For the purposes of the code review I think we can ignore the mathematical part and focus on some other aspects:
The aim of this package is to model gene expression with a general linear mixed model (glmm). This allows us to include random effects as well as mixed effects. For the purpose of the package we use the glmer function in lme4 package which fits glmm via REML or maximum likelihood.
| Package | Differences/Limitations | Reference |
|---|---|---|
| Limma | Inflexible cannot return interactions | Limma |
| DESeq | No possibility for time/longitudinal analysis | DESeq2 |
| Dream | … | … |
| MCMseq | … | … |
| rmRNA-seq | voom-like, shrinkage estimate | … |
To load the package as a library you can run the code in ./package_creator then:
library(glmmSeq)Else you can source the functions individually:
functions = list.files(paste0(path_package, "/R"), full.names = TRUE)
invisible(lapply(functions, source))But you will need to load in the additional libraries then:
library(MASS)
library(car)
library(ggplot2)
library(ggpubr)
library(lme4)
library(methods)
library(parallel)
library(plotly)
library(qvalue)
library(stats)
library(gghalves)To get started first we load in the package
library(glmmSeq)Then we can load in the example data set:
data(PEAC_minimal_load)
data(PEAC_dispersions)
metadata$EULAR_bin = NA
metadata$EULAR_bin[metadata$EULAR_6m %in% c("Good responder", "Moderate responder" )] = "responder"
metadata$EULAR_bin[metadata$EULAR_6m %in% c("Non responder")] = "non_responder"
metadata = metadata[! is.na(metadata$EULAR_bin), ]
tpm = tpm[, metadata$SAMID]The metadata contains the following, where EULAR is a rheumatoid arthritis response metric:
kable(head(metadata), row.names = F) %>% kable_styling()| SAMID | PATID | Timepoint | EULAR_6m | EULAR_bin |
|---|---|---|---|---|
| SAM20389187 | PAT359 | 6 | Good responder | responder |
| SAM20389185 | PAT232 | 6 | Good responder | responder |
| SAM20389181 | PAT242 | 6 | Moderate responder | responder |
| SAM20389179 | PAT234 | 6 | Good responder | responder |
| SAM20389177 | PAT239 | 6 | Good responder | responder |
| SAM20389176 | PAT235 | 6 | Good responder | responder |
To model one gene over time using the model:
gene expression ~ fixed effects + random effects
In R the formula is defined by both the fixed-effects and random-effects part of the model, with the response on the left of a ~ operator and the terms, separated by + operators, on the right. Random-effects terms are distinguished by vertical bars (“|”) separating expressions for design matrices from grouping factors.
We want to use time and response as fixed effects and the patients as random effects:
gene expression ~ time + response + (1 | patient)
To achieve this we use a negative binomial model with gene dispersions passed in. These dispersions were previously created using DESeq2
For a specific gene, say MS4A1, we view the lmer fit using glmmGene:
metadata$Dummy = factor(sample(c("a", "b", "c", "d"), nrow(metadata), replace=T))
MS4A1fit <- glmmGene(~ Timepoint * EULAR_6m + Dummy + (1 | PATID),
gene = "MS4A1",
id = "PATID",
countdata = tpm,
metadata = metadata,
dispersion = disp["MS4A1"],
pairedOnly=TRUE)
MS4A1fit## Generalized linear mixed model fit by maximum likelihood (Laplace
## Approximation) [glmerMod]
## Family: Negative Binomial(0.5589) ( log )
## Formula:
## count ~ Timepoint + EULAR_6m + Dummy + (1 | PATID) + Timepoint:EULAR_6m
## Data: data
## Offset: offset
## AIC BIC logLik deviance df.resid
## 619.0965 646.0944 -298.5483 597.0965 75
## Random effects:
## Groups Name Std.Dev.
## PATID (Intercept) 0.6433
## Number of obs: 86, groups: PATID, 43
## Fixed Effects:
## (Intercept) Timepoint6
## 2.79223 0.04196
## EULAR_6mModerate responder EULAR_6mNon responder
## 0.43192 -0.97788
## Dummyb Dummyc
## -1.04272 0.23035
## Dummyd Timepoint6:EULAR_6mModerate responder
## -0.48935 -1.28024
## Timepoint6:EULAR_6mNon responder
## 0.05075
## optimizer (bobyqa) convergence code: 0 (OK) ; 0 optimizer warnings; 1 lme4 warnings
Or to create a GlmmSeq object, we can use glmmSeq, which contains the following slots:
metadata$EULAR_bin = metadata$EULAR_6m
MS4A1glmm <- glmmSeq(~ Timepoint * EULAR_bin + (1 | PATID),
id = "PATID",
countdata = tpm["MS4A1", ],
metadata = metadata,
dispersion = disp["MS4A1"],
verbose=FALSE)
names(attributes(MS4A1glmm))## [1] "formula" "stats" "predict" "reducedFormula"
## [5] "countdata" "metadata" "modelData" "optInfo"
## [9] "errors" "variables" "class"
To fit for all genes we can use the glmmSeq function. This creates an object of class GlmmSeq.
Note that this analysis can take some time:
Therefore I will only run it for 1000 genes here.
genes = rownames(tpm)
resultTable <- glmmSeq(~ Timepoint * EULAR_bin + (1 | PATID),
id = "PATID",
countdata = tpm[genes, ],
metadata = metadata,
pairedOnly=TRUE,
dispersion = disp[genes])##
## n=86 samples, 43 individuals
## Time difference of 1.006739 mins
## Errors in 6 gene(s):IGHV1-58, IGHV1-67, IGHV3OR16-10, IL20RB, MMP7, THRIL
The variables used by the model are in the @modeldata slot
kable(resultTable@modelData) %>% kable_styling()| Timepoint | EULAR_bin |
|---|---|
| 0 | Good responder |
| 6 | Good responder |
| 0 | Moderate responder |
| 6 | Moderate responder |
| 0 | Non responder |
| 6 | Non responder |
The model fit statistics can be viewed in the @stats slot:
stats = data.frame(resultTable@stats)
kable(stats[order(stats$P_Timepoint.EULAR_bin), ]) %>%
kable_styling() %>%
scroll_box(width = "100%", height = "400px")| Dispersion | AIC | logLik | X.Intercept. | Timepoint6 | EULAR_binModerate.responder | EULAR_binNon.responder | Timepoint6.EULAR_binModerate.responder | Timepoint6.EULAR_binNon.responder | Chisq_Timepoint | Chisq_EULAR_bin | Chisq_Timepoint.EULAR_bin | P_Timepoint | P_EULAR_bin | P_Timepoint.EULAR_bin | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CILP2 | 1.4411270 | 482.92532 | -233.46266 | 1.2885943 | 0.6167530 | -1.7375263 | -0.3560534 | 1.5214677 | -0.1827549 | 3.097892e+03 | 2.402378e+04 | 1.851556e+04 | 0.0000000 | 0.0000000 | 0.0000000 |
| FGFR3 | 1.3106020 | 330.77960 | -157.38980 | 0.7554035 | -0.8167682 | -0.5428591 | -0.0714576 | -0.5076933 | -0.3984177 | 1.384412e+04 | 6.085041e+03 | 5.326355e+03 | 0.0000000 | 0.0000000 | 0.0000000 |
| IGHV1-69-2 | 3.9214968 | 582.35011 | -283.17506 | 1.7492908 | -0.2351499 | 0.8465027 | -0.3483394 | -1.2134510 | -0.8904520 | 1.489443e+03 | 2.241260e+04 | 6.058835e+04 | 0.0000000 | 0.0000000 | 0.0000000 |
| IGHV5-78 | 2.9921665 | 380.79639 | -182.39819 | 0.8469865 | -0.1485160 | 0.0225659 | 0.8423153 | -0.8849723 | -0.9759983 | 4.069807e+01 | 6.491509e+02 | 1.618085e+03 | 0.0000000 | 0.0000000 | 0.0000000 |
| RGS4 | 0.6829379 | 348.05870 | -166.02935 | 0.5750804 | -0.2071724 | -0.2459392 | 0.0788603 | -0.2760689 | 0.8788462 | 6.047874e+02 | 9.294062e+02 | 1.176238e+04 | 0.0000000 | 0.0000000 | 0.0000000 |
| FGFRL1 | 0.2438707 | 495.99805 | -239.99902 | 1.7059370 | 0.0475056 | -0.0007756 | 0.1998243 | -0.0327591 | -0.1896873 | 8.325402e+01 | 8.598530e+02 | 1.288341e+03 | 0.0000000 | 0.0000000 | 0.0000000 |
| CD109 | 0.2595885 | 531.68749 | -257.84374 | 1.7302086 | 0.4305650 | -0.0839433 | 0.1046032 | 0.1425346 | -0.1279601 | 5.845855e+03 | 5.673686e+02 | 1.159563e+03 | 0.0000000 | 0.0000000 | 0.0000000 |
| CXCL13 | 3.0430032 | 678.65852 | -331.32926 | 3.4712702 | -0.4797138 | 0.3589819 | -1.4843860 | -1.3792856 | 0.6504407 | 1.190692e+02 | 1.141089e+03 | 1.142492e+03 | 0.0000000 | 0.0000000 | 0.0000000 |
| IL2RG | 0.6209438 | 758.37047 | -371.18524 | 3.4293268 | -0.4390963 | 0.2093960 | -0.4598898 | -0.2695497 | 0.2611503 | 1.340777e+03 | 1.775791e+03 | 9.817679e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| CXCL6 | 2.8545998 | 393.56693 | -188.78347 | 0.8355028 | -0.1390280 | -0.0485956 | 0.6850474 | -0.2745304 | -0.5060130 | 5.345025e+01 | 1.275103e+03 | 8.982257e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| CXCL9 | 2.3744785 | 708.71899 | -346.35949 | 3.3234160 | -0.7379555 | 0.1213946 | -1.3053692 | 0.2943391 | 0.6132494 | 9.220811e+02 | 3.034296e+03 | 7.462908e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| PFKFB1 | 1.7018059 | 261.30839 | -122.65420 | -0.3507725 | -0.7258154 | 0.5968370 | 0.7552377 | -0.2363562 | 0.5984363 | 7.135278e+03 | 1.073649e+04 | 6.073131e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| S100B | 0.9590636 | 687.25596 | -335.62798 | 2.4447110 | -0.0381928 | 0.5195408 | 0.4010798 | -0.5426512 | 0.4531701 | 4.989205e+01 | 4.114379e+02 | 4.525652e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| IGHD | 2.3226913 | 483.90728 | -233.95364 | 2.0112496 | -0.9457765 | -0.2758959 | 0.3055079 | -0.2303206 | -0.4210911 | 1.558221e+03 | 1.496587e+00 | 3.082843e+02 | 0.0000000 | 0.4731735 | 0.0000000 |
| CXCL1 | 1.7535172 | 697.44496 | -340.72248 | 2.6523817 | -0.5583380 | 0.3619117 | 0.4440293 | -0.3368270 | -0.2362412 | 5.043091e+02 | 4.594248e+02 | 2.489196e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| IGHA2 | 2.8563652 | 838.82913 | -411.41456 | 3.9142383 | -0.6554242 | 0.5478273 | -0.2162295 | -0.4527288 | 1.1992418 | 3.537865e+01 | 2.585064e+01 | 1.525620e+02 | 0.0000000 | 0.0000024 | 0.0000000 |
| IGHM | 2.9121674 | 1229.54657 | -606.77329 | 6.2604297 | -0.7770905 | 0.6835071 | -0.3082630 | -0.5896470 | -0.9103001 | 7.820583e+01 | 4.953413e+01 | 1.128145e+02 | 0.0000000 | 0.0000000 | 0.0000000 |
| MS4A1 | 1.7891158 | 618.92016 | -301.46008 | 2.1974932 | 0.0879270 | 0.5825285 | -0.7230743 | -1.0580361 | -0.1806808 | 2.373247e+01 | 1.643254e+03 | 1.062194e+02 | 0.0000011 | 0.0000000 | 0.0000000 |
| IGHG4 | 3.5445281 | 1294.32152 | -639.16076 | 6.2481295 | -0.6119740 | 1.0211899 | -0.2890794 | -1.0042152 | -0.2995753 | 1.762922e+02 | 4.260411e+02 | 3.329386e+01 | 0.0000000 | 0.0000000 | 0.0000001 |
| IGHV3-6 | 5.5318804 | 504.82497 | -244.41248 | 2.1567633 | -0.2805404 | 1.0471157 | -1.2925343 | -2.0045538 | 3.1459442 | 5.086919e-01 | 2.419250e-01 | 1.329986e+01 | 0.4757056 | 0.8860672 | 0.0012941 |
| ADAM12 | 1.1835027 | 444.32998 | -214.16499 | 1.9894865 | -1.1509420 | -0.4409071 | -0.5803316 | 0.1466447 | 1.9263961 | 6.328959e+00 | 4.773444e+00 | 8.886023e+00 | 0.0118782 | 0.0919305 | 0.0117605 |
| IGHV3-22 | 4.6800429 | 335.97354 | -159.98677 | 0.1147006 | 0.7333562 | 1.5325665 | 1.4615052 | -3.1901210 | -1.6973333 | 2.218791e+00 | 8.758038e-01 | 7.699474e+00 | 0.1363398 | 0.6453891 | 0.0212853 |
| IGHV3-63 | 5.0137038 | 527.35278 | -255.67639 | 2.4027591 | 0.3857720 | 1.0559461 | -0.6905488 | -2.7291652 | -2.2048254 | 4.661773e+00 | 7.106920e+00 | 6.691286e+00 | 0.0308413 | 0.0286254 | 0.0352376 |
| IGHV3-23 | 3.6261089 | 1122.54094 | -553.27047 | 6.8739172 | -0.1230068 | 0.3019696 | -0.5703320 | -1.8065561 | -2.2319972 | 9.425698e+00 | 9.383919e+00 | 5.682533e+00 | 0.0021397 | 0.0091687 | 0.0583517 |
| USP9Y | 7.8919766 | 317.86150 | -150.93075 | -1.0184547 | 1.3837211 | 2.1678654 | 2.4180948 | -0.9728379 | -4.0878753 | 9.025870e-02 | 5.141694e+00 | 5.203867e+00 | 0.7638486 | 0.0764707 | 0.0741301 |
| IGHV3-38 | 5.6480925 | 389.71875 | -186.85938 | 1.0427845 | -0.4731288 | 2.2091507 | -0.0570427 | -2.6588017 | -0.6893595 | 9.039556e+00 | 4.093196e+00 | 5.077355e+00 | 0.0026420 | 0.1291736 | 0.0789708 |
| FGF1 | 0.5690355 | 289.48497 | -136.74248 | 0.0321119 | 0.3871638 | 0.5989142 | 0.4518460 | -1.0850177 | 0.1485961 | 3.163410e-02 | 3.164987e+00 | 5.010509e+00 | 0.8588330 | 0.2054622 | 0.0816548 |
| IGHV3-62 | 6.2203919 | 492.70969 | -238.35485 | 1.6744587 | 0.8530747 | 0.9229385 | 0.2268159 | -2.6528298 | -1.4058648 | 5.847652e-01 | 5.980906e-01 | 4.657388e+00 | 0.4444506 | 0.7415258 | 0.0974229 |
| IGHV3-74 | 4.0954404 | 759.62327 | -371.81164 | 3.7971253 | 0.4266690 | 0.9240223 | 0.2291054 | -1.8807762 | -1.5209145 | 1.820967e+00 | 9.460558e-01 | 3.988482e+00 | 0.1771982 | 0.6231127 | 0.1361169 |
| IGHV3-49 | 5.1180623 | 849.52989 | -416.76494 | 4.9905272 | -0.4434283 | 0.2625095 | 1.5029531 | -1.8323920 | -2.1357556 | 1.033749e+01 | 2.931138e+00 | 3.897518e+00 | 0.0013036 | 0.2309466 | 0.1424507 |
| IGHV1OR15-9 | 6.1805309 | 432.57658 | -208.28829 | 1.3461300 | -0.0745026 | 0.6359060 | 0.1846313 | 0.6405569 | -2.3947480 | 2.226957e-01 | 5.778416e+00 | 3.818624e+00 | 0.6369935 | 0.0556202 | 0.1481823 |
| CILP | 1.3221469 | 769.18803 | -376.59402 | 2.2335037 | 1.2648596 | -0.4001068 | 0.7848699 | 0.2477525 | -1.2070644 | 1.424820e+01 | 5.233349e-01 | 3.789438e+00 | 0.0001602 | 0.7697670 | 0.1503606 |
| IGHV3OR16-12 | 7.8753152 | 337.42746 | -160.71373 | 0.9438135 | 0.6696589 | 0.1253670 | -0.1558517 | -2.7709936 | -1.5969402 | 9.390085e-01 | 2.961565e+00 | 3.738790e+00 | 0.3325330 | 0.2274596 | 0.1542170 |
| FGF23 | 0.8956050 | 223.57820 | -103.78910 | -0.3298898 | 0.2100079 | -0.2501233 | -0.4945870 | -0.0778325 | 1.4885275 | 2.370653e+00 | 3.399454e+00 | 3.651907e+00 | 0.1236353 | 0.1827334 | 0.1610640 |
| IGHV7-27 | 6.2003274 | 263.14385 | -123.57193 | 1.4537065 | -2.9491822 | -0.8277109 | -1.9629138 | 0.9217863 | 3.1072421 | 9.405880e+00 | 6.456797e-01 | 3.635641e+00 | 0.0021629 | 0.7240898 | 0.1623793 |
| IL1B | 1.0478707 | 401.70222 | -192.85111 | 1.3740769 | -0.6789238 | -0.1555105 | -0.4436456 | -0.3037805 | 1.2409838 | 4.552215e+00 | 8.289140e-01 | 3.585914e+00 | 0.0328762 | 0.6606990 | 0.1664672 |
| IGHV1OR15-2 | 5.4222427 | 422.77278 | -203.38639 | 1.4087907 | 0.3326940 | 1.1407250 | -0.5956683 | -2.1335873 | -0.9365555 | 1.597284e+00 | 2.966236e+00 | 3.404559e+00 | 0.2062885 | 0.2269291 | 0.1822675 |
| IGHV3-69-1 | 4.8504900 | 728.71536 | -356.35768 | 3.6331381 | 0.2076780 | 0.5773100 | 0.6037990 | -1.5666299 | -2.0506954 | 2.835452e+00 | 4.459185e-01 | 3.384899e+00 | 0.0922049 | 0.8001474 | 0.1840681 |
| IGHV3-21 | 4.1333989 | 1012.03252 | -498.01626 | 6.1171856 | -0.5001746 | 0.4234043 | -0.4806345 | -1.4536223 | -1.8661366 | 1.062653e+01 | 5.897808e+00 | 3.362419e+00 | 0.0011148 | 0.0523971 | 0.1861487 |
| IGHV1-17 | 4.0566639 | 265.72849 | -124.86424 | -0.1793647 | -0.8260531 | 2.3112843 | 0.5418265 | -2.0735076 | -1.0525363 | 1.308625e+01 | 7.510451e+00 | 3.261540e+00 | 0.0002975 | 0.0233952 | 0.1957788 |
| RAB3IL1 | 0.1185099 | 669.48757 | -326.74378 | 2.8799007 | 0.1576318 | 0.0319388 | 0.3053523 | 0.2092953 | -0.2109951 | 4.643721e+00 | 1.662551e+00 | 3.190662e+00 | 0.0311674 | 0.4354936 | 0.2028414 |
| IGHV3-7 | 3.9610364 | 987.64501 | -485.82250 | 5.7888871 | -0.4293143 | 0.6472207 | -0.3811185 | -1.7028595 | -0.6268721 | 7.724116e+00 | 1.462392e+00 | 3.123618e+00 | 0.0054488 | 0.4813330 | 0.2097563 |
| IGHA1 | 3.1078425 | 1307.50098 | -645.75049 | 7.2817510 | -0.3514026 | 0.4826388 | -0.2934548 | -1.1113049 | 0.6608198 | 2.813025e+00 | 2.152750e-02 | 3.104980e+00 | 0.0935019 | 0.9892940 | 0.2117202 |
| IGHV3-41 | 5.5282437 | 424.16701 | -204.08350 | 1.4750686 | -0.1014696 | 0.8468584 | 0.1659012 | -2.0468839 | -1.0957735 | 4.230656e+00 | 2.936902e-01 | 3.026554e+00 | 0.0397001 | 0.8634277 | 0.2201872 |
| IGHG3 | 3.4055290 | 1217.72177 | -600.86088 | 7.3800803 | -1.4326492 | 0.0326085 | -0.8306498 | -0.7173448 | 1.3447050 | 1.223220e+01 | 3.053774e-01 | 2.989718e+00 | 0.0004697 | 0.8583969 | 0.2242802 |
| IL24 | 0.9105298 | 280.89840 | -132.44920 | 0.5495696 | -0.4464317 | 0.0635065 | -0.8008211 | -0.3709541 | 1.0042449 | 1.858327e+00 | 3.639499e-01 | 2.935616e+00 | 0.1728180 | 0.8336222 | 0.2304301 |
| IL1RAP | 0.1744432 | 325.77654 | -154.88827 | 0.9904554 | -0.1939306 | -0.1126976 | -0.2069255 | 0.2494767 | 0.7337603 | 1.431556e-01 | 9.813829e-01 | 2.924274e+00 | 0.7051639 | 0.6122030 | 0.2317405 |
| IGHV3-60 | 5.4771794 | 367.31709 | -175.65854 | 0.9696813 | -0.2746268 | 0.4730220 | 0.8873514 | -1.6482163 | -2.1148903 | 5.826566e+00 | 2.727155e-01 | 2.917796e+00 | 0.0157859 | 0.8725304 | 0.2324924 |
| CARMIL2 | 0.9443373 | 442.31812 | -213.15906 | 1.5332155 | -0.4499192 | 0.3199380 | -0.2515739 | -0.5478312 | 0.5585103 | 5.048509e+00 | 8.119930e-02 | 2.892451e+00 | 0.0246471 | 0.9602135 | 0.2354574 |
| IGHV1-69 | 5.4329672 | 814.59539 | -399.29770 | 4.4162108 | 0.2600999 | 0.7642761 | 0.5861487 | -0.6598959 | -2.2862440 | 8.456826e-01 | 2.086572e+00 | 2.883806e+00 | 0.3577766 | 0.3522951 | 0.2364773 |
| IGHV3-47 | 5.9314716 | 402.79650 | -193.39825 | 0.9975866 | 0.4039019 | 0.7441095 | 0.0117277 | -1.8271393 | -1.9139246 | 1.421645e+00 | 1.541137e+00 | 2.831362e+00 | 0.2331328 | 0.4627499 | 0.2427602 |
| EMILIN3 | 1.7437861 | 331.36784 | -157.68392 | 0.2935695 | 1.0085827 | -1.5698200 | -0.9008988 | 1.3939911 | 0.6329607 | 1.824874e+01 | 2.554883e+00 | 2.748804e+00 | 0.0000194 | 0.2787496 | 0.2529909 |
| IGHV7-56 | 7.3352622 | 369.50063 | -176.75031 | 1.4800824 | 0.0448606 | 0.5623886 | -1.2957158 | -1.9994719 | -2.1959690 | 2.989392e+00 | 6.389843e+00 | 2.741300e+00 | 0.0838116 | 0.0409697 | 0.2539419 |
| IGHV1-45 | 6.5262502 | 427.53604 | -205.76802 | 3.7234764 | -1.6974738 | -2.1094400 | -4.5118167 | 0.8948972 | 3.1154101 | 1.310547e+00 | 7.714505e+00 | 2.708753e+00 | 0.2522956 | 0.0211260 | 0.2581082 |
| SAA1 | 2.7550934 | 509.14265 | -246.57133 | 1.8985313 | -0.7917104 | -0.7873416 | 0.5312670 | -0.6915477 | 1.0251778 | 4.014912e+00 | 9.493480e+00 | 2.697353e+00 | 0.0450996 | 0.0086799 | 0.2595836 |
| COLGALT2 | 0.6515204 | 463.83102 | -223.91551 | 1.0174207 | 0.6158436 | -0.2499688 | 0.2696535 | 0.4880521 | -0.4077493 | 1.137135e+01 | 3.171240e-02 | 2.627624e+00 | 0.0007459 | 0.9842689 | 0.2687935 |
| CXCR1 | 1.1823573 | 461.97248 | -222.98624 | 1.1508817 | 0.2917865 | 0.5977859 | 0.4545711 | -0.9722748 | -0.4159209 | 3.154192e-01 | 3.491200e-01 | 2.624103e+00 | 0.5743736 | 0.8398264 | 0.2692671 |
| HILPDA | 0.3336806 | 526.35726 | -255.17863 | 2.1813298 | -0.2030473 | 0.0420321 | 0.0381714 | -0.0230094 | 0.5482300 | 3.886169e-01 | 3.078300e+00 | 2.573699e+00 | 0.5330273 | 0.2145634 | 0.2761393 |
| IGHJ3 | 4.5828262 | 1096.33595 | -540.16798 | 6.7199044 | -0.8578507 | 0.3504850 | -0.2019400 | -1.2057383 | 0.6664868 | 6.384704e+00 | 4.283947e-01 | 2.524530e+00 | 0.0115108 | 0.8071891 | 0.2830123 |
| CLEC17A | 1.7161799 | 209.69152 | -96.84576 | -0.2433997 | -0.2447279 | 0.3004883 | -0.7767356 | -0.9180404 | 0.8353068 | 1.032727e+00 | 2.574878e-01 | 2.466864e+00 | 0.3095191 | 0.8791991 | 0.2912911 |
| PADI4 | 1.1925883 | 294.08413 | -139.04207 | -0.0232832 | 0.3010949 | 0.6896938 | 0.8255479 | -1.0247606 | -0.8275468 | 7.972631e-01 | 1.057711e+00 | 2.405939e+00 | 0.3719129 | 0.5892789 | 0.3003012 |
| BLK | 1.0940018 | 385.49525 | -184.74762 | 0.9776621 | 0.1366645 | 0.2935813 | -0.3179190 | -0.8307705 | 0.0561788 | 3.607897e-01 | 6.163545e-01 | 2.397389e+00 | 0.5480680 | 0.7347851 | 0.3015876 |
