256415 3.080529e+03 1.384646e+03 4.493055e+03 1.168460e+03 2.683074e+03 2.355379e+03
IGHG3 1.603719e+03 382.7687704 1.656875e+03 193.0008786 6.988460e+02 640.0115603 486.2803095 128.6018683 582.8935370 66.2353656 169.8800798 97.8927802 5.288952e+03 1.139268e+03 4.709669e+03 5.623784e+02 2.874886e+03 4.184321e+03
IGHG4 5.170448e+02 280.3826946 1.435573e+03 285.1827242 3.872421e+02 155.6330069 469.7302318 243.7117460 1250.6158259 83.6808839 337.2858534 128.9032486 5.691252e+02 3.225715e+02 1.647884e+03 9.718968e+02 4.445975e+02 1.879055e+02
IGHGP 2.303206e+01 12.1639954 4.599909e+01 8.4954917 2.855545e+01 20.3003741 8.5747082 4.5036345 16.1840856 2.9473704 7.0701917 5.0111296 6.186518e+01 3.285408e+01 1.307405e+02 2.448738e+01 1.153312e+02 8.223798e+01
IGHJ1 2.221458e+02 105.4774230 5.260252e+02 59.8830372 7.294829e+01 18.1245512 62.0697284 24.3140474 111.6361751 16.5450434 15.0340151 2.2289018 7.950532e+02 4.575744e+02 2.478610e+03 2.167403e+02 3.539608e+02 1.473817e+02
IGHJ2 6.202368e+02 202.2303300 4.318717e+02 81.9224971 1.412095e+02 78.4909830 232.6917590 75.7976025 152.5828787 28.9046613 35.2344954 19.5680474 1.653233e+03 5.395567e+02 1.222373e+03 2.321873e+02 5.659260e+02 3.148416e+02
IGHJ3 8.287383e+02 351.4451573 1.176606e+03 149.4258549 6.771985e+02 559.2521416 308.4048200 130.6960843 412.1627369 52.3021205 167.2132728 138.0919433 2.226966e+03 9.450451e+02 3.358872e+03 4.269059e+02 2.742592e+03 2.264889e+03
IGHJ3P 1.131274e+02 89.7206616 1.440889e+02 27.4714155 3.914703e+01 19.0138716 42.2663611 33.5136289 50.7228709 9.6381326 9.7028695 4.6932689 3.027896e+02 2.401947e+02 4.093145e+02 7.830134e+01 1.579420e+02 7.703103e+01
IGHJ4 5.483556e+03 2826.1884393 5.075786e+03 1198.6970897 3.194487e+03 543.5156615 2251.7313969 1157.2740142 1972.5859059 465.1478025 903.3493039 153.7909734 1.335390e+04 6.901858e+03 1.306083e+04 3.089071e+03 1.129657e+04 1.920849e+03
IGHJ5 3.803266e+03 1940.7037068 4.430187e+03 961.4343330 1.314158e+03 589.3446388 1540.1331388 785.0083929 1696.6236810 368.0138176 365.4867491 163.7706976 9.391936e+03 4.797822e+03 1.156801e+04 2.511743e+03 4.725235e+03 2.120813e+03
IGHJ6 2.623171e+02 234.5646977 1.523116e+02 68.1940498 5.202627e+02 107.2576857 18.0533447 11.3885200 4.1071394 2.4827475 54.4742460 3.5716996 3.811496e+03 4.831233e+03 5.648417e+03 1.873098e+03 4.968830e+03 3.220935e+03
IGHM 5.234438e+02 240.6489212 1.036844e+03 264.3302159 3.845857e+02 71.1489855 438.4528934 187.7359988 800.8676528 186.4240990 294.9841788 49.1583727 6.249096e+02 3.084752e+02 1.342351e+03 3.747931e+02 5.014037e+02 1.029769e+02
IGHMBP2 9.174861e+00 11.3785322 1.001741e+01 10.9553333 1.192193e+01 11.6092670 6.9477673 8.6787717 7.4910088 8.2220850 8.1763361 7.9283702 1.211585e+01 1.491812e+01 1.339586e+01 1.459719e+01 1.738338e+01 1.699909e+01
IGHV1-12 2.333929e+01 9.9356108 1.658456e+01 12.4175739 2.403890e+00 8.9547098 7.3802619 3.1250624 4.8822510 3.6483051 0.4496255 1.7418812 7.380798e+01 3.158860e+01 5.633625e+01 4.226514e+01 1.285222e+01 4.603461e+01
IGHV1-14 2.320047e+00 2.2025331 1.084655e+00 0.7933056 9.420911e-01 0.3775211 0.7208903 0.6829430 0.2996449 0.2124214 0.1666022 0.0554527 7.466623e+00 7.103304e+00 3.926238e+00 2.962666e+00 5.327275e+00 2.570158e+00
IGHV1-17 8.358010e-01 0.3658917 8.431035e+00 0.4641066 1.436862e+00 0.2195604 0.2899040 0.1097892 3.0977508 0.1368531 0.3458192 0.0322794 2.409636e+00 1.219399e+00 2.294644e+01 1.573914e+00 5.970093e+00 1.493422e+00
IGHV1-18 4.386948e+02 271.4185068 8.400642e+02 139.4095391 4.310643e+02 64.1177645 171.0124244 105.7251193 309.2334827 51.2643421 113.6977713 16.8697359 1.125375e+03 6.967881e+02 2.282120e+03 3.791138e+02 1.634302e+03 2.436960e+02
IGHV1-2 2.872257e+02 157.0867974 3.014324e+02 176.8741868 2.513886e+02 74.2053697 115.7752257 63.2859312 114.9720349 67.4380176 69.5222664 20.4889405 7.125756e+02 3.899170e+02 7.902923e+02 4.638997e+02 9.090074e+02 2.687517e+02
IGHV1-24 9.801009e+01 103.4450484 1.087733e+02 87.9572989 5.500477e+01 38.1623186 37.8045458 39.9028755 39.6054174 32.0176569 14.2806405 9.8952580 2.540958e+02 2.681731e+02 2.987375e+02 2.416319e+02 2.118620e+02 1.471778e+02
IGHV1-3 1.673501e+02 69.7447024 2.323113e+02 101.9958539 1.450687e+02 18.0564216 60.0874541 25.0188936 78.3982659 34.3989016 34.0663470 4.2102466 4.660882e+02 1.944260e+02 6.883892e+02 3.024269e+02 6.177626e+02 7.743830e+01
IGHV1-45 4.140810e+01 7.5837109 5.023046e+00 2.2511920 4.545987e-01 1.8768522 3.6289820 0.9098353 0.9424914 0.3388696 0.0594085 0.1533885 4.724825e+02 6.321218e+01 2.677052e+01 1.495521e+01 3.478628e+00 2.296504e+01
IGHV1-46 5.176906e+01 32.6142915 1.648659e+02 29.5652082 6.526858e+01 20.8960795 19.9403313 12.5456961 60.0251355 10.7284411 16.9429735 5.3965671 1.344028e+02 8.478541e+01 4.528233e+02 8.147517e+01 2.514310e+02 8.091183e+01
IGHV1-69 8.278201e+01 107.3732063 1.777693e+02 119.1866693 1.487638e+02 19.6134466 28.1732235 36.5477346 56.7041403 38.0049452 32.4164310 4.2471255 2.432402e+02 3.154506e+02 5.573128e+02 3.737793e+02 6.826987e+02 9.057592e+01
IGHV1-69-2 5.750523e+00 4.5455146 1.340722e+01 3.1493394 4.059060e+00 1.3169910 5.6821586 4.4691986 13.1822868 3.0748560 3.9909375 1.2858277 5.819710e+00 4.623134e+00 1.363600e+01 3.225627e+00 4.128345e+00 1.348909e+00
IGHV1-69D 3.882562e+02 248.0900598 8.197487e+02 201.9673888 3.607102e+02 52.5378898 149.3470027 95.3795952 297.5187266 73.2576671 93.3488564 13.5606405 1.009346e+03 6.453024e+02 2.258641e+03 5.568131e+02 1.393824e+03 2.035472e+02
IGHV1OR15-1 1.188263e+01 5.0969954 1.683623e+01 4.4362891 4.089338e+00 1.9733753 4.8632007 2.1584936 7.1676891 1.6727523 1.2276308 0.5459743 2.903376e+01 1.203588e+01 3.954672e+01 1.176544e+01 1.362191e+01 7.132589e+00
IGHV1OR15-2 4.091005e+00 5.7058083 1.280090e+01 2.1140856 2.254938e+00 1.2327665 1.3621743 1.9126741 4.0565451 0.6433268 0.4633895 0.2412570 1.228648e+01 1.702133e+01 4.039475e+01 6.947259e+00 1.097294e+01 6.299147e+00
IGHV1OR15-4 9.526106e+00 7.7575959 1.770323e+01 7.7846859 4.685520e+00 3.8663946 3.6470371 2.9620914 6.4308865 2.8039537 1.1849749 0.9709957 2.488231e+01 2.031683e+01 4.873421e+01 2.161282e+01 1.852705e+01 1.539554e+01
IGHV1OR15-9 3.842526e+00 3.5666523 7.257504e+00 12.7826694 4.621694e+00 0.3912184 1.1896762 1.1022521 2.1177585 3.7517784 0.8854452 0.0567210 1.241095e+01 1.154092e+01 2.487128e+01 4.355178e+01 2.412352e+01 2.698328e+00
IGHV1OR16-1 8.679019e+00 3.4579328 9.968367e+00 4.6173788 3.947022e+00 0.7393921 2.6998387 1.0588299 2.8930644 1.3251070 0.7436370 0.1217048 2.789995e+01 1.129294e+01 3.434709e+01 1.608941e+01 2.094972e+01 4.492022e+00
IGHV1OR16-3 2.492962e+00 22.4138036 1.250000e-01 0.1250000 1.250000e-01 0.3960744 0.1809553 1.6509436 0.0056725 0.0056727 0.0020238 0.0086027 3.434471e+01 3.042978e+02 2.754528e+00 2.754397e+00 7.720620e+00 1.823565e+01
IGHV1OR16-4 9.248222e+00 4.7024995 7.868377e+00 8.6327624 3.339053e+00 0.9907734 2.2763807 1.1483471 1.7761419 1.9504721 0.4505434 0.1241201 3.757263e+01 1.925681e+01 3.485721e+01 3.820849e+01 2.474628e+01 7.908725e+00
IGHV1OR21-1 2.694153e-01 1.0814244 1.531507e+00 0.8619757 2.051256e-01 0.1250000 0.0489595 0.2363010 0.3114268 0.1687811 0.0166289 0.0078704 1.482544e+00 4.949106e+00 7.531503e+00 4.402165e+00 2.530321e+00 1.985298e+00
IGHV2-26 9.939640e+01 58.3648442 1.632633e+02 16.4242989 2.263043e+01 6.4496680 32.8329540 19.2649400 50.4440591 5.0462641 4.7024764 1.3202535 3.009063e+02 1.768215e+02 5.284051e+02 5.345689e+01 1.089078e+02 3.150775e+01
IGHV2-5 2.415927e+02 143.1526324 3.638482e+02 76.8012302 1.651712e+02 62.0041816 88.5611211 52.4392593 125.4921995 26.4529092 39.9248325 14.9634627 6.590592e+02 3.907888e+02 1.054930e+03 2.229785e+02 6.833224e+02 2.569271e+02