| FGFBP2 | 1.1321851 | 983.30787 | -483.65393 | 3.5430098 | 1.2077227 | 0.3662783 | 0.9114524 | -0.2146277 | -1.0092331 | 1.236011e+01 | 9.675659e-01 | 2.356731e+00 | 0.0004386 | 0.6164470 | 0.3077814 |
| IGHV3-71 | 5.0763883 | 438.80131 | -211.40066 | 2.0531426 | -0.4671179 | 0.2438695 | -0.6720273 | -1.6881414 | -0.3692058 | 5.295689e+00 | 1.937207e+00 | 2.334900e+00 | 0.0213783 | 0.3796127 | 0.3111594 |
| CXCR2 | 1.0879657 | 488.73706 | -236.36853 | 1.2934094 | 0.2892210 | 0.5082808 | 0.2969800 | -0.8736023 | -0.4845694 | 2.758665e-01 | 3.435820e-02 | 2.332327e+00 | 0.5994233 | 0.9829676 | 0.3115599 |
| PILRB | 0.2039455 | 710.76593 | -347.38296 | 3.0599094 | 0.1014714 | 0.2199776 | 0.4965024 | -0.2354488 | -0.4241344 | 5.171360e-01 | 2.052458e+00 | 2.319997e+00 | 0.4720660 | 0.3583557 | 0.3134866 |
| IGHV1-18 | 4.1610769 | 1017.86794 | -500.93397 | 6.0838039 | -0.4801420 | 0.6496744 | -0.0175466 | -1.3159204 | -1.4253939 | 8.297033e+00 | 1.798471e+00 | 2.317220e+00 | 0.0039710 | 0.4068806 | 0.3139223 |
| IGHV2-26 | 5.7395474 | 733.34272 | -358.67136 | 4.5991159 | -0.5324022 | 0.4962482 | -1.4798203 | -1.7642001 | -0.7228647 | 6.672854e+00 | 7.178250e+00 | 2.294102e+00 | 0.0097892 | 0.0276225 | 0.3175718 |
| IGHGP | 2.9509749 | 766.91573 | -375.45787 | 3.1368873 | -0.6384069 | 0.6917343 | 0.2149604 | -1.0506791 | 0.2971985 | 6.611823e+00 | 2.677664e-01 | 2.277638e+00 | 0.0101304 | 0.8746922 | 0.3201970 |
| IGLV4-3 | 3.4400643 | 323.87649 | -153.93825 | 1.2561948 | -1.2868808 | 0.6401132 | -1.0739818 | -1.4962490 | 0.3805190 | 9.725807e+00 | 1.764352e+00 | 2.262901e+00 | 0.0018170 | 0.4138813 | 0.3225650 |
| IGHV5-51 | 3.9223263 | 1011.31620 | -497.65810 | 5.8663505 | -0.2516110 | 0.6444579 | -0.1705353 | -1.4431107 | -0.7054314 | 4.797726e+00 | 8.851163e-01 | 2.247735e+00 | 0.0284973 | 0.6423910 | 0.3250204 |
| IGHV1-12 | 6.1679293 | 529.67646 | -256.83823 | 3.1501380 | -0.8540126 | -0.3416657 | -2.2730497 | 0.5646531 | 2.1691040 | 1.361227e-01 | 2.922638e+00 | 2.233077e+00 | 0.7121664 | 0.2319302 | 0.3274112 |
| IGHV3OR16-8 | 6.1207754 | 513.76958 | -248.88479 | 2.9677966 | -0.6980120 | -0.2491531 | -0.5103878 | -1.0206819 | 1.1366854 | 2.383925e+00 | 1.896047e+00 | 2.192012e+00 | 0.1225892 | 0.3875063 | 0.3342033 |
| IL20RA | 1.1995780 | 205.79494 | -94.89747 | 0.4485148 | -1.3781255 | -1.3232823 | -0.9496444 | 1.2689732 | 0.9662118 | 3.095314e+00 | 2.595948e+00 | 2.150360e+00 | 0.0785180 | 0.2730846 | 0.3412364 |
| IGHV3-15 | 3.9887966 | 908.01143 | -446.00572 | 5.6129625 | -0.5086199 | 0.0278748 | -0.4365632 | -0.8733728 | -1.6194471 | 7.375979e+00 | 4.630893e+00 | 2.104870e+00 | 0.0066101 | 0.0987221 | 0.3490867 |
| LILRA5 | 0.6373128 | 549.14768 | -266.57384 | 2.2656022 | -0.3778815 | 0.1131676 | -0.3244438 | -0.0626535 | 0.7052435 | 1.952824e+00 | 2.548447e-01 | 2.062708e+00 | 0.1622828 | 0.8803618 | 0.3565239 |
| SVIL | 0.1553703 | 585.03527 | -284.51764 | 2.3189297 | 0.1788285 | -0.2382911 | 0.0817165 | 0.2625475 | -0.1260486 | 5.248961e+00 | 3.634554e-01 | 2.037427e+00 | 0.0219599 | 0.8338283 | 0.3610591 |
| IGHV3OR16-15 | 4.6772884 | 254.10977 | -119.05489 | 0.5034365 | -0.7907149 | -0.0022401 | -2.0487177 | -0.8787121 | 1.4040025 | 2.605313e+00 | 2.547587e+00 | 1.979617e+00 | 0.1065061 | 0.2797682 | 0.3716479 |
| IL1RN | 0.7888388 | 519.50152 | -251.75076 | 2.3111797 | -0.6612931 | -0.4992137 | -0.7657782 | 0.2460911 | 0.8951327 | 3.317251e+00 | 2.284100e+00 | 1.969016e+00 | 0.0685564 | 0.3191640 | 0.3736230 |
| IGHV4-34 | 3.5615779 | 890.96849 | -437.48425 | 4.7947364 | -0.5162039 | 1.1132983 | -0.3770085 | -1.3113325 | -0.7955251 | 7.250318e+00 | 3.956565e+00 | 1.956500e+00 | 0.0070888 | 0.1383066 | 0.3759685 |
| SAA2 | 1.6899371 | 325.15842 | -154.57921 | 0.6473300 | -0.6996460 | -0.8129330 | -0.2850470 | -0.6151155 | 0.8039186 | 3.069007e+00 | 3.772731e+00 | 1.928413e+00 | 0.0797982 | 0.1516219 | 0.3812857 |
| FGF14 | 0.8081567 | 285.49968 | -134.74984 | -0.2043500 | 0.8129736 | -0.0246494 | 0.8667644 | -0.0040735 | -0.8762681 | 4.654659e+00 | 1.807642e+00 | 1.920091e+00 | 0.0309694 | 0.4050191 | 0.3828755 |
| IGHJ3P | 4.5329147 | 773.09670 | -378.54835 | 4.7285148 | -0.2318137 | 0.2419155 | -1.0611902 | -1.4254706 | -0.4903421 | 3.527071e+00 | 4.495381e+00 | 1.916993e+00 | 0.0603744 | 0.1056429 | 0.3834691 |
| PIGH | 0.0617623 | 601.35547 | -292.67774 | 2.8788051 | 0.1608922 | -0.0074943 | 0.1156364 | 0.1700511 | -0.0754871 | 8.416875e+00 | 7.700424e-01 | 1.893619e+00 | 0.0037175 | 0.6804362 | 0.3879769 |
| IGHV3-72 | 4.7494022 | 591.66600 | -287.83300 | 3.1320079 | -1.3002576 | 0.7025219 | -1.1319959 | -0.3627797 | 1.3837656 | 5.853720e+00 | 2.337975e+00 | 1.882240e+00 | 0.0155442 | 0.3106813 | 0.3901905 |
| IFI44L | 0.4803384 | 591.33008 | -287.66504 | 2.4700102 | -0.0953480 | -0.0949526 | -0.7113016 | 0.4945113 | 0.3257848 | 9.081971e-01 | 7.208960e+00 | 1.845546e+00 | 0.3405932 | 0.0272016 | 0.3974154 |
| IGHV3-64 | 6.3489795 | 514.39127 | -249.19564 | 3.1608778 | -0.8713987 | -0.0316254 | -1.1239615 | -1.5491233 | -0.0145153 | 6.859512e+00 | 2.896281e+00 | 1.825815e+00 | 0.0088171 | 0.2350068 | 0.4013556 |
| IL11RA | 0.1749202 | 745.37809 | -364.68904 | 3.2301700 | 0.3332186 | 0.0300043 | 0.2645817 | 0.0445919 | -0.3025251 | 8.127414e+00 | 3.226086e-01 | 1.806638e+00 | 0.0043601 | 0.8510330 | 0.4052225 |
| IL17D | 0.5110845 | 624.97599 | -304.48800 | 2.1017195 | 0.6366629 | -0.1968985 | 0.4305658 | 0.2863507 | -0.3222526 | 1.518117e+01 | 1.233514e+00 | 1.782587e+00 | 0.0000977 | 0.5396917 | 0.4101248 |
| IGHV1-69D | 4.2784356 | 1021.79786 | -502.89893 | 5.9616654 | -0.4478735 | 0.7473324 | -0.0735905 | -0.9530180 | -1.4786667 | 6.203013e+00 | 3.221151e+00 | 1.780130e+00 | 0.0127533 | 0.1997726 | 0.4106290 |
| IGHV5-10-1 | 6.0333580 | 814.84755 | -399.42377 | 5.0701558 | -0.2403186 | 0.2757988 | 0.1867337 | -1.4182028 | 0.0960463 | 1.987686e+00 | 9.765778e-01 | 1.752308e+00 | 0.1585830 | 0.6136756 | 0.4163813 |
| IL32 | 0.5488618 | 984.19822 | -484.09911 | 4.9878791 | -0.2928202 | -0.1134586 | -0.4548681 | 0.0833045 | 0.5519362 | 8.280575e-01 | 6.918068e-01 | 1.728926e+00 | 0.3628348 | 0.7075808 | 0.4212777 |
| IGHV3-35 | 6.4000443 | 443.99049 | -213.99524 | 1.4631532 | 0.0445084 | 0.7448214 | -1.0052740 | -0.9448412 | 1.0373667 | 3.149060e-02 | 9.517741e-01 | 1.727096e+00 | 0.8591504 | 0.6213337 | 0.4216633 |
| IGHV3-11 | 4.3828316 | 902.12061 | -443.06031 | 5.4194833 | -0.6856472 | 0.3698290 | -0.1673849 | -0.9770951 | -1.4561728 | 8.959479e+00 | 2.322812e+00 | 1.723274e+00 | 0.0027603 | 0.3130457 | 0.4224699 |
| NFKBIL1 | 0.1895656 | 544.11362 | -264.05681 | 2.5065871 | 0.2190723 | -0.1154484 | 0.2490120 | 0.1543474 | -0.2347139 | 4.137774e+00 | 1.292417e+00 | 1.689044e+00 | 0.0419363 | 0.5240288 | 0.4297628 |
| IL1R2 | 0.5338219 | 410.71830 | -197.35915 | 1.2375002 | -0.0788107 | -0.1805904 | 0.0416776 | 0.1148654 | 0.7491646 | 2.286716e-01 | 2.790890e+00 | 1.652858e+00 | 0.6325106 | 0.2477227 | 0.4376093 |
| LILRA4 | 1.6473777 | 301.71318 | -142.85659 | 0.7327773 | -0.8910053 | 0.0300121 | -0.6390106 | -0.4200249 | 0.7962296 | 6.351074e+00 | 2.628978e-01 | 1.644912e+00 | 0.0117310 | 0.8768241 | 0.4393512 |
| IGHV3-53 | 5.2617476 | 711.88556 | -347.94278 | 4.4172513 | -0.6716714 | 0.4779408 | -0.5864928 | -1.0278519 | -1.5724604 | 7.721876e+00 | 4.837276e+00 | 1.634949e+00 | 0.0054556 | 0.0890428 | 0.4415455 |
| LILRA2 | 0.4296738 | 542.38042 | -263.19021 | 1.9837630 | 0.3477269 | 0.1381031 | 0.4610630 | -0.1134522 | -0.5284261 | 1.470705e+00 | 8.802293e-01 | 1.616218e+00 | 0.2252345 | 0.6439626 | 0.4457001 |
| IGHV1OR21-1 | 9.9142574 | 270.62657 | -127.31329 | -1.3115011 | 1.3897802 | 1.7377530 | -0.2726319 | -1.9645603 | -1.8850887 | 1.215816e-01 | 3.102418e+00 | 1.611415e+00 | 0.7273254 | 0.2119915 | 0.4467718 |
| HHIP | 1.5362580 | 358.40351 | -171.20175 | 0.1328932 | 0.3345041 | 0.3952143 | 1.2560058 | 0.3786608 | -0.6467127 | 1.131261e+00 | 5.921484e+00 | 1.608036e+00 | 0.2875065 | 0.0517805 | 0.4475273 |
| LTA | 0.9249689 | 247.65422 | -115.82711 | 0.2355334 | -0.4768142 | 0.1227363 | -0.7427583 | -0.1894211 | 0.8882514 | 1.592338e+00 | 5.123197e-01 | 1.600496e+00 | 0.2069925 | 0.7740182 | 0.4492176 |
| IGHV1-46 | 4.2459510 | 765.72865 | -374.86433 | 3.9467926 | -0.4620421 | 1.1583400 | 0.2317182 | -1.2564923 | -0.6769072 | 5.780494e+00 | 1.544808e+00 | 1.572660e+00 | 0.0162050 | 0.4619013 | 0.4555134 |
| NEIL1 | 0.1770385 | 653.56976 | -318.78488 | 2.8031210 | 0.2021667 | 0.1631807 | 0.3570077 | -0.2464690 | -0.2907475 | 2.024944e-01 | 1.845626e+00 | 1.572652e+00 | 0.6527149 | 0.3973995 | 0.4555153 |
| SKIL | 0.1136944 | 478.74083 | -231.37041 | 1.7873814 | 0.1052905 | 0.0807877 | 0.1661918 | 0.2687992 | -0.0258706 | 3.532298e+00 | 3.095061e+00 | 1.552980e+00 | 0.0601843 | 0.2127728 | 0.4600179 |
| PPIL6 | 0.3948141 | 313.17608 | -148.58804 | 0.1349914 | 0.7063593 | 0.2069363 | 0.7461138 | 0.0311301 | -0.5835023 | 7.554952e+00 | 2.691394e+00 | 1.549428e+00 | 0.0059845 | 0.2603581 | 0.4608355 |
| IGHV6-1 | 4.2954588 | 805.40528 | -394.70264 | 4.9776875 | -0.7060587 | 0.4454137 | -0.6322524 | -1.1823534 | -1.0114982 | 9.173463e+00 | 3.832960e+00 | 1.544530e+00 | 0.0024555 | 0.1471239 | 0.4619656 |
| IGHV3-43 | 4.6255201 | 835.41161 | -409.70581 | 5.2809693 | -0.8655013 | -0.1697740 | -0.9863137 | -0.5431405 | 1.0281163 | 3.368142e+00 | 9.251360e-01 | 1.533453e+00 | 0.0664687 | 0.6296646 | 0.4645312 |
| CXCL12 | 0.3448525 | 1193.42111 | -588.71055 | 5.7661373 | 0.0625487 | 0.1860995 | 0.1433931 | 0.1484293 | -0.2886310 | 2.035939e-01 | 2.511673e+00 | 1.524424e+00 | 0.6518355 | 0.2848375 | 0.4666330 |
| PIWIL4 | 0.2058325 | 430.16015 | -207.08008 | 1.2948353 | 0.2155826 | 0.0324278 | 0.2701021 | 0.2493748 | -0.2003071 | 3.604071e+00 | 9.840342e-01 | 1.518917e+00 | 0.0576383 | 0.6113919 | 0.4679198 |
| IL4I1 | 1.3620275 | 528.00406 | -256.00203 | 1.8786334 | -0.5816736 | 0.1110627 | -0.2524904 | -0.0114181 | 0.8856581 | 2.099652e+00 | 1.174757e-01 | 1.518260e+00 | 0.1473327 | 0.9429539 | 0.4680735 |
| IL1RL2 | 0.2869679 | 201.30063 | -92.65032 | -0.0764845 | -0.1989275 | -0.4172909 | 0.0599226 | 0.5680635 | -0.2857566 | 4.531560e-02 | 1.222256e-01 | 1.498484e+00 | 0.8314248 | 0.9407171 | 0.4727248 |
| FGF14-AS2 | 0.3313764 | 403.12419 | -193.56209 | 0.9507309 | 0.6346271 | 0.3081078 | 0.4996256 | -0.2921382 | -0.5139398 | 6.064395e+00 | 1.177912e+00 | 1.469271e+00 | 0.0137934 | 0.5549062 | 0.4796802 |
| LGALSL | 0.2482274 | 560.81209 | -272.40605 | 2.1874928 | 0.0314576 | -0.2276721 | -0.0439360 | 0.3339869 | 0.0174188 | 1.480725e+00 | 7.153210e-02 | 1.450659e+00 | 0.2236610 | 0.9648660 | 0.4841650 |
| IFNLR1 | 1.0229762 | 184.62266 | -84.31133 | -0.4393335 | -0.0734795 | 0.1237486 | -0.8281954 | -0.6959707 | 0.5730202 | 3.620931e-01 | 8.042210e-01 | 1.431597e+00 | 0.5473461 | 0.6689068 | 0.4888016 |
| CXCR6 | 1.0002408 | 286.82303 | -135.41151 | 0.8283213 | -1.0969310 | -0.0428494 | -0.9243985 | 0.3334078 | 0.9888635 | 7.099988e+00 | 1.909220e+00 | 1.422710e+00 | 0.0077084 | 0.3849623 | 0.4909784 |
| IGHJ1 | 4.8593009 | 880.38397 | -432.19198 | 5.4033337 | -0.7448368 | 0.8620154 | -1.1135829 | -1.4281191 | -0.6476466 | 7.103022e+00 | 4.738630e+00 | 1.399711e+00 | 0.0076954 | 0.0935448 | 0.4966569 |
| FGF11 | 0.3177769 | 344.41584 | -164.20792 | 1.0943614 | -0.3727706 | -0.1886793 | -0.0549540 | 0.1361854 | 0.5521568 | 1.129714e+00 | 2.035875e+00 | 1.390291e+00 | 0.2878363 | 0.3613395 | 0.4990019 |
| SVIL-AS1 | 0.0569996 | 641.07262 | -312.53631 | 2.9171692 | 0.1161941 | 0.1283254 | 0.0578126 | 0.0016574 | 0.1996717 | 5.277121e+00 | 1.695259e+00 | 1.382119e+00 | 0.0216075 | 0.4284293 | 0.5010450 |
| DUSP4 | 0.6229931 | 314.48258 | -149.24129 | 0.6350515 | -0.9309107 | 0.2931255 | 0.0196910 | 0.1771041 | 0.7591560 | 7.205898e+00 | 1.604691e+00 | 1.375592e+00 | 0.0072664 | 0.4482764 | 0.5026828 |
| FGF18 | 0.5512359 | 447.34906 | -215.67453 | 1.0427626 | 0.4477057 | 0.1167212 | 0.1644230 | 0.2795650 | -0.3369492 | 6.107531e+00 | 1.366360e+00 | 1.375362e+00 | 0.0134607 | 0.5050086 | 0.5027405 |
| IGHV3-66 | 4.6401528 | 758.59791 | -371.29896 | 5.3181190 | -1.4823603 | -0.9149140 | -1.0191590 | -0.5231714 | 0.9641892 | 1.000346e+01 | 4.999169e+00 | 1.364479e+00 | 0.0015625 | 0.0821191 | 0.5054836 |
| IL10 | 0.8107031 | 450.08345 | -217.04172 | 1.4566865 | -0.1921039 | 0.1326389 | -0.4298377 | 0.2674464 | 0.7010656 | 5.563780e-02 | 1.637940e+00 | 1.362542e+00 | 0.8135284 | 0.4408855 | 0.5059735 |
| IL10RB | 0.0588211 | 636.75546 | -310.37773 | 3.2773222 | -0.1099203 | 0.0025650 | -0.0867889 | 0.1664421 | 0.1451550 | 6.089740e-02 | 1.458868e+00 | 1.356633e+00 | 0.8050831 | 0.4821819 | 0.5074705 |
| IGHV3OR15-7 | 5.4030956 | 372.25237 | -178.12619 | 0.6463981 | 0.1724349 | 0.6297945 | 0.3349415 | -0.1868876 | -1.6150854 | 1.643455e-01 | 1.759776e+00 | 1.348222e+00 | 0.6851868 | 0.4148293 | 0.5096093 |
| FGFR1 | 0.1784490 | 876.02828 | -430.01414 | 3.6583528 | 0.1934197 | 0.1432198 | 0.3384047 | 0.1339267 | -0.1689350 | 4.623031e+00 | 1.323256e+00 | 1.345068e+00 | 0.0315455 | 0.5160105 | 0.5104135 |
| IL12RB2 | 0.4869271 | 191.29516 | -87.64758 | 0.0967225 | -0.8850147 | -0.4086487 | -0.7350302 | 0.7679047 | 0.5895136 | 2.332573e+00 | 1.343253e+00 | 1.323697e+00 | 0.1266923 | 0.5108769 | 0.5158969 |
| IGHV4-80 | 6.0288770 | 447.65319 | -215.82660 | 1.8552711 | -0.1625738 | 0.8511690 | -0.2915145 | -1.3878615 | -0.5644640 | 2.186919e+00 | 1.030450e+00 | 1.317995e+00 | 0.1391875 | 0.5973660 | 0.5173698 |
| IGHV3-19 | 5.6504384 | 627.17293 | -305.58647 | 3.2086006 | 0.0856310 | 0.4237892 | -0.4094945 | -1.2942500 | -0.9420310 | 1.318650e+00 | 1.637090e+00 | 1.314059e+00 | 0.2508346 | 0.4410729 | 0.5183890 |
| XBP1 | 0.4853172 | 1034.41376 | -509.20688 | 5.1616562 | -0.3282259 | 0.2845946 | -0.1965975 | -0.3913744 | -0.1061421 | 1.020996e+01 | 1.954595e+00 | 1.300609e+00 | 0.0013968 | 0.3763268 | 0.5218868 |
| ILF3-AS1 | 0.1509798 | 524.96388 | -254.48194 | 2.3121530 | 0.4022699 | 0.0311340 | 0.3195922 | -0.1259312 | -0.3100407 | 7.710784e+00 | 2.075767e+00 | 1.292434e+00 | 0.0054892 | 0.3542036 | 0.5240244 |
| IGHV3OR16-9 | 5.2911942 | 647.54801 | -315.77400 | 3.5924760 | -0.9425704 | 0.5715768 | -0.6488834 | -0.2060325 | -1.4744219 | 6.914494e+00 | 7.106421e+00 | 1.248964e+00 | 0.0085500 | 0.0286326 | 0.5355388 |
| FGFR2 | 1.2147242 | 282.38613 | -133.19307 | 0.8205801 | -0.8372991 | -0.9113778 | -1.1082279 | 0.2277330 | 0.9762693 | 2.784819e+00 | 3.637824e+00 | 1.243607e+00 | 0.0951615 | 0.1622021 | 0.5369750 |
| FRZB | 0.6480875 | 508.00298 | -246.00149 | 1.6992693 | 0.5090009 | -0.6018768 | -0.1303816 | 0.1829540 | -0.4236336 | 5.670899e+00 | 3.442249e+00 | 1.230113e+00 | 0.0172486 | 0.1788649 | 0.5406104 |
| LILRB5 | 0.2315324 | 829.47672 | -406.73836 | 3.3690342 | 0.2537090 | 0.4483112 | 0.5174154 | 0.0123111 | -0.2974254 | 2.986222e+00 | 6.780831e+00 | 1.226453e+00 | 0.0839759 | 0.0336947 | 0.5416006 |
| PAX5 | 1.5557622 | 187.64812 | -85.82406 | -0.2626672 | -0.3717196 | -0.1079792 | -0.8013917 | -0.7103589 | 0.5920012 | 1.348380e+00 | 1.002282e+00 | 1.219423e+00 | 0.2455615 | 0.6058391 | 0.5435077 |
| IGHJ4 | 3.7319498 | 1387.46185 | -685.73093 | 8.6095091 | -0.6628248 | -0.0772725 | -0.5403273 | -0.7804213 | -1.1082984 | 8.091805e+00 | 3.903968e+00 | 1.216027e+00 | 0.0044466 | 0.1419921 | 0.5444313 |
| IGHV4-39 | 3.9754180 | 1058.78813 | -521.39406 | 6.4498721 | -0.5371045 | 0.3155041 | -0.1919211 | -1.0446428 | -0.3809378 | 5.463874e+00 | 4.724183e-01 | 1.173488e+00 | 0.0194136 | 0.7896155 | 0.5561352 |
| IGHV3-75 | 5.8079757 | 299.00235 | -141.50117 | 0.2004681 | 0.4180237 | 0.8864706 | -1.1103903 | -1.3265418 | -0.7134985 | 1.593679e-01 | 4.465186e+00 | 1.160746e+00 | 0.6897391 | 0.1072500 | 0.5596895 |
| A1BG | 0.7315062 | 659.24245 | -321.62123 | 2.5750839 | 0.1589435 | 0.2041418 | 0.3195477 | -0.1876172 | 0.3732159 | 7.752708e-01 | 4.062941e+00 | 1.159966e+00 | 0.3785914 | 0.1311425 | 0.5599078 |
| IL2RA | 0.8172636 | 383.82561 | -183.91280 | 1.3778415 | -0.9252582 | -0.0644002 | -0.7371289 | 0.2600296 | 0.7209681 | 7.886036e+00 | 1.543227e+00 | 1.143131e+00 | 0.0049818 | 0.4622665 | 0.5646407 |
| ILF2 | 0.0567107 | 796.59232 | -390.29616 | 4.2326316 | -0.0883269 | -0.0240809 | -0.0254403 | 0.1284804 | 0.1191407 | 6.807190e-02 | 2.364437e-01 | 1.134719e+00 | 0.7941651 | 0.8884989 | 0.5670207 |
| IGHV3-73 | 5.5748075 | 622.52588 | -303.26294 | 3.2677890 | 0.0258433 | 0.0097916 | 0.0408851 | -1.0668258 | -1.1599586 | 1.430406e+00 | 1.036315e+00 | 1.130299e+00 | 0.2316982 | 0.5956170 | 0.5682751 |
| IGHV3-20 | 5.0532969 | 752.29260 | -368.14630 | 4.2400766 | -0.4093831 | 0.6716454 | -0.2041699 | -0.7856899 | -1.3075785 | 4.017931e+00 | 2.973567e+00 | 1.128805e+00 | 0.0450189 | 0.2260988 | 0.5686997 |
| LILRB2 | 0.3688626 | 720.04140 | -352.02070 | 3.3138241 | -0.4485540 | 0.1439515 | -0.2042463 | 0.0553091 | 0.4023511 | 6.034736e+00 | 1.239931e+00 | 1.128667e+00 | 0.0140271 | 0.5379629 | 0.5687390 |
| IL1R1 | 0.1506835 | 759.63388 | -371.81694 | 3.2914650 | 0.0343785 | 0.0546949 | 0.1182757 | 0.1130738 | -0.1607552 | 2.318468e-01 | 4.432693e-01 | 1.117071e+00 | 0.6301578 | 0.8012080 | 0.5720461 |
| IGHV3OR16-7 | 7.6010564 | 262.63683 | -123.31841 | 0.4331590 | -0.5729409 | -1.2754148 | 0.4335564 | -0.0861267 | -1.7851055 | 2.056197e+00 | 3.134214e+00 | 1.101136e+00 | 0.1515881 | 0.2086479 | 0.5766221 |
| IGHV1-3 | 4.9109382 | 821.42033 | -402.71017 | 5.1200880 | -0.8752466 | 0.3279901 | -0.1428809 | 0.0521006 | -1.2084592 | 5.358915e+00 | 2.825650e+00 | 1.097854e+00 | 0.0206166 | 0.2434545 | 0.5775692 |
| IL5RA | 0.8578468 | 253.64362 | -118.82181 | 0.0504819 | 0.0800551 | 0.2657266 | -0.3010222 | -0.6170539 | 0.0546611 | 2.282164e-01 | 4.923693e-01 | 1.093758e+00 | 0.6328495 | 0.7817778 | 0.5787532 |
| IGHG2 | 2.9568575 | 1231.30910 | -607.65455 | 6.9509736 | -0.7929588 | 0.4323255 | -0.3730065 | -0.5142149 | 0.5759276 | 5.137912e+00 | 2.844710e-01 | 1.087005e+00 | 0.0234088 | 0.8674170 | 0.5807107 |
| IGHV3-30 | 3.7607324 | 1119.75224 | -551.87612 | 6.9289606 | -0.6114027 | 0.2442451 | -0.8450346 | -0.9524191 | -0.6462363 | 6.925764e+00 | 4.481132e+00 | 1.058646e+00 | 0.0084963 | 0.1063983 | 0.5890035 |
| CD27 | 1.2304771 | 689.70332 | -336.85166 | 2.7373035 | -0.1598486 | 0.5031703 | -0.3994594 | -0.4567183 | 0.1738945 | 1.393549e+00 | 2.110340e+00 | 1.009589e+00 | 0.2378067 | 0.3481333 | 0.6036295 |
| IL7R | 0.7740563 | 569.29512 | -276.64756 | 1.9773962 | -0.2265893 | 0.2511303 | -0.3789873 | -0.2350837 | 0.3743340 | 1.159026e+00 | 6.553051e-01 | 9.953304e-01 | 0.2816676 | 0.7206134 | 0.6079484 |
| UBFD1 | 0.0873723 | 501.35866 | -242.67933 | 2.1289503 | -0.1940922 | -0.0485517 | -0.0153496 | 0.1416840 | 0.2525556 | 7.472853e-01 | 4.599354e-01 | 9.880261e-01 | 0.3873371 | 0.7945593 | 0.6101728 |
| IGHV3-64D | 5.5198810 | 769.34542 | -376.67271 | 4.8970506 | -0.7133577 | -0.3703652 | 0.0107832 | -0.3665819 | -1.3409468 | 4.953697e+00 | 1.342254e+00 | 9.786097e-01 | 0.0260349 | 0.5111322 | 0.6130524 |
| IL21R | 0.9134103 | 398.34952 | -191.17476 | 1.5213549 | -0.8934772 | 0.2088124 | -0.6065805 | -0.2304301 | 0.4468168 | 1.309745e+01 | 2.146682e+00 | 9.618040e-01 | 0.0002957 | 0.3418645 | 0.6182255 |
| RALA | 0.0897153 | 589.80242 | -286.90121 | 2.7007652 | 0.0104430 | 0.0813353 | -0.0361392 | 0.0417318 | 0.2184599 | 7.339002e-01 | 1.059109e+00 | 9.599155e-01 | 0.3916219 | 0.5888671 | 0.6188095 |
| IL1RL1 | 0.5025456 | 167.99839 | -75.99920 | -0.6280073 | -0.2110235 | -0.1960041 | -0.2183785 | 0.7335873 | 0.2182680 | 1.379293e-01 | 5.251253e-01 | 9.588389e-01 | 0.7103483 | 0.7690782 | 0.6191427 |
| LILRB1 | 0.4202910 | 599.44431 | -291.72215 | 2.4473229 | -0.4822116 | 0.1623151 | -0.2440362 | 0.0255586 | 0.4043087 | 5.734222e+00 | 8.001336e-01 | 9.571815e-01 | 0.0166374 | 0.6702753 | 0.6196560 |
| IGHV2-5 | 4.7185316 | 907.76953 | -445.88476 | 5.4872531 | -0.5233417 | 0.4094835 | -0.3802705 | -1.0321743 | -0.4564391 | 4.575220e+00 | 9.789643e-01 | 9.559675e-01 | 0.0324376 | 0.6129437 | 0.6200323 |
| ZWILCH | 0.0900126 | 394.19571 | -189.09786 | 1.3412829 | -0.0722834 | 0.0772149 | -0.0010805 | 0.1963727 | 0.3068517 | 3.281703e-01 | 1.675502e+00 | 9.552656e-01 | 0.5667385 | 0.4326826 | 0.6202499 |
| C1GALT1 | 0.4006421 | 623.14677 | -303.57339 | 2.6524425 | -0.4214557 | 0.0110845 | -0.1528614 | 0.2133810 | 0.3839864 | 2.833930e+00 | 3.359477e-01 | 9.286080e-01 | 0.0922923 | 0.8453759 | 0.6285724 |
| IL17B | 0.8823973 | 240.63478 | -112.31739 | -0.1653491 | 0.3223773 | 0.0695275 | 0.0431675 | -0.6438616 | -0.0947409 | 7.423460e-02 | 5.572682e-01 | 9.183091e-01 | 0.7852681 | 0.7568168 | 0.6318176 |
| IL7 | 0.3356518 | 291.06203 | -137.53101 | 0.6925051 | -0.4048981 | -0.0142284 | -0.1207384 | 0.3326767 | -0.1839628 | 2.051368e+00 | 1.306889e+00 | 9.177841e-01 | 0.1520695 | 0.5202506 | 0.6319835 |
| IL18 | 0.3726359 | 650.65968 | -317.32984 | 3.0960978 | -0.3954662 | -0.0727600 | -0.2719333 | 0.2106991 | 0.3335364 | 3.072336e+00 | 5.244720e-01 | 8.905126e-01 | 0.0796350 | 0.7693294 | 0.6406600 |
| IL13RA1 | 0.0801684 | 783.57956 | -383.78978 | 3.5101484 | 0.0780218 | 0.1617373 | 0.0500070 | 0.1446072 | 0.0247028 | 3.818839e+00 | 3.568132e+00 | 8.849723e-01 | 0.0506794 | 0.1679539 | 0.6424373 |
| ISG15 | 0.7635947 | 962.78711 | -473.39356 | 4.3546988 | 0.1189553 | -0.0205703 | -0.3120895 | 0.3937507 | 0.0977166 | 2.268733e+00 | 1.984494e+00 | 8.823427e-01 | 0.1320078 | 0.3707427 | 0.6432825 |
| IGHJ5 | 3.8397040 | 1324.09044 | -654.04522 | 8.2436155 | -0.6728095 | 0.1525815 | -1.0626642 | -0.8549612 | -0.1291306 | 5.803515e+00 | 4.025226e+00 | 8.762228e-01 | 0.0159942 | 0.1336390 | 0.6452539 |
| RILPL2 | 0.0916242 | 391.62388 | -187.81194 | 1.5439327 | 0.3251196 | 0.0802266 | 0.1718770 | -0.0940749 | -0.2782589 | 4.220832e+00 | 5.851100e-02 | 8.601253e-01 | 0.0399306 | 0.9711683 | 0.6504684 |
| IGHE | 3.1391557 | 398.44729 | -191.22365 | 1.0428698 | -0.1749112 | 0.3240153 | 0.1665488 | -0.8256708 | -0.6085286 | 2.098311e+00 | 5.015100e-02 | 8.510176e-01 | 0.1474619 | 0.9752363 | 0.6534372 |
| CXCR4 | 0.5232822 | 789.09586 | -386.54793 | 3.4755226 | -0.2194088 | 0.0729468 | -0.1454852 | -0.2049316 | 0.2145784 | 2.251049e+00 | 2.187850e-02 | 8.420746e-01 | 0.1335239 | 0.9891203 | 0.6563656 |
| HP | 2.2796151 | 454.81656 | -219.40828 | 1.9300346 | -1.0250095 | -1.3033898 | -0.2166393 | 0.6670524 | 0.7437288 | 2.557942e+00 | 4.951229e+00 | 8.381203e-01 | 0.1097414 | 0.0841113 | 0.6576646 |
| IFNAR2 | 0.1371482 | 601.21373 | -292.60687 | 2.9662056 | -0.0631647 | 0.1929372 | -0.0892558 | -0.1606412 | 0.0385769 | 1.541031e+00 | 2.328515e+00 | 8.284147e-01 | 0.2144644 | 0.3121543 | 0.6608639 |
| CXCL5 | 1.8931942 | 213.06715 | -98.53357 | -0.6464177 | 0.0774972 | -0.3849540 | 0.5539001 | -1.0106829 | -0.4125022 | 3.953205e-01 | 2.881171e+00 | 8.276328e-01 | 0.5295159 | 0.2367891 | 0.6611223 |
| IGHV3-52 | 5.4873958 | 275.89718 | -129.94859 | 0.1496761 | -1.1413114 | 0.7693762 | -0.3189468 | -0.9412742 | 0.3584229 | 5.922919e+00 | 5.624326e-01 | 8.258003e-01 | 0.0149452 | 0.7548650 | 0.6617283 |
| LAMP5 | 1.1306199 | 338.93732 | -161.46866 | 0.8214996 | -0.6149346 | 0.1701641 | -0.4711498 | -0.5150147 | 0.0701669 | 7.499833e+00 | 9.104360e-01 | 8.087949e-01 | 0.0061705 | 0.6343097 | 0.6673788 |
| IL36G | 13.0972755 | 250.37590 | -117.18795 | 1.5873949 | -2.8553044 | -2.5167642 | -2.2506782 | 1.6945845 | 1.3602836 | 5.224139e+00 | 3.938268e+00 | 8.076322e-01 | 0.0222755 | 0.1395777 | 0.6677669 |
| NEIL3 | 0.7218268 | 104.48231 | -44.24115 | -1.2812819 | -0.7551232 | -0.2333040 | -0.3897848 | 0.3113608 | 1.2029242 | 4.192494e-01 | 2.626793e-01 | 8.069621e-01 | 0.5173118 | 0.8769199 | 0.6679907 |
| IGHV4-55 | 5.0546902 | 776.43992 | -380.21996 | 4.2645812 | -0.2072914 | 0.4884851 | -0.3532144 | 0.2066248 | -0.9412292 | 4.514171e-01 | 4.559299e+00 | 7.896188e-01 | 0.5016628 | 0.1023200 | 0.6738085 |
| GATA1 | 0.7087481 | 185.27709 | -84.63854 | -0.9293877 | 0.5128685 | 0.4877094 | 0.4383256 | -0.5316869 | -0.7426346 | 1.731065e-01 | 2.558783e-01 | 7.871709e-01 | 0.6773656 | 0.8799069 | 0.6746337 |
| FGF10 | 0.6728256 | 609.03451 | -296.51725 | 2.0476560 | 0.0776409 | 0.1823735 | 0.2079691 | 0.3245756 | -0.0795877 | 8.673627e-01 | 1.592526e+00 | 7.755291e-01 | 0.3516865 | 0.4510112 | 0.6785721 |
| IGHV2-70D | 5.7476866 | 588.52127 | -286.26064 | 3.5361891 | -0.5498974 | -0.1318975 | -0.8716215 | -0.8347660 | -1.0674966 | 4.171722e+00 | 2.950136e+00 | 7.707126e-01 | 0.0411040 | 0.2287632 | 0.6802082 |
| IGHJ2 | 4.5078685 | 961.62234 | -472.81117 | 6.4301014 | -1.1206941 | -0.3619729 | -1.4798569 | -0.5416608 | 0.5334334 | 6.982680e+00 | 4.145301e+00 | 7.648530e-01 | 0.0082302 | 0.1258518 | 0.6822040 |
| EAF2 | 0.5317739 | 504.98658 | -244.49329 | 2.0968998 | -0.4622582 | 0.1802003 | -0.3622584 | -0.1706221 | 0.2631477 | 6.903139e+00 | 1.670895e+00 | 7.613361e-01 | 0.0086045 | 0.4336804 | 0.6834047 |
| ILVBL | 0.0968703 | 584.42863 | -284.21432 | 2.9129848 | -0.0722184 | -0.0149202 | 0.2322071 | 0.1345410 | -0.0365253 | 1.325419e-01 | 3.844234e+00 | 7.541905e-01 | 0.7158109 | 0.1462969 | 0.6858508 |
| IGHV4-31 | 4.5025298 | 839.42936 | -411.71468 | 5.0730935 | -0.6207908 | 0.4423085 | -0.7330294 | -0.8306194 | -0.7121596 | 5.537747e+00 | 3.814508e+00 | 7.287134e-01 | 0.0186105 | 0.1484876 | 0.6946434 |
| IGHMBP2 | 0.1623800 | 553.21979 | -268.60989 | 2.2164673 | 0.2152612 | 0.0878573 | 0.2619122 | -0.1257593 | -0.2418370 | 1.115331e+00 | 5.825060e-01 | 7.282167e-01 | 0.2909261 | 0.7473266 | 0.6948159 |
| FGF12 | 0.6138578 | 153.01277 | -68.50639 | -0.9073266 | -0.0275109 | 0.1230625 | -0.0005961 | -0.3827590 | 0.4714259 | 1.308560e-02 | 4.549671e-01 | 7.246263e-01 | 0.9089268 | 0.7965355 | 0.6960644 |
| OASL | 0.4851495 | 420.61489 | -202.30745 | 1.4552966 | -0.1293267 | -0.0890858 | -0.6921828 | 0.3140775 | 0.3431409 | 9.095810e-02 | 4.396695e+00 | 7.160696e-01 | 0.7629626 | 0.1109864 | 0.6990488 |
| IGHV7-34-1 | 6.4794561 | 347.17338 | -165.58669 | 0.6717124 | -0.8429642 | 1.0865939 | -1.0715000 | -0.4461881 | 0.9183842 | 2.097911e+00 | 3.773823e+00 | 7.109777e-01 | 0.1475006 | 0.1515391 | 0.7008308 |
| MMP10 | 2.8949821 | 144.27037 | -64.13518 | -1.7328498 | 0.4273943 | 0.1153113 | 1.1210261 | -0.5415113 | -1.2307174 | 1.621210e-02 | 9.851887e-01 | 7.079137e-01 | 0.8986817 | 0.6110391 | 0.7019053 |
| FGFR1OP2 | 0.0617269 | 598.74936 | -291.37468 | 2.8632482 | 0.0065042 | 0.0814856 | -0.0622989 | 0.1196130 | 0.1350071 | 1.206632e+00 | 2.372019e+00 | 7.065082e-01 | 0.2720001 | 0.3054377 | 0.7023987 |
| IGHV4-61 | 4.2715546 | 822.56169 | -403.28085 | 4.3527726 | -0.3897712 | 0.8312234 | -0.6765639 | -0.9592656 | -0.7040025 | 2.386299e+00 | 2.829213e+00 | 7.054062e-01 | 0.1224031 | 0.2430213 | 0.7027858 |
| IGHJ6 | 7.8492731 | 845.16912 | -414.58456 | 5.5695540 | -0.1118225 | -0.5436253 | 0.6847799 | -0.6917488 | -1.4672772 | 9.148758e-01 | 8.579877e-01 | 7.051772e-01 | 0.3388240 | 0.6511639 | 0.7028663 |
| CD38 | 0.7257801 | 467.59925 | -225.79962 | 1.8662532 | -0.6743817 | 0.2347239 | -0.3693754 | -0.2250468 | 0.2541107 | 1.123567e+01 | 1.468163e+00 | 6.883003e-01 | 0.0008024 | 0.4799462 | 0.7088225 |
| PHOSPHO1 | 0.7415235 | 452.46491 | -218.23246 | 1.5126435 | -0.0546034 | 0.1030844 | 0.2253072 | -0.3919313 | -0.1941337 | 1.150360e+00 | 5.603647e-01 | 6.590700e-01 | 0.2834739 | 0.7556459 | 0.7192581 |
| IL17RC | 0.0716512 | 604.09741 | -294.04871 | 2.9248925 | 0.0166850 | -0.0588301 | 0.1562546 | 0.0841883 | -0.0786741 | 1.614139e-01 | 1.128165e+00 | 6.531159e-01 | 0.6878581 | 0.5688820 | 0.7214026 |
| IGHV3-48 | 4.4702133 | 918.49438 | -451.24719 | 5.6756797 | -0.5869577 | -0.3211707 | -0.9555437 | -0.1318878 | 0.8277601 | 1.028905e+00 | 9.777582e-01 | 6.455050e-01 | 0.3104160 | 0.6133135 | 0.7241530 |
| RSAD2 | 0.4760226 | 474.49566 | -229.24783 | 1.6154121 | 0.1992986 | 0.0204843 | -0.4761773 | 0.3121229 | 0.1222856 | 3.671734e+00 | 5.316481e+00 | 6.366080e-01 | 0.0553426 | 0.0700714 | 0.7273816 |
| TIGIT | 1.1108144 | 405.91026 | -194.95513 | 1.3674899 | -0.2637062 | 0.1108858 | -0.8601870 | -0.4022617 | 0.0977692 | 2.160186e+00 | 4.618969e+00 | 6.315203e-01 | 0.1416275 | 0.0993124 | 0.7292343 |
| CXCL10 | 2.0447383 | 726.57736 | -355.28868 | 3.2165568 | -0.5254700 | 0.1299150 | -1.0690666 | -0.1239497 | 0.6076779 | 1.462720e+00 | 2.225669e+00 | 6.294470e-01 | 0.2264978 | 0.3286262 | 0.7299907 |
| CARMIL1 | 0.1028348 | 442.96319 | -213.48160 | 1.4705383 | 0.2716922 | 0.1618838 | 0.3546988 | -0.0254269 | -0.2232918 | 3.430854e+00 | 1.845207e+00 | 6.098819e-01 | 0.0639890 | 0.3974828 | 0.7371669 |
| VIL1 | 1.7371784 | 165.35256 | -74.67628 | -1.2457883 | 0.5407374 | -0.0038141 | 0.3781710 | -0.2338293 | -0.9686868 | 3.082558e-01 | 7.520300e-02 | 6.097192e-01 | 0.5787525 | 0.9630967 | 0.7372269 |
| IL11 | 1.2359912 | 185.35393 | -84.67697 | -0.8405012 | 0.2691142 | 0.0718713 | 0.2071962 | -0.4698923 | 0.3089184 | 2.392190e-01 | 1.164908e+00 | 6.038425e-01 | 0.6247708 | 0.5585260 | 0.7393963 |
| STIL | 0.1350939 | 180.36947 | -82.18473 | -0.2446167 | -0.2513391 | -0.0044314 | -0.1113825 | 0.0467554 | 0.5115106 | 1.897534e-01 | 2.305244e-01 | 5.986259e-01 | 0.6631220 | 0.8911325 | 0.7413274 |
| IFNG-AS1 | 0.7898257 | 203.07394 | -93.53697 | -0.2695855 | -0.2931844 | 0.3458390 | -0.4074723 | -0.3878166 | 0.2945886 | 1.445584e+00 | 9.173885e-01 | 5.984400e-01 | 0.2292379 | 0.6321085 | 0.7413963 |
| ODC1 | 0.1071104 | 651.75450 | -317.87725 | 3.2227289 | -0.0934069 | 0.0160838 | -0.1026194 | -0.0435622 | 0.1311395 | 9.731222e-01 | 8.868390e-02 | 5.979078e-01 | 0.3239027 | 0.9566268 | 0.7415936 |
| IGHV7-81 | 5.5504870 | 375.07333 | -179.53666 | 1.0100528 | -0.2880539 | 0.6231212 | -0.4235900 | -0.7321743 | -0.9537986 | 1.973229e+00 | 2.356260e+00 | 5.803820e-01 | 0.1601055 | 0.3078539 | 0.7481206 |
| IL16 | 0.1837841 | 678.68234 | -331.34117 | 3.1713932 | -0.0569805 | -0.0269019 | -0.2932704 | 0.1016969 | 0.2092840 | 5.552200e-02 | 1.622432e+00 | 5.783028e-01 | 0.8137190 | 0.4443174 | 0.7488988 |
| FGF5 | 1.1820533 | 89.11771 | -36.55885 | -2.0196140 | -0.1909579 | -0.0824378 | -0.1871443 | 0.1729210 | 1.1952056 | 7.187250e-02 | 6.236293e-01 | 5.770793e-01 | 0.7886296 | 0.7321172 | 0.7493571 |
| IGHG1 | 4.7130203 | 1612.98282 | -798.49141 | 9.3727395 | -0.7650183 | 0.3052766 | -0.1083078 | -0.7522207 | -0.0496045 | 5.087473e+00 | 4.715710e-02 | 5.765223e-01 | 0.0240993 | 0.9766972 | 0.7495658 |
| FGF16 | 1.4281904 | 186.24654 | -85.12327 | -1.1537274 | 0.4091612 | 0.4562552 | -0.1667826 | -0.0291260 | 0.7659686 | 1.771694e+00 | 9.784339e-01 | 5.712466e-01 | 0.1831726 | 0.6131063 | 0.7515457 |
| IGHV1OR16-4 | 9.0994974 | 428.85833 | -206.42917 | 2.2244313 | -0.6763371 | -0.1615795 | -1.0187440 | 0.7690499 | -0.5386195 | 5.622984e-01 | 2.904866e+00 | 5.707478e-01 | 0.4533357 | 0.2340003 | 0.7517331 |
| IGHV1OR16-3 | 31.8328345 | 355.05770 | -169.52885 | 0.9134714 | 2.1962056 | -2.9929130 | -2.9929130 | -2.1962056 | -1.0429171 | 9.492821e-01 | 9.128012e+00 | 5.661972e-01 | 0.3299021 | 0.0104202 | 0.7534455 |
| IGHV3-42 | 8.4017375 | 274.32550 | -129.16275 | 0.0228469 | 0.5795276 | -0.3068978 | -1.7159310 | -1.0105787 | 0.1678855 | 1.162027e-01 | 3.029758e+00 | 5.636080e-01 | 0.7331901 | 0.2198347 | 0.7544215 |
| IL23A | 0.2621430 | 236.86579 | -110.43289 | 0.1334847 | -0.1690630 | 0.1450965 | 0.0289176 | -0.0480551 | 0.3826365 | 1.865310e-01 | 6.103215e-01 | 5.634099e-01 | 0.6658196 | 0.7370049 | 0.7544963 |
| IL17RE | 0.3869151 | 398.68640 | -191.34320 | 1.1600298 | -0.1234049 | 0.1054213 | 0.3666515 | -0.2902773 | -0.0238639 | 1.603465e+00 | 2.436382e+00 | 5.577856e-01 | 0.2054129 | 0.2957647 | 0.7566210 |
| IL34 | 0.3022231 | 523.93937 | -253.96969 | 2.0603261 | 0.0855798 | -0.1052474 | -0.2146705 | 0.1265642 | -0.1674320 | 4.905531e-01 | 1.568111e+00 | 5.469453e-01 | 0.4836807 | 0.4565506 | 0.7607331 |
| IGHV1OR15-1 | 1.9851716 | 569.17261 | -276.58630 | 2.4750781 | -0.8464268 | 0.3484549 | -1.0666950 | -0.4872879 | 0.1177892 | 8.427608e+00 | 4.531914e+00 | 5.457324e-01 | 0.0036957 | 0.1037307 | 0.7611946 |
| IL21R-AS1 | 0.7340196 | 114.51307 | -49.25653 | -1.5094977 | -0.1281104 | 0.3166125 | -0.1135932 | -0.2813499 | 0.6665638 | 3.254040e-02 | 2.396852e-01 | 5.445186e-01 | 0.8568467 | 0.8870600 | 0.7616567 |
| PPIL4 | 0.1227801 | 561.00798 | -272.50399 | 2.2052055 | -0.0044885 | 0.0574514 | -0.0173857 | 0.1322839 | 0.1812214 | 6.767741e-01 | 5.783453e-01 | 5.444995e-01 | 0.4106998 | 0.7488829 | 0.7616640 |
| FTCDNL1 | 0.5041412 | 258.30312 | -121.15156 | 0.2199378 | -0.1372520 | 0.1417741 | -0.2117290 | 0.0340093 | 0.4664227 | 1.405920e-02 | 3.418699e-01 | 5.382792e-01 | 0.9056148 | 0.8428764 | 0.7640366 |
| IL27RA | 0.2036813 | 446.84024 | -215.42012 | 1.7102894 | -0.1785276 | 0.1513903 | -0.1931274 | -0.0355409 | 0.2279208 | 1.186576e+00 | 1.185725e+00 | 5.362452e-01 | 0.2760214 | 0.5527427 | 0.7648140 |
| CXCL11 | 2.3669596 | 367.35717 | -175.67859 | 1.3327075 | -0.4474993 | -0.2847792 | -1.6257457 | 0.0452374 | 0.7334161 | 5.358692e-01 | 4.988457e+00 | 5.256637e-01 | 0.4641497 | 0.0825601 | 0.7688712 |
| IMPAD1 | 0.0612541 | 537.68592 | -260.84296 | 2.1849938 | 0.0614114 | 0.2079468 | 0.0885599 | 0.0274183 | 0.1606260 | 1.564225e+00 | 3.719340e+00 | 5.188564e-01 | 0.2110476 | 0.1557240 | 0.7714926 |
| IL26 | 1.1769603 | 192.97014 | -88.48507 | -0.5320617 | -0.1497382 | 0.3773432 | 0.0413561 | -0.4810704 | -0.6513274 | 1.432385e+00 | 5.511574e-01 | 5.058414e-01 | 0.2313756 | 0.7591327 | 0.7765295 |
| IL12RB1 | 0.3537914 | 409.97698 | -196.98849 | 1.4359069 | -0.3163418 | 0.2573398 | -0.2816855 | 0.0666026 | 0.3271704 | 1.800330e+00 | 3.890074e+00 | 5.016685e-01 | 0.1796726 | 0.1429820 | 0.7781513 |
| IGLL5 | 3.1663664 | 1054.45397 | -519.22698 | 6.0530861 | -0.6179434 | 0.1360618 | -0.5808466 | -0.5172405 | 0.1114836 | 4.201341e+00 | 1.061057e+00 | 4.988475e-01 | 0.0403920 | 0.5882941 | 0.7792497 |
| FGFR1OP | 0.0690095 | 432.06088 | -208.03044 | 1.7512256 | -0.1975644 | 0.0804926 | -0.0025490 | 0.0944423 | 0.2002521 | 1.208402e+00 | 1.072490e+00 | 4.964954e-01 | 0.2716489 | 0.5849407 | 0.7801667 |
| CXCL8 | 1.5200815 | 426.79517 | -205.39759 | 1.0984717 | -0.5694004 | -0.3104100 | 0.1881102 | 0.0855506 | 0.7358033 | 1.526139e+00 | 1.500179e+00 | 4.915820e-01 | 0.2166928 | 0.4723243 | 0.7820857 |
| IL31RA | 0.9998531 | 104.09403 | -44.04702 | -1.5324347 | -0.1762438 | -0.2583872 | -0.7871957 | 0.3309227 | 1.0907490 | 5.788040e-02 | 3.575930e-02 | 4.805492e-01 | 0.8098780 | 0.9822793 | 0.7864119 |
| HYAL3 | 0.1288294 | 257.09937 | -120.54968 | 0.5455092 | -0.0525411 | -0.2072548 | -0.1740612 | 0.2887051 | 0.1668928 | 2.130145e-01 | 1.526625e-01 | 4.784604e-01 | 0.6444148 | 0.9265092 | 0.7872336 |
| FGF2 | 0.3792747 | 362.90064 | -173.45032 | 0.4762895 | 0.5319026 | 0.4403356 | 0.2558395 | -0.2505106 | -0.3087428 | 3.616090e+00 | 1.623161e+00 | 4.762900e-01 | 0.0572232 | 0.4441555 | 0.7880884 |
| FGF7P3 | 0.7650171 | 220.21285 | -102.10642 | -0.4845040 | 0.1175023 | 0.1551021 | 0.7234411 | 0.0639219 | -0.4553387 | 7.649300e-03 | 1.650271e+00 | 4.757265e-01 | 0.9303057 | 0.4381757 | 0.7883105 |
| PI16 | 1.8354171 | 622.89736 | -303.44868 | 2.6935450 | -1.1831491 | 0.1765288 | 0.7527440 | 0.3973588 | 0.5032503 | 9.056431e+00 | 5.407174e+00 | 4.740141e-01 | 0.0026177 | 0.0669649 | 0.7889857 |
| FGFBP1 | 3.1844309 | 300.68243 | -142.34122 | 1.8797046 | -1.7817149 | -1.4702584 | -1.2045930 | 0.3728966 | 0.8605560 | 7.663651e+00 | 2.857138e+00 | 4.721976e-01 | 0.0056344 | 0.2396516 | 0.7897026 |
| STAG3L5P-PVRIG2P-PILRB | 0.1965810 | 517.08168 | -250.54084 | 1.8868572 | 0.0148123 | 0.1953153 | 0.2506258 | -0.1303705 | -0.2163778 | 4.270272e-01 | 5.787994e-01 | 4.670850e-01 | 0.5134513 | 0.7487129 | 0.7917240 |
| FGFBP3 | 0.1364815 | 232.37947 | -108.18973 | -0.0037964 | 0.3400642 | 0.0791045 | 0.3773624 | 0.0151099 | -0.3257293 | 1.671356e+00 | 5.995794e-01 | 4.658205e-01 | 0.1960770 | 0.7409740 | 0.7922247 |
| PDCD1 | 1.0394244 | 375.95438 | -179.97719 | 1.3384284 | -0.7301784 | 0.0395046 | -0.6279106 | -0.0120242 | 0.4425558 | 6.183987e+00 | 1.735498e+00 | 4.540735e-01 | 0.0128912 | 0.4198958 | 0.7968915 |
| IGHV1OR15-4 | 4.2143279 | 511.95438 | -247.97719 | 2.2540360 | -0.2053635 | 0.6197109 | -0.7095592 | -0.6162249 | 0.0132092 | 9.320032e-01 | 2.717435e+00 | 4.468094e-01 | 0.3343429 | 0.2569902 | 0.7997911 |
| IGHV3-33 | 4.1705169 | 1033.79046 | -508.89523 | 6.1563693 | -0.6124224 | 0.0794686 | -0.1628623 | -0.5650635 | 0.1122094 | 3.290072e+00 | 1.675962e-01 | 4.459135e-01 | 0.0697000 | 0.9196169 | 0.8001495 |
| MILR1 | 0.2303157 | 613.66713 | -298.83356 | 2.6349849 | -0.2531382 | 0.1173176 | -0.0155932 | 0.1386273 | 0.1939895 | 1.758717e+00 | 1.124530e+00 | 4.452726e-01 | 0.1847846 | 0.5699167 | 0.8004059 |
| XCR1 | 0.9625341 | 223.37687 | -103.68844 | -0.1556596 | -0.6625253 | 0.4185931 | -0.4366387 | 0.3909869 | 0.5602890 | 1.369375e+00 | 3.993616e+00 | 4.397415e-01 | 0.2419193 | 0.1357680 | 0.8026225 |
| IL15 | 0.1854734 | 461.67742 | -222.83871 | 1.8157712 | 0.0504169 | 0.2224258 | 0.1117720 | -0.1020974 | -0.2198225 | 7.464100e-02 | 1.761291e+00 | 4.337339e-01 | 0.7846956 | 0.4145152 | 0.8050371 |