IGHV2-70 9.882273e+01 33.7141092 1.805899e+02 51.9635910 4.223248e+01 7.2147421 33.5996149 11.4389906 57.5353276 16.5299766 9.1650653 1.5409053 2.906561e+02 9.936551e+01 5.668294e+02 1.633526e+02 1.946066e+02 3.378047e+01
IGHV2-70D 3.433582e+01 19.8120760 3.009297e+01 7.5355225 1.436174e+01 2.8495855 6.9479652 3.6523593 8.9295239 2.2058865 2.8557065 0.5065204 1.696825e+02 1.074698e+02 1.014149e+02 2.574208e+01 7.222714e+01 1.603121e+01
IGHV3-11 2.257624e+02 113.7310084 3.267882e+02 61.9650186 1.909666e+02 22.4272871 85.7890640 43.1964064 117.1041476 22.1727261 48.5923602 5.6721760 5.941163e+02 2.994402e+02 9.119278e+02 1.731706e+02 7.504931e+02 8.867553e+01
IGHV3-13 4.588447e+01 7.9167172 4.946975e+01 4.6127337 2.218585e+01 2.8673564 11.1422845 2.4301487 14.4768923 1.4462853 4.8151815 0.4869634 1.889545e+02 2.579036e+01 1.690457e+02 1.471170e+01 1.022209e+02 1.688368e+01
IGHV3-15 2.739546e+02 164.7357308 2.816985e+02 70.7282142 1.770442e+02 21.0801577 108.8602716 65.4325316 105.8353082 26.5359260 47.9746121 5.6732732 6.894263e+02 4.147457e+02 7.497879e+02 1.885173e+02 6.533588e+02 7.832746e+01
IGHV3-19 2.474443e+01 26.9566939 3.780305e+01 11.2883457 1.642995e+01 6.9776085 8.2198648 8.9575672 11.7623538 3.4900564 3.4479301 1.4479240 7.448870e+01 8.112285e+01 1.214953e+02 3.651137e+01 7.829144e+01 3.362540e+01
IGHV3-20 6.941317e+01 46.0944956 1.358732e+02 41.1263531 5.659421e+01 10.1649461 24.5351975 16.2801726 45.1258174 13.6331502 12.9962947 2.3072211 1.963786e+02 1.305086e+02 4.091123e+02 1.240635e+02 2.464475e+02 4.478380e+01
IGHV3-21 4.535863e+02 275.0659894 6.926951e+02 98.1790722 2.804936e+02 26.3176513 177.3531157 107.4838118 255.8117890 36.2109218 74.2722546 6.9300767 1.160062e+03 7.039320e+02 1.875701e+03 2.661940e+02 1.059301e+03 9.994388e+01
IGHV3-22 1.121538e+00 2.3351048 5.192769e+00 0.4450816 4.836570e+00 1.8445377 0.3769068 0.8219488 1.7605816 0.1225645 1.1410466 0.4144623 3.337288e+00 6.633886e+00 1.531588e+01 1.616272e+00 2.050083e+01 8.208996e+00
IGHV3-23 9.667280e+02 854.8366241 1.307519e+03 189.8670079 5.465278e+02 51.8617322 401.2777152 354.6567451 514.3539800 74.6303584 157.4429639 14.8972159 2.328968e+03 2.060431e+03 3.323793e+03 4.830404e+02 1.897148e+03 1.805464e+02
IGHV3-30 1.021432e+03 554.2179130 1.304018e+03 272.9760312 4.387483e+02 124.7469231 417.2044298 226.2105373 504.2480810 105.4909909 123.5683779 35.0925353 2.500747e+03 1.357839e+03 3.372276e+03 7.063723e+02 1.557843e+03 4.434503e+02
IGHV3-33 4.717123e+02 255.6851842 5.107284e+02 157.3310217 4.008178e+02 243.0565416 183.6428756 99.5056526 187.7172422 57.7971094 105.5382118 63.9776157 1.211659e+03 6.569970e+02 1.389555e+03 4.282749e+02 1.522244e+03 9.233930e+02
IGHV3-35 4.319559e+00 4.5161580 9.097272e+00 3.6974443 1.580718e+00 4.6634444 1.3145385 1.3756013 2.6058660 1.0430035 0.2795105 0.8688989 1.419402e+01 1.482674e+01 3.175925e+01 1.310743e+01 8.939446e+00 2.502905e+01
IGHV3-38 2.837106e+00 1.7676584 2.584030e+01 1.1275023 2.679799e+00 0.8379922 0.9149834 0.5588207 8.0320907 0.3221911 0.5393367 0.1517370 8.797067e+00 5.591447e+00 8.313166e+01 3.945675e+00 1.331510e+01 4.627948e+00
IGHV3-41 4.371336e+00 3.9495393 1.019530e+01 1.1895481 5.160171e+00 1.5585044 1.4428414 1.3005630 3.1888183 0.3454100 1.0812789 0.3075534 1.324371e+01 1.199393e+01 3.259646e+01 4.096652e+00 2.462581e+01 7.897608e+00
IGHV3-42 1.023110e+00 1.8264506 7.527283e-01 0.4891422 1.839513e-01 0.3884189 0.2485905 0.4585753 0.1632429 0.1003793 0.0161885 0.0445922 4.210756e+00 7.274534e+00 3.470901e+00 2.383560e+00 2.090255e+00 3.383313e+00
IGHV3-43 1.965603e+02 82.7205474 1.658685e+02 40.5507223 7.330697e+01 86.2517785 72.7525579 30.5895886 57.7841910 14.0962332 17.9488547 21.1244338 5.310598e+02 2.236934e+02 4.761227e+02 1.166525e+02 2.994013e+02 3.521689e+02
IGHV3-47 2.711729e+00 4.0612403 5.707015e+00 1.3750068 2.743719e+00 0.6061011 0.8504568 1.2882067 1.7003210 0.3883035 0.5325966 0.1002990 8.646501e+00 1.280359e+01 1.915522e+01 4.868984e+00 1.413451e+01 3.662634e+00
IGHV3-48 2.916865e+02 162.1824604 2.115601e+02 103.0962926 1.121835e+02 142.7276622 109.7880488 61.0264909 75.0353755 36.5447878 28.1441007 35.8189620 7.749572e+02 4.310120e+02 5.964875e+02 2.908444e+02 4.471679e+02 5.687263e+02
IGHV3-49 1.470139e+02 94.3582658 1.911458e+02 19.6330898 6.608192e+02 50.1137961 51.6750393 33.1451428 63.0527499 6.4441959 150.7491871 11.3974409 4.182501e+02 2.686210e+02 5.794629e+02 5.981479e+01 2.896746e+03 2.203471e+02
IGHV3-52 1.161458e+00 0.3709696 2.506914e+00 0.3123805 8.442803e-01 0.3859069 0.3626488 0.0989476 0.7635549 0.0736905 0.1561673 0.0602573 3.719810e+00 1.390821e+00 8.230732e+00 1.324208e+00 4.564395e+00 2.471472e+00
IGHV3-53 8.286819e+01 42.3335464 1.336457e+02 24.4265033 4.609749e+01 4.8872347 28.6840664 14.6360372 43.3978820 7.9035017 10.2679055 1.0609018 2.394060e+02 1.224463e+02 4.115677e+02 7.549237e+01 2.069534e+02 2.251392e+01
IGHV3-6 8.643117e+00 6.5287983 2.462788e+01 2.5062429 2.373176e+00 41.6638072 2.8832299 2.1699972 7.7460757 0.7599301 0.4819802 8.9323062 2.590965e+01 1.964298e+01 7.830188e+01 8.265568e+00 1.168505e+01 1.943365e+02
IGHV3-60 2.637104e+00 2.0038183 4.232121e+00 0.6186969 6.404704e+00 0.5871444 0.8621812 0.6477140 1.3118827 0.1677659 1.3585054 0.1019616 8.065958e+00 6.199168e+00 1.365278e+01 2.281667e+00 3.019512e+01 3.381064e+00
IGHV3-62 5.335906e+00 12.5225804 1.342874e+01 2.2202995 6.694422e+00 3.8515844 1.6570407 3.9273515 3.9275618 0.6263047 1.2870637 0.7300604 1.718238e+01 3.992895e+01 4.591426e+01 7.871137e+00 3.481979e+01 2.031983e+01
IGHV3-63 1.105363e+01 16.2571227 3.177581e+01 3.0505198 5.541196e+00 0.8986667 3.8924649 5.7418334 10.5707730 0.9829840 1.2500921 0.1783591 3.138957e+01 4.602956e+01 9.551826e+01 9.466757e+00 2.456207e+01 4.527953e+00
IGHV3-64 2.359129e+01 9.8697947 2.285688e+01 2.0314103 7.666930e+00 3.1613598 7.3374290 3.0532026 6.6217270 0.5638900 1.4533745 0.5852467 7.585070e+01 3.190514e+01 7.889741e+01 7.318143e+00 4.044505e+01 1.707689e+01
IGHV3-64D 1.338943e+02 65.6076917 9.245161e+01 31.3980511 1.353459e+02 17.3489038 45.1990410 22.1279923 29.2054511 9.8967339 29.1337649 3.7082958 3.966385e+02 1.945215e+02 2.926611e+02 9.961242e+01 6.287727e+02 8.116517e+01
IGHV3-66 2.039998e+02 46.3285610 8.171234e+01 10.9975581 7.362319e+01 43.8506198 75.3792877 17.0869162 28.3975185 3.7881359 17.9860573 10.6973953 5.520869e+02 1.256128e+02 2.351229e+02 3.192765e+01 3.013653e+02 1.797519e+02
IGHV3-69-1 3.783135e+01 46.5634613 6.738673e+01 17.3136668 6.919559e+01 10.9563563 13.6394045 16.7957814 22.8656818 5.8469560 16.3781092 2.5639807 1.049321e+02 1.290893e+02 1.985933e+02 5.126823e+01 2.923433e+02 4.681851e+01
IGHV3-7 3.266493e+02 212.6341064 6.239734e+02 73.9903036 2.231332e+02 77.6011591 130.2262379 84.7375705 235.2818203 27.8561493 60.7486827 21.0980669 8.193416e+02 5.335681e+02 1.654794e+03 1.965299e+02 8.195800e+02 2.854261e+02
IGHV3-71 7.792351e+00 4.8842940 9.944426e+00 1.1522919 3.979337e+00 1.7242491 2.7160939 1.6893989 3.2612674 0.3489223 0.8808276 0.3645703 2.235591e+01 1.412119e+01 3.032306e+01 3.805365e+00 1.797755e+01 8.154902e+00
IGHV3-72 2.291995e+01 6.2448073 4.627166e+01 8.7713652 7.389145e+00 8.0326942 8.3363157 2.2437034 15.8672390 2.9769193 1.7437667 1.8986844 6.301637e+01 1.738092e+01 1.349363e+02 2.584445e+01 3.131122e+01 3.398362e+01
IGHV3-73 2.625323e+01 26.9405406 2.651155e+01 9.3614302 2.734884e+01 8.7983014 8.7874417 9.0181873 8.3040451 2.9113782 5.8185164 1.8521213 7.843375e+01 8.048100e+01 8.464098e+01 3.010134e+01 1.285481e+02 4.179538e+01