| IGHV7-4-1 | 5.5413997 | 726.28453 | -355.14226 | 4.9464079 | -1.6348527 | 0.8667185 | -2.0852260 | -0.7118372 | -0.6593898 | 1.439987e+01 | 1.536405e+01 | 4.239237e-01 | 0.0001478 | 0.0004610 | 0.8089955 |
| CXCL2 | 0.5853667 | 527.11356 | -255.55678 | 2.0078174 | -0.3973195 | -0.1346121 | -0.1696973 | 0.1254617 | 0.3355780 | 2.131684e+00 | 7.990670e-02 | 4.214858e-01 | 0.1442822 | 0.9608343 | 0.8099823 |
| FGFR4 | 0.5799627 | 165.13249 | -74.56625 | -0.6828577 | -0.1900089 | -0.3323093 | 0.2502846 | 0.5176440 | 0.1319809 | 2.747800e-03 | 7.242737e-01 | 4.123747e-01 | 0.9581942 | 0.6961871 | 0.8136806 |
| CXCL14 | 1.0392313 | 944.27380 | -464.13690 | 4.9085575 | -0.9752076 | -0.2840320 | -0.6578199 | 0.3354798 | 0.2618381 | 1.102271e+01 | 2.211101e+00 | 4.101956e-01 | 0.0009000 | 0.3310287 | 0.8145676 |
| VILL | 0.1258849 | 431.92818 | -207.96409 | 1.8265553 | 0.0769352 | 0.0849171 | 0.2433713 | -0.1249958 | -0.1714025 | 4.100100e-03 | 1.208061e+00 | 4.076200e-01 | 0.9489448 | 0.5466040 | 0.8156173 |
| IGHV4-28 | 4.9646684 | 668.07077 | -326.03539 | 3.8530319 | -0.5631419 | 0.0373668 | -0.6496586 | 0.5032995 | -0.2839508 | 8.116606e-01 | 2.716447e+00 | 4.072836e-01 | 0.3676297 | 0.2571172 | 0.8157545 |
| COIL | 0.0171416 | 374.95826 | -179.47913 | 1.5111783 | 0.0562886 | 0.0361560 | 0.1245671 | 0.1140593 | -0.0414524 | 8.092169e-01 | 9.290124e-01 | 4.069429e-01 | 0.3683519 | 0.6284454 | 0.8158935 |
| FGF20 | 1.5540806 | 138.32441 | -61.16221 | -1.7627536 | 0.2949364 | 0.3121851 | 0.8652911 | 0.2478575 | -0.5436782 | 2.614053e-01 | 1.035904e+00 | 3.989397e-01 | 0.6091564 | 0.5957393 | 0.8191649 |
| IGHV1-2 | 3.8667624 | 965.48702 | -474.74351 | 5.6602683 | -0.6034698 | 0.0482776 | -0.1332682 | 0.0703626 | -0.6166938 | 2.769550e+00 | 8.787422e-01 | 3.931980e-01 | 0.0960731 | 0.6444416 | 0.8215200 |
| RILPL1 | 0.1145048 | 526.17188 | -255.08594 | 2.2411685 | 0.0207750 | -0.0836560 | 0.1867887 | 0.0402634 | -0.1261545 | 5.610200e-03 | 1.265372e+00 | 3.847288e-01 | 0.9402933 | 0.5311632 | 0.8250062 |
| IL6 | 1.7518860 | 516.59632 | -250.29816 | 2.0992472 | -1.3250283 | -0.4098507 | 0.1779651 | 0.3301030 | -0.1030650 | 7.893237e+02 | 5.396863e-01 | 3.794731e-01 | 0.0000000 | 0.7634992 | 0.8271770 |
| CXCR5 | 2.8048181 | 447.22158 | -215.61079 | 1.1096194 | -0.0035314 | 0.1067084 | 0.3301688 | -0.3377401 | -0.6035082 | 4.447966e-01 | 3.806070e-02 | 3.779376e-01 | 0.5048164 | 0.9811496 | 0.8278123 |
| IGHV1OR16-1 | 6.2737699 | 448.06447 | -216.03224 | 2.1609085 | -0.9202375 | 0.1385083 | -0.7879471 | 0.1506479 | -0.7546508 | 3.333162e+00 | 3.280969e+00 | 3.641875e-01 | 0.0678962 | 0.1938861 | 0.8335232 |
| IL2RB | 0.6578507 | 401.62465 | -192.81233 | 1.4152525 | -0.6766291 | 0.0512408 | -0.3695113 | 0.0485149 | 0.3507614 | 7.199433e+00 | 7.567891e-01 | 3.606767e-01 | 0.0072927 | 0.6849602 | 0.8349877 |
| EMILIN2 | 0.2099529 | 724.12953 | -354.06477 | 3.3685866 | -0.1563030 | 0.2751906 | 0.2831379 | 0.1301881 | -0.0023829 | 1.027734e+00 | 8.936038e+00 | 3.602829e-01 | 0.3106915 | 0.0114700 | 0.8351521 |
| LILRB4 | 0.5771483 | 880.90978 | -432.45489 | 3.9579631 | -0.3393928 | 0.2028156 | -0.1049390 | 0.1851578 | 0.2397312 | 1.549199e+00 | 1.648888e+00 | 3.431994e-01 | 0.2132538 | 0.4384787 | 0.8423163 |
| SIL1 | 0.3509430 | 745.83151 | -364.91576 | 3.5815283 | -0.0202192 | 0.1251435 | 0.2319395 | -0.1225643 | 0.0764270 | 1.402141e-01 | 2.378407e+00 | 3.398429e-01 | 0.7080683 | 0.3044637 | 0.8437311 |
| CXCR3 | 0.9621586 | 420.19236 | -202.09618 | 1.5795176 | -0.7533636 | 0.1902980 | -0.4824692 | -0.0021414 | 0.3578279 | 7.866802e+00 | 2.227993e+00 | 3.389410e-01 | 0.0050351 | 0.3282444 | 0.8441117 |
| IL18BP | 0.4037688 | 630.39579 | -307.19789 | 2.9254876 | -0.3846910 | 0.0717069 | -0.1624949 | -0.0720922 | 0.1631207 | 6.525910e+00 | 3.475811e-01 | 3.388928e-01 | 0.0106314 | 0.8404729 | 0.8441320 |
| IGHV3-13 | 4.3335421 | 604.92102 | -294.46051 | 3.8261268 | -1.7571501 | 0.0752347 | -0.7266719 | -0.6153906 | -0.2889143 | 1.775105e+01 | 1.624753e+00 | 3.251277e-01 | 0.0000252 | 0.4438021 | 0.8499618 |
| IL12A | 0.3067847 | 160.70623 | -72.35311 | -0.5272648 | -0.0319105 | -0.1703801 | -0.4267201 | -0.0962169 | 0.4133806 | 1.768900e-03 | 4.059892e-01 | 3.191501e-01 | 0.9664522 | 0.8162827 | 0.8525060 |
| FGF9 | 1.1886771 | 151.84508 | -67.92254 | -0.9926468 | 0.5491007 | -0.8216629 | -0.2521326 | 0.2514642 | -0.4842403 | 1.413438e+00 | 1.955093e+00 | 3.186990e-01 | 0.2344864 | 0.3762330 | 0.8526983 |
| RADIL | 0.4588615 | 342.96514 | -163.48257 | 0.5452758 | 0.3222814 | 0.1129023 | 0.4064493 | 0.0357462 | -0.2557050 | 1.813233e+00 | 1.038172e+00 | 3.170191e-01 | 0.1781209 | 0.5950641 | 0.8534148 |
| LY6E | 0.3515667 | 1038.90552 | -511.45276 | 5.2056655 | 0.0174271 | 0.0624345 | -0.0759116 | 0.1026287 | -0.0899762 | 7.672610e-02 | 1.545187e+00 | 3.109108e-01 | 0.7817842 | 0.4618139 | 0.8560253 |
| ILK | 0.0598387 | 898.76387 | -441.38193 | 4.4572478 | 0.1944982 | 0.0894017 | 0.2697250 | -0.0152733 | -0.0839609 | 8.804341e+00 | 2.470614e+00 | 3.101507e-01 | 0.0030051 | 0.2907456 | 0.8563506 |
| PPIL2 | 0.0863844 | 581.04649 | -282.52324 | 2.6550205 | 0.0313032 | 0.1469112 | 0.2780844 | -0.0995643 | -0.0842632 | 8.821390e-02 | 3.579401e+00 | 3.084355e-01 | 0.7664602 | 0.1670102 | 0.8570854 |
| IGHV1-14 | 5.9704622 | 307.45234 | -145.72617 | 0.8415873 | -0.0519792 | -0.7603251 | -0.9012406 | -0.2608297 | -0.8624963 | 2.920129e-01 | 3.529256e+00 | 3.035130e-01 | 0.5889335 | 0.1712505 | 0.8591975 |
| IFNGR1 | 0.0896459 | 842.22713 | -413.11356 | 3.7689703 | 0.0018582 | 0.0828696 | -0.0293806 | 0.0856279 | 0.0109413 | 2.510632e-01 | 1.199598e+00 | 2.957383e-01 | 0.6163275 | 0.5489218 | 0.8625440 |
| NFIL3 | 0.1758007 | 583.42483 | -283.71242 | 2.5602439 | -0.3321835 | -0.0427128 | 0.0477579 | 0.0807963 | 0.1579587 | 5.727681e+00 | 4.513974e-01 | 2.905580e-01 | 0.0166995 | 0.7979585 | 0.8647810 |
| FGF7P6 | 0.7079634 | 167.04922 | -75.52461 | -0.3947204 | -0.3037851 | -0.8189977 | -0.0933151 | 0.4652084 | 0.1348022 | 1.545600e-01 | 2.001304e+00 | 2.899070e-01 | 0.6942152 | 0.3676396 | 0.8650625 |
| IL17RD | 0.3281740 | 312.07710 | -148.03855 | 0.2193467 | 0.4520956 | 0.0949993 | 0.2761579 | 0.1617941 | -0.1169531 | 5.712008e+00 | 7.759953e-01 | 2.852014e-01 | 0.0168493 | 0.6784139 | 0.8671002 |
| FILIP1 | 0.2056906 | 286.50128 | -135.25064 | 0.4755125 | 0.1632489 | -0.0469531 | 0.0958986 | 0.1501351 | -0.1119867 | 1.063720e+00 | 3.773330e-02 | 2.802529e-01 | 0.3023682 | 0.9813102 | 0.8692483 |
| PILRA | 0.3305271 | 682.92297 | -333.46149 | 3.1063427 | -0.2132186 | 0.0968656 | 0.0126248 | 0.0123243 | 0.1821180 | 1.647871e+00 | 5.332772e-01 | 2.788111e-01 | 0.1992489 | 0.7659498 | 0.8698752 |
| IGHV7-40 | 10.1273807 | 302.89795 | -143.44897 | 1.5321191 | -2.5802560 | -0.7584716 | -1.6733151 | 0.5537552 | 1.0315883 | 8.383313e+00 | 1.478465e+00 | 2.729301e-01 | 0.0037868 | 0.4774801 | 0.8724368 |
| IL9R | 1.3943970 | 192.95215 | -88.47607 | -0.4573984 | -0.3557234 | 0.2111375 | -0.2413711 | -0.3478284 | 0.1767977 | 1.303714e+00 | 1.649708e-01 | 2.705038e-01 | 0.2535359 | 0.9208249 | 0.8734958 |
| IGHV2-70 | 5.4446515 | 730.92775 | -357.46387 | 4.5933277 | -1.0754113 | 0.6029011 | -0.8501381 | -0.1702742 | -0.6916518 | 6.458830e+00 | 6.165761e+00 | 2.638390e-01 | 0.0110402 | 0.0458271 | 0.8764115 |
| EMILIN1 | 0.4067200 | 771.87037 | -377.93519 | 3.5887758 | -0.3551333 | 0.0082157 | 0.3757877 | 0.0769673 | -0.1249557 | 5.611555e+00 | 2.388827e+00 | 2.622821e-01 | 0.0178424 | 0.3028815 | 0.8770940 |
| IL4R | 0.1139512 | 728.84092 | -356.42046 | 3.2340008 | -0.0643989 | 0.2119544 | 0.0580025 | -0.0918541 | -0.0066135 | 1.404714e+00 | 1.034229e+00 | 2.614293e-01 | 0.2359359 | 0.5962386 | 0.8774681 |
| IFNG | 1.8887340 | 175.81194 | -79.90597 | -0.3291726 | -0.9412817 | -0.1829109 | -1.0242451 | 0.2354921 | 0.6965298 | 2.511750e+00 | 1.160698e+00 | 2.609617e-01 | 0.1130004 | 0.5597031 | 0.8776733 |
| IL10RB-AS1 | 0.9984176 | 433.63013 | -208.81506 | 1.2444396 | -0.0540258 | 0.0649436 | 0.2727779 | 0.1341338 | -0.1975684 | 3.528760e-02 | 3.788010e-01 | 2.538552e-01 | 0.8509943 | 0.8274551 | 0.8807974 |
| CXCL3 | 0.8644953 | 460.23847 | -222.11923 | 1.3956229 | -0.4361336 | -0.1303082 | 0.1632599 | 0.0992228 | 0.3350210 | 1.882036e+00 | 9.149163e-01 | 2.537097e-01 | 0.1701029 | 0.6328903 | 0.8808615 |
| ILDR1 | 0.7637869 | 87.25219 | -35.62609 | -1.7330402 | -0.2631261 | -0.0666995 | -0.4684799 | -0.1974347 | 0.6465778 | 1.111708e-01 | 4.675820e-02 | 2.513788e-01 | 0.7388152 | 0.9768921 | 0.8818887 |
| PADI1 | 10.3670246 | 177.16407 | -80.58203 | -1.7923927 | 0.4435987 | -0.3990174 | 0.3136718 | -0.6796462 | -1.0393680 | 3.750000e-05 | 5.349791e-01 | 2.340410e-01 | 0.9951160 | 0.7652983 | 0.8895669 |
| IFNGR2 | 0.1417711 | 823.70418 | -403.85209 | 4.1638047 | 0.0531543 | 0.0956479 | 0.0724840 | 0.0904032 | 0.0503509 | 1.312666e+00 | 2.249569e+00 | 2.233509e-01 | 0.2519125 | 0.3247225 | 0.8943345 |
| FGF7 | 0.7236335 | 596.78414 | -290.39207 | 2.4445507 | -0.4701105 | -0.3070267 | -0.0421748 | 0.2199497 | 0.0969517 | 3.084252e+00 | 5.117830e-01 | 2.224588e-01 | 0.0790536 | 0.7742260 | 0.8947335 |
| TRIL | 0.3773539 | 311.01172 | -147.50586 | 0.3384053 | 0.2608191 | 0.1101203 | 0.4143410 | -0.0493074 | -0.2463348 | 7.804348e-01 | 9.752062e-01 | 2.177320e-01 | 0.3770082 | 0.6140966 | 0.8968506 |
| IL10RA | 0.1815313 | 778.10738 | -381.05369 | 3.4772089 | -0.1273802 | 0.2544776 | 0.0189644 | 0.0795878 | 0.1147855 | 5.180717e-01 | 3.477724e+00 | 2.152413e-01 | 0.4716654 | 0.1757202 | 0.8979682 |
| IL3RA | 0.2278045 | 623.88790 | -303.94395 | 2.9192369 | 0.0167550 | -0.0390552 | 0.1487953 | 0.0380615 | -0.1048366 | 5.569300e-03 | 5.896715e-01 | 2.138196e-01 | 0.9405107 | 0.7446539 | 0.8986067 |
| PPIL1 | 0.1337270 | 508.32109 | -246.16054 | 2.4670481 | -0.1721822 | 0.0369424 | -0.0161521 | 0.0047970 | 0.1178856 | 2.029119e+00 | 1.506525e-01 | 2.138176e-01 | 0.1543100 | 0.9274408 | 0.8986076 |
| CXCL16 | 0.2304216 | 805.66471 | -394.83236 | 3.7284736 | -0.1833163 | 0.1197400 | 0.0399015 | 0.1064988 | 0.0885273 | 1.249024e+00 | 1.226670e+00 | 1.984975e-01 | 0.2637391 | 0.5415417 | 0.9055175 |
| NEIL2 | 0.0914181 | 432.55777 | -208.27888 | 2.0115262 | -0.0206489 | -0.0195390 | 0.0616411 | 0.0598909 | 0.1168323 | 7.116360e-02 | 9.009791e-01 | 1.973649e-01 | 0.7896501 | 0.6373161 | 0.9060304 |
| IL18RAP | 0.5748740 | 276.80783 | -130.40391 | 0.0652429 | -0.0205913 | 0.5735076 | 0.1904431 | -0.2176965 | 0.0165226 | 1.927077e-01 | 2.816428e+00 | 1.968272e-01 | 0.6606725 | 0.2445797 | 0.9062740 |
| IL13RA2 | 0.5422414 | 454.87162 | -219.43581 | 1.2851583 | 0.2072706 | -0.1461028 | 0.0571981 | 0.0519137 | 0.2244101 | 1.997664e+00 | 8.313245e-01 | 1.911084e-01 | 0.1575418 | 0.6599031 | 0.9088691 |
| AVIL | 0.2307442 | 487.36206 | -235.68103 | 1.9260852 | -0.3565907 | 0.1704880 | 0.1961734 | 0.0987273 | -0.0445950 | 5.960846e+00 | 1.833049e+00 | 1.877980e-01 | 0.0146270 | 0.3999065 | 0.9103747 |
| IGHV3OR16-13 | 5.8254344 | 396.54358 | -190.27179 | 1.9811997 | -1.2915883 | -0.1318277 | -1.3814710 | -0.4471699 | 0.0728775 | 7.026048e+00 | 3.297699e+00 | 1.759446e-01 | 0.0080332 | 0.1922710 | 0.9157862 |
| IL33 | 0.3454783 | 674.04423 | -329.02212 | 2.6710312 | -0.0510368 | 0.0600236 | 0.0535397 | 0.1011619 | -0.0484743 | 2.412610e-02 | 2.033907e-01 | 1.745251e-01 | 0.8765646 | 0.9033047 | 0.9164365 |
| LILRA6 | 0.3247321 | 610.30991 | -297.15495 | 2.2112534 | 0.0772776 | 0.3331260 | 0.4026142 | 0.0322190 | -0.1223800 | 2.078075e-01 | 3.826830e+00 | 1.715544e-01 | 0.6484913 | 0.1475756 | 0.9177987 |
| CARMIL3 | 0.6885289 | 178.42051 | -81.21026 | -0.3184232 | -0.6095959 | -0.3631838 | 0.0753417 | 0.3059944 | 0.2564815 | 1.599784e+00 | 8.315403e-01 | 1.623703e-01 | 0.2059339 | 0.6598319 | 0.9220230 |
| CXCR2P1 | 1.0977879 | 185.02870 | -84.51435 | -0.5902085 | -0.0698627 | 0.1913614 | -0.4778839 | 0.0467542 | -0.4204691 | 7.606420e-02 | 2.165846e+00 | 1.599058e-01 | 0.7827036 | 0.3386043 | 0.9231598 |
| SDK2 | 0.6493056 | 242.90227 | -113.45114 | -0.0752330 | 0.3192844 | -0.3623568 | -0.1555088 | 0.2370088 | 0.0140592 | 2.041892e+00 | 5.322530e-01 | 1.531832e-01 | 0.1530192 | 0.7663422 | 0.9262681 |
| LILRP1 | 1.9654449 | 84.33710 | -34.16855 | -2.0701129 | -0.2385485 | -0.3260609 | -0.5583284 | 0.3275105 | 0.7787249 | 1.334900e-03 | 4.630710e-02 | 1.520479e-01 | 0.9708550 | 0.9771124 | 0.9267940 |
| IL17RA | 0.1165206 | 438.61650 | -211.30825 | 1.6219450 | -0.0088598 | 0.2940470 | 0.1477453 | -0.0928958 | -0.0900067 | 3.108295e-01 | 3.205373e+00 | 1.479440e-01 | 0.5771716 | 0.2013549 | 0.9286977 |
| IGHV1-24 | 4.2421426 | 820.93135 | -402.46567 | 4.5850704 | 0.0539701 | 0.1041951 | -0.5776505 | -0.2663842 | -0.4195415 | 8.914400e-02 | 2.002321e+00 | 1.429375e-01 | 0.7652682 | 0.3674528 | 0.9310254 |
| IL6ST | 0.1632442 | 693.65057 | -338.82528 | 2.7298922 | 0.2237663 | 0.3070552 | 0.1937496 | -0.0384958 | -0.1033885 | 3.358500e+00 | 2.790825e+00 | 1.419701e-01 | 0.0668590 | 0.2477308 | 0.9314758 |
| LILRA1 | 0.3367641 | 314.25762 | -149.12881 | 0.8514207 | -0.3087270 | 0.0514880 | -0.1520792 | 0.0194710 | 0.1832385 | 1.800941e+00 | 2.221048e-01 | 1.273006e-01 | 0.1795988 | 0.8948919 | 0.9383331 |
| IL36RN | 19.4325345 | 296.08369 | -140.04184 | 1.4681399 | -2.5155077 | -2.0578324 | -1.3288273 | 0.8261137 | 0.3887552 | 4.361784e+00 | 2.229550e+00 | 1.247028e-01 | 0.0367538 | 0.3279891 | 0.9395527 |
| IL27 | 0.8439578 | 175.81549 | -79.90775 | -0.6536505 | -0.0569313 | 0.0211854 | -0.2510657 | -0.0584625 | 0.2873973 | 3.757900e-03 | 4.228830e-02 | 1.221553e-01 | 0.9511191 | 0.9790778 | 0.9407502 |
| IL22RA1 | 1.5096769 | 147.90593 | -65.95296 | -0.4584790 | -1.0020745 | -0.6416982 | -0.4148671 | 0.0858790 | -0.4280920 | 4.001124e+00 | 1.229769e+00 | 1.165993e-01 | 0.0454699 | 0.5407035 | 0.9433672 |
| NKILA | 0.1821951 | 173.78531 | -78.89265 | -0.4425051 | 0.0611145 | -0.1200179 | 0.1165499 | 0.0935140 | -0.1580821 | 4.404580e-02 | 9.260750e-02 | 1.072320e-01 | 0.8337685 | 0.9547519 | 0.9477960 |
| EDIL3 | 0.7388625 | 553.95041 | -268.97521 | 1.6810405 | 0.3729077 | -0.1631396 | 0.1990618 | 0.0458290 | 0.1833911 | 4.211646e+00 | 1.349177e+00 | 1.068181e-01 | 0.0401474 | 0.5093660 | 0.9479921 |
| IGHV4-59 | 3.9423711 | 1006.43490 | -495.21745 | 6.1742830 | -0.8556174 | -0.1375892 | -0.5046838 | -0.3106751 | -0.1976579 | 5.585105e+00 | 1.149838e+00 | 1.060279e-01 | 0.0181138 | 0.5627505 | 0.9483668 |
| FILIP1L | 0.2714560 | 825.29943 | -404.64971 | 3.3919372 | 0.1883811 | 0.2616398 | 0.1522384 | 0.0635989 | -0.0338102 | 2.841369e+00 | 1.874185e+00 | 9.823720e-02 | 0.0918659 | 0.3917652 | 0.9520682 |
| PPIL3 | 0.1086377 | 708.84448 | -346.42224 | 3.1199801 | 0.1242206 | 0.1004742 | 0.2319891 | -0.0475003 | -0.0604047 | 1.248966e+00 | 1.281002e+00 | 9.743050e-02 | 0.2637501 | 0.5270284 | 0.9524523 |
| SVILP1 | 0.4449481 | 108.74436 | -46.37218 | -1.4485948 | -0.0293806 | -0.1420410 | -0.0937396 | 0.1856124 | 0.3639567 | 6.302940e-02 | 5.876700e-02 | 9.073230e-02 | 0.8017703 | 0.9710440 | 0.9556475 |
| DBIL5P | 0.7122845 | 139.33581 | -61.66791 | -1.2527909 | 0.1637047 | 0.1945332 | 0.2438806 | -0.2417144 | 0.0152856 | 3.541510e-02 | 2.237035e-01 | 8.342860e-02 | 0.8507285 | 0.8941768 | 0.9591438 |
| ILKAP | 0.0892046 | 658.45695 | -321.22848 | 3.2236644 | 0.1312096 | 0.0700191 | 0.2293183 | 0.0222581 | -0.0367687 | 2.994959e+00 | 3.668773e+00 | 8.285460e-02 | 0.0835240 | 0.1597114 | 0.9594191 |
| USP18 | 0.2836978 | 390.87054 | -187.43527 | 1.2533858 | 0.2157307 | 0.1180230 | -0.2524189 | -0.0898634 | -0.0925170 | 1.045899e+00 | 2.782888e+00 | 7.861910e-02 | 0.3064536 | 0.2487159 | 0.9614531 |
| FGF10-AS1 | 0.4620062 | 148.22106 | -66.11053 | -1.2065188 | 0.3485410 | 0.1302423 | 0.2192506 | 0.2018073 | 0.0161896 | 1.355377e+00 | 4.138021e-01 | 6.674860e-02 | 0.2443403 | 0.8131001 | 0.9671765 |
| LILRB3 | 0.3186235 | 661.27696 | -322.63848 | 2.7765132 | -0.2364748 | 0.3025602 | 0.0657595 | -0.0132292 | 0.0776738 | 2.712545e+00 | 2.487071e+00 | 6.256260e-02 | 0.0995620 | 0.2883629 | 0.9692029 |
| IL9RP3 | 1.5399351 | 96.89330 | -40.44665 | -1.9984678 | -0.0989243 | 0.4152088 | 0.0144230 | -0.2938250 | -0.0335794 | 1.315345e-01 | 1.999710e-01 | 4.915500e-02 | 0.7168462 | 0.9048505 | 0.9757220 |
| IFI27 | 0.4806181 | 1334.71061 | -659.35531 | 6.7493379 | 0.1915578 | 0.1924554 | -0.2301413 | 0.0305536 | -0.0594235 | 1.620016e+00 | 5.295594e+00 | 4.842940e-02 | 0.2030896 | 0.0708070 | 0.9760761 |
| IFNAR1 | 0.0677559 | 528.34170 | -256.17085 | 2.4641090 | 0.0299623 | 0.1928424 | 0.0660823 | -0.0113381 | 0.0356009 | 1.615075e-01 | 4.127820e+00 | 4.552850e-02 | 0.6877723 | 0.1269566 | 0.9774929 |
| IL15RA | 0.2142398 | 543.91649 | -263.95824 | 2.4558890 | -0.1989596 | 0.1448958 | -0.1048902 | -0.0524882 | -0.0043828 | 3.380282e+00 | 2.010988e+00 | 4.322810e-02 | 0.0659808 | 0.3658638 | 0.9786179 |
| PIWIL2 | 0.2456914 | 148.04245 | -66.02123 | -1.1609633 | 0.3421433 | 0.1491316 | 0.4118402 | 0.0271803 | 0.1704348 | 1.346317e+00 | 1.472241e+00 | 4.248930e-02 | 0.2459230 | 0.4789684 | 0.9789794 |
| FGF22 | 1.7704760 | 144.15292 | -64.07646 | -0.6345037 | -0.9807215 | -0.5725046 | 0.1218545 | 0.2363705 | 0.0530904 | 3.073783e+00 | 1.052258e+00 | 3.973890e-02 | 0.0795641 | 0.5908878 | 0.9803266 |
| IL12B | 0.3434760 | 78.71428 | -31.35714 | -2.1717064 | 0.0463511 | 0.2248875 | 0.1107223 | -0.0473762 | 0.2484901 | 1.944340e-02 | 1.265064e-01 | 3.709980e-02 | 0.8891027 | 0.9387058 | 0.9816211 |
| FGF13 | 0.4019804 | 305.66985 | -144.83493 | 0.5760937 | -0.0321708 | 0.0774785 | 0.1015108 | -0.0870693 | -0.0696459 | 1.421141e-01 | 6.013680e-02 | 3.633390e-02 | 0.7061882 | 0.9703792 | 0.9819971 |
| ILF3 | 0.0523578 | 818.43229 | -401.21615 | 3.7182880 | -0.0284730 | 0.0858392 | 0.0947299 | 0.0234323 | 0.0101815 | 8.271530e-02 | 6.581165e-01 | 2.980510e-02 | 0.7736509 | 0.7196011 | 0.9852080 |
| IGHV4-4 | 5.1731053 | 843.04654 | -413.52327 | 4.8432616 | -0.7571471 | 0.1079372 | -0.1259593 | -0.1987467 | -0.1507834 | 2.185205e+00 | 7.152720e-02 | 2.976700e-02 | 0.1393425 | 0.9648684 | 0.9852267 |
| RILP | 0.2004065 | 592.59134 | -288.29567 | 2.8914214 | 0.0798216 | 0.0138905 | 0.0668859 | 0.0247016 | -0.0243904 | 5.987112e-01 | 1.473093e-01 | 2.860480e-02 | 0.4390702 | 0.9289925 | 0.9857994 |
| IL37 | 8.0979107 | 222.18704 | -103.09352 | 0.9766282 | -2.4119149 | -0.9530405 | -0.8436230 | 0.2544044 | 0.0623393 | 9.816607e+00 | 1.378841e+00 | 2.403460e-02 | 0.0017294 | 0.5018669 | 0.9880546 |
| PADI2 | 0.6567632 | 286.25720 | -135.12860 | 0.4008216 | -0.7071289 | -0.2046819 | 0.1935694 | -0.0259778 | -0.0851058 | 6.419281e+03 | 7.663396e-01 | 2.401140e-02 | 0.0000000 | 0.6816971 | 0.9880661 |
| FGF17 | 0.6366124 | 110.10344 | -47.05172 | -1.7107698 | 0.2358667 | 0.1266420 | 0.3675500 | -0.0921985 | -0.1436032 | 1.160264e-01 | 2.209599e-01 | 1.432140e-02 | 0.7333848 | 0.8954043 | 0.9928649 |
| BCL2L12 | 0.1661472 | 534.54728 | -259.27364 | 2.6422769 | -0.0288726 | -0.0059884 | 0.0671048 | 0.0153657 | -0.0167846 | 6.471280e-02 | 2.037043e-01 | 1.292520e-02 | 0.7991965 | 0.9031631 | 0.9935582 |
| IL18R1 | 0.2900986 | 271.14232 | -127.57116 | 0.4267697 | -0.1218438 | 0.1117918 | -0.1728590 | 0.0088336 | 0.0594292 | 2.536368e-01 | 7.835873e-01 | 1.053080e-02 | 0.6145258 | 0.6758435 | 0.9947485 |
| IL6R | 0.1064792 | 502.91740 | -243.45870 | 1.9751130 | 0.0329182 | 0.1643320 | -0.0115767 | 0.0048683 | 0.0137561 | 1.308856e-01 | 1.512278e+00 | 2.358700e-03 | 0.7175155 | 0.4694755 | 0.9988214 |
| ILDR2 | 1.0211017 | 54.19758 | -19.09879 | -2.9239006 | 0.1915436 | -0.1753325 | 0.1620144 | -0.0799469 | -0.0194411 | 3.001070e-02 | 9.147460e-02 | 1.387700e-03 | 0.8624660 | 0.9552929 | 0.9993064 |
| IL17RB | 0.1069132 | 190.17334 | -87.08667 | -0.0457732 | -0.1113093 | -0.0747753 | -0.2118919 | 0.0154167 | -0.0082807 | 1.907085e-01 | 4.024344e-01 | 1.382400e-03 | 0.6623276 | 0.8177348 | 0.9993090 |
And the final model output in the @predict slot:
predict = data.frame(resultTable@predict)
kable(predict) %>%
kable_styling() %>%
scroll_box(width = "100%", height = "400px")| y_0_Good.responder | y_6_Good.responder | y_0_Moderate.responder | y_6_Moderate.responder | y_0_Non.responder | y_6_Non.responder | LCI_0_Good.responder | LCI_6_Good.responder | LCI_0_Moderate.responder | LCI_6_Moderate.responder | LCI_0_Non.responder | LCI_6_Non.responder | UCI_0_Good.responder | UCI_6_Good.responder | UCI_0_Moderate.responder | UCI_6_Moderate.responder | UCI_0_Non.responder | UCI_6_Non.responder | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1BG | 1.313242e+01 | 15.3947641 | 1.610655e+01 | 15.6512711 | 1.807684e+01 | 30.7777198 | 8.6703465 | 10.1933737 | 10.4094593 | 10.1102021 | 10.1259795 | 17.3871686 | 1.989083e+01 | 2.325028e+01 | 2.492164e+01 | 2.422922e+01 | 3.227067e+01 | 5.448087e+01 |
| ADAM12 | 7.311778e+00 | 2.3129980 | 4.704782e+00 | 1.7233707 | 4.092495e+00 | 8.8871726 | 4.3002032 | 1.2856949 | 2.6369463 | 0.8990015 | 1.8747357 | 4.2242156 | 1.243246e+01 | 4.161142e+00 | 8.394169e+00 | 3.303673e+00 | 8.933802e+00 | 1.869740e+01 |
| AVIL | 6.862592e+00 | 4.8042190 | 8.138234e+00 | 6.2884195 | 8.349975e+00 | 5.5905230 | 5.0666769 | 3.4682404 | 5.9258491 | 4.5305643 | 5.4971080 | 3.5860270 | 9.295080e+00 | 6.654821e+00 | 1.117660e+01 | 8.728321e+00 | 1.268341e+01 | 8.715480e+00 |
| BCL2L12 | 1.404515e+01 | 13.6454249 | 1.396129e+01 | 13.7739842 | 1.501999e+01 | 14.3496340 | 11.2145304 | 10.8846226 | 10.9940534 | 10.8412541 | 10.9594617 | 10.4483792 | 1.759023e+01 | 1.710648e+01 | 1.772937e+01 | 1.750006e+01 | 2.058495e+01 | 1.970755e+01 |
| BLK | 2.658234e+00 | 3.0475152 | 3.565283e+00 | 1.7809329 | 1.934295e+00 | 2.3457058 | 1.4131620 | 1.6524364 | 1.9641134 | 0.9277103 | 0.8333840 | 0.9650958 | 5.000283e+00 | 5.620397e+00 | 6.471745e+00 | 3.418871e+00 | 4.489525e+00 | 5.701336e+00 |
| C1GALT1 | 1.418865e+01 | 9.3090470 | 1.434680e+01 | 11.6517008 | 1.217739e+01 | 11.7295557 | 9.6383440 | 6.4080140 | 9.8267920 | 7.9339723 | 7.2942700 | 7.0046930 | 2.088718e+01 | 1.352343e+01 | 2.094587e+01 | 1.711150e+01 | 2.032950e+01 | 1.964147e+01 |
| CARMIL1 | 4.351577e+00 | 5.7100655 | 5.116252e+00 | 6.5449083 | 6.204266e+00 | 6.5119410 | 3.2402068 | 4.3419906 | 3.7951662 | 4.9423116 | 4.2514062 | 4.4745598 | 5.844140e+00 | 7.509194e+00 | 6.897204e+00 | 8.667164e+00 | 9.054162e+00 | 9.476994e+00 |
| CARMIL2 | 4.633051e+00 | 2.9544021 | 6.379907e+00 | 2.3523223 | 3.602549e+00 | 4.0157843 | 2.6337905 | 1.6740391 | 3.6801633 | 1.2785792 | 1.7185708 | 1.7652352 | 8.149911e+00 | 5.214031e+00 | 1.106016e+01 | 4.327789e+00 | 7.551832e+00 | 9.135623e+00 |
| CARMIL3 | 7.272950e-01 | 0.3953361 | 5.058035e-01 | 0.3733614 | 7.842076e-01 | 0.5509034 | 0.3745445 | 0.1726048 | 0.2272714 | 0.1519331 | 0.3139216 | 0.1959341 | 1.412270e+00 | 9.054826e-01 | 1.125690e+00 | 9.175005e-01 | 1.959029e+00 | 1.548963e+00 |
| CD109 | 5.641830e+00 | 8.6778475 | 5.187570e+00 | 9.2014847 | 6.263955e+00 | 8.4775088 | 5.5798926 | 8.5433726 | 5.1072480 | 9.0005658 | 6.1669618 | 8.2923481 | 5.704456e+00 | 8.814439e+00 | 5.269154e+00 | 9.406889e+00 | 6.362474e+00 | 8.666804e+00 |
| CD27 | 1.544528e+01 | 13.1635935 | 2.554582e+01 | 13.7894931 | 1.035888e+01 | 10.5054068 | 8.0092712 | 6.7666875 | 13.2575364 | 6.8409903 | 4.2909395 | 3.5251511 | 2.978507e+01 | 2.560783e+01 | 4.922401e+01 | 2.779570e+01 | 2.500767e+01 | 3.130747e+01 |
| CD38 | 6.464032e+00 | 3.2932388 | 8.174153e+00 | 3.3252624 | 4.467718e+00 | 2.9347045 | 3.9428305 | 1.9400334 | 5.0727005 | 1.9727307 | 2.2099327 | 1.4426568 | 1.059739e+01 | 5.590327e+00 | 1.317183e+01 | 5.605109e+00 | 9.032177e+00 | 5.969882e+00 |
| CILP | 9.332507e+00 | 33.0612951 | 6.255099e+00 | 28.3892069 | 2.045799e+01 | 21.6751989 | 3.9027127 | 14.2695061 | 2.5715358 | 11.9706220 | 6.2762690 | 6.8178909 | 2.231671e+01 | 7.660035e+01 | 1.521513e+01 | 6.732708e+01 | 6.668443e+01 | 6.890903e+01 |
| CILP2 | 3.627684e+00 | 6.7217420 | 6.383095e-01 | 5.4156273 | 2.540957e+00 | 3.9217541 | 3.5490285 | 6.5169190 | 0.6188398 | 5.1841267 | 0.8396780 | 1.2973571 | 3.708082e+00 | 6.933002e+00 | 6.583918e-01 | 5.657466e+00 | 7.689215e+00 | 1.185499e+01 |
| CLEC17A | 7.839581e-01 | 0.6137746 | 1.058750e+00 | 0.3309858 | 3.605461e-01 | 0.6507977 | 0.3525846 | 0.2636568 | 0.4760750 | 0.1139269 | 0.0903119 | 0.2003139 | 1.743100e+00 | 1.428824e+00 | 2.354568e+00 | 9.615955e-01 | 1.439383e+00 | 2.114370e+00 |
| COIL | 4.532068e+00 | 4.7944879 | 4.698928e+00 | 5.5715998 | 5.133283e+00 | 5.2100092 | 3.6179243 | 3.8496589 | 3.7149330 | 4.4835055 | 3.7998629 | 3.8645434 | 5.677189e+00 | 5.971208e+00 | 5.943558e+00 | 6.923762e+00 | 6.934618e+00 | 7.023908e+00 |
| COLGALT2 | 2.766051e+00 | 5.1205630 | 2.154270e+00 | 6.4970467 | 3.622173e+00 | 4.4600883 | 1.6234900 | 3.1111653 | 1.1997396 | 3.8700004 | 1.7490074 | 2.1870009 | 4.712711e+00 | 8.427763e+00 | 3.868239e+00 | 1.090739e+01 | 7.501478e+00 | 9.095738e+00 |
| CXCL1 | 1.418779e+01 | 8.1176746 | 2.037469e+01 | 8.3238791 | 2.211843e+01 | 9.9924706 | 13.4937646 | 7.5704301 | 18.9661790 | 7.5682514 | 20.5862810 | 9.0977495 | 1.491751e+01 | 8.704478e+00 | 2.188780e+01 | 9.154950e+00 | 2.376460e+01 | 1.097518e+01 |
| CXCL10 | 2.494209e+01 | 14.7476955 | 2.840235e+01 | 14.8359335 | 8.563339e+00 | 9.2970586 | 10.2392124 | 5.4003390 | 11.5600667 | 5.8124142 | 2.5043913 | 2.5539000 | 6.075741e+01 | 4.027423e+01 | 6.978277e+01 | 3.786807e+01 | 2.928088e+01 | 3.384443e+01 |
| CXCL11 | 3.791295e+00 | 2.4234891 | 2.851737e+00 | 1.9072576 | 7.459937e-01 | 0.9929039 | 1.5589996 | 0.7970634 | 1.2312606 | 0.7682953 | 0.2080571 | 0.2890835 | 9.219961e+00 | 7.368672e+00 | 6.604942e+00 | 4.734679e+00 | 2.674779e+00 | 3.410289e+00 |
| CXCL12 | 3.193020e+02 | 339.9117231 | 3.846127e+02 | 474.9524798 | 3.685331e+02 | 293.9612953 | 231.8665785 | 249.0086484 | 276.8996099 | 341.8993477 | 235.9709324 | 186.4961275 | 4.397087e+02 | 4.639999e+02 | 5.342258e+02 | 6.597844e+02 | 5.755650e+02 | 4.633514e+02 |
| CXCL13 | 3.217759e+01 | 19.9166568 | 4.607415e+01 | 7.1796651 | 7.292775e+00 | 8.6504474 | 29.4894149 | 17.6185573 | 40.7318754 | 6.0384831 | 6.4434142 | 7.2680675 | 3.511081e+01 | 2.251451e+01 | 5.211711e+01 | 8.536513e+00 | 8.254098e+00 | 1.029575e+01 |
| CXCL14 | 1.354439e+02 | 51.0777954 | 1.019544e+02 | 53.7744053 | 7.015714e+01 | 34.3763246 | 68.4028570 | 29.5468780 | 57.6822921 | 30.1125224 | 33.0098585 | 16.1751871 | 2.681912e+02 | 8.829837e+01 | 1.802060e+02 | 9.602937e+01 | 1.491077e+02 | 7.305830e+01 |
| CXCL16 | 4.161554e+01 | 34.6451339 | 4.690919e+01 | 43.4406712 | 4.330964e+01 | 39.3929196 | 31.5603246 | 26.3581657 | 35.3192461 | 32.6415371 | 29.6285152 | 26.7645915 | 5.487437e+01 | 4.553751e+01 | 6.230235e+01 | 5.781259e+01 | 6.330808e+01 | 5.797967e+01 |
| CXCL2 | 7.447045e+00 | 5.0053028 | 6.509127e+00 | 4.9597113 | 6.284712e+00 | 5.9084208 | 4.5909574 | 3.0434139 | 3.9436093 | 2.9624854 | 3.2031238 | 2.9977108 | 1.207994e+01 | 8.231892e+00 | 1.074364e+01 | 8.303412e+00 | 1.233097e+01 | 1.164537e+01 |
| CXCL3 | 4.037489e+00 | 2.6103631 | 3.544208e+00 | 2.5304672 | 4.753507e+00 | 4.2963685 | 2.2056672 | 1.3908075 | 1.8908105 | 1.3138687 | 2.0622319 | 1.7040244 | 7.390650e+00 | 4.899309e+00 | 6.643399e+00 | 4.873595e+00 | 1.095698e+01 | 1.083246e+01 |
| CXCL5 | 5.239192e-01 | 0.5661362 | 3.565176e-01 | 0.1402179 | 9.116332e-01 | 0.6521226 | 0.1966190 | 0.2156827 | 0.1155061 | 0.0312542 | 0.2606754 | 0.1738786 | 1.396057e+00 | 1.486027e+00 | 1.100416e+00 | 6.290693e-01 | 3.188160e+00 | 2.445752e+00 |
| CXCL6 | 2.305973e+00 | 2.0066662 | 2.196592e+00 | 1.4525907 | 4.574741e+00 | 2.4000968 | 2.2210233 | 1.9030737 | 2.0830611 | 1.3477308 | 4.3380634 | 2.2266291 | 2.394172e+00 | 2.115898e+00 | 2.316311e+00 | 1.565609e+00 | 4.824332e+00 | 2.587079e+00 |
| CXCL8 | 2.999578e+00 | 1.6973552 | 2.199130e+00 | 1.3555563 | 3.620391e+00 | 4.2758582 | 1.2868654 | 0.7335989 | 0.9434111 | 0.5259256 | 1.1630419 | 0.8721107 | 6.991773e+00 | 3.927234e+00 | 5.126262e+00 | 3.493902e+00 | 1.126978e+01 | 2.096404e+01 |
| CXCL9 | 2.775500e+01 | 13.2693976 | 3.133735e+01 | 20.1095367 | 7.523615e+00 | 6.6415183 | 26.4687183 | 12.4064506 | 29.2752711 | 18.2753594 | 7.0353162 | 6.0343045 | 2.910379e+01 | 1.419237e+01 | 3.354467e+01 | 2.212780e+01 | 8.045805e+00 | 7.309834e+00 |
| CXCR1 | 3.160979e+00 | 4.2319726 | 5.746940e+00 | 2.9100761 | 4.980114e+00 | 4.3987409 | 1.7105183 | 2.3372398 | 2.6888572 | 1.4931844 | 2.1357176 | 1.7883458 | 5.841379e+00 | 7.662711e+00 | 1.228303e+01 | 5.671465e+00 | 1.161274e+01 | 1.081945e+01 |
| CXCR2 | 3.645193e+00 | 4.8677434 | 6.059882e+00 | 3.3780851 | 4.905659e+00 | 4.0351399 | 1.9542107 | 2.6531698 | 2.9359259 | 1.7074533 | 2.0581593 | 1.6177634 | 6.799387e+00 | 8.930799e+00 | 1.250786e+01 | 6.683321e+00 | 1.169272e+01 | 1.006473e+01 |
| CXCR2P1 | 5.542117e-01 | 0.5168145 | 6.710933e-01 | 0.6557631 | 3.436634e-01 | 0.2104674 | 0.2522791 | 0.2311727 | 0.3051026 | 0.2965608 | 0.0929212 | 0.0433474 | 1.217503e+00 | 1.155401e+00 | 1.476114e+00 | 1.450041e+00 | 1.271019e+00 | 1.021897e+00 |
| CXCR3 | 4.852614e+00 | 2.2845156 | 5.869771e+00 | 2.7574618 | 2.995312e+00 | 2.0168013 | 2.9452414 | 1.3225444 | 3.4846132 | 1.5688112 | 1.4237247 | 0.9163375 | 7.995224e+00 | 3.946190e+00 | 9.887527e+00 | 4.846724e+00 | 6.301705e+00 | 4.438853e+00 |
| CXCR4 | 3.231471e+01 | 25.9484981 | 3.476007e+01 | 22.7400778 | 2.793939e+01 | 27.8047521 | 20.6479851 | 16.5809016 | 21.9572271 | 14.1728739 | 15.1935266 | 14.5513698 | 5.057348e+01 | 4.060844e+01 | 5.502801e+01 | 3.648598e+01 | 5.137776e+01 | 5.312931e+01 |
| CXCR5 | 3.033204e+00 | 3.0225112 | 3.374772e+00 | 2.3990105 | 4.219802e+00 | 2.2996307 | 1.3387217 | 1.3337973 | 1.4239551 | 0.9955678 | 1.3502982 | 0.7095012 | 6.872471e+00 | 6.849297e+00 | 7.998207e+00 | 5.780873e+00 | 1.318726e+01 | 7.453549e+00 |
| CXCR6 | 2.289472e+00 | 0.7644416 | 2.193442e+00 | 1.0221914 | 9.083939e-01 | 0.8153444 | 1.3159038 | 0.3788908 | 1.2143208 | 0.5130989 | 0.3523643 | 0.3075678 | 3.983333e+00 | 1.542320e+00 | 3.962040e+00 | 2.036401e+00 | 2.341837e+00 | 2.161431e+00 |
| DBIL5P | 2.857063e-01 | 0.3365238 | 3.470599e-01 | 0.3210150 | 3.646161e-01 | 0.4360841 | 0.1106975 | 0.1386541 | 0.1370864 | 0.1230837 | 0.1082531 | 0.1404999 | 7.373977e-01 | 8.167684e-01 | 8.786473e-01 | 8.372405e-01 | 1.228093e+00 | 1.353519e+00 |
| DUSP4 | 1.887119e+00 | 0.7438921 | 2.529893e+00 | 1.1904963 | 1.924647e+00 | 1.6209100 | 1.0512008 | 0.3796650 | 1.4459142 | 0.6353943 | 0.9092888 | 0.7447012 | 3.387763e+00 | 1.457536e+00 | 4.426513e+00 | 2.230554e+00 | 4.073805e+00 | 3.528058e+00 |
| EAF2 | 8.140892e+00 | 5.1276197 | 9.748370e+00 | 5.1769689 | 5.666895e+00 | 4.6437898 | 5.3428306 | 3.3450348 | 6.4192159 | 3.3568599 | 3.1911859 | 2.5668941 | 1.240431e+01 | 7.860153e+00 | 1.480410e+01 | 7.983952e+00 | 1.006325e+01 | 8.401120e+00 |
| EDIL3 | 5.371142e+00 | 7.7986310 | 4.562638e+00 | 6.9353926 | 6.554176e+00 | 11.4318245 | 3.0225777 | 4.6329414 | 2.5755185 | 3.9839409 | 3.1393434 | 5.4283320 | 9.544557e+00 | 1.312744e+01 | 8.082903e+00 | 1.207339e+01 | 1.368350e+01 | 2.407491e+01 |
| EMILIN1 | 3.618974e+01 | 25.3719066 | 3.648829e+01 | 27.6278829 | 5.269726e+01 | 32.6052898 | 25.3471275 | 18.3268570 | 25.7906502 | 19.5169818 | 33.3594319 | 20.7060554 | 5.167045e+01 | 3.512515e+01 | 5.162319e+01 | 3.910953e+01 | 8.324486e+01 | 5.134271e+01 |
| EMILIN2 | 2.903746e+01 | 24.8357362 | 3.823599e+01 | 37.2503841 | 3.854107e+01 | 32.8857246 | 23.1085786 | 19.7113537 | 30.1348505 | 29.3478356 | 28.0616466 | 23.8725927 | 3.648748e+01 | 3.129231e+01 | 4.851495e+01 | 4.728087e+01 | 5.293397e+01 | 4.530178e+01 |
| EMILIN3 | 1.341206e+00 | 3.6772022 | 2.790818e-01 | 3.0842955 | 5.448039e-01 | 2.8128948 | 0.5211719 | 1.5265409 | 0.0868342 | 1.3536048 | 0.1524217 | 0.9201170 | 3.451519e+00 | 8.857814e+00 | 8.969579e-01 | 7.027811e+00 | 1.947304e+00 | 8.599317e+00 |
| FGF1 | 1.032633e+00 | 1.5208595 | 1.879538e+00 | 0.9353562 | 1.622483e+00 | 2.7724122 | 0.5823358 | 0.9117735 | 1.1239588 | 0.4995840 | 0.7966354 | 1.4766214 | 1.831127e+00 | 2.536829e+00 | 3.143054e+00 | 1.751239e+00 | 3.304462e+00 | 5.205308e+00 |
| FGF10 | 7.749714e+00 | 8.3753836 | 9.300140e+00 | 13.9049649 | 9.541256e+00 | 9.5226990 | 4.7048459 | 5.1873158 | 5.5453286 | 8.3901684 | 4.8536864 | 4.7705908 | 1.276515e+01 | 1.352280e+01 | 1.559738e+01 | 2.304460e+01 | 1.875596e+01 | 1.900850e+01 |
| FGF10-AS1 | 2.992372e-01 | 0.4240187 | 3.408624e-01 | 0.5910066 | 3.725932e-01 | 0.5365811 | 0.1215375 | 0.1951821 | 0.1381762 | 0.2879170 | 0.1169434 | 0.1981209 | 7.367510e-01 | 9.211493e-01 | 8.408625e-01 | 1.213158e+00 | 1.187118e+00 | 1.453251e+00 |
| FGF11 | 2.987274e+00 | 2.0577039 | 2.473619e+00 | 1.9524733 | 2.827541e+00 | 3.3831034 | 2.0568582 | 1.3599088 | 1.6311964 | 1.2494452 | 1.6554224 | 2.0281399 | 4.338563e+00 | 3.113551e+00 | 3.751105e+00 | 3.051076e+00 | 4.829575e+00 | 5.643294e+00 |
| FGF12 | 4.036018e-01 | 0.3926497 | 4.564555e-01 | 0.3028451 | 4.033613e-01 | 0.6287587 | 0.1791358 | 0.1727084 | 0.2009153 | 0.1148448 | 0.1278444 | 0.2383529 | 9.093349e-01 | 8.926826e-01 | 1.037012e+00 | 7.986010e-01 | 1.272643e+00 | 1.658623e+00 |
| FGF13 | 1.779075e+00 | 1.7227518 | 1.922396e+00 | 1.7063082 | 1.969155e+00 | 1.7785311 | 1.1303101 | 1.0898267 | 1.2008481 | 1.0484059 | 1.0559364 | 0.9363569 | 2.800213e+00 | 2.723253e+00 | 3.077496e+00 | 2.777061e+00 | 3.672164e+00 | 3.378170e+00 |
| FGF14 | 8.151770e-01 | 1.8378999 | 7.953290e-01 | 1.7858609 | 1.939469e+00 | 1.8205156 | 0.4217436 | 1.0740181 | 0.3932854 | 1.0067888 | 0.9145913 | 0.8503753 | 1.575634e+00 | 3.145083e+00 | 1.608369e+00 | 3.167794e+00 | 4.112811e+00 | 3.897429e+00 |
| FGF14-AS2 | 2.587600e+00 | 4.8810383 | 3.521330e+00 | 4.9596125 | 4.264634e+00 | 4.8116674 | 1.7494845 | 3.4800849 | 2.3975776 | 3.4680499 | 2.6088096 | 2.9781355 | 3.827228e+00 | 6.845964e+00 | 5.171788e+00 | 7.092676e+00 | 6.971420e+00 | 7.774040e+00 |
| FGF16 | 3.154588e-01 | 0.4749403 | 4.978422e-01 | 0.7280126 | 2.669991e-01 | 0.8646936 | 0.1171429 | 0.1992892 | 0.2007145 | 0.3205791 | 0.0604136 | 0.3024805 | 8.495111e-01 | 1.131864e+00 | 1.234823e+00 | 1.653265e+00 | 1.180009e+00 | 2.471878e+00 |
| FGF17 | 1.807266e-01 | 0.2288009 | 2.051266e-01 | 0.2368189 | 2.610039e-01 | 0.2862309 | 0.0573673 | 0.0813772 | 0.0649267 | 0.0804112 | 0.0655981 | 0.0758700 | 5.693508e-01 | 6.432987e-01 | 6.480686e-01 | 6.974545e-01 | 1.038490e+00 | 1.079849e+00 |
| FGF18 | 2.837044e+00 | 4.4391737 | 3.188287e+00 | 6.5979197 | 3.344060e+00 | 3.7357252 | 1.7535426 | 2.7480779 | 1.9325387 | 4.1243016 | 1.7244260 | 1.9560536 | 4.590032e+00 | 7.170926e+00 | 5.260010e+00 | 1.055513e+01 | 6.484902e+00 | 7.134591e+00 |
| FGF2 | 1.610089e+00 | 2.7406417 | 2.500836e+00 | 3.3135398 | 2.079503e+00 | 2.5994213 | 0.9910134 | 1.7795637 | 1.5247150 | 2.1367179 | 1.0981916 | 1.4181294 | 2.615895e+00 | 4.220763e+00 | 4.101869e+00 | 5.138510e+00 | 3.937686e+00 | 4.764721e+00 |
| FGF20 | 1.715718e-01 | 0.2304279 | 2.344370e-01 | 0.4034210 | 4.076026e-01 | 0.3178409 | 0.0489000 | 0.0750676 | 0.0718886 | 0.1508010 | 0.1102126 | 0.0771007 | 6.019811e-01 | 7.073224e-01 | 7.645262e-01 | 1.079227e+00 | 1.507449e+00 | 1.310272e+00 |
| FGF22 | 5.301986e-01 | 0.1988459 | 2.990907e-01 | 0.1420808 | 5.989069e-01 | 0.2368614 | 0.2191715 | 0.0596138 | 0.0987567 | 0.0331851 | 0.1782738 | 0.0478543 | 1.282605e+00 | 6.632642e-01 | 9.058147e-01 | 6.083145e-01 | 2.012014e+00 | 1.172377e+00 |
| FGF23 | 7.190029e-01 | 0.8870252 | 5.598910e-01 | 0.6390084 | 4.384643e-01 | 2.3966181 | 0.3575640 | 0.4598035 | 0.2509686 | 0.2962785 | 0.1368516 | 1.1336796 | 1.445798e+00 | 1.711196e+00 | 1.249072e+00 | 1.378202e+00 | 1.404813e+00 | 5.066492e+00 |
| FGF5 | 1.327067e-01 | 0.1096379 | 1.222054e-01 | 0.1200210 | 1.100568e-01 | 0.3004390 | 0.0339245 | 0.0248863 | 0.0272810 | 0.0264770 | 0.0135644 | 0.0750157 | 5.191253e-01 | 4.830150e-01 | 5.474199e-01 | 5.440577e-01 | 8.929626e-01 | 1.203263e+00 |
| FGF7 | 1.152537e+01 | 7.2025867 | 8.478419e+00 | 6.6019381 | 1.104940e+01 | 7.6081274 | 6.6225372 | 4.1986721 | 4.9785426 | 3.8498342 | 5.3770798 | 3.6042561 | 2.005789e+01 | 1.235563e+01 | 1.443868e+01 | 1.132142e+01 | 2.270548e+01 | 1.605979e+01 |
| FGF7P3 | 6.160027e-01 | 0.6928085 | 7.193539e-01 | 0.8624504 | 1.269899e+00 | 0.9058339 | 0.3016582 | 0.3487036 | 0.3503777 | 0.4370370 | 0.5626446 | 0.3708070 | 1.257912e+00 | 1.376480e+00 | 1.476892e+00 | 1.701963e+00 | 2.866184e+00 | 2.212836e+00 |
| FGF7P6 | 6.738684e-01 | 0.4973280 | 2.970906e-01 | 0.3491357 | 6.138311e-01 | 0.5183947 | 0.3400425 | 0.2321816 | 0.1105006 | 0.1382897 | 0.2260908 | 0.1794327 | 1.335417e+00 | 1.065266e+00 | 7.987546e-01 | 8.814521e-01 | 1.666536e+00 | 1.497682e+00 |
| FGF9 | 3.705945e-01 | 0.6417566 | 1.629504e-01 | 0.3628576 | 2.880044e-01 | 0.3073036 | 0.1490518 | 0.2984312 | 0.0432599 | 0.1371154 | 0.0702806 | 0.0775363 | 9.214266e-01 | 1.380055e+00 | 6.137982e-01 | 9.602543e-01 | 1.180219e+00 | 1.217953e+00 |
| FGFBP1 | 6.551570e+00 | 1.1029514 | 1.505984e+00 | 0.3681105 | 1.964252e+00 | 0.7818853 | 0.9049733 | 0.2914602 | 0.4934511 | 0.1091642 | 0.5213588 | 0.1861546 | 4.743020e+01 | 4.173818e+00 | 4.596173e+00 | 1.241299e+00 | 7.400445e+00 | 3.284069e+00 |