IGHV3-74 4.457287e+01 68.2921156 1.122970e+02 26.2335837 5.604924e+01 18.7648461 17.4556790 26.7680942 41.6151233 9.6873019 14.8975605 4.9592215 1.138163e+02 1.742303e+02 3.030299e+02 7.104155e+01 2.108746e+02 7.100297e+01
IGHV3-75 1.221975e+00 1.8561266 2.965183e+00 1.1953280 4.025555e-01 0.2995731 0.3720505 0.5796385 0.8800788 0.3380193 0.0613438 0.0415341 4.013493e+00 5.943715e+00 9.990366e+00 4.227004e+00 2.641686e+00 2.160733e+00
IGHV3OR15-7 1.908654e+00 2.2678515 3.582972e+00 3.5315606 2.668028e+00 0.6304566 0.6087702 0.7290033 1.0927734 1.0766489 0.5407958 0.1094814 5.984128e+00 7.055044e+00 1.174780e+01 1.158402e+01 1.316277e+01 3.630531e+00
IGHV3OR16-12 2.569762e+00 5.0202131 2.912991e+00 0.3562387 2.198910e+00 0.8699500 0.6809481 1.3508561 0.7149339 0.0718143 0.3336505 0.1222113 9.697771e+00 1.865672e+01 1.186896e+01 1.767140e+00 1.449183e+01 6.192659e+00
IGHV3OR16-13 7.251438e+00 1.9929411 6.355827e+00 1.1169636 1.821625e+00 0.5384924 2.3468609 0.6234860 1.9171741 0.3135882 0.3500161 0.0880508 2.240582e+01 6.370334e+00 2.107088e+01 3.978491e+00 9.480467e+00 3.293258e+00
IGHV3OR16-15 1.654397e+00 0.7503028 1.650695e+00 0.3109166 2.132519e-01 0.3937679 0.5721916 0.2417533 0.5352239 0.0784798 0.0288746 0.0680767 4.783413e+00 2.328631e+00 5.090942e+00 1.231772e+00 1.574960e+00 2.277623e+00
IGHV3OR16-7 1.542121e+00 0.8695479 4.307377e-01 0.2228351 2.379084e+00 0.2250729 0.4091337 0.2217054 0.0920187 0.0405593 0.3739432 0.0233142 5.812620e+00 3.410443e+00 2.016276e+00 1.224269e+00 1.513609e+01 2.172827e+00
IGHV3OR16-8 1.944902e+01 9.6773164 1.515974e+01 2.7181451 1.167452e+01 18.1030822 6.1721310 3.0563684 4.4810337 0.7801852 2.2927453 3.5695284 6.128585e+01 3.064109e+01 5.128679e+01 9.469948e+00 5.944596e+01 9.181089e+01
IGHV3OR16-9 3.632390e+01 14.1527031 6.433172e+01 20.3982669 1.898393e+01 1.6931663 12.5162181 4.8557093 20.8063336 6.5739199 4.1925180 0.3471858 1.054173e+02 4.125021e+01 1.989091e+02 6.329394e+01 8.596015e+01 8.257286e+00
IGHV4-28 4.713576e+01 26.8399122 4.893039e+01 46.0881713 2.461543e+01 10.5516339 16.8018829 9.5513612 16.3848452 15.4310565 5.7070588 2.4271615 1.322340e+02 7.542180e+01 1.461218e+02 1.376522e+02 1.061701e+02 4.587127e+01
IGHV4-31 1.596675e+02 85.8243446 2.484898e+02 58.2061972 7.671245e+01 20.2289281 59.8701840 32.1606400 87.8139275 20.5378230 19.1393841 5.0188936 4.258164e+02 2.290321e+02 7.031596e+02 1.649621e+02 3.074707e+02 8.153381e+01
IGHV4-34 1.208725e+02 72.1345046 3.679823e+02 59.1749509 8.290770e+01 22.3315145 46.5363768 24.5594957 117.9589277 18.0619620 22.0943311 4.5170531 3.139515e+02 2.118686e+02 1.147950e+03 1.938701e+02 3.111063e+02 1.104031e+02
IGHV4-39 6.326214e+02 369.7279858 8.672924e+02 178.3287715 5.221480e+02 208.4936680 251.8884371 147.1456283 326.4920299 67.0868250 141.8983712 56.6230453 1.588838e+03 9.290034e+02 2.303873e+03 4.740297e+02 1.921365e+03 7.677017e+02
IGHV4-4 1.268825e+02 59.5082216 1.413443e+02 54.3424080 1.118661e+02 45.1220846 33.7946152 12.0383162 28.2028842 8.7782955 18.5536145 5.6109532 4.763828e+02 2.941631e+02 7.083748e+02 3.364090e+02 6.744786e+02 3.628621e+02
IGHV4-55 7.113512e+01 57.8173977 1.159392e+02 115.8619797 4.996720e+01 15.8448739 25.1440020 20.4285279 38.4960120 38.4694102 11.4680424 3.6140511 2.012490e+02 1.636364e+02 3.491767e+02 3.489525e+02 2.177112e+02 6.946776e+01
IGHV4-59 4.802386e+02 204.1113308 4.185071e+02 130.3732291 2.899183e+02 101.1216147 191.9015580 81.5240738 158.1557864 49.2341837 79.1893304 27.5918068 1.201809e+03 5.110323e+02 1.107441e+03 3.452313e+02 1.061414e+03 3.706021e+02
IGHV4-61 7.769358e+01 52.6150100 1.783943e+02 46.2915429 3.949637e+01 13.2293128 19.1231530 11.4563580 42.8674000 9.5131468 6.7756061 1.3935586 3.156536e+02 2.416422e+02 7.423943e+02 2.252574e+02 2.302323e+02 1.255883e+02
IGHV4-80 6.393431e+00 5.4341182 1.497587e+01 3.1772141 4.776732e+00 2.3087788 2.0265470 1.7180519 4.4667613 0.9248399 0.9342308 0.4386371 2.017025e+01 1.718786e+01 5.021012e+01 1.091507e+01 2.442348e+01 1.215232e+01
IGHV5-10-1 1.591991e+02 125.1905690 2.097580e+02 39.9421889 1.918837e+02 166.1045024 51.1600717 40.2210338 62.9250467 11.9574463 38.5303598 33.3524422 4.953934e+02 3.896637e+02 6.992196e+02 1.334213e+02 9.555933e+02 8.272469e+02
IGHV5-51 3.529585e+02 274.4418858 6.723698e+02 123.4809357 2.976193e+02 114.2938600 141.3432959 109.8906600 254.7298649 46.7430048 81.5583047 31.2943328 8.813981e+02 6.853935e+02 1.774747e+03 3.261994e+02 1.086061e+03 4.174266e+02
IGHV5-78 2.332607e+00 2.0106751 2.385843e+00 0.8487965 5.415698e+00 1.7590739 2.2276476 1.8838538 0.8890569 0.2861359 5.0691388 1.6120167 2.442512e+00 2.146034e+00 6.402567e+00 2.517878e+00 5.785951e+00 1.919547e+00
IGHV6-1 1.451384e+02 71.6382241 2.265807e+02 34.2843558 7.712558e+01 13.8443629 55.6758967 27.4562739 82.0300486 12.3751599 19.8719831 3.5341588 3.783530e+02 1.869167e+02 6.258538e+02 9.498197e+01 2.993338e+02 5.423253e+01
IGHV7-27 4.278945e+00 0.2241419 1.870107e+00 0.2462519 6.009718e-01 0.7038800 1.3256213 0.0495910 0.5243198 0.0512506 0.0961951 0.1159314 1.381192e+01 1.013078e+00 6.670164e+00 1.183205e+00 3.754526e+00 4.273621e+00
IGHV7-34-1 1.957587e+00 0.8426093 5.802601e+00 1.5986411 6.704624e-01 0.7229844 0.5771340 0.2344879 1.6397634 0.4330315 0.1060003 0.1157497 6.639957e+00 3.027834e+00 2.053356e+01 5.901773e+00 4.240742e+00 4.515836e+00
IGHV7-4-1 1.406688e+02 27.4277471 3.346638e+02 32.0224251 1.748218e+01 1.7628634 25.2048420 6.0477385 82.5527363 8.9844477 3.4485991 0.3133635 7.850753e+02 1.243905e+02 1.356707e+03 1.141345e+02 8.862338e+01 9.917196e+00
IGHV7-40 4.627974e+00 0.3505903 2.167658e+00 0.2856885 8.683191e-01 0.1845447 1.0474451 0.0663701 0.4400704 0.0468072 0.0967759 0.0140399 2.044798e+01 1.851942e+00 1.067725e+01 1.743704e+00 7.790969e+00 2.425709e+00
IGHV7-56 4.393308e+00 4.5948816 7.709636e+00 1.0918349 1.202457e+00 0.1399120 1.2332366 1.2908771 2.0212036 0.2672273 0.1858733 0.0116432 1.565081e+01 1.635550e+01 2.940747e+01 4.461009e+00 7.778966e+00 1.681272e+00
IGHV7-81 2.745746e+00 2.0585440 5.120100e+00 1.8458611 1.797619e+00 0.5192397 0.8927216 0.6616487 1.5818910 0.5507384 0.3577027 0.0870040 8.445098e+00 6.404613e+00 1.657221e+01 6.186609e+00 9.033851e+00 3.098823e+00
IGLL5 4.254239e+02 229.3255619 4.874306e+02 156.6421565 2.379926e+02 143.4203234 186.9995882 100.7415652 203.7929408 65.4420011 74.3652507 44.7889012 9.678390e+02 5.220309e+02 1.165833e+03 3.749391e+02 7.616523e+02 4.592519e+02
IGLV4-3 3.512032e+00 0.9697800 6.661256e+00 0.4119630 1.199870e+00 0.4847370 1.0744253 0.3154836 1.2213943 0.1135686 0.2629825 0.0929356 1.147997e+01 2.981053e+00 3.632924e+01 1.494369e+00 5.474461e+00 2.528310e+00
IL10 4.291715e+00 3.5416139 4.900442e+00 5.2839177 2.792253e+00 4.6450885 2.6770683 2.1849411 2.9913391 3.2371022 1.3778343 2.3965822 6.880220e+00 5.740671e+00 8.027953e+00 8.624932e+00 5.658646e+00 9.003175e+00
IL10RA 3.236925e+01 28.4978512 4.174946e+01 39.8010820 3.298897e+01 32.5760885 24.7458420 21.7531577 31.6051131 30.0778070 22.6961791 22.3533987 4.234119e+01 3.733378e+01 5.514986e+01 5.266761e+01 4.794957e+01 4.747383e+01
IL10RB 2.650470e+01 23.7457092 2.657278e+01 28.1179730 2.430138e+01 25.1728988 22.7793684 20.3728501 22.6523717 24.0083719 19.5888081 20.2727897 3.083928e+01 2.767697e+01 3.117168e+01 3.293103e+01 3.014768e+01 3.125741e+01
IL10RB-AS1 3.470989e+00 3.2884416 3.703888e+00 4.0128076 4.559521e+00 3.5453020 2.0553443 1.9409367 2.1329966 2.3214133 2.2172252 1.6926959 5.861678e+00 5.571458e+00 6.431697e+00 6.936561e+00 9.376238e+00 7.425531e+00
IL11 4.314942e-01 0.5647416 4.636478e-01 0.3793075 5.308345e-01 0.9462272 0.1806197 0.2534857 0.1880236 0.1446198 0.1674135 0.3518488 1.030825e+00 1.258190e+00 1.143310e+00 9.948439e-01 1.683169e+00 2.544690e+00
IL11RA 2.528396e+01 35.2825529 2.605408e+01 38.0151502 3.294211e+01 33.9688912 19.0993431 26.8661060 19.4348598 28.4898416 22.3745391 23.0192121 3.347123e+01 4.633565e+01 3.492770e+01 5.072516e+01 4.850077e+01 5.012707e+01
IL12A 5.902171e-01 0.5716803 4.977562e-01 0.4378966 3.852030e-01 0.5641051 0.3070409 0.2947597 0.2361436 0.1990064 0.1265506 0.2198844 1.134560e+00 1.108762e+00 1.049197e+00 9.635542e-01 1.172506e+00 1.447190e+00
IL12B 1.139830e-01 0.1193905 1.427274e-01 0.1425811 1.273286e-01 0.1709912 0.0282518 0.0305159 0.0378079 0.0377446 0.0196138 0.0336466 4.598679e-01 4.671036e-01 5.388061e-01 5.386035e-01 8.265918e-01 8.689746e-01
IL12RB1 4.203455e+00 3.0635216 5.437105e+00 4.2355259 3.171553e+00 3.2060832 2.9462925 2.0928980 3.7959509 2.9071305 1.8585680 1.8813564 5.997041e+00 4.484291e+00 7.787800e+00 6.170923e+00 5.412096e+00 5.463595e+00
IL12RB2 1.101555e+00 0.4546205 7.320355e-01 0.6511364 5.281855e-01 0.3930538 0.6383514 0.2132041 0.3757110 0.3243530 0.1927690 0.1260261 1.900869e+00 9.693992e-01 1.426298e+00 1.307152e+00 1.447224e+00 1.225868e+00
IL13RA1 3.345323e+01 36.1678337 3.932599e+01 49.1322032 3.516866e+01 38.9734229 27.2457034 29.5146106 31.7599747 39.7959137 26.3554965 29.2638195 4.107505e+01 4.432084e+01 4.869443e+01 6.065883e+01 4.692891e+01 5.190463e+01
IL13RA2 3.615240e+00 4.4478856 3.123817e+00 4.0480680 3.828054e+00 5.8946021 2.1957899 2.7943186 1.8667952 2.4465446 1.9730848 3.0975691 5.952282e+00 7.079968e+00 5.227263e+00 6.697959e+00 7.426945e+00 1.121729e+01
IL15 6.145814e+00 6.4636111 7.676756e+00 7.2900953 6.872605e+00 5.8016225 4.6794075 4.9369038 5.8291066 5.5189475 4.7193716 3.9248022 8.071755e+00 8.462443e+00 1.011005e+01 9.629642e+00 1.000826e+01 8.575929e+00
IL15RA 1.165679e+01 9.5537083 1.347431e+01 10.4786205 1.049605e+01 8.5647626 9.0507063 7.3598607 10.3565121 7.9777852 7.2974396 5.8813031 1.501328e+01 1.240150e+01 1.753071e+01 1.376340e+01 1.509667e+01 1.247260e+01
IL16 2.384068e+01 22.5202001 2.320787e+01 24.2691922 1.778086e+01 20.7060585 18.5422819 17.5120168 17.8270347 18.6223133 12.4198330 14.4789296 3.065307e+01 2.896065e+01 3.021282e+01 3.162838e+01 2.545599e+01 2.961136e+01
IL17B 8.475977e-01 1.1700285 9.086261e-01 0.6588193 8.849876e-01 1.1112158 0.4365885 0.6364504 0.4557423 0.3083707 0.3502936 0.4645126 1.645536e+00 2.150940e+00 1.811553e+00 1.407536e+00 2.235847e+00 2.658271e+00
IL17D 8.180223e+00 15.4619534 6.718205e+00 16.9088071 1.258223e+01 17.2307493 5.1631047 10.1447026 4.2128006 10.9894630 7.0176904 9.6160110 1.296043e+01 2.356619e+01 1.071360e+01 2.601654e+01 2.255905e+01 3.087546e+01
IL17RA 5.062928e+00 5.0182698 6.793675e+00 6.1363891 5.869035e+00 5.3165456 3.8735602 3.8325516 5.2173702 4.6792516 4.0858199 3.6634501 6.617489e+00 6.570827e+00 8.846223e+00 8.047285e+00 8.430517e+00 7.715584e+00
IL17RB 9.552586e-01 0.8546335 8.864340e-01 0.8053799 7.728540e-01 0.6857411 0.5815868 0.5070539 0.5142251 0.4559069 0.3566763 0.3028174 1.569016e+00 1.440475e+00 1.528057e+00 1.422740e+00 1.674637e+00 1.552886e+00
IL17RC 1.863222e+01 18.9457083 1.756771e+01 19.4322799 2.178338e+01 20.4740441 15.4014004 15.6890889 14.3605828 15.9353683 16.8004743 15.7543992 2.254079e+01 2.287831e+01 2.149107e+01 2.369657e+01 2.824417e+01 2.660758e+01
IL17RD 1.245263e+00 1.9570578 1.369363e+00 2.5300413 1.641326e+00 2.2948030 0.7450415 1.2422486 0.8016519 1.6114327 0.8449240 1.2452961 2.081333e+00 3.083180e+00 2.339115e+00 3.972309e+00 3.188395e+00 4.228810e+00
IL17RE 3.190028e+00 2.8196840 3.544691e+00 2.3437890 4.602876e+00 3.9725666 2.0692364 1.8497831 2.2843413 1.4727471 2.6375248 2.2753705 4.917891e+00 4.298135e+00 5.500419e+00 3.730000e+00 8.032707e+00 6.935699e+00
IL18 2.211150e+01 14.8891318 2.055980e+01 17.0913193 1.684686e+01 15.8351883 16.4030321 10.9600962 14.9588082 12.3892450 10.9654843 10.2876305 2.980658e+01 2.022667e+01 2.825796e+01 2.357797e+01 2.588274e+01 2.437424e+01
IL18BP 1.864331e+01 12.6897753 2.002927e+01 12.6848877 1.584720e+01 12.6977194 13.6405201 9.2061685 14.3988096 9.0251061 10.1409709 8.0654701 2.548093e+01 1.749158e+01 2.786143e+01 1.782875e+01 2.476426e+01 1.999041e+01
IL18R1 1.532300e+00 1.3565245 1.713540e+00 1.5304341 1.289057e+00 1.2110602 0.9784567 0.8493290 1.0838862 0.9508424 0.6566569 0.6073587 2.399639e+00 2.166603e+00 2.708975e+00 2.463319e+00 2.530496e+00 2.414828e+00
IL18RAP 1.067418e+00 1.0456635 1.894113e+00 1.4925151 1.291347e+00 1.2861037 0.6048557 0.5903695 1.1322134 0.8639402 0.6045863 0.6015976 1.883725e+00 1.852081e+00 3.168716e+00 2.578421e+00 2.758212e+00 2.749451e+00
IL1B 3.951428e+00 2.0040159 3.382335e+00 1.2659997 2.535603e+00 4.4481636 2.1445948 1.0741398 1.8271963 0.6312177 1.1046936 1.4496218 7.280527e+00 3.738880e+00 6.261064e+00 2.539148e+00 5.819967e+00 1.364919e+01
IL1R1 2.688222e+01 27.8224553 2.839349e+01 32.9045885 3.025740e+01 26.6653216 20.4708466 21.2334003 21.3541857 24.8044837 20.6521400 18.1112285 3.530160e+01 3.645620e+01 3.775327e+01 4.364985e+01 4.433003e+01 3.925959e+01
IL1R2 3.446986e+00 3.1857555 2.877465e+00 2.9831044 3.593684e+00 7.0253964 2.2359042 2.0623373 1.7931131 1.8699641 1.9715118 3.2103136 5.314052e+00 4.921134e+00 4.617560e+00 4.758868e+00 6.550588e+00 1.537426e+01
IL1RAP 2.692460e+00 2.2178202 2.405500e+00 2.5428969 2.189186e+00 3.7560189 1.9138929 1.5391065 1.6509181 1.7578837 1.3027207 2.4342806 3.787747e+00 3.195832e+00 3.504977e+00 3.678471e+00 3.678867e+00 5.795420e+00
IL1RL1 5.336542e-01 0.4321292 4.386685e-01 0.7397467 4.289625e-01 0.4320814 0.2618002 0.1990174 0.1937234 0.3795744 0.1428170 0.1443266 1.087802e+00 9.382878e-01 9.933235e-01 1.441681e+00 1.288424e+00 1.293554e+00
IL1RL2 9.263672e-01 0.7592592 6.103178e-01 0.8828151 9.835745e-01 0.6057754 0.5398232 0.4229470 0.3092194 0.4923911 0.4664864 0.2439713 1.589699e+00 1.362995e+00 1.204607e+00 1.582812e+00 2.073841e+00 1.504127e+00
IL1RN 1.008632e+01 5.2063895 6.122472e+00 4.0420985 4.689854e+00 5.9253583 6.0455064 3.1649480 3.6510346 2.3438780 2.3323792 2.6673376 1.682800e+01 8.564593e+00 1.026686e+01 6.970738e+00 9.430170e+00 1.316289e+01
IL20RA 1.565985e+00 0.3947073 4.169590e-01 0.3738428 6.058459e-01 0.4013011 0.5956622 0.1574669 0.1589785 0.1400095 0.1950894 0.1124862 4.116944e+00 9.893756e-01 1.093574e+00 9.982070e-01 1.881441e+00 1.431665e+00
IL21R 4.578424e+00 1.8736298 5.641598e+00 1.8335610 2.496212e+00 1.5969794 2.5629179 1.0010494 3.2407172 0.9714540 1.1479034 0.6756833 8.178946e+00 3.506809e+00 9.821167e+00 3.460736e+00 5.428222e+00 3.774465e+00
IL21R-AS1 2.210210e-01 0.1944446 3.033448e-01 0.2014235 1.972880e-01 0.3380243 0.0766218 0.0634474 0.1134235 0.0625324 0.0408888 0.0963223 6.375508e-01 5.959060e-01 8.112789e-01 6.488064e-01 9.519123e-01 1.186231e+00
IL22RA1 6.322445e-01 0.2321078 3.328121e-01 0.1331375 4.175520e-01 0.0999073 0.1800111 0.0715234 0.1097320 0.0304640 0.1087579 0.0112582 2.220603e+00 7.532362e-01 1.009403e+00 5.818547e-01 1.603099e+00 8.865960e-01
IL23A 1.142804e+00 0.9650472 1.321254e+00 1.0633913 1.176333e+00 1.4564119 0.6982619 0.5700791 0.8056937 0.6213439 0.5905969 0.7707435 1.870359e+00 1.633661e+00 2.166719e+00 1.819928e+00 2.342986e+00 2.752064e+00
IL24 1.732507e+00 1.1086443 1.846101e+00 0.8152098 7.778267e-01 1.3587452 0.9861812 0.5952208 1.0228451 0.3982600 0.2953905 0.5875638 3.043640e+00 2.064935e+00 3.331971e+00 1.668677e+00 2.048185e+00 3.142108e+00
IL26 5.873927e-01 0.5057060 8.566563e-01 0.4558793 6.121943e-01 0.2747837 0.2682118 0.2226181 0.4045579 0.1854228 0.2047482 0.0655093 1.286409e+00 1.148777e+00 1.813980e+00 1.120822e+00 1.830453e+00 1.152601e+00