| FGFBP2 | 3.457081e+01 | 115.6689800 | 4.986344e+01 | 134.6101908 | 8.600988e+01 | 104.8941593 | 17.9713862 | 61.5745232 | 23.4758170 | 70.3223645 | 35.1051348 | 43.8221977 | 6.650244e+01 | 2.172865e+02 | 1.059117e+02 | 2.576691e+02 | 2.107298e+02 | 2.510779e+02 |
| FGFBP3 | 9.962108e-01 | 1.3997139 | 1.078216e+00 | 1.5379991 | 1.452907e+00 | 1.4738838 | 0.6082842 | 0.9140392 | 0.6504349 | 0.9958863 | 0.8027068 | 0.8171792 | 1.631533e+00 | 2.143452e+00 | 1.787343e+00 | 2.375212e+00 | 2.629774e+00 | 2.658332e+00 |
| FGFR1 | 3.879738e+01 | 47.0764323 | 4.477153e+01 | 62.1107471 | 5.442140e+01 | 55.7703390 | 27.8041471 | 33.7910468 | 31.4955140 | 43.7927157 | 34.1023079 | 34.9554221 | 5.413713e+01 | 6.558514e+01 | 6.364368e+01 | 8.809102e+01 | 8.684716e+01 | 8.897992e+01 |
| FGFR1OP | 5.761660e+00 | 4.7287519 | 6.244607e+00 | 5.6327410 | 5.746992e+00 | 5.7624597 | 4.5661704 | 3.6865477 | 4.9146213 | 4.3912692 | 4.1377628 | 4.1525917 | 7.270146e+00 | 6.065592e+00 | 7.934512e+00 | 7.225194e+00 | 7.982072e+00 | 7.996438e+00 |
| FGFR1OP2 | 1.751834e+01 | 17.6326522 | 1.900560e+01 | 21.5602433 | 1.646026e+01 | 18.9624481 | 14.6750912 | 14.7858739 | 15.8123208 | 18.0094631 | 12.7841214 | 14.8262777 | 2.091245e+01 | 2.102753e+01 | 2.284376e+01 | 2.581110e+01 | 2.119350e+01 | 2.425251e+01 |
| FGFR2 | 2.271817e+00 | 0.9834200 | 9.132025e-01 | 0.4964047 | 7.500257e-01 | 0.8618469 | 0.9790152 | 0.4484346 | 0.4020954 | 0.1974703 | 0.2493475 | 0.2935326 | 5.271782e+00 | 2.156646e+00 | 2.073982e+00 | 1.247872e+00 | 2.256043e+00 | 2.530486e+00 |
| FGFR3 | 2.128470e+00 | 0.9404802 | 1.236821e+00 | 0.3289278 | 1.981682e+00 | 0.5878755 | 2.0996851 | 0.9225307 | 1.2132316 | 0.3200826 | 0.6229696 | 0.1581285 | 2.157650e+00 | 9.587789e-01 | 1.260869e+00 | 3.380174e-01 | 6.303778e+00 | 2.185549e+00 |
| FGFR4 | 5.051713e-01 | 0.4177523 | 3.623419e-01 | 0.5028155 | 6.488374e-01 | 0.6122582 | 0.2412442 | 0.1883372 | 0.1479848 | 0.2292659 | 0.2505478 | 0.2316409 | 1.057841e+00 | 9.266197e-01 | 8.871970e-01 | 1.102752e+00 | 1.680278e+00 | 1.618281e+00 |
| FGFRL1 | 5.506543e+00 | 5.7744476 | 5.502274e+00 | 5.5840144 | 6.724525e+00 | 5.8332812 | 5.4506805 | 5.6917827 | 5.4235386 | 5.4713572 | 6.6267321 | 5.7215753 | 5.562978e+00 | 5.858313e+00 | 5.582152e+00 | 5.698991e+00 | 6.823762e+00 | 5.947168e+00 |
| FILIP1 | 1.608839e+00 | 1.8941334 | 1.535045e+00 | 2.1000128 | 1.770764e+00 | 1.8639043 | 1.0568870 | 1.2751535 | 0.9752212 | 1.4011895 | 0.9979595 | 1.0616457 | 2.449043e+00 | 2.813576e+00 | 2.416233e+00 | 3.147364e+00 | 3.142017e+00 | 3.272409e+00 |
| FILIP1L | 2.972348e+01 | 35.8849612 | 3.861254e+01 | 49.6777431 | 3.461114e+01 | 40.3966349 | 20.9198275 | 25.5185664 | 26.8738970 | 34.6040574 | 21.1583964 | 24.6568187 | 4.223195e+01 | 5.046249e+01 | 5.547867e+01 | 7.131760e+01 | 5.661729e+01 | 6.618405e+01 |
| FRZB | 5.469949e+00 | 9.0999618 | 2.996343e+00 | 5.9855457 | 4.801304e+00 | 5.2291825 | 3.1778253 | 5.6511683 | 1.7519107 | 3.6164640 | 2.4269171 | 2.6186998 | 9.415351e+00 | 1.465348e+01 | 5.124731e+00 | 9.906571e+00 | 9.498687e+00 | 1.044196e+01 |
| FTCDNL1 | 1.245999e+00 | 1.0862004 | 1.435785e+00 | 1.2949462 | 1.008243e+00 | 1.4012707 | 0.7348023 | 0.6257848 | 0.8392929 | 0.7444447 | 0.4534449 | 0.6814081 | 2.112832e+00 | 1.885363e+00 | 2.456209e+00 | 2.252532e+00 | 2.241845e+00 | 2.881621e+00 |
| GATA1 | 3.947954e-01 | 0.6593378 | 6.429564e-01 | 0.6309702 | 6.119761e-01 | 0.4863493 | 0.1718444 | 0.3309828 | 0.3075947 | 0.3004164 | 0.2251322 | 0.1641152 | 9.070028e-01 | 1.313441e+00 | 1.343954e+00 | 1.325238e+00 | 1.663532e+00 | 1.441278e+00 |
| HHIP | 1.142128e+00 | 1.5958353 | 1.695720e+00 | 3.4600132 | 4.010432e+00 | 2.9349500 | 0.5573519 | 0.8089476 | 0.8299842 | 1.7847333 | 1.6750959 | 1.1991397 | 2.340454e+00 | 3.148153e+00 | 3.464484e+00 | 6.707832e+00 | 9.601578e+00 | 7.183426e+00 |
| HILPDA | 8.858078e+00 | 7.2303144 | 9.238337e+00 | 7.3691710 | 9.202739e+00 | 12.9965494 | 6.5052495 | 5.2640397 | 6.6700178 | 5.2677297 | 5.9594366 | 8.5508279 | 1.206188e+01 | 9.931051e+00 | 1.279560e+01 | 1.030893e+01 | 1.421114e+01 | 1.975368e+01 |
| HP | 6.889749e+00 | 2.4719940 | 1.871321e+00 | 1.3082465 | 5.547766e+00 | 4.1875449 | 2.7101167 | 0.8922296 | 0.7234478 | 0.4798256 | 1.6797132 | 1.2153951 | 1.751535e+01 | 6.848859e+00 | 4.840493e+00 | 3.566940e+00 | 1.832319e+01 | 1.442784e+01 |
| HYAL3 | 1.725487e+00 | 1.6371683 | 1.402497e+00 | 1.7760973 | 1.449832e+00 | 1.6254744 | 1.1696290 | 1.1003824 | 0.8946433 | 1.1815714 | 0.8027981 | 0.9251969 | 2.545512e+00 | 2.435808e+00 | 2.198640e+00 | 2.669768e+00 | 2.618359e+00 | 2.855789e+00 |
| IFI27 | 8.534934e+02 | 1033.6956677 | 1.034624e+03 | 1291.9457252 | 6.780334e+02 | 773.8135210 | 619.3761718 | 750.1801922 | 736.3882178 | 919.5939276 | 430.7684054 | 491.6631644 | 1.176104e+03 | 1.424360e+03 | 1.453645e+03 | 1.815066e+03 | 1.067231e+03 | 1.217881e+03 |
| IFI44L | 1.182257e+01 | 10.7473824 | 1.075163e+01 | 16.0261378 | 5.804936e+00 | 7.3092848 | 8.0327478 | 7.2319148 | 7.1836798 | 10.7249419 | 3.2525067 | 4.1699582 | 1.740041e+01 | 1.597174e+01 | 1.609170e+01 | 2.394764e+01 | 1.036040e+01 | 1.281203e+01 |
| IFNAR1 | 1.175300e+01 | 12.1104805 | 1.425277e+01 | 14.5207048 | 1.255591e+01 | 13.4066979 | 9.8109597 | 10.1244411 | 11.8814544 | 12.1151776 | 9.7704160 | 10.4778156 | 1.407947e+01 | 1.448611e+01 | 1.709736e+01 | 1.740386e+01 | 1.613553e+01 | 1.715430e+01 |
| IFNAR2 | 1.941810e+01 | 18.2294962 | 2.355040e+01 | 18.8278446 | 1.776002e+01 | 17.3286651 | 15.8878280 | 14.8888222 | 19.1342233 | 15.2046934 | 13.3243251 | 12.9872017 | 2.373280e+01 | 2.231973e+01 | 2.898583e+01 | 2.331436e+01 | 2.367237e+01 | 2.312143e+01 |
| IFNG | 7.195188e-01 | 0.2807041 | 5.992458e-01 | 0.2958588 | 2.583558e-01 | 0.2022664 | 0.3117161 | 0.0954581 | 0.2378086 | 0.0960771 | 0.0538619 | 0.0366645 | 1.660830e+00 | 8.254388e-01 | 1.510019e+00 | 9.110645e-01 | 1.239238e+00 | 1.115841e+00 |
| IFNG-AS1 | 7.636960e-01 | 0.5696290 | 1.079236e+00 | 0.5462123 | 5.081098e-01 | 0.5088237 | 0.3910448 | 0.2725822 | 0.5679602 | 0.2470968 | 0.1716933 | 0.1720281 | 1.491470e+00 | 1.190383e+00 | 2.050761e+00 | 1.207413e+00 | 1.503701e+00 | 1.504996e+00 |
| IFNGR1 | 4.333542e+01 | 43.4160164 | 4.707960e+01 | 51.3839506 | 4.208072e+01 | 42.6227885 | 34.9851794 | 35.0908874 | 37.6218036 | 41.0796975 | 31.0974205 | 31.4466076 | 5.367868e+01 | 5.371624e+01 | 5.891501e+01 | 6.427288e+01 | 5.694320e+01 | 5.777100e+01 |
| IFNGR2 | 6.431576e+01 | 67.8269074 | 7.077123e+01 | 81.6964152 | 6.915074e+01 | 76.6917368 | 53.5474616 | 56.4972638 | 58.3220011 | 67.4045850 | 53.4128218 | 59.3073884 | 7.724954e+01 | 8.142853e+01 | 8.587784e+01 | 9.901855e+01 | 8.952578e+01 | 9.917183e+01 |
| IFNLR1 | 6.444658e-01 | 0.5988088 | 7.293622e-01 | 0.3378899 | 2.815265e-01 | 0.4639455 | 0.3070925 | 0.2805715 | 0.3417261 | 0.1270860 | 0.0696019 | 0.1447489 | 1.352479e+00 | 1.278006e+00 | 1.556712e+00 | 8.983647e-01 | 1.138720e+00 | 1.487027e+00 |
| IGHA1 | 1.453531e+03 | 1022.8502600 | 2.355221e+03 | 545.4888342 | 1.083873e+03 | 1476.9187819 | 520.9876784 | 342.3585368 | 881.2114786 | 200.5951416 | 320.6572552 | 347.4346698 | 4.055283e+03 | 3.055927e+03 | 6.294818e+03 | 1.483376e+03 | 3.663666e+03 | 6.278271e+03 |
| IGHA2 | 5.011089e+01 | 26.0186644 | 8.666635e+01 | 28.6144737 | 4.036685e+01 | 69.5347388 | 40.0357895 | 19.0896160 | 63.9277996 | 18.7354880 | 29.9541792 | 45.9184395 | 6.272141e+01 | 3.546278e+01 | 1.174928e+02 | 4.370252e+01 | 5.439917e+01 | 1.052971e+02 |
| IGHD | 7.472649e+00 | 2.9022117 | 5.670933e+00 | 1.7493716 | 1.014273e+01 | 2.5854250 | 7.1291761 | 2.7154106 | 2.4142463 | 0.7077185 | 4.0551741 | 1.0316011 | 7.832671e+00 | 3.101863e+00 | 1.332071e+01 | 4.324178e+00 | 2.536883e+01 | 6.479658e+00 |
| IGHE | 2.837348e+00 | 2.3820432 | 3.923112e+00 | 1.4423923 | 3.351535e+00 | 1.5310883 | 0.8307487 | 0.6701824 | 1.3681754 | 0.4320646 | 0.6473407 | 0.3216117 | 9.690708e+00 | 8.466545e+00 | 1.124915e+01 | 4.815242e+00 | 1.735221e+01 | 7.289012e+00 |
| IGHG1 | 1.176330e+04 | 5473.7609107 | 1.596280e+04 | 3500.9062311 | 1.055581e+04 | 4674.1796137 | 4329.3050198 | 2003.3890728 | 5520.5108822 | 1206.9668114 | 2551.9638752 | 1132.6906648 | 3.196244e+04 | 1.495569e+04 | 4.615712e+04 | 1.015467e+04 | 4.366250e+04 | 1.928855e+04 |
| IGHG2 | 1.044166e+03 | 472.4891374 | 1.608889e+03 | 435.3391387 | 7.190760e+02 | 578.7877746 | 353.9269905 | 161.2297019 | 576.1165157 | 162.1965246 | 192.7156313 | 142.2256415 | 3.080529e+03 | 1.384646e+03 | 4.493055e+03 | 1.168460e+03 | 2.683074e+03 | 2.355379e+03 |
| IGHG3 | 1.603719e+03 | 382.7687704 | 1.656875e+03 | 193.0008786 | 6.988460e+02 | 640.0115603 | 486.2803095 | 128.6018683 | 582.8935370 | 66.2353656 | 169.8800798 | 97.8927802 | 5.288952e+03 | 1.139268e+03 | 4.709669e+03 | 5.623784e+02 | 2.874886e+03 | 4.184321e+03 |
| IGHG4 | 5.170448e+02 | 280.3826946 | 1.435573e+03 | 285.1827242 | 3.872421e+02 | 155.6330069 | 469.7302318 | 243.7117460 | 1250.6158259 | 83.6808839 | 337.2858534 | 128.9032486 | 5.691252e+02 | 3.225715e+02 | 1.647884e+03 | 9.718968e+02 | 4.445975e+02 | 1.879055e+02 |
| IGHGP | 2.303206e+01 | 12.1639954 | 4.599909e+01 | 8.4954917 | 2.855545e+01 | 20.3003741 | 8.5747082 | 4.5036345 | 16.1840856 | 2.9473704 | 7.0701917 | 5.0111296 | 6.186518e+01 | 3.285408e+01 | 1.307405e+02 | 2.448738e+01 | 1.153312e+02 | 8.223798e+01 |
| IGHJ1 | 2.221458e+02 | 105.4774230 | 5.260252e+02 | 59.8830372 | 7.294829e+01 | 18.1245512 | 62.0697284 | 24.3140474 | 111.6361751 | 16.5450434 | 15.0340151 | 2.2289018 | 7.950532e+02 | 4.575744e+02 | 2.478610e+03 | 2.167403e+02 | 3.539608e+02 | 1.473817e+02 |
| IGHJ2 | 6.202368e+02 | 202.2303300 | 4.318717e+02 | 81.9224971 | 1.412095e+02 | 78.4909830 | 232.6917590 | 75.7976025 | 152.5828787 | 28.9046613 | 35.2344954 | 19.5680474 | 1.653233e+03 | 5.395567e+02 | 1.222373e+03 | 2.321873e+02 | 5.659260e+02 | 3.148416e+02 |
| IGHJ3 | 8.287383e+02 | 351.4451573 | 1.176606e+03 | 149.4258549 | 6.771985e+02 | 559.2521416 | 308.4048200 | 130.6960843 | 412.1627369 | 52.3021205 | 167.2132728 | 138.0919433 | 2.226966e+03 | 9.450451e+02 | 3.358872e+03 | 4.269059e+02 | 2.742592e+03 | 2.264889e+03 |
| IGHJ3P | 1.131274e+02 | 89.7206616 | 1.440889e+02 | 27.4714155 | 3.914703e+01 | 19.0138716 | 42.2663611 | 33.5136289 | 50.7228709 | 9.6381326 | 9.7028695 | 4.6932689 | 3.027896e+02 | 2.401947e+02 | 4.093145e+02 | 7.830134e+01 | 1.579420e+02 | 7.703103e+01 |
| IGHJ4 | 5.483556e+03 | 2826.1884393 | 5.075786e+03 | 1198.6970897 | 3.194487e+03 | 543.5156615 | 2251.7313969 | 1157.2740142 | 1972.5859059 | 465.1478025 | 903.3493039 | 153.7909734 | 1.335390e+04 | 6.901858e+03 | 1.306083e+04 | 3.089071e+03 | 1.129657e+04 | 1.920849e+03 |
| IGHJ5 | 3.803266e+03 | 1940.7037068 | 4.430187e+03 | 961.4343330 | 1.314158e+03 | 589.3446388 | 1540.1331388 | 785.0083929 | 1696.6236810 | 368.0138176 | 365.4867491 | 163.7706976 | 9.391936e+03 | 4.797822e+03 | 1.156801e+04 | 2.511743e+03 | 4.725235e+03 | 2.120813e+03 |
| IGHJ6 | 2.623171e+02 | 234.5646977 | 1.523116e+02 | 68.1940498 | 5.202627e+02 | 107.2576857 | 18.0533447 | 11.3885200 | 4.1071394 | 2.4827475 | 54.4742460 | 3.5716996 | 3.811496e+03 | 4.831233e+03 | 5.648417e+03 | 1.873098e+03 | 4.968830e+03 | 3.220935e+03 |
| IGHM | 5.234438e+02 | 240.6489212 | 1.036844e+03 | 264.3302159 | 3.845857e+02 | 71.1489855 | 438.4528934 | 187.7359988 | 800.8676528 | 186.4240990 | 294.9841788 | 49.1583727 | 6.249096e+02 | 3.084752e+02 | 1.342351e+03 | 3.747931e+02 | 5.014037e+02 | 1.029769e+02 |
| IGHMBP2 | 9.174861e+00 | 11.3785322 | 1.001741e+01 | 10.9553333 | 1.192193e+01 | 11.6092670 | 6.9477673 | 8.6787717 | 7.4910088 | 8.2220850 | 8.1763361 | 7.9283702 | 1.211585e+01 | 1.491812e+01 | 1.339586e+01 | 1.459719e+01 | 1.738338e+01 | 1.699909e+01 |
| IGHV1-12 | 2.333929e+01 | 9.9356108 | 1.658456e+01 | 12.4175739 | 2.403890e+00 | 8.9547098 | 7.3802619 | 3.1250624 | 4.8822510 | 3.6483051 | 0.4496255 | 1.7418812 | 7.380798e+01 | 3.158860e+01 | 5.633625e+01 | 4.226514e+01 | 1.285222e+01 | 4.603461e+01 |
| IGHV1-14 | 2.320047e+00 | 2.2025331 | 1.084655e+00 | 0.7933056 | 9.420911e-01 | 0.3775211 | 0.7208903 | 0.6829430 | 0.2996449 | 0.2124214 | 0.1666022 | 0.0554527 | 7.466623e+00 | 7.103304e+00 | 3.926238e+00 | 2.962666e+00 | 5.327275e+00 | 2.570158e+00 |
| IGHV1-17 | 8.358010e-01 | 0.3658917 | 8.431035e+00 | 0.4641066 | 1.436862e+00 | 0.2195604 | 0.2899040 | 0.1097892 | 3.0977508 | 0.1368531 | 0.3458192 | 0.0322794 | 2.409636e+00 | 1.219399e+00 | 2.294644e+01 | 1.573914e+00 | 5.970093e+00 | 1.493422e+00 |
| IGHV1-18 | 4.386948e+02 | 271.4185068 | 8.400642e+02 | 139.4095391 | 4.310643e+02 | 64.1177645 | 171.0124244 | 105.7251193 | 309.2334827 | 51.2643421 | 113.6977713 | 16.8697359 | 1.125375e+03 | 6.967881e+02 | 2.282120e+03 | 3.791138e+02 | 1.634302e+03 | 2.436960e+02 |
| IGHV1-2 | 2.872257e+02 | 157.0867974 | 3.014324e+02 | 176.8741868 | 2.513886e+02 | 74.2053697 | 115.7752257 | 63.2859312 | 114.9720349 | 67.4380176 | 69.5222664 | 20.4889405 | 7.125756e+02 | 3.899170e+02 | 7.902923e+02 | 4.638997e+02 | 9.090074e+02 | 2.687517e+02 |
| IGHV1-24 | 9.801009e+01 | 103.4450484 | 1.087733e+02 | 87.9572989 | 5.500477e+01 | 38.1623186 | 37.8045458 | 39.9028755 | 39.6054174 | 32.0176569 | 14.2806405 | 9.8952580 | 2.540958e+02 | 2.681731e+02 | 2.987375e+02 | 2.416319e+02 | 2.118620e+02 | 1.471778e+02 |
| IGHV1-3 | 1.673501e+02 | 69.7447024 | 2.323113e+02 | 101.9958539 | 1.450687e+02 | 18.0564216 | 60.0874541 | 25.0188936 | 78.3982659 | 34.3989016 | 34.0663470 | 4.2102466 | 4.660882e+02 | 1.944260e+02 | 6.883892e+02 | 3.024269e+02 | 6.177626e+02 | 7.743830e+01 |
| IGHV1-45 | 4.140810e+01 | 7.5837109 | 5.023046e+00 | 2.2511920 | 4.545987e-01 | 1.8768522 | 3.6289820 | 0.9098353 | 0.9424914 | 0.3388696 | 0.0594085 | 0.1533885 | 4.724825e+02 | 6.321218e+01 | 2.677052e+01 | 1.495521e+01 | 3.478628e+00 | 2.296504e+01 |
| IGHV1-46 | 5.176906e+01 | 32.6142915 | 1.648659e+02 | 29.5652082 | 6.526858e+01 | 20.8960795 | 19.9403313 | 12.5456961 | 60.0251355 | 10.7284411 | 16.9429735 | 5.3965671 | 1.344028e+02 | 8.478541e+01 | 4.528233e+02 | 8.147517e+01 | 2.514310e+02 | 8.091183e+01 |
| IGHV1-69 | 8.278201e+01 | 107.3732063 | 1.777693e+02 | 119.1866693 | 1.487638e+02 | 19.6134466 | 28.1732235 | 36.5477346 | 56.7041403 | 38.0049452 | 32.4164310 | 4.2471255 | 2.432402e+02 | 3.154506e+02 | 5.573128e+02 | 3.737793e+02 | 6.826987e+02 | 9.057592e+01 |
| IGHV1-69-2 | 5.750523e+00 | 4.5455146 | 1.340722e+01 | 3.1493394 | 4.059060e+00 | 1.3169910 | 5.6821586 | 4.4691986 | 13.1822868 | 3.0748560 | 3.9909375 | 1.2858277 | 5.819710e+00 | 4.623134e+00 | 1.363600e+01 | 3.225627e+00 | 4.128345e+00 | 1.348909e+00 |
| IGHV1-69D | 3.882562e+02 | 248.0900598 | 8.197487e+02 | 201.9673888 | 3.607102e+02 | 52.5378898 | 149.3470027 | 95.3795952 | 297.5187266 | 73.2576671 | 93.3488564 | 13.5606405 | 1.009346e+03 | 6.453024e+02 | 2.258641e+03 | 5.568131e+02 | 1.393824e+03 | 2.035472e+02 |
| IGHV1OR15-1 | 1.188263e+01 | 5.0969954 | 1.683623e+01 | 4.4362891 | 4.089338e+00 | 1.9733753 | 4.8632007 | 2.1584936 | 7.1676891 | 1.6727523 | 1.2276308 | 0.5459743 | 2.903376e+01 | 1.203588e+01 | 3.954672e+01 | 1.176544e+01 | 1.362191e+01 | 7.132589e+00 |
| IGHV1OR15-2 | 4.091005e+00 | 5.7058083 | 1.280090e+01 | 2.1140856 | 2.254938e+00 | 1.2327665 | 1.3621743 | 1.9126741 | 4.0565451 | 0.6433268 | 0.4633895 | 0.2412570 | 1.228648e+01 | 1.702133e+01 | 4.039475e+01 | 6.947259e+00 | 1.097294e+01 | 6.299147e+00 |
| IGHV1OR15-4 | 9.526106e+00 | 7.7575959 | 1.770323e+01 | 7.7846859 | 4.685520e+00 | 3.8663946 | 3.6470371 | 2.9620914 | 6.4308865 | 2.8039537 | 1.1849749 | 0.9709957 | 2.488231e+01 | 2.031683e+01 | 4.873421e+01 | 2.161282e+01 | 1.852705e+01 | 1.539554e+01 |
| IGHV1OR15-9 | 3.842526e+00 | 3.5666523 | 7.257504e+00 | 12.7826694 | 4.621694e+00 | 0.3912184 | 1.1896762 | 1.1022521 | 2.1177585 | 3.7517784 | 0.8854452 | 0.0567210 | 1.241095e+01 | 1.154092e+01 | 2.487128e+01 | 4.355178e+01 | 2.412352e+01 | 2.698328e+00 |
| IGHV1OR16-1 | 8.679019e+00 | 3.4579328 | 9.968367e+00 | 4.6173788 | 3.947022e+00 | 0.7393921 | 2.6998387 | 1.0588299 | 2.8930644 | 1.3251070 | 0.7436370 | 0.1217048 | 2.789995e+01 | 1.129294e+01 | 3.434709e+01 | 1.608941e+01 | 2.094972e+01 | 4.492022e+00 |
| IGHV1OR16-3 | 2.492962e+00 | 22.4138036 | 1.250000e-01 | 0.1250000 | 1.250000e-01 | 0.3960744 | 0.1809553 | 1.6509436 | 0.0056725 | 0.0056727 | 0.0020238 | 0.0086027 | 3.434471e+01 | 3.042978e+02 | 2.754528e+00 | 2.754397e+00 | 7.720620e+00 | 1.823565e+01 |
| IGHV1OR16-4 | 9.248222e+00 | 4.7024995 | 7.868377e+00 | 8.6327624 | 3.339053e+00 | 0.9907734 | 2.2763807 | 1.1483471 | 1.7761419 | 1.9504721 | 0.4505434 | 0.1241201 | 3.757263e+01 | 1.925681e+01 | 3.485721e+01 | 3.820849e+01 | 2.474628e+01 | 7.908725e+00 |
| IGHV1OR21-1 | 2.694153e-01 | 1.0814244 | 1.531507e+00 | 0.8619757 | 2.051256e-01 | 0.1250000 | 0.0489595 | 0.2363010 | 0.3114268 | 0.1687811 | 0.0166289 | 0.0078704 | 1.482544e+00 | 4.949106e+00 | 7.531503e+00 | 4.402165e+00 | 2.530321e+00 | 1.985298e+00 |
| IGHV2-26 | 9.939640e+01 | 58.3648442 | 1.632633e+02 | 16.4242989 | 2.263043e+01 | 6.4496680 | 32.8329540 | 19.2649400 | 50.4440591 | 5.0462641 | 4.7024764 | 1.3202535 | 3.009063e+02 | 1.768215e+02 | 5.284051e+02 | 5.345689e+01 | 1.089078e+02 | 3.150775e+01 |
| IGHV2-5 | 2.415927e+02 | 143.1526324 | 3.638482e+02 | 76.8012302 | 1.651712e+02 | 62.0041816 | 88.5611211 | 52.4392593 | 125.4921995 | 26.4529092 | 39.9248325 | 14.9634627 | 6.590592e+02 | 3.907888e+02 | 1.054930e+03 | 2.229785e+02 | 6.833224e+02 | 2.569271e+02 |
| IGHV2-70 | 9.882273e+01 | 33.7141092 | 1.805899e+02 | 51.9635910 | 4.223248e+01 | 7.2147421 | 33.5996149 | 11.4389906 | 57.5353276 | 16.5299766 | 9.1650653 | 1.5409053 | 2.906561e+02 | 9.936551e+01 | 5.668294e+02 | 1.633526e+02 | 1.946066e+02 | 3.378047e+01 |
| IGHV2-70D | 3.433582e+01 | 19.8120760 | 3.009297e+01 | 7.5355225 | 1.436174e+01 | 2.8495855 | 6.9479652 | 3.6523593 | 8.9295239 | 2.2058865 | 2.8557065 | 0.5065204 | 1.696825e+02 | 1.074698e+02 | 1.014149e+02 | 2.574208e+01 | 7.222714e+01 | 1.603121e+01 |
| IGHV3-11 | 2.257624e+02 | 113.7310084 | 3.267882e+02 | 61.9650186 | 1.909666e+02 | 22.4272871 | 85.7890640 | 43.1964064 | 117.1041476 | 22.1727261 | 48.5923602 | 5.6721760 | 5.941163e+02 | 2.994402e+02 | 9.119278e+02 | 1.731706e+02 | 7.504931e+02 | 8.867553e+01 |
| IGHV3-13 | 4.588447e+01 | 7.9167172 | 4.946975e+01 | 4.6127337 | 2.218585e+01 | 2.8673564 | 11.1422845 | 2.4301487 | 14.4768923 | 1.4462853 | 4.8151815 | 0.4869634 | 1.889545e+02 | 2.579036e+01 | 1.690457e+02 | 1.471170e+01 | 1.022209e+02 | 1.688368e+01 |