IL27 5.201435e-01 0.4913582 5.312805e-01 0.4733790 4.046567e-01 0.5095383 0.2412198 0.2243689 0.2365692 0.2038485 0.1231584 0.1705446 1.121588e+00 1.076053e+00 1.193135e+00 1.099285e+00 1.329565e+00 1.522354e+00
IL27RA 5.530562e+00 4.6263201 6.434536e+00 5.1945563 4.559268e+00 4.7901188 4.0516443 3.3448947 4.6817355 3.7234663 2.9051331 3.0606330 7.549308e+00 6.398658e+00 8.843569e+00 7.246854e+00 7.155239e+00 7.496893e+00
IL2RA 3.966331e+00 1.5723689 3.718950e+00 1.9121202 1.897833e+00 1.5471624 2.2565086 0.8268023 2.1209413 1.0314441 0.8479207 0.6597620 6.971736e+00 2.990248e+00 6.520966e+00 3.544742e+00 4.247766e+00 3.628144e+00
IL2RB 4.117526e+00 2.0930523 4.334010e+00 2.3126154 2.845507e+00 2.0541735 2.5225081 1.2364212 2.6393165 1.3104069 1.4352270 0.9665665 6.721096e+00 3.543184e+00 7.116859e+00 4.081320e+00 5.641553e+00 4.365585e+00
IL2RG 3.085586e+01 19.8902661 3.804322e+01 18.7290684 1.948095e+01 16.3053137 30.1379448 19.2391544 36.7997547 17.8691278 18.8435122 15.5554470 3.159088e+01 2.056341e+01 3.932870e+01 1.963039e+01 2.013995e+01 1.709133e+01
IL31RA 2.160091e-01 0.1811050 1.668230e-01 0.1947297 9.830990e-02 0.2453363 0.0721848 0.0556630 0.0456521 0.0578537 0.0110719 0.0562996 6.463951e-01 5.892426e-01 6.096083e-01 6.554404e-01 8.729162e-01 1.069101e+00
IL32 1.466251e+02 109.4052443 1.308983e+02 106.1554702 9.303828e+01 120.5575152 103.9080368 77.4758706 90.8205815 73.6103475 57.0695274 74.0292029 2.069034e+02 1.544934e+02 1.886616e+02 1.530897e+02 1.516768e+02 1.963295e+02
IL33 1.445487e+01 13.7356458 1.534907e+01 16.1380502 1.524987e+01 13.8053996 9.5588865 9.1429334 10.0662268 10.5817629 8.5847888 7.8044946 2.185853e+01 2.063539e+01 2.340439e+01 2.461184e+01 2.708960e+01 2.442042e+01
IL34 7.848529e+00 8.5497830 7.064475e+00 8.7339938 6.332250e+00 5.8345862 5.5093539 6.0495050 4.8678722 6.0212805 3.8255814 3.5112131 1.118088e+01 1.208343e+01 1.025228e+01 1.266884e+01 1.048138e+01 9.695338e+00
IL36G 4.890991e+00 0.2814193 3.948026e-01 0.1236761 5.151571e-01 0.1155209 0.9071089 0.0427231 0.0568927 0.0129674 0.0408903 0.0054863 2.637146e+01 1.853723e+00 2.739703e+00 1.179555e+00 6.490209e+00 2.432430e+00
IL36RN 4.341152e+00 0.3508600 5.544977e-01 0.1023777 1.149483e+00 0.1370458 0.5597062 0.0396338 0.0579768 0.0072490 0.0605370 0.0046766 3.367053e+01 3.106004e+00 5.303286e+00 1.445874e+00 2.182654e+01 4.016113e+00
IL37 2.655488e+00 0.2380471 1.023868e+00 0.1183720 1.142256e+00 0.1089822 0.6919649 0.0471030 0.2339872 0.0161300 0.1613650 0.0072127 1.019071e+01 1.203033e+00 4.480184e+00 8.686886e-01 8.085697e+00 1.646705e+00
IL3RA 1.852714e+01 18.8401831 1.781751e+01 18.8214704 2.149956e+01 19.6868451 14.3376390 14.6279563 13.6611466 14.4693378 15.1911582 13.8059761 2.394084e+01 2.426535e+01 2.323844e+01 2.448265e+01 3.042763e+01 2.807276e+01
IL4I1 6.544555e+00 3.6581582 7.313311e+00 4.0414535 5.084227e+00 6.8903893 3.3104808 1.7891342 3.6303650 1.8959189 1.9791413 2.1966814 1.293806e+01 7.479663e+00 1.473255e+01 8.615002e+00 1.306090e+01 2.161327e+01
IL4R 2.538100e+01 23.7980082 3.137323e+01 26.8348689 2.689669e+01 25.0529308 19.5945479 18.3386820 23.9440251 20.4319861 18.6893367 17.3605689 3.287624e+01 3.088255e+01 4.110754e+01 3.524426e+01 3.870827e+01 3.615373e+01
IL5RA 1.051778e+00 1.1394401 1.371916e+00 0.8018849 7.783802e-01 0.8906319 0.5650700 0.6199863 0.7400578 0.3938847 0.2991364 0.3551218 1.957699e+00 2.094117e+00 2.543253e+00 1.632507e+00 2.025416e+00 2.233671e+00
IL6 8.160025e+00 2.1688975 5.416211e+00 2.0026499 9.749465e+00 2.3375868 7.4398721 1.9034323 2.2339149 0.7923023 2.9341709 0.6370518 8.949886e+00 2.471386e+00 1.313181e+01 5.061965e+00 3.239486e+01 8.577501e+00
IL6R 7.207434e+00 7.4486378 8.494722e+00 8.8218491 7.124477e+00 7.4648893 5.5456657 5.7417564 6.4928442 6.7520431 4.9161043 5.1737102 9.367155e+00 9.662933e+00 1.111382e+01 1.152614e+01 1.032488e+01 1.077072e+01
IL6ST 1.533123e+01 19.1759796 2.084153e+01 25.0836894 1.860893e+01 20.9894412 11.4947332 14.5176296 15.5532821 18.7680978 12.5023314 14.1474654 2.044821e+01 2.532908e+01 2.792781e+01 3.352452e+01 2.769823e+01 3.114032e+01
IL7 1.998716e+00 1.3332332 1.970479e+00 1.8331856 1.771394e+00 0.9830511 1.3101121 0.8238555 1.2565186 1.1573051 0.9530372 0.4597778 3.049256e+00 2.157552e+00 3.090116e+00 2.903789e+00 3.292459e+00 2.101862e+00
IL7R 7.223909e+00 5.7592475 9.286172e+00 5.8524092 4.945158e+00 5.7325103 4.0465694 3.1799292 5.1491911 3.1243080 2.1961161 2.4825016 1.289607e+01 1.043071e+01 1.674690e+01 1.096265e+01 1.113538e+01 1.323732e+01
IL9R 6.329281e-01 0.4434715 7.817182e-01 0.3868135 4.971967e-01 0.4157400 0.2853214 0.1834805 0.3508236 0.1455387 0.1489028 0.1163404 1.404024e+00 1.071868e+00 1.741854e+00 1.028075e+00 1.660174e+00 1.485638e+00
IL9RP3 1.355428e-01 0.1227762 2.053049e-01 0.1386215 1.375119e-01 0.1204466 0.0341141 0.0291563 0.0593732 0.0325244 0.0197724 0.0155107 5.385413e-01 5.170069e-01 7.099176e-01 5.908153e-01 9.563611e-01 9.353131e-01
ILDR1 1.767462e-01 0.1358551 1.653419e-01 0.1043191 1.106349e-01 0.1623390 0.0548184 0.0364080 0.0460228 0.0215650 0.0143065 0.0290952 5.698677e-01 5.069383e-01 5.940084e-01 5.046352e-01 8.555579e-01 9.057851e-01
ILDR2 5.372370e-02 0.0650658 4.508380e-02 0.0504064 6.317250e-02 0.0750363 0.0069364 0.0100252 0.0042557 0.0053772 0.0043230 0.0063169 4.161002e-01 4.222926e-01 4.776013e-01 4.725170e-01 9.231410e-01 8.913309e-01
ILF2 6.889831e+01 63.0737503 6.725899e+01 70.0146259 6.716762e+01 69.2695269 59.4741693 54.4421919 57.5723865 59.9753746 54.5945249 56.2901177 7.981577e+01 7.307380e+01 7.857537e+01 8.173434e+01 8.263630e+01 8.524174e+01
ILF3 4.119381e+01 40.0374404 4.488605e+01 44.6603691 4.528690e+01 44.4660668 33.5983316 32.6440962 36.2306776 36.0419508 34.0224008 33.3904945 5.050638e+01 4.910525e+01 5.560917e+01 5.533964e+01 6.028098e+01 5.921539e+01
ILF3-AS1 1.009614e+01 15.0958944 1.041541e+01 13.7305819 1.389800e+01 15.2407733 8.0136953 12.1716391 8.1642558 10.8896593 10.2089938 11.2449116 1.271972e+01 1.872271e+01 1.328729e+01 1.731265e+01 1.892003e+01 2.065656e+01
ILK 8.624980e+01 104.7677527 9.431587e+01 112.8291080 1.129531e+02 126.1548493 71.5174557 87.0048252 77.4253799 92.7279265 86.9156529 97.1572394 1.040170e+02 1.261572e+02 1.148910e+02 1.372877e+02 1.467906e+02 1.638071e+02
ILKAP 2.512000e+01 28.6419953 2.694192e+01 31.4107822 3.159449e+01 34.7237423 21.0690600 24.1249850 22.4419458 26.2282626 24.8886789 27.4228052 2.994982e+01 3.400474e+01 3.234422e+01 3.761733e+01 4.010706e+01 4.396845e+01
ILVBL 1.841167e+01 17.1288891 1.813901e+01 19.3054471 2.322413e+01 20.8311247 15.3844540 14.2782700 14.9846654 15.9818681 18.1886716 16.2448061 2.203456e+01 2.054863e+01 2.195735e+01 2.332020e+01 2.965364e+01 2.671228e+01
IMPAD1 8.890594e+00 9.4536913 1.094563e+01 11.9624235 9.713860e+00 12.1289015 7.1710415 7.6535830 8.8172495 9.6797265 7.2210015 9.1465449 1.102248e+01 1.167718e+01 1.358779e+01 1.478343e+01 1.306731e+01 1.608370e+01
ISG15 7.784337e+01 87.6765189 7.625847e+01 127.3366662 5.697481e+01 70.7591059 49.5990977 55.8841350 47.2775762 79.0508527 30.0766017 37.3960322 1.221714e+02 1.375555e+02 1.230045e+02 2.051164e+02 1.079287e+02 1.338872e+02
LAMP5 2.273907e+00 1.2294477 2.695716e+00 0.8708500 1.419564e+00 0.8233138 1.1020817 0.5708834 1.3435561 0.3874708 0.5152900 0.2725370 4.691716e+00 2.647724e+00 5.408693e+00 1.957256e+00 3.910734e+00 2.487169e+00
LGALSL 8.912839e+00 9.1976720 7.098055e+00 10.2293933 8.529722e+00 8.9569806 6.2767611 6.5576342 4.9127519 7.1850274 5.2888931 5.5619271 1.265600e+01 1.290056e+01 1.025543e+01 1.456369e+01 1.375641e+01 1.442441e+01
LILRA1 2.342973e+00 1.7206355 2.466768e+00 1.8471663 2.012427e+00 1.7750933 1.5647620 1.1052558 1.6173389 1.1670506 1.1082804 0.9550487 3.508216e+00 2.678644e+00 3.762318e+00 2.923629e+00 3.654186e+00 3.299262e+00
LILRA2 7.270048e+00 10.2932657 8.346699e+00 10.5501578 1.152854e+01 9.6227183 5.1337092 7.3608459 5.8045578 7.3985567 7.2089799 5.9708111 1.029540e+01 1.439391e+01 1.200218e+01 1.504426e+01 1.843635e+01 1.550823e+01
LILRA4 2.080852e+00 0.8536551 2.144249e+00 0.5779657 1.098304e+00 0.9989915 0.9010590 0.3436364 0.9926188 0.2265138 0.3491901 0.3127800 4.805395e+00 2.120634e+00 4.631994e+00 1.474719e+00 3.454481e+00 3.190690e+00
LILRA5 9.636926e+00 6.6042977 1.079162e+01 6.9464779 6.966816e+00 9.6650884 6.2316932 4.3527411 7.0485281 4.4729871 3.8886930 4.7599826 1.490291e+01 1.002052e+01 1.652246e+01 1.078777e+01 1.248145e+01 1.962485e+01
LILRA6 9.127149e+00 9.8604424 1.273532e+01 14.2090053 1.365175e+01 13.0497012 6.4208580 6.9388571 8.8818709 9.9018943 8.5061094 8.0430593 1.297410e+01 1.401215e+01 1.826061e+01 2.038962e+01 2.191016e+01 2.117288e+01
LILRB1 1.155737e+01 7.1357069 1.359413e+01 8.6105228 9.054725e+00 8.3761118 7.6941332 4.6649463 8.9684684 5.6000598 5.1291971 4.6989255 1.736033e+01 1.091509e+01 2.060556e+01 1.323934e+01 1.598458e+01 1.493091e+01
LILRB2 2.749005e+01 17.5537932 3.174628e+01 21.4244046 2.241158e+01 21.3996548 19.6698630 12.6704656 22.7718557 15.2506122 14.3740704 13.2600346 3.841932e+01 2.431921e+01 4.425754e+01 3.009749e+01 3.494340e+01 3.453575e+01
LILRB3 1.606291e+01 12.6801576 2.173825e+01 16.9347776 1.715471e+01 14.6358172 11.5267942 9.0279416 15.4460420 11.9099627 10.8409045 8.9999131 2.238413e+01 1.780986e+01 3.059370e+01 2.407956e+01 2.714571e+01 2.380102e+01
LILRB4 5.235058e+01 37.2842221 6.412143e+01 54.9565945 4.713539e+01 42.6642974 33.9156363 23.9851032 41.0624691 34.8347477 25.9301893 22.9560416 8.080590e+01 5.795736e+01 1.001293e+02 8.670157e+01 8.568179e+01 7.929251e+01
LILRB5 2.905046e+01 37.4401319 4.548331e+01 59.3448566 4.873754e+01 46.6528102 21.3669392 27.6954417 33.0868456 43.3265838 32.0866750 30.6571983 3.949695e+01 5.061351e+01 6.252428e+01 8.128525e+01 7.402910e+01 7.099425e+01
LILRP1 1.261715e-01 0.0993942 9.106570e-02 0.0995384 7.219090e-02 0.1239019 0.0295097 0.0200254 0.0156192 0.0182160 0.0053705 0.0156382 5.394587e-01 4.933327e-01 5.309470e-01 5.439122e-01 9.704014e-01 9.816779e-01
LTA 1.265584e+00 0.7856210 1.430851e+00 0.7349406 6.021643e-01 0.9086569 0.6910922 0.3960690 0.7663322 0.3503717 0.2106031 0.3585776 2.317639e+00 1.558315e+00 2.671603e+00 1.541613e+00 1.721731e+00 2.302590e+00
LY6E 1.823022e+02 185.5070076 1.940469e+02 218.7995034 1.689755e+02 157.1506329 136.1505049 137.2060701 142.6265998 159.7760266 112.2904135 104.4707371 2.440981e+02 2.508114e+02 2.640055e+02 2.996271e+02 2.542758e+02 2.363946e+02
MILR1 1.394310e+01 10.8248745 1.567869e+01 13.9822909 1.372737e+01 12.9389610 10.3035232 7.9477089 11.4793711 10.2166687 9.0334577 8.4726222 1.886831e+01 1.474361e+01 2.141418e+01 1.913583e+01 2.086031e+01 1.975973e+01
MMP10 1.767799e-01 0.2710490 1.983864e-01 0.1769912 5.423609e-01 0.2428900 0.0457837 0.0828363 0.0498926 0.0422558 0.1308050 0.0430585 6.825819e-01 8.869006e-01 7.888371e-01 7.413389e-01 2.248807e+00 1.370125e+00
MS4A1 9.002418e+00 9.8298156 1.611937e+01 6.1099131 4.368496e+00 3.9815255 8.6932421 9.3554203 6.9390350 2.5614388 4.1578457 3.7123624 9.322589e+00 1.032827e+01 3.744528e+01 1.457425e+01 4.589819e+00 4.270204e+00
NEIL1 1.649605e+01 20.1920239 1.941997e+01 18.5783957 2.357363e+01 21.5752728 12.8694016 15.8981126 14.9898368 14.3935713 16.8668611 15.3823767 2.114470e+01 2.564568e+01 2.515938e+01 2.397993e+01 3.294721e+01 3.026141e+01
NEIL2 7.474717e+00 7.3219541 7.330086e+00 7.6234509 7.949963e+00 8.7525985 6.0032023 5.8725541 5.8013834 6.0499419 5.8631074 6.5081711 9.306930e+00 9.129079e+00 9.261611e+00 9.606209e+00 1.077959e+01 1.177105e+01
NEIL3 2.776811e-01 0.1304970 2.198992e-01 0.1410913 1.880464e-01 0.2942676 0.1062645 0.0342479 0.0714052 0.0358766 0.0377533 0.0781283 7.256119e-01 4.972417e-01 6.772011e-01 5.548676e-01 9.366444e-01 1.108349e+00
NFIL3 1.293897e+01 9.2818456 1.239795e+01 9.6421481 1.357190e+01 11.4018653 9.6861646 6.9079279 9.1715522 7.0691779 9.0877556 7.5647988 1.728414e+01 1.247156e+01 1.675934e+01 1.315160e+01 2.026866e+01 1.718519e+01
NFKBIL1 1.226301e+01 15.2664779 1.092593e+01 15.8720302 1.573046e+01 15.4863287 9.6411800 12.0895499 8.4262386 12.4075185 11.3236060 11.1406224 1.559781e+01 1.927825e+01 1.416717e+01 2.030393e+01 2.185235e+01 2.152720e+01
NKILA 6.424251e-01 0.6829111 5.697697e-01 0.6650491 7.218376e-01 0.6551292 0.3493494 0.3775007 0.2880742 0.3520047 0.3185615 0.2788951 1.181367e+00 1.235408e+00 1.126923e+00 1.256490e+00 1.635632e+00 1.538910e+00
OASL 4.285754e+00 3.7658360 3.920467e+00 4.7160024 2.144945e+00 2.6562836 2.8273214 2.3763610 2.5189480 3.0494360 1.1095545 1.4089864 6.496499e+00 5.967747e+00 6.101778e+00 7.293374e+00 4.146518e+00 5.007744e+00
ODC1 2.509651e+01 22.8584776 2.550342e+01 22.2389145 2.264886e+01 23.5197895 20.7063699 18.8263569 20.8382745 18.1136946 17.2100681 17.8752450 3.041745e+01 2.775417e+01 3.121298e+01 2.730361e+01 2.980644e+01 3.094674e+01
PADI1 1.665612e-01 0.2595531 1.117590e-01 0.0882609 2.279290e-01 0.1256204 0.0256910 0.0454619 0.0129728 0.0090057 0.0185316 0.0076621 1.079858e+00 1.481853e+00 9.627928e-01 8.650022e-01 2.803403e+00 2.059540e+00
PADI2 1.493051e+00 0.7361604 1.216697e+00 0.5845184 1.811927e+00 0.8204981 1.4674514 0.7183546 0.6247351 0.2651219 0.7837796 0.3081209 1.519097e+00 7.544075e-01 2.369566e+00 1.288697e+00 4.188779e+00 2.184912e+00
PADI4 9.769857e-01 1.3202375 1.947235e+00 0.9443531 2.230587e+00 1.3176012 0.4911450 0.6925959 1.0267273 0.4527105 0.9659524 0.5289407 1.943420e+00 2.516658e+00 3.693021e+00 1.969919e+00 5.150893e+00 3.282169e+00
PAX5 7.689978e-01 0.5302605 6.902880e-01 0.2339320 3.450524e-01 0.4300829 0.3522498 0.2250510 0.2952368 0.0716544 0.0869115 0.1187373 1.678802e+00 1.249389e+00 1.613951e+00 7.637241e-01 1.369913e+00 1.557820e+00
PDCD1 3.813046e+00 1.8372135 3.966694e+00 1.8884010 2.035045e+00 1.5263744 2.2509516 1.0272338 2.2729346 1.0222064 0.9068055 0.6520805 6.459189e+00 3.285867e+00 6.922620e+00 3.488589e+00 4.567029e+00 3.572901e+00
PFKFB1 7.041439e-01 0.3407562 1.278982e+00 0.4886508 1.498501e+00 1.3192798 0.6914587 0.3319566 1.2465404 0.4720709 1.4604278 0.4246625 7.170618e-01 3.497892e-01 1.312268e+00 5.058131e-01 1.537566e+00 4.098547e+00
PHOSPHO1 4.538713e+00 4.2975285 5.031549e+00 3.2193940 5.685680e+00 4.4336074 2.8272491 2.7128514 2.9245096 1.9208488 2.9421381 2.3164539 7.286204e+00 6.807874e+00 8.656659e+00 5.395791e+00 1.098757e+01 8.485761e+00
PI16 1.478399e+01 4.5285233 1.763832e+01 8.0388292 3.138371e+01 15.9011307 6.9341825 2.2135073 7.9535110 3.4710618 12.1486878 5.6046802 3.152014e+01 9.264719e+00 3.911609e+01 1.861758e+01 8.107354e+01 4.511336e+01
PIGH 1.779300e+01 20.8989160 1.766015e+01 24.5878910 1.997420e+01 21.7550635 14.8630972 17.5428271 14.5877386 20.5197006 15.5573948 17.0123766 2.130046e+01 2.489705e+01 2.137967e+01 2.946263e+01 2.564495e+01 2.781991e+01
PILRA 2.233919e+01 18.0496101 2.461136e+01 20.1320688 2.262301e+01 21.9302487 16.4627445 13.3301245 18.0613641 14.6673420 14.9949837 14.0549613 3.031327e+01 2.444001e+01 3.353674e+01 2.763283e+01 3.413145e+01 3.421822e+01
PILRB 2.132563e+01 23.6031655 2.657277e+01 23.2408056 3.503725e+01 25.3746047 16.0688339 17.8368430 19.7412023 17.2540833 23.6497069 17.0416519 2.830213e+01 3.123363e+01 3.576845e+01 3.130477e+01 5.190800e+01 3.778217e+01
PIWIL2 3.131844e-01 0.4409517 3.635525e-01 0.5259716 4.727809e-01 0.7893503 0.1329689 0.2119848 0.1556701 0.2565384 0.1732584 0.3534357 7.376497e-01 9.172278e-01 8.490418e-01 1.078381e+00 1.290107e+00 1.762906e+00