| IGHV3-15 | 2.739546e+02 | 164.7357308 | 2.816985e+02 | 70.7282142 | 1.770442e+02 | 21.0801577 | 108.8602716 | 65.4325316 | 105.8353082 | 26.5359260 | 47.9746121 | 5.6732732 | 6.894263e+02 | 4.147457e+02 | 7.497879e+02 | 1.885173e+02 | 6.533588e+02 | 7.832746e+01 |
| IGHV3-19 | 2.474443e+01 | 26.9566939 | 3.780305e+01 | 11.2883457 | 1.642995e+01 | 6.9776085 | 8.2198648 | 8.9575672 | 11.7623538 | 3.4900564 | 3.4479301 | 1.4479240 | 7.448870e+01 | 8.112285e+01 | 1.214953e+02 | 3.651137e+01 | 7.829144e+01 | 3.362540e+01 |
| IGHV3-20 | 6.941317e+01 | 46.0944956 | 1.358732e+02 | 41.1263531 | 5.659421e+01 | 10.1649461 | 24.5351975 | 16.2801726 | 45.1258174 | 13.6331502 | 12.9962947 | 2.3072211 | 1.963786e+02 | 1.305086e+02 | 4.091123e+02 | 1.240635e+02 | 2.464475e+02 | 4.478380e+01 |
| IGHV3-21 | 4.535863e+02 | 275.0659894 | 6.926951e+02 | 98.1790722 | 2.804936e+02 | 26.3176513 | 177.3531157 | 107.4838118 | 255.8117890 | 36.2109218 | 74.2722546 | 6.9300767 | 1.160062e+03 | 7.039320e+02 | 1.875701e+03 | 2.661940e+02 | 1.059301e+03 | 9.994388e+01 |
| IGHV3-22 | 1.121538e+00 | 2.3351048 | 5.192769e+00 | 0.4450816 | 4.836570e+00 | 1.8445377 | 0.3769068 | 0.8219488 | 1.7605816 | 0.1225645 | 1.1410466 | 0.4144623 | 3.337288e+00 | 6.633886e+00 | 1.531588e+01 | 1.616272e+00 | 2.050083e+01 | 8.208996e+00 |
| IGHV3-23 | 9.667280e+02 | 854.8366241 | 1.307519e+03 | 189.8670079 | 5.465278e+02 | 51.8617322 | 401.2777152 | 354.6567451 | 514.3539800 | 74.6303584 | 157.4429639 | 14.8972159 | 2.328968e+03 | 2.060431e+03 | 3.323793e+03 | 4.830404e+02 | 1.897148e+03 | 1.805464e+02 |
| IGHV3-30 | 1.021432e+03 | 554.2179130 | 1.304018e+03 | 272.9760312 | 4.387483e+02 | 124.7469231 | 417.2044298 | 226.2105373 | 504.2480810 | 105.4909909 | 123.5683779 | 35.0925353 | 2.500747e+03 | 1.357839e+03 | 3.372276e+03 | 7.063723e+02 | 1.557843e+03 | 4.434503e+02 |
| IGHV3-33 | 4.717123e+02 | 255.6851842 | 5.107284e+02 | 157.3310217 | 4.008178e+02 | 243.0565416 | 183.6428756 | 99.5056526 | 187.7172422 | 57.7971094 | 105.5382118 | 63.9776157 | 1.211659e+03 | 6.569970e+02 | 1.389555e+03 | 4.282749e+02 | 1.522244e+03 | 9.233930e+02 |
| IGHV3-35 | 4.319559e+00 | 4.5161580 | 9.097272e+00 | 3.6974443 | 1.580718e+00 | 4.6634444 | 1.3145385 | 1.3756013 | 2.6058660 | 1.0430035 | 0.2795105 | 0.8688989 | 1.419402e+01 | 1.482674e+01 | 3.175925e+01 | 1.310743e+01 | 8.939446e+00 | 2.502905e+01 |
| IGHV3-38 | 2.837106e+00 | 1.7676584 | 2.584030e+01 | 1.1275023 | 2.679799e+00 | 0.8379922 | 0.9149834 | 0.5588207 | 8.0320907 | 0.3221911 | 0.5393367 | 0.1517370 | 8.797067e+00 | 5.591447e+00 | 8.313166e+01 | 3.945675e+00 | 1.331510e+01 | 4.627948e+00 |
| IGHV3-41 | 4.371336e+00 | 3.9495393 | 1.019530e+01 | 1.1895481 | 5.160171e+00 | 1.5585044 | 1.4428414 | 1.3005630 | 3.1888183 | 0.3454100 | 1.0812789 | 0.3075534 | 1.324371e+01 | 1.199393e+01 | 3.259646e+01 | 4.096652e+00 | 2.462581e+01 | 7.897608e+00 |
| IGHV3-42 | 1.023110e+00 | 1.8264506 | 7.527283e-01 | 0.4891422 | 1.839513e-01 | 0.3884189 | 0.2485905 | 0.4585753 | 0.1632429 | 0.1003793 | 0.0161885 | 0.0445922 | 4.210756e+00 | 7.274534e+00 | 3.470901e+00 | 2.383560e+00 | 2.090255e+00 | 3.383313e+00 |
| IGHV3-43 | 1.965603e+02 | 82.7205474 | 1.658685e+02 | 40.5507223 | 7.330697e+01 | 86.2517785 | 72.7525579 | 30.5895886 | 57.7841910 | 14.0962332 | 17.9488547 | 21.1244338 | 5.310598e+02 | 2.236934e+02 | 4.761227e+02 | 1.166525e+02 | 2.994013e+02 | 3.521689e+02 |
| IGHV3-47 | 2.711729e+00 | 4.0612403 | 5.707015e+00 | 1.3750068 | 2.743719e+00 | 0.6061011 | 0.8504568 | 1.2882067 | 1.7003210 | 0.3883035 | 0.5325966 | 0.1002990 | 8.646501e+00 | 1.280359e+01 | 1.915522e+01 | 4.868984e+00 | 1.413451e+01 | 3.662634e+00 |
| IGHV3-48 | 2.916865e+02 | 162.1824604 | 2.115601e+02 | 103.0962926 | 1.121835e+02 | 142.7276622 | 109.7880488 | 61.0264909 | 75.0353755 | 36.5447878 | 28.1441007 | 35.8189620 | 7.749572e+02 | 4.310120e+02 | 5.964875e+02 | 2.908444e+02 | 4.471679e+02 | 5.687263e+02 |
| IGHV3-49 | 1.470139e+02 | 94.3582658 | 1.911458e+02 | 19.6330898 | 6.608192e+02 | 50.1137961 | 51.6750393 | 33.1451428 | 63.0527499 | 6.4441959 | 150.7491871 | 11.3974409 | 4.182501e+02 | 2.686210e+02 | 5.794629e+02 | 5.981479e+01 | 2.896746e+03 | 2.203471e+02 |
| IGHV3-52 | 1.161458e+00 | 0.3709696 | 2.506914e+00 | 0.3123805 | 8.442803e-01 | 0.3859069 | 0.3626488 | 0.0989476 | 0.7635549 | 0.0736905 | 0.1561673 | 0.0602573 | 3.719810e+00 | 1.390821e+00 | 8.230732e+00 | 1.324208e+00 | 4.564395e+00 | 2.471472e+00 |
| IGHV3-53 | 8.286819e+01 | 42.3335464 | 1.336457e+02 | 24.4265033 | 4.609749e+01 | 4.8872347 | 28.6840664 | 14.6360372 | 43.3978820 | 7.9035017 | 10.2679055 | 1.0609018 | 2.394060e+02 | 1.224463e+02 | 4.115677e+02 | 7.549237e+01 | 2.069534e+02 | 2.251392e+01 |
| IGHV3-6 | 8.643117e+00 | 6.5287983 | 2.462788e+01 | 2.5062429 | 2.373176e+00 | 41.6638072 | 2.8832299 | 2.1699972 | 7.7460757 | 0.7599301 | 0.4819802 | 8.9323062 | 2.590965e+01 | 1.964298e+01 | 7.830188e+01 | 8.265568e+00 | 1.168505e+01 | 1.943365e+02 |
| IGHV3-60 | 2.637104e+00 | 2.0038183 | 4.232121e+00 | 0.6186969 | 6.404704e+00 | 0.5871444 | 0.8621812 | 0.6477140 | 1.3118827 | 0.1677659 | 1.3585054 | 0.1019616 | 8.065958e+00 | 6.199168e+00 | 1.365278e+01 | 2.281667e+00 | 3.019512e+01 | 3.381064e+00 |
| IGHV3-62 | 5.335906e+00 | 12.5225804 | 1.342874e+01 | 2.2202995 | 6.694422e+00 | 3.8515844 | 1.6570407 | 3.9273515 | 3.9275618 | 0.6263047 | 1.2870637 | 0.7300604 | 1.718238e+01 | 3.992895e+01 | 4.591426e+01 | 7.871137e+00 | 3.481979e+01 | 2.031983e+01 |
| IGHV3-63 | 1.105363e+01 | 16.2571227 | 3.177581e+01 | 3.0505198 | 5.541196e+00 | 0.8986667 | 3.8924649 | 5.7418334 | 10.5707730 | 0.9829840 | 1.2500921 | 0.1783591 | 3.138957e+01 | 4.602956e+01 | 9.551826e+01 | 9.466757e+00 | 2.456207e+01 | 4.527953e+00 |
| IGHV3-64 | 2.359129e+01 | 9.8697947 | 2.285688e+01 | 2.0314103 | 7.666930e+00 | 3.1613598 | 7.3374290 | 3.0532026 | 6.6217270 | 0.5638900 | 1.4533745 | 0.5852467 | 7.585070e+01 | 3.190514e+01 | 7.889741e+01 | 7.318143e+00 | 4.044505e+01 | 1.707689e+01 |
| IGHV3-64D | 1.338943e+02 | 65.6076917 | 9.245161e+01 | 31.3980511 | 1.353459e+02 | 17.3489038 | 45.1990410 | 22.1279923 | 29.2054511 | 9.8967339 | 29.1337649 | 3.7082958 | 3.966385e+02 | 1.945215e+02 | 2.926611e+02 | 9.961242e+01 | 6.287727e+02 | 8.116517e+01 |
| IGHV3-66 | 2.039998e+02 | 46.3285610 | 8.171234e+01 | 10.9975581 | 7.362319e+01 | 43.8506198 | 75.3792877 | 17.0869162 | 28.3975185 | 3.7881359 | 17.9860573 | 10.6973953 | 5.520869e+02 | 1.256128e+02 | 2.351229e+02 | 3.192765e+01 | 3.013653e+02 | 1.797519e+02 |
| IGHV3-69-1 | 3.783135e+01 | 46.5634613 | 6.738673e+01 | 17.3136668 | 6.919559e+01 | 10.9563563 | 13.6394045 | 16.7957814 | 22.8656818 | 5.8469560 | 16.3781092 | 2.5639807 | 1.049321e+02 | 1.290893e+02 | 1.985933e+02 | 5.126823e+01 | 2.923433e+02 | 4.681851e+01 |
| IGHV3-7 | 3.266493e+02 | 212.6341064 | 6.239734e+02 | 73.9903036 | 2.231332e+02 | 77.6011591 | 130.2262379 | 84.7375705 | 235.2818203 | 27.8561493 | 60.7486827 | 21.0980669 | 8.193416e+02 | 5.335681e+02 | 1.654794e+03 | 1.965299e+02 | 8.195800e+02 | 2.854261e+02 |
| IGHV3-71 | 7.792351e+00 | 4.8842940 | 9.944426e+00 | 1.1522919 | 3.979337e+00 | 1.7242491 | 2.7160939 | 1.6893989 | 3.2612674 | 0.3489223 | 0.8808276 | 0.3645703 | 2.235591e+01 | 1.412119e+01 | 3.032306e+01 | 3.805365e+00 | 1.797755e+01 | 8.154902e+00 |
| IGHV3-72 | 2.291995e+01 | 6.2448073 | 4.627166e+01 | 8.7713652 | 7.389145e+00 | 8.0326942 | 8.3363157 | 2.2437034 | 15.8672390 | 2.9769193 | 1.7437667 | 1.8986844 | 6.301637e+01 | 1.738092e+01 | 1.349363e+02 | 2.584445e+01 | 3.131122e+01 | 3.398362e+01 |
| IGHV3-73 | 2.625323e+01 | 26.9405406 | 2.651155e+01 | 9.3614302 | 2.734884e+01 | 8.7983014 | 8.7874417 | 9.0181873 | 8.3040451 | 2.9113782 | 5.8185164 | 1.8521213 | 7.843375e+01 | 8.048100e+01 | 8.464098e+01 | 3.010134e+01 | 1.285481e+02 | 4.179538e+01 |
| IGHV3-74 | 4.457287e+01 | 68.2921156 | 1.122970e+02 | 26.2335837 | 5.604924e+01 | 18.7648461 | 17.4556790 | 26.7680942 | 41.6151233 | 9.6873019 | 14.8975605 | 4.9592215 | 1.138163e+02 | 1.742303e+02 | 3.030299e+02 | 7.104155e+01 | 2.108746e+02 | 7.100297e+01 |
| IGHV3-75 | 1.221975e+00 | 1.8561266 | 2.965183e+00 | 1.1953280 | 4.025555e-01 | 0.2995731 | 0.3720505 | 0.5796385 | 0.8800788 | 0.3380193 | 0.0613438 | 0.0415341 | 4.013493e+00 | 5.943715e+00 | 9.990366e+00 | 4.227004e+00 | 2.641686e+00 | 2.160733e+00 |
| IGHV3OR15-7 | 1.908654e+00 | 2.2678515 | 3.582972e+00 | 3.5315606 | 2.668028e+00 | 0.6304566 | 0.6087702 | 0.7290033 | 1.0927734 | 1.0766489 | 0.5407958 | 0.1094814 | 5.984128e+00 | 7.055044e+00 | 1.174780e+01 | 1.158402e+01 | 1.316277e+01 | 3.630531e+00 |
| IGHV3OR16-12 | 2.569762e+00 | 5.0202131 | 2.912991e+00 | 0.3562387 | 2.198910e+00 | 0.8699500 | 0.6809481 | 1.3508561 | 0.7149339 | 0.0718143 | 0.3336505 | 0.1222113 | 9.697771e+00 | 1.865672e+01 | 1.186896e+01 | 1.767140e+00 | 1.449183e+01 | 6.192659e+00 |
| IGHV3OR16-13 | 7.251438e+00 | 1.9929411 | 6.355827e+00 | 1.1169636 | 1.821625e+00 | 0.5384924 | 2.3468609 | 0.6234860 | 1.9171741 | 0.3135882 | 0.3500161 | 0.0880508 | 2.240582e+01 | 6.370334e+00 | 2.107088e+01 | 3.978491e+00 | 9.480467e+00 | 3.293258e+00 |
| IGHV3OR16-15 | 1.654397e+00 | 0.7503028 | 1.650695e+00 | 0.3109166 | 2.132519e-01 | 0.3937679 | 0.5721916 | 0.2417533 | 0.5352239 | 0.0784798 | 0.0288746 | 0.0680767 | 4.783413e+00 | 2.328631e+00 | 5.090942e+00 | 1.231772e+00 | 1.574960e+00 | 2.277623e+00 |
| IGHV3OR16-7 | 1.542121e+00 | 0.8695479 | 4.307377e-01 | 0.2228351 | 2.379084e+00 | 0.2250729 | 0.4091337 | 0.2217054 | 0.0920187 | 0.0405593 | 0.3739432 | 0.0233142 | 5.812620e+00 | 3.410443e+00 | 2.016276e+00 | 1.224269e+00 | 1.513609e+01 | 2.172827e+00 |
| IGHV3OR16-8 | 1.944902e+01 | 9.6773164 | 1.515974e+01 | 2.7181451 | 1.167452e+01 | 18.1030822 | 6.1721310 | 3.0563684 | 4.4810337 | 0.7801852 | 2.2927453 | 3.5695284 | 6.128585e+01 | 3.064109e+01 | 5.128679e+01 | 9.469948e+00 | 5.944596e+01 | 9.181089e+01 |
| IGHV3OR16-9 | 3.632390e+01 | 14.1527031 | 6.433172e+01 | 20.3982669 | 1.898393e+01 | 1.6931663 | 12.5162181 | 4.8557093 | 20.8063336 | 6.5739199 | 4.1925180 | 0.3471858 | 1.054173e+02 | 4.125021e+01 | 1.989091e+02 | 6.329394e+01 | 8.596015e+01 | 8.257286e+00 |
| IGHV4-28 | 4.713576e+01 | 26.8399122 | 4.893039e+01 | 46.0881713 | 2.461543e+01 | 10.5516339 | 16.8018829 | 9.5513612 | 16.3848452 | 15.4310565 | 5.7070588 | 2.4271615 | 1.322340e+02 | 7.542180e+01 | 1.461218e+02 | 1.376522e+02 | 1.061701e+02 | 4.587127e+01 |
| IGHV4-31 | 1.596675e+02 | 85.8243446 | 2.484898e+02 | 58.2061972 | 7.671245e+01 | 20.2289281 | 59.8701840 | 32.1606400 | 87.8139275 | 20.5378230 | 19.1393841 | 5.0188936 | 4.258164e+02 | 2.290321e+02 | 7.031596e+02 | 1.649621e+02 | 3.074707e+02 | 8.153381e+01 |
| IGHV4-34 | 1.208725e+02 | 72.1345046 | 3.679823e+02 | 59.1749509 | 8.290770e+01 | 22.3315145 | 46.5363768 | 24.5594957 | 117.9589277 | 18.0619620 | 22.0943311 | 4.5170531 | 3.139515e+02 | 2.118686e+02 | 1.147950e+03 | 1.938701e+02 | 3.111063e+02 | 1.104031e+02 |
| IGHV4-39 | 6.326214e+02 | 369.7279858 | 8.672924e+02 | 178.3287715 | 5.221480e+02 | 208.4936680 | 251.8884371 | 147.1456283 | 326.4920299 | 67.0868250 | 141.8983712 | 56.6230453 | 1.588838e+03 | 9.290034e+02 | 2.303873e+03 | 4.740297e+02 | 1.921365e+03 | 7.677017e+02 |
| IGHV4-4 | 1.268825e+02 | 59.5082216 | 1.413443e+02 | 54.3424080 | 1.118661e+02 | 45.1220846 | 33.7946152 | 12.0383162 | 28.2028842 | 8.7782955 | 18.5536145 | 5.6109532 | 4.763828e+02 | 2.941631e+02 | 7.083748e+02 | 3.364090e+02 | 6.744786e+02 | 3.628621e+02 |
| IGHV4-55 | 7.113512e+01 | 57.8173977 | 1.159392e+02 | 115.8619797 | 4.996720e+01 | 15.8448739 | 25.1440020 | 20.4285279 | 38.4960120 | 38.4694102 | 11.4680424 | 3.6140511 | 2.012490e+02 | 1.636364e+02 | 3.491767e+02 | 3.489525e+02 | 2.177112e+02 | 6.946776e+01 |
| IGHV4-59 | 4.802386e+02 | 204.1113308 | 4.185071e+02 | 130.3732291 | 2.899183e+02 | 101.1216147 | 191.9015580 | 81.5240738 | 158.1557864 | 49.2341837 | 79.1893304 | 27.5918068 | 1.201809e+03 | 5.110323e+02 | 1.107441e+03 | 3.452313e+02 | 1.061414e+03 | 3.706021e+02 |
| IGHV4-61 | 7.769358e+01 | 52.6150100 | 1.783943e+02 | 46.2915429 | 3.949637e+01 | 13.2293128 | 19.1231530 | 11.4563580 | 42.8674000 | 9.5131468 | 6.7756061 | 1.3935586 | 3.156536e+02 | 2.416422e+02 | 7.423943e+02 | 2.252574e+02 | 2.302323e+02 | 1.255883e+02 |
| IGHV4-80 | 6.393431e+00 | 5.4341182 | 1.497587e+01 | 3.1772141 | 4.776732e+00 | 2.3087788 | 2.0265470 | 1.7180519 | 4.4667613 | 0.9248399 | 0.9342308 | 0.4386371 | 2.017025e+01 | 1.718786e+01 | 5.021012e+01 | 1.091507e+01 | 2.442348e+01 | 1.215232e+01 |
| IGHV5-10-1 | 1.591991e+02 | 125.1905690 | 2.097580e+02 | 39.9421889 | 1.918837e+02 | 166.1045024 | 51.1600717 | 40.2210338 | 62.9250467 | 11.9574463 | 38.5303598 | 33.3524422 | 4.953934e+02 | 3.896637e+02 | 6.992196e+02 | 1.334213e+02 | 9.555933e+02 | 8.272469e+02 |
| IGHV5-51 | 3.529585e+02 | 274.4418858 | 6.723698e+02 | 123.4809357 | 2.976193e+02 | 114.2938600 | 141.3432959 | 109.8906600 | 254.7298649 | 46.7430048 | 81.5583047 | 31.2943328 | 8.813981e+02 | 6.853935e+02 | 1.774747e+03 | 3.261994e+02 | 1.086061e+03 | 4.174266e+02 |
| IGHV5-78 | 2.332607e+00 | 2.0106751 | 2.385843e+00 | 0.8487965 | 5.415698e+00 | 1.7590739 | 2.2276476 | 1.8838538 | 0.8890569 | 0.2861359 | 5.0691388 | 1.6120167 | 2.442512e+00 | 2.146034e+00 | 6.402567e+00 | 2.517878e+00 | 5.785951e+00 | 1.919547e+00 |
| IGHV6-1 | 1.451384e+02 | 71.6382241 | 2.265807e+02 | 34.2843558 | 7.712558e+01 | 13.8443629 | 55.6758967 | 27.4562739 | 82.0300486 | 12.3751599 | 19.8719831 | 3.5341588 | 3.783530e+02 | 1.869167e+02 | 6.258538e+02 | 9.498197e+01 | 2.993338e+02 | 5.423253e+01 |
| IGHV7-27 | 4.278945e+00 | 0.2241419 | 1.870107e+00 | 0.2462519 | 6.009718e-01 | 0.7038800 | 1.3256213 | 0.0495910 | 0.5243198 | 0.0512506 | 0.0961951 | 0.1159314 | 1.381192e+01 | 1.013078e+00 | 6.670164e+00 | 1.183205e+00 | 3.754526e+00 | 4.273621e+00 |
| IGHV7-34-1 | 1.957587e+00 | 0.8426093 | 5.802601e+00 | 1.5986411 | 6.704624e-01 | 0.7229844 | 0.5771340 | 0.2344879 | 1.6397634 | 0.4330315 | 0.1060003 | 0.1157497 | 6.639957e+00 | 3.027834e+00 | 2.053356e+01 | 5.901773e+00 | 4.240742e+00 | 4.515836e+00 |
| IGHV7-4-1 | 1.406688e+02 | 27.4277471 | 3.346638e+02 | 32.0224251 | 1.748218e+01 | 1.7628634 | 25.2048420 | 6.0477385 | 82.5527363 | 8.9844477 | 3.4485991 | 0.3133635 | 7.850753e+02 | 1.243905e+02 | 1.356707e+03 | 1.141345e+02 | 8.862338e+01 | 9.917196e+00 |
| IGHV7-40 | 4.627974e+00 | 0.3505903 | 2.167658e+00 | 0.2856885 | 8.683191e-01 | 0.1845447 | 1.0474451 | 0.0663701 | 0.4400704 | 0.0468072 | 0.0967759 | 0.0140399 | 2.044798e+01 | 1.851942e+00 | 1.067725e+01 | 1.743704e+00 | 7.790969e+00 | 2.425709e+00 |
| IGHV7-56 | 4.393308e+00 | 4.5948816 | 7.709636e+00 | 1.0918349 | 1.202457e+00 | 0.1399120 | 1.2332366 | 1.2908771 | 2.0212036 | 0.2672273 | 0.1858733 | 0.0116432 | 1.565081e+01 | 1.635550e+01 | 2.940747e+01 | 4.461009e+00 | 7.778966e+00 | 1.681272e+00 |
| IGHV7-81 | 2.745746e+00 | 2.0585440 | 5.120100e+00 | 1.8458611 | 1.797619e+00 | 0.5192397 | 0.8927216 | 0.6616487 | 1.5818910 | 0.5507384 | 0.3577027 | 0.0870040 | 8.445098e+00 | 6.404613e+00 | 1.657221e+01 | 6.186609e+00 | 9.033851e+00 | 3.098823e+00 |
| IGLL5 | 4.254239e+02 | 229.3255619 | 4.874306e+02 | 156.6421565 | 2.379926e+02 | 143.4203234 | 186.9995882 | 100.7415652 | 203.7929408 | 65.4420011 | 74.3652507 | 44.7889012 | 9.678390e+02 | 5.220309e+02 | 1.165833e+03 | 3.749391e+02 | 7.616523e+02 | 4.592519e+02 |
| IGLV4-3 | 3.512032e+00 | 0.9697800 | 6.661256e+00 | 0.4119630 | 1.199870e+00 | 0.4847370 | 1.0744253 | 0.3154836 | 1.2213943 | 0.1135686 | 0.2629825 | 0.0929356 | 1.147997e+01 | 2.981053e+00 | 3.632924e+01 | 1.494369e+00 | 5.474461e+00 | 2.528310e+00 |
| IL10 | 4.291715e+00 | 3.5416139 | 4.900442e+00 | 5.2839177 | 2.792253e+00 | 4.6450885 | 2.6770683 | 2.1849411 | 2.9913391 | 3.2371022 | 1.3778343 | 2.3965822 | 6.880220e+00 | 5.740671e+00 | 8.027953e+00 | 8.624932e+00 | 5.658646e+00 | 9.003175e+00 |
| IL10RA | 3.236925e+01 | 28.4978512 | 4.174946e+01 | 39.8010820 | 3.298897e+01 | 32.5760885 | 24.7458420 | 21.7531577 | 31.6051131 | 30.0778070 | 22.6961791 | 22.3533987 | 4.234119e+01 | 3.733378e+01 | 5.514986e+01 | 5.266761e+01 | 4.794957e+01 | 4.747383e+01 |
| IL10RB | 2.650470e+01 | 23.7457092 | 2.657278e+01 | 28.1179730 | 2.430138e+01 | 25.1728988 | 22.7793684 | 20.3728501 | 22.6523717 | 24.0083719 | 19.5888081 | 20.2727897 | 3.083928e+01 | 2.767697e+01 | 3.117168e+01 | 3.293103e+01 | 3.014768e+01 | 3.125741e+01 |
| IL10RB-AS1 | 3.470989e+00 | 3.2884416 | 3.703888e+00 | 4.0128076 | 4.559521e+00 | 3.5453020 | 2.0553443 | 1.9409367 | 2.1329966 | 2.3214133 | 2.2172252 | 1.6926959 | 5.861678e+00 | 5.571458e+00 | 6.431697e+00 | 6.936561e+00 | 9.376238e+00 | 7.425531e+00 |
| IL11 | 4.314942e-01 | 0.5647416 | 4.636478e-01 | 0.3793075 | 5.308345e-01 | 0.9462272 | 0.1806197 | 0.2534857 | 0.1880236 | 0.1446198 | 0.1674135 | 0.3518488 | 1.030825e+00 | 1.258190e+00 | 1.143310e+00 | 9.948439e-01 | 1.683169e+00 | 2.544690e+00 |
| IL11RA | 2.528396e+01 | 35.2825529 | 2.605408e+01 | 38.0151502 | 3.294211e+01 | 33.9688912 | 19.0993431 | 26.8661060 | 19.4348598 | 28.4898416 | 22.3745391 | 23.0192121 | 3.347123e+01 | 4.633565e+01 | 3.492770e+01 | 5.072516e+01 | 4.850077e+01 | 5.012707e+01 |
| IL12A | 5.902171e-01 | 0.5716803 | 4.977562e-01 | 0.4378966 | 3.852030e-01 | 0.5641051 | 0.3070409 | 0.2947597 | 0.2361436 | 0.1990064 | 0.1265506 | 0.2198844 | 1.134560e+00 | 1.108762e+00 | 1.049197e+00 | 9.635542e-01 | 1.172506e+00 | 1.447190e+00 |
| IL12B | 1.139830e-01 | 0.1193905 | 1.427274e-01 | 0.1425811 | 1.273286e-01 | 0.1709912 | 0.0282518 | 0.0305159 | 0.0378079 | 0.0377446 | 0.0196138 | 0.0336466 | 4.598679e-01 | 4.671036e-01 | 5.388061e-01 | 5.386035e-01 | 8.265918e-01 | 8.689746e-01 |
| IL12RB1 | 4.203455e+00 | 3.0635216 | 5.437105e+00 | 4.2355259 | 3.171553e+00 | 3.2060832 | 2.9462925 | 2.0928980 | 3.7959509 | 2.9071305 | 1.8585680 | 1.8813564 | 5.997041e+00 | 4.484291e+00 | 7.787800e+00 | 6.170923e+00 | 5.412096e+00 | 5.463595e+00 |
| IL12RB2 | 1.101555e+00 | 0.4546205 | 7.320355e-01 | 0.6511364 | 5.281855e-01 | 0.3930538 | 0.6383514 | 0.2132041 | 0.3757110 | 0.3243530 | 0.1927690 | 0.1260261 | 1.900869e+00 | 9.693992e-01 | 1.426298e+00 | 1.307152e+00 | 1.447224e+00 | 1.225868e+00 |
| IL13RA1 | 3.345323e+01 | 36.1678337 | 3.932599e+01 | 49.1322032 | 3.516866e+01 | 38.9734229 | 27.2457034 | 29.5146106 | 31.7599747 | 39.7959137 | 26.3554965 | 29.2638195 | 4.107505e+01 | 4.432084e+01 | 4.869443e+01 | 6.065883e+01 | 4.692891e+01 | 5.190463e+01 |