PIWIL4 3.650395e+00 4.5286226 3.770709e+00 6.0027662 4.782375e+00 4.8559891 2.5710041 3.2416263 2.6060031 4.2793733 2.9939443 3.0396680 5.182948e+00 6.326584e+00 5.455959e+00 8.420205e+00 7.639125e+00 7.757633e+00
PPIL1 1.178760e+01 9.9231053 1.223121e+01 10.3460556 1.159874e+01 10.9857556 9.4979057 7.9339578 9.7428213 8.1777288 8.5377286 8.0596144 1.462928e+01 1.241096e+01 1.535514e+01 1.308931e+01 1.575720e+01 1.497427e+01
PPIL2 1.422528e+01 14.6776180 1.647644e+01 15.3892718 1.878587e+01 17.8168563 11.6999124 12.0814216 13.4536752 12.5296242 14.4500298 13.6669360 1.729573e+01 1.783172e+01 2.017837e+01 1.890158e+01 2.442271e+01 2.322689e+01
PPIL3 2.264593e+01 25.6412074 2.503949e+01 27.0361445 2.855892e+01 30.4408390 17.7793479 20.1975735 19.4376070 21.0063899 20.3970694 21.7723796 2.884460e+01 3.255201e+01 3.225584e+01 3.479670e+01 3.998671e+01 4.256056e+01
PPIL4 9.072116e+00 9.0314871 9.608585e+00 10.9184321 8.915754e+00 10.6392796 6.8981408 6.8660256 7.2079189 8.2241349 6.0399224 7.2757346 1.193123e+01 1.187991e+01 1.280881e+01 1.449540e+01 1.316088e+01 1.555778e+01
PPIL6 1.144527e+00 2.3194979 1.407659e+00 2.9429638 2.413566e+00 2.7290736 0.6802263 1.5242469 0.8409651 1.9337127 1.3410032 1.5433193 1.925744e+00 3.529658e+00 2.356225e+00 4.478967e+00 4.343986e+00 4.825860e+00
RAB3IL1 1.781250e+01 20.8537220 1.839060e+01 26.5430117 2.417340e+01 22.9172431 13.9732028 16.4126311 14.2542355 20.7569716 17.3702123 16.4492819 2.270670e+01 2.649653e+01 2.372726e+01 3.394192e+01 3.364112e+01 3.192845e+01
RADIL 1.725084e+00 2.3810872 1.931271e+00 2.7626926 2.590174e+00 2.7684884 1.0643466 1.5251198 1.1444005 1.7405645 1.4067194 1.5161937 2.796002e+00 3.717463e+00 3.259179e+00 4.385055e+00 4.769253e+00 5.055111e+00
RALA 1.489112e+01 15.0474446 1.615292e+01 17.0180633 1.436258e+01 18.0569164 12.2829074 12.4399744 13.2179538 13.9611050 10.9522163 13.9031574 1.805318e+01 1.820145e+01 1.973957e+01 2.074438e+01 1.883487e+01 2.345167e+01
RGS4 1.777273e+00 1.4447091 1.389774e+00 0.8571862 1.923104e+00 3.7644977 1.7479761 1.4111253 1.3575052 0.8291745 1.8784049 3.6411572 1.807062e+00 1.479092e+00 1.422810e+00 8.861442e-01 1.968867e+00 3.892016e+00
RILP 1.801890e+01 19.5161631 1.827094e+01 20.2840540 1.926533e+01 20.3633862 14.2637561 15.4791765 14.2649718 15.8787075 13.8756138 14.6932677 2.276265e+01 2.460600e+01 2.340189e+01 2.591161e+01 2.674859e+01 2.822160e+01
RILPL1 9.404314e+00 9.6017321 8.649595e+00 9.1939979 1.133570e+01 10.2019376 7.3486132 7.5306723 6.6544612 7.0865579 8.1324415 7.2763686 1.203508e+01 1.224237e+01 1.124291e+01 1.192816e+01 1.580068e+01 1.430377e+01
RILPL2 4.682971e+00 6.4821506 5.074151e+00 6.3930025 5.561177e+00 5.8279800 3.6281740 5.1550093 3.8996144 5.0086368 3.9567474 4.1681997 6.044422e+00 8.150960e+00 6.602450e+00 8.160001e+00 7.816189e+00 8.148686e+00
RSAD2 5.029960e+00 6.1392998 5.134058e+00 8.5618641 3.124377e+00 4.3094875 3.3935342 4.0134351 3.3975008 5.7155865 1.7186462 2.4494694 7.455501e+00 9.391208e+00 7.758218e+00 1.282555e+01 5.679895e+00 7.581921e+00
S100B 1.152722e+01 11.0952624 1.938020e+01 10.8417865 1.721517e+01 26.0695521 10.9670937 10.3439825 18.2339220 9.9511805 7.8799957 11.5075509 1.211595e+01 1.190111e+01 2.059853e+01 1.181210e+01 3.760940e+01 5.905875e+01
SAA1 6.676082e+00 3.0247273 3.037971e+00 0.6893072 1.135659e+01 14.3430531 2.5982396 1.1492104 1.0933006 0.2182713 3.0292405 3.8388418 1.715395e+01 7.961097e+00 8.441654e+00 2.176852e+00 4.257575e+01 5.358991e+01
SAA2 1.910433e+00 0.9490289 8.473825e-01 0.2275547 1.436605e+00 1.5944926 0.7976090 0.3705237 0.3134613 0.0622948 0.4107106 0.4611602 4.575870e+00 2.430765e+00 2.290736e+00 8.312272e-01 5.025035e+00 5.513066e+00
SDK2 9.275273e-01 1.2764099 6.455905e-01 1.1260358 7.939445e-01 1.1080502 0.5053932 0.7342369 0.3122059 0.6133297 0.3219397 0.4910245 1.702253e+00 2.218933e+00 1.334975e+00 2.067333e+00 1.957968e+00 2.500436e+00
SIL1 3.592841e+01 35.2092605 4.071806e+01 35.3001892 4.530728e+01 47.9268384 27.0369978 26.4901676 30.1567427 26.1048672 30.4000941 32.1785155 4.774385e+01 4.679819e+01 5.497811e+01 4.773452e+01 6.752446e+01 7.138247e+01
SKIL 5.973789e+00 6.6370790 6.476428e+00 9.4145740 7.053848e+00 7.6369106 4.6361256 5.1923337 4.9789457 7.3919182 5.0166152 5.4679552 7.697409e+00 8.483819e+00 8.424298e+00 1.199069e+01 9.918395e+00 1.066622e+01
STAG3L5P-PVRIG2P-PILRB 6.598598e+00 6.6970657 8.021877e+00 7.1464390 8.478071e+00 6.9303993 4.7345161 4.8050692 5.6900196 5.0383587 5.3636176 4.3453518 9.196610e+00 9.334036e+00 1.130937e+01 1.013655e+01 1.340097e+01 1.105329e+01
STIL 7.830046e-01 0.6089885 7.795424e-01 0.6353165 7.004732e-01 0.9086205 0.4522066 0.3289605 0.4349525 0.3347994 0.3095246 0.4395184 1.355788e+00 1.127391e+00 1.397133e+00 1.205579e+00 1.585214e+00 1.878400e+00
SVIL 1.016479e+01 12.1552139 8.009582e+00 12.4536609 1.103030e+01 11.6281179 7.4713948 8.9959992 5.7390601 9.0598324 7.1793828 7.5729220 1.382914e+01 1.642388e+01 1.117838e+01 1.711882e+01 1.694680e+01 1.785482e+01
SVIL-AS1 1.848888e+01 20.7669603 2.102043e+01 23.6495989 1.958927e+01 26.8656251 15.1381053 17.0630742 17.0771334 19.2678175 14.7991162 20.5153815 2.258133e+01 2.527485e+01 2.587427e+01 2.902786e+01 2.592989e+01 3.518150e+01
SVILP1 2.349001e-01 0.2280990 2.037960e-01 0.2382573 2.138812e-01 0.2988665 0.0862627 0.0826476 0.0655985 0.0828989 0.0487659 0.0837585 6.396518e-01 6.295304e-01 6.331361e-01 6.847688e-01 9.380564e-01 1.066414e+00
TIGIT 3.925485e+00 3.0155547 4.385816e+00 2.2533273 1.660806e+00 1.4068681 2.1615211 1.5471642 2.3948947 1.1460992 0.6880979 0.5179250 7.128977e+00 5.877573e+00 8.031828e+00 4.430231e+00 4.008552e+00 3.821553e+00
TRIL 1.402709e+00 1.8207061 1.566002e+00 1.9348643 2.122822e+00 2.1537932 0.8489065 1.1410232 0.9400106 1.1939327 1.1204860 1.1307290 2.317796e+00 2.905261e+00 2.608865e+00 3.135604e+00 4.021802e+00 4.102508e+00
UBFD1 8.406039e+00 6.9230618 8.007660e+00 7.5988008 8.277994e+00 8.7763811 6.6236697 5.3944382 6.2018834 5.8663064 5.9044410 6.2829038 1.066803e+01 8.884852e+00 1.033922e+01 9.842952e+00 1.160570e+01 1.225944e+01
USP18 3.502181e+00 4.3453945 3.940899e+00 4.4694981 2.720912e+00 3.0776942 2.4715262 3.1204089 2.7516095 3.1525973 1.6059867 1.8487140 4.962630e+00 6.051275e+00 5.644218e+00 6.336494e+00 4.609851e+00 5.123671e+00
USP9Y 3.611526e-01 1.4408979 3.156332e+00 4.7602203 4.053741e+00 0.2713043 0.0799096 0.3721661 0.7753121 1.1800427 0.6286297 0.0293763 1.632235e+00 5.578656e+00 1.284958e+01 1.920244e+01 2.614069e+01 2.505630e+00
VIL1 2.877140e-01 0.4940834 2.866187e-01 0.3895768 4.199510e-01 0.2737427 0.1002034 0.2016967 0.0935016 0.1409627 0.1115278 0.0600605 8.261137e-01 1.210324e+00 8.785981e-01 1.076668e+00 1.581300e+00 1.247660e+00
VILL 6.212449e+00 6.7092718 6.763039e+00 6.4456901 7.924241e+00 7.2099303 4.8507215 5.2659304 5.2336037 4.9711585 5.7082012 5.1520798 7.956451e+00 8.548220e+00 8.739427e+00 8.357593e+00 1.100059e+01 1.008973e+01
XBP1 1.744531e+02 125.6412109 2.318871e+02 112.9167156 1.433170e+02 92.8226464 119.4843495 85.9554396 157.5397551 77.4005966 85.7629227 55.9612136 2.547104e+02 1.836500e+02 3.413211e+02 1.647298e+02 2.394945e+02 1.539646e+02
XCR1 8.558504e-01 0.4412318 1.300740e+00 0.9914319 5.530547e-01 0.4993068 0.4360302 0.1923731 0.6826263 0.4982976 0.1864124 0.1620938 1.679884e+00 1.012020e+00 2.478552e+00 1.972591e+00 1.640822e+00 1.538043e+00
ZWILCH 3.823946e+00 3.5572915 4.130910e+00 4.6766732 3.819816e+00 4.8296336 2.8916771 2.6720017 3.0957909 3.5423517 2.5770418 3.3578092 5.056776e+00 4.735896e+00 5.512136e+00 6.174224e+00 5.661917e+00 6.946601e+00

Finally the qvalues from each of the pvalues can be calculated. This will output a significance table based on the cut-off (default p=0.05):

resultTable <- glmmQvals(resultTable, pi0=1)
## 
## q_Timepoint
## -----------
## Not Significant     Significant 
##             266              76 
## 
## q_EULAR_bin
## -----------
## Not Significant     Significant 
##             323              19 
## 
## q_Timepoint:EULAR_bin
## ---------------------
## Not Significant     Significant 
##             322              20

Paired Plots

For variables which are paired according to an ID, we can view the model using paired plots. In this case the samples can be paired over time.

Plots can be viewed either in base graphics:

plotColours <- c("skyblue", "goldenrod1", "mediumvioletred")
modColours <- rep(c("dodgerblue3", "goldenrod3", "deeppink4"), each=2)

pairedPlot(glmmResult=resultTable,
           geneName = "MS4A1",
           x1Label = "Timepoint",
           x2Label="EULAR_bin",
           IDColumn = "PATID",
           graphics = "ggplot",
           colours = plotColours,
           modColour = modColours,
           modLineColour = modColours,
           fontSize=8,
           logTransform=TRUE,
           addViolin = TRUE, 
           pairedOnly = TRUE)

Or using ggplot, with or without the model fit overlaid:

library(ggpubr)
## Loading required package: ggplot2
p1 = pairedPlot(glmmResult=resultTable,
                geneName = "ADAM12",
                x1Label = "Timepoint",
                x2Label="EULAR_bin",
                IDColumn = "PATID",
                graphics="ggplot",
                addViolins=FALSE,
                fontSize=8,
                colours=plotColours,
                modSize = 1) 

p2 = pairedPlot(glmmResult=resultTable,
                geneName = "ADAM12",
                x1Label = "Timepoint",
                x2Label="EULAR_bin",
                IDColumn = "PATID",
                addModel=FALSE,
                graphics="ggplot",
                fontSize=8,
                colours=plotColours) 

ggarrange(p1, p2, ncol=2)

Model plots

Alternatively to plot the model fits alone you can use the modelPlot function:

p1 <- modelPlot(resultTable,
                "ADAM12", 
                x1Label="Timepoint", 
                x2Label="EULAR_bin", 
                xTitle="Time", 
                fontSize=8,
                overlap=FALSE, 
                colours = plotColours)

p2 <- modelPlot(resultTable, 
                "ADAM12", 
                x1Label="Timepoint", 
                x2Label="EULAR_bin",
                xTitle="Time", 
                fontSize=8,
                addErrorbars = FALSE,
                overlap=TRUE, 
                colours = plotColours)

ggarrange(p1, p2, ncol=2, common.legend = T, legend="bottom")

Fold Change Plots

The fold change all genes can be plotted on fold change plots to highlight significance. Genes on the x-y plane are associated in the same direction. Genes on the x=-y axis have association in opposite directions.

This can be plotted with plotly or ggplot:

labels = c("IGHV7-4-1", "IGHV3-49", "IGHV3-23", "ADAM12", "FGFRL1", "IL36G",
           "BLK", "SAA1", "CILP", "EMILIN3", "EMILIN2", "IGHJ6", "CXCL9")

fcPlot(glmmResult=resultTable,
       x1Label="Timepoint",
       x2Label="EULAR_bin",
       x2Values=c("Good responder", "Non responder"),
       pCutoff=0.05,
       labels=labels,
       useAdjusted = FALSE,
       plotCutoff = 1,
       graphics="plotly")

Or flipping the x1 and x2 labels we can look at the fold change between response at different timepoints. This might be interesting to see if there are differences at certain timepoints which to not present at others.

fcPlot(glmmResult=resultTable,
       x2Label="Timepoint",
       x1Label="EULAR_bin",
       x1Values=c("Good responder", "Non responder"),
       labels=labels,
       pCutoff=0.05,
       useAdjusted = F,
       plotCutoff = 1,
       graphics="plotly")

This has a allowed us to pick out genes of potential interest we can then have another closer look at:

p1 <- pairedPlot(glmmResult=resultTable,
                 geneName = "ADAM12",
                 x1Label = "Timepoint",
                 x2Label="EULAR_bin",
                 IDColumn = "PATID",
                 graphics="ggplot",
                 colours = "grey60",
                 modColour = rep(plotColours, each=2),
                 modLineColour =rep(plotColours, each=2), 
                 addViolins=FALSE, 
                 fontSize=8,
                 logTransform=T) + theme(plot.subtitle=element_text(size=9))

p2 <- pairedPlot(glmmResult=resultTable,
                 geneName = "CXCL9",
                 x1Label = "Timepoint",
                 x2Label="EULAR_bin",
                 IDColumn = "PATID",
                 graphics="ggplot",
                 addViolins = FALSE,
                 colours = c("blue"),
                 fontSize=8,
                 logTransform=T) + theme(plot.subtitle=element_text(size=9))

ggarrange(p1, p2, ncol=2)

MA plots

An MA plot is an application of a Bland–Altman plot. The plot visualizes the differences between measurements taken in two samples, by transforming the data onto M (log ratio) and A (mean average) scales, then plotting these values.

maPlots <- maPlot(resultTable,
                  x1Label="Timepoint",
                  x2Label="EULAR_bin",
                  x2Values=c("Good responder", "Non responder"),
                  labels=labels)

maPlots$combined

maPlots <- maPlot(resultTable,
                  x2Label="Timepoint",
                  x1Label="EULAR_bin",
                  x1Values=c("Good responder", "Non responder"),
                  labels=labels)

maPlots$combined