| IL13RA2 | 3.615240e+00 | 4.4478856 | 3.123817e+00 | 4.0480680 | 3.828054e+00 | 5.8946021 | 2.1957899 | 2.7943186 | 1.8667952 | 2.4465446 | 1.9730848 | 3.0975691 | 5.952282e+00 | 7.079968e+00 | 5.227263e+00 | 6.697959e+00 | 7.426945e+00 | 1.121729e+01 |
| IL15 | 6.145814e+00 | 6.4636111 | 7.676756e+00 | 7.2900953 | 6.872605e+00 | 5.8016225 | 4.6794075 | 4.9369038 | 5.8291066 | 5.5189475 | 4.7193716 | 3.9248022 | 8.071755e+00 | 8.462443e+00 | 1.011005e+01 | 9.629642e+00 | 1.000826e+01 | 8.575929e+00 |
| IL15RA | 1.165679e+01 | 9.5537083 | 1.347431e+01 | 10.4786205 | 1.049605e+01 | 8.5647626 | 9.0507063 | 7.3598607 | 10.3565121 | 7.9777852 | 7.2974396 | 5.8813031 | 1.501328e+01 | 1.240150e+01 | 1.753071e+01 | 1.376340e+01 | 1.509667e+01 | 1.247260e+01 |
| IL16 | 2.384068e+01 | 22.5202001 | 2.320787e+01 | 24.2691922 | 1.778086e+01 | 20.7060585 | 18.5422819 | 17.5120168 | 17.8270347 | 18.6223133 | 12.4198330 | 14.4789296 | 3.065307e+01 | 2.896065e+01 | 3.021282e+01 | 3.162838e+01 | 2.545599e+01 | 2.961136e+01 |
| IL17B | 8.475977e-01 | 1.1700285 | 9.086261e-01 | 0.6588193 | 8.849876e-01 | 1.1112158 | 0.4365885 | 0.6364504 | 0.4557423 | 0.3083707 | 0.3502936 | 0.4645126 | 1.645536e+00 | 2.150940e+00 | 1.811553e+00 | 1.407536e+00 | 2.235847e+00 | 2.658271e+00 |
| IL17D | 8.180223e+00 | 15.4619534 | 6.718205e+00 | 16.9088071 | 1.258223e+01 | 17.2307493 | 5.1631047 | 10.1447026 | 4.2128006 | 10.9894630 | 7.0176904 | 9.6160110 | 1.296043e+01 | 2.356619e+01 | 1.071360e+01 | 2.601654e+01 | 2.255905e+01 | 3.087546e+01 |
| IL17RA | 5.062928e+00 | 5.0182698 | 6.793675e+00 | 6.1363891 | 5.869035e+00 | 5.3165456 | 3.8735602 | 3.8325516 | 5.2173702 | 4.6792516 | 4.0858199 | 3.6634501 | 6.617489e+00 | 6.570827e+00 | 8.846223e+00 | 8.047285e+00 | 8.430517e+00 | 7.715584e+00 |
| IL17RB | 9.552586e-01 | 0.8546335 | 8.864340e-01 | 0.8053799 | 7.728540e-01 | 0.6857411 | 0.5815868 | 0.5070539 | 0.5142251 | 0.4559069 | 0.3566763 | 0.3028174 | 1.569016e+00 | 1.440475e+00 | 1.528057e+00 | 1.422740e+00 | 1.674637e+00 | 1.552886e+00 |
| IL17RC | 1.863222e+01 | 18.9457083 | 1.756771e+01 | 19.4322799 | 2.178338e+01 | 20.4740441 | 15.4014004 | 15.6890889 | 14.3605828 | 15.9353683 | 16.8004743 | 15.7543992 | 2.254079e+01 | 2.287831e+01 | 2.149107e+01 | 2.369657e+01 | 2.824417e+01 | 2.660758e+01 |
| IL17RD | 1.245263e+00 | 1.9570578 | 1.369363e+00 | 2.5300413 | 1.641326e+00 | 2.2948030 | 0.7450415 | 1.2422486 | 0.8016519 | 1.6114327 | 0.8449240 | 1.2452961 | 2.081333e+00 | 3.083180e+00 | 2.339115e+00 | 3.972309e+00 | 3.188395e+00 | 4.228810e+00 |
| IL17RE | 3.190028e+00 | 2.8196840 | 3.544691e+00 | 2.3437890 | 4.602876e+00 | 3.9725666 | 2.0692364 | 1.8497831 | 2.2843413 | 1.4727471 | 2.6375248 | 2.2753705 | 4.917891e+00 | 4.298135e+00 | 5.500419e+00 | 3.730000e+00 | 8.032707e+00 | 6.935699e+00 |
| IL18 | 2.211150e+01 | 14.8891318 | 2.055980e+01 | 17.0913193 | 1.684686e+01 | 15.8351883 | 16.4030321 | 10.9600962 | 14.9588082 | 12.3892450 | 10.9654843 | 10.2876305 | 2.980658e+01 | 2.022667e+01 | 2.825796e+01 | 2.357797e+01 | 2.588274e+01 | 2.437424e+01 |
| IL18BP | 1.864331e+01 | 12.6897753 | 2.002927e+01 | 12.6848877 | 1.584720e+01 | 12.6977194 | 13.6405201 | 9.2061685 | 14.3988096 | 9.0251061 | 10.1409709 | 8.0654701 | 2.548093e+01 | 1.749158e+01 | 2.786143e+01 | 1.782875e+01 | 2.476426e+01 | 1.999041e+01 |
| IL18R1 | 1.532300e+00 | 1.3565245 | 1.713540e+00 | 1.5304341 | 1.289057e+00 | 1.2110602 | 0.9784567 | 0.8493290 | 1.0838862 | 0.9508424 | 0.6566569 | 0.6073587 | 2.399639e+00 | 2.166603e+00 | 2.708975e+00 | 2.463319e+00 | 2.530496e+00 | 2.414828e+00 |
| IL18RAP | 1.067418e+00 | 1.0456635 | 1.894113e+00 | 1.4925151 | 1.291347e+00 | 1.2861037 | 0.6048557 | 0.5903695 | 1.1322134 | 0.8639402 | 0.6045863 | 0.6015976 | 1.883725e+00 | 1.852081e+00 | 3.168716e+00 | 2.578421e+00 | 2.758212e+00 | 2.749451e+00 |
| IL1B | 3.951428e+00 | 2.0040159 | 3.382335e+00 | 1.2659997 | 2.535603e+00 | 4.4481636 | 2.1445948 | 1.0741398 | 1.8271963 | 0.6312177 | 1.1046936 | 1.4496218 | 7.280527e+00 | 3.738880e+00 | 6.261064e+00 | 2.539148e+00 | 5.819967e+00 | 1.364919e+01 |
| IL1R1 | 2.688222e+01 | 27.8224553 | 2.839349e+01 | 32.9045885 | 3.025740e+01 | 26.6653216 | 20.4708466 | 21.2334003 | 21.3541857 | 24.8044837 | 20.6521400 | 18.1112285 | 3.530160e+01 | 3.645620e+01 | 3.775327e+01 | 4.364985e+01 | 4.433003e+01 | 3.925959e+01 |
| IL1R2 | 3.446986e+00 | 3.1857555 | 2.877465e+00 | 2.9831044 | 3.593684e+00 | 7.0253964 | 2.2359042 | 2.0623373 | 1.7931131 | 1.8699641 | 1.9715118 | 3.2103136 | 5.314052e+00 | 4.921134e+00 | 4.617560e+00 | 4.758868e+00 | 6.550588e+00 | 1.537426e+01 |
| IL1RAP | 2.692460e+00 | 2.2178202 | 2.405500e+00 | 2.5428969 | 2.189186e+00 | 3.7560189 | 1.9138929 | 1.5391065 | 1.6509181 | 1.7578837 | 1.3027207 | 2.4342806 | 3.787747e+00 | 3.195832e+00 | 3.504977e+00 | 3.678471e+00 | 3.678867e+00 | 5.795420e+00 |
| IL1RL1 | 5.336542e-01 | 0.4321292 | 4.386685e-01 | 0.7397467 | 4.289625e-01 | 0.4320814 | 0.2618002 | 0.1990174 | 0.1937234 | 0.3795744 | 0.1428170 | 0.1443266 | 1.087802e+00 | 9.382878e-01 | 9.933235e-01 | 1.441681e+00 | 1.288424e+00 | 1.293554e+00 |
| IL1RL2 | 9.263672e-01 | 0.7592592 | 6.103178e-01 | 0.8828151 | 9.835745e-01 | 0.6057754 | 0.5398232 | 0.4229470 | 0.3092194 | 0.4923911 | 0.4664864 | 0.2439713 | 1.589699e+00 | 1.362995e+00 | 1.204607e+00 | 1.582812e+00 | 2.073841e+00 | 1.504127e+00 |
| IL1RN | 1.008632e+01 | 5.2063895 | 6.122472e+00 | 4.0420985 | 4.689854e+00 | 5.9253583 | 6.0455064 | 3.1649480 | 3.6510346 | 2.3438780 | 2.3323792 | 2.6673376 | 1.682800e+01 | 8.564593e+00 | 1.026686e+01 | 6.970738e+00 | 9.430170e+00 | 1.316289e+01 |
| IL20RA | 1.565985e+00 | 0.3947073 | 4.169590e-01 | 0.3738428 | 6.058459e-01 | 0.4013011 | 0.5956622 | 0.1574669 | 0.1589785 | 0.1400095 | 0.1950894 | 0.1124862 | 4.116944e+00 | 9.893756e-01 | 1.093574e+00 | 9.982070e-01 | 1.881441e+00 | 1.431665e+00 |
| IL21R | 4.578424e+00 | 1.8736298 | 5.641598e+00 | 1.8335610 | 2.496212e+00 | 1.5969794 | 2.5629179 | 1.0010494 | 3.2407172 | 0.9714540 | 1.1479034 | 0.6756833 | 8.178946e+00 | 3.506809e+00 | 9.821167e+00 | 3.460736e+00 | 5.428222e+00 | 3.774465e+00 |
| IL21R-AS1 | 2.210210e-01 | 0.1944446 | 3.033448e-01 | 0.2014235 | 1.972880e-01 | 0.3380243 | 0.0766218 | 0.0634474 | 0.1134235 | 0.0625324 | 0.0408888 | 0.0963223 | 6.375508e-01 | 5.959060e-01 | 8.112789e-01 | 6.488064e-01 | 9.519123e-01 | 1.186231e+00 |
| IL22RA1 | 6.322445e-01 | 0.2321078 | 3.328121e-01 | 0.1331375 | 4.175520e-01 | 0.0999073 | 0.1800111 | 0.0715234 | 0.1097320 | 0.0304640 | 0.1087579 | 0.0112582 | 2.220603e+00 | 7.532362e-01 | 1.009403e+00 | 5.818547e-01 | 1.603099e+00 | 8.865960e-01 |
| IL23A | 1.142804e+00 | 0.9650472 | 1.321254e+00 | 1.0633913 | 1.176333e+00 | 1.4564119 | 0.6982619 | 0.5700791 | 0.8056937 | 0.6213439 | 0.5905969 | 0.7707435 | 1.870359e+00 | 1.633661e+00 | 2.166719e+00 | 1.819928e+00 | 2.342986e+00 | 2.752064e+00 |
| IL24 | 1.732507e+00 | 1.1086443 | 1.846101e+00 | 0.8152098 | 7.778267e-01 | 1.3587452 | 0.9861812 | 0.5952208 | 1.0228451 | 0.3982600 | 0.2953905 | 0.5875638 | 3.043640e+00 | 2.064935e+00 | 3.331971e+00 | 1.668677e+00 | 2.048185e+00 | 3.142108e+00 |
| IL26 | 5.873927e-01 | 0.5057060 | 8.566563e-01 | 0.4558793 | 6.121943e-01 | 0.2747837 | 0.2682118 | 0.2226181 | 0.4045579 | 0.1854228 | 0.2047482 | 0.0655093 | 1.286409e+00 | 1.148777e+00 | 1.813980e+00 | 1.120822e+00 | 1.830453e+00 | 1.152601e+00 |
| IL27 | 5.201435e-01 | 0.4913582 | 5.312805e-01 | 0.4733790 | 4.046567e-01 | 0.5095383 | 0.2412198 | 0.2243689 | 0.2365692 | 0.2038485 | 0.1231584 | 0.1705446 | 1.121588e+00 | 1.076053e+00 | 1.193135e+00 | 1.099285e+00 | 1.329565e+00 | 1.522354e+00 |
| IL27RA | 5.530562e+00 | 4.6263201 | 6.434536e+00 | 5.1945563 | 4.559268e+00 | 4.7901188 | 4.0516443 | 3.3448947 | 4.6817355 | 3.7234663 | 2.9051331 | 3.0606330 | 7.549308e+00 | 6.398658e+00 | 8.843569e+00 | 7.246854e+00 | 7.155239e+00 | 7.496893e+00 |
| IL2RA | 3.966331e+00 | 1.5723689 | 3.718950e+00 | 1.9121202 | 1.897833e+00 | 1.5471624 | 2.2565086 | 0.8268023 | 2.1209413 | 1.0314441 | 0.8479207 | 0.6597620 | 6.971736e+00 | 2.990248e+00 | 6.520966e+00 | 3.544742e+00 | 4.247766e+00 | 3.628144e+00 |
| IL2RB | 4.117526e+00 | 2.0930523 | 4.334010e+00 | 2.3126154 | 2.845507e+00 | 2.0541735 | 2.5225081 | 1.2364212 | 2.6393165 | 1.3104069 | 1.4352270 | 0.9665665 | 6.721096e+00 | 3.543184e+00 | 7.116859e+00 | 4.081320e+00 | 5.641553e+00 | 4.365585e+00 |
| IL2RG | 3.085586e+01 | 19.8902661 | 3.804322e+01 | 18.7290684 | 1.948095e+01 | 16.3053137 | 30.1379448 | 19.2391544 | 36.7997547 | 17.8691278 | 18.8435122 | 15.5554470 | 3.159088e+01 | 2.056341e+01 | 3.932870e+01 | 1.963039e+01 | 2.013995e+01 | 1.709133e+01 |
| IL31RA | 2.160091e-01 | 0.1811050 | 1.668230e-01 | 0.1947297 | 9.830990e-02 | 0.2453363 | 0.0721848 | 0.0556630 | 0.0456521 | 0.0578537 | 0.0110719 | 0.0562996 | 6.463951e-01 | 5.892426e-01 | 6.096083e-01 | 6.554404e-01 | 8.729162e-01 | 1.069101e+00 |
| IL32 | 1.466251e+02 | 109.4052443 | 1.308983e+02 | 106.1554702 | 9.303828e+01 | 120.5575152 | 103.9080368 | 77.4758706 | 90.8205815 | 73.6103475 | 57.0695274 | 74.0292029 | 2.069034e+02 | 1.544934e+02 | 1.886616e+02 | 1.530897e+02 | 1.516768e+02 | 1.963295e+02 |
| IL33 | 1.445487e+01 | 13.7356458 | 1.534907e+01 | 16.1380502 | 1.524987e+01 | 13.8053996 | 9.5588865 | 9.1429334 | 10.0662268 | 10.5817629 | 8.5847888 | 7.8044946 | 2.185853e+01 | 2.063539e+01 | 2.340439e+01 | 2.461184e+01 | 2.708960e+01 | 2.442042e+01 |
| IL34 | 7.848529e+00 | 8.5497830 | 7.064475e+00 | 8.7339938 | 6.332250e+00 | 5.8345862 | 5.5093539 | 6.0495050 | 4.8678722 | 6.0212805 | 3.8255814 | 3.5112131 | 1.118088e+01 | 1.208343e+01 | 1.025228e+01 | 1.266884e+01 | 1.048138e+01 | 9.695338e+00 |
| IL36G | 4.890991e+00 | 0.2814193 | 3.948026e-01 | 0.1236761 | 5.151571e-01 | 0.1155209 | 0.9071089 | 0.0427231 | 0.0568927 | 0.0129674 | 0.0408903 | 0.0054863 | 2.637146e+01 | 1.853723e+00 | 2.739703e+00 | 1.179555e+00 | 6.490209e+00 | 2.432430e+00 |
| IL36RN | 4.341152e+00 | 0.3508600 | 5.544977e-01 | 0.1023777 | 1.149483e+00 | 0.1370458 | 0.5597062 | 0.0396338 | 0.0579768 | 0.0072490 | 0.0605370 | 0.0046766 | 3.367053e+01 | 3.106004e+00 | 5.303286e+00 | 1.445874e+00 | 2.182654e+01 | 4.016113e+00 |
| IL37 | 2.655488e+00 | 0.2380471 | 1.023868e+00 | 0.1183720 | 1.142256e+00 | 0.1089822 | 0.6919649 | 0.0471030 | 0.2339872 | 0.0161300 | 0.1613650 | 0.0072127 | 1.019071e+01 | 1.203033e+00 | 4.480184e+00 | 8.686886e-01 | 8.085697e+00 | 1.646705e+00 |
| IL3RA | 1.852714e+01 | 18.8401831 | 1.781751e+01 | 18.8214704 | 2.149956e+01 | 19.6868451 | 14.3376390 | 14.6279563 | 13.6611466 | 14.4693378 | 15.1911582 | 13.8059761 | 2.394084e+01 | 2.426535e+01 | 2.323844e+01 | 2.448265e+01 | 3.042763e+01 | 2.807276e+01 |
| IL4I1 | 6.544555e+00 | 3.6581582 | 7.313311e+00 | 4.0414535 | 5.084227e+00 | 6.8903893 | 3.3104808 | 1.7891342 | 3.6303650 | 1.8959189 | 1.9791413 | 2.1966814 | 1.293806e+01 | 7.479663e+00 | 1.473255e+01 | 8.615002e+00 | 1.306090e+01 | 2.161327e+01 |
| IL4R | 2.538100e+01 | 23.7980082 | 3.137323e+01 | 26.8348689 | 2.689669e+01 | 25.0529308 | 19.5945479 | 18.3386820 | 23.9440251 | 20.4319861 | 18.6893367 | 17.3605689 | 3.287624e+01 | 3.088255e+01 | 4.110754e+01 | 3.524426e+01 | 3.870827e+01 | 3.615373e+01 |
| IL5RA | 1.051778e+00 | 1.1394401 | 1.371916e+00 | 0.8018849 | 7.783802e-01 | 0.8906319 | 0.5650700 | 0.6199863 | 0.7400578 | 0.3938847 | 0.2991364 | 0.3551218 | 1.957699e+00 | 2.094117e+00 | 2.543253e+00 | 1.632507e+00 | 2.025416e+00 | 2.233671e+00 |
| IL6 | 8.160025e+00 | 2.1688975 | 5.416211e+00 | 2.0026499 | 9.749465e+00 | 2.3375868 | 7.4398721 | 1.9034323 | 2.2339149 | 0.7923023 | 2.9341709 | 0.6370518 | 8.949886e+00 | 2.471386e+00 | 1.313181e+01 | 5.061965e+00 | 3.239486e+01 | 8.577501e+00 |
| IL6R | 7.207434e+00 | 7.4486378 | 8.494722e+00 | 8.8218491 | 7.124477e+00 | 7.4648893 | 5.5456657 | 5.7417564 | 6.4928442 | 6.7520431 | 4.9161043 | 5.1737102 | 9.367155e+00 | 9.662933e+00 | 1.111382e+01 | 1.152614e+01 | 1.032488e+01 | 1.077072e+01 |
| IL6ST | 1.533123e+01 | 19.1759796 | 2.084153e+01 | 25.0836894 | 1.860893e+01 | 20.9894412 | 11.4947332 | 14.5176296 | 15.5532821 | 18.7680978 | 12.5023314 | 14.1474654 | 2.044821e+01 | 2.532908e+01 | 2.792781e+01 | 3.352452e+01 | 2.769823e+01 | 3.114032e+01 |
| IL7 | 1.998716e+00 | 1.3332332 | 1.970479e+00 | 1.8331856 | 1.771394e+00 | 0.9830511 | 1.3101121 | 0.8238555 | 1.2565186 | 1.1573051 | 0.9530372 | 0.4597778 | 3.049256e+00 | 2.157552e+00 | 3.090116e+00 | 2.903789e+00 | 3.292459e+00 | 2.101862e+00 |
| IL7R | 7.223909e+00 | 5.7592475 | 9.286172e+00 | 5.8524092 | 4.945158e+00 | 5.7325103 | 4.0465694 | 3.1799292 | 5.1491911 | 3.1243080 | 2.1961161 | 2.4825016 | 1.289607e+01 | 1.043071e+01 | 1.674690e+01 | 1.096265e+01 | 1.113538e+01 | 1.323732e+01 |
| IL9R | 6.329281e-01 | 0.4434715 | 7.817182e-01 | 0.3868135 | 4.971967e-01 | 0.4157400 | 0.2853214 | 0.1834805 | 0.3508236 | 0.1455387 | 0.1489028 | 0.1163404 | 1.404024e+00 | 1.071868e+00 | 1.741854e+00 | 1.028075e+00 | 1.660174e+00 | 1.485638e+00 |
| IL9RP3 | 1.355428e-01 | 0.1227762 | 2.053049e-01 | 0.1386215 | 1.375119e-01 | 0.1204466 | 0.0341141 | 0.0291563 | 0.0593732 | 0.0325244 | 0.0197724 | 0.0155107 | 5.385413e-01 | 5.170069e-01 | 7.099176e-01 | 5.908153e-01 | 9.563611e-01 | 9.353131e-01 |
| ILDR1 | 1.767462e-01 | 0.1358551 | 1.653419e-01 | 0.1043191 | 1.106349e-01 | 0.1623390 | 0.0548184 | 0.0364080 | 0.0460228 | 0.0215650 | 0.0143065 | 0.0290952 | 5.698677e-01 | 5.069383e-01 | 5.940084e-01 | 5.046352e-01 | 8.555579e-01 | 9.057851e-01 |
| ILDR2 | 5.372370e-02 | 0.0650658 | 4.508380e-02 | 0.0504064 | 6.317250e-02 | 0.0750363 | 0.0069364 | 0.0100252 | 0.0042557 | 0.0053772 | 0.0043230 | 0.0063169 | 4.161002e-01 | 4.222926e-01 | 4.776013e-01 | 4.725170e-01 | 9.231410e-01 | 8.913309e-01 |
| ILF2 | 6.889831e+01 | 63.0737503 | 6.725899e+01 | 70.0146259 | 6.716762e+01 | 69.2695269 | 59.4741693 | 54.4421919 | 57.5723865 | 59.9753746 | 54.5945249 | 56.2901177 | 7.981577e+01 | 7.307380e+01 | 7.857537e+01 | 8.173434e+01 | 8.263630e+01 | 8.524174e+01 |
| ILF3 | 4.119381e+01 | 40.0374404 | 4.488605e+01 | 44.6603691 | 4.528690e+01 | 44.4660668 | 33.5983316 | 32.6440962 | 36.2306776 | 36.0419508 | 34.0224008 | 33.3904945 | 5.050638e+01 | 4.910525e+01 | 5.560917e+01 | 5.533964e+01 | 6.028098e+01 | 5.921539e+01 |
| ILF3-AS1 | 1.009614e+01 | 15.0958944 | 1.041541e+01 | 13.7305819 | 1.389800e+01 | 15.2407733 | 8.0136953 | 12.1716391 | 8.1642558 | 10.8896593 | 10.2089938 | 11.2449116 | 1.271972e+01 | 1.872271e+01 | 1.328729e+01 | 1.731265e+01 | 1.892003e+01 | 2.065656e+01 |
| ILK | 8.624980e+01 | 104.7677527 | 9.431587e+01 | 112.8291080 | 1.129531e+02 | 126.1548493 | 71.5174557 | 87.0048252 | 77.4253799 | 92.7279265 | 86.9156529 | 97.1572394 | 1.040170e+02 | 1.261572e+02 | 1.148910e+02 | 1.372877e+02 | 1.467906e+02 | 1.638071e+02 |
| ILKAP | 2.512000e+01 | 28.6419953 | 2.694192e+01 | 31.4107822 | 3.159449e+01 | 34.7237423 | 21.0690600 | 24.1249850 | 22.4419458 | 26.2282626 | 24.8886789 | 27.4228052 | 2.994982e+01 | 3.400474e+01 | 3.234422e+01 | 3.761733e+01 | 4.010706e+01 | 4.396845e+01 |
| ILVBL | 1.841167e+01 | 17.1288891 | 1.813901e+01 | 19.3054471 | 2.322413e+01 | 20.8311247 | 15.3844540 | 14.2782700 | 14.9846654 | 15.9818681 | 18.1886716 | 16.2448061 | 2.203456e+01 | 2.054863e+01 | 2.195735e+01 | 2.332020e+01 | 2.965364e+01 | 2.671228e+01 |
| IMPAD1 | 8.890594e+00 | 9.4536913 | 1.094563e+01 | 11.9624235 | 9.713860e+00 | 12.1289015 | 7.1710415 | 7.6535830 | 8.8172495 | 9.6797265 | 7.2210015 | 9.1465449 | 1.102248e+01 | 1.167718e+01 | 1.358779e+01 | 1.478343e+01 | 1.306731e+01 | 1.608370e+01 |
| ISG15 | 7.784337e+01 | 87.6765189 | 7.625847e+01 | 127.3366662 | 5.697481e+01 | 70.7591059 | 49.5990977 | 55.8841350 | 47.2775762 | 79.0508527 | 30.0766017 | 37.3960322 | 1.221714e+02 | 1.375555e+02 | 1.230045e+02 | 2.051164e+02 | 1.079287e+02 | 1.338872e+02 |
| LAMP5 | 2.273907e+00 | 1.2294477 | 2.695716e+00 | 0.8708500 | 1.419564e+00 | 0.8233138 | 1.1020817 | 0.5708834 | 1.3435561 | 0.3874708 | 0.5152900 | 0.2725370 | 4.691716e+00 | 2.647724e+00 | 5.408693e+00 | 1.957256e+00 | 3.910734e+00 | 2.487169e+00 |
| LGALSL | 8.912839e+00 | 9.1976720 | 7.098055e+00 | 10.2293933 | 8.529722e+00 | 8.9569806 | 6.2767611 | 6.5576342 | 4.9127519 | 7.1850274 | 5.2888931 | 5.5619271 | 1.265600e+01 | 1.290056e+01 | 1.025543e+01 | 1.456369e+01 | 1.375641e+01 | 1.442441e+01 |
| LILRA1 | 2.342973e+00 | 1.7206355 | 2.466768e+00 | 1.8471663 | 2.012427e+00 | 1.7750933 | 1.5647620 | 1.1052558 | 1.6173389 | 1.1670506 | 1.1082804 | 0.9550487 | 3.508216e+00 | 2.678644e+00 | 3.762318e+00 | 2.923629e+00 | 3.654186e+00 | 3.299262e+00 |
| LILRA2 | 7.270048e+00 | 10.2932657 | 8.346699e+00 | 10.5501578 | 1.152854e+01 | 9.6227183 | 5.1337092 | 7.3608459 | 5.8045578 | 7.3985567 | 7.2089799 | 5.9708111 | 1.029540e+01 | 1.439391e+01 | 1.200218e+01 | 1.504426e+01 | 1.843635e+01 | 1.550823e+01 |
| LILRA4 | 2.080852e+00 | 0.8536551 | 2.144249e+00 | 0.5779657 | 1.098304e+00 | 0.9989915 | 0.9010590 | 0.3436364 | 0.9926188 | 0.2265138 | 0.3491901 | 0.3127800 | 4.805395e+00 | 2.120634e+00 | 4.631994e+00 | 1.474719e+00 | 3.454481e+00 | 3.190690e+00 |
| LILRA5 | 9.636926e+00 | 6.6042977 | 1.079162e+01 | 6.9464779 | 6.966816e+00 | 9.6650884 | 6.2316932 | 4.3527411 | 7.0485281 | 4.4729871 | 3.8886930 | 4.7599826 | 1.490291e+01 | 1.002052e+01 | 1.652246e+01 | 1.078777e+01 | 1.248145e+01 | 1.962485e+01 |
| LILRA6 | 9.127149e+00 | 9.8604424 | 1.273532e+01 | 14.2090053 | 1.365175e+01 | 13.0497012 | 6.4208580 | 6.9388571 | 8.8818709 | 9.9018943 | 8.5061094 | 8.0430593 | 1.297410e+01 | 1.401215e+01 | 1.826061e+01 | 2.038962e+01 | 2.191016e+01 | 2.117288e+01 |
| LILRB1 | 1.155737e+01 | 7.1357069 | 1.359413e+01 | 8.6105228 | 9.054725e+00 | 8.3761118 | 7.6941332 | 4.6649463 | 8.9684684 | 5.6000598 | 5.1291971 | 4.6989255 | 1.736033e+01 | 1.091509e+01 | 2.060556e+01 | 1.323934e+01 | 1.598458e+01 | 1.493091e+01 |
| LILRB2 | 2.749005e+01 | 17.5537932 | 3.174628e+01 | 21.4244046 | 2.241158e+01 | 21.3996548 | 19.6698630 | 12.6704656 | 22.7718557 | 15.2506122 | 14.3740704 | 13.2600346 | 3.841932e+01 | 2.431921e+01 | 4.425754e+01 | 3.009749e+01 | 3.494340e+01 | 3.453575e+01 |
| LILRB3 | 1.606291e+01 | 12.6801576 | 2.173825e+01 | 16.9347776 | 1.715471e+01 | 14.6358172 | 11.5267942 | 9.0279416 | 15.4460420 | 11.9099627 | 10.8409045 | 8.9999131 | 2.238413e+01 | 1.780986e+01 | 3.059370e+01 | 2.407956e+01 | 2.714571e+01 | 2.380102e+01 |
| LILRB4 | 5.235058e+01 | 37.2842221 | 6.412143e+01 | 54.9565945 | 4.713539e+01 | 42.6642974 | 33.9156363 | 23.9851032 | 41.0624691 | 34.8347477 | 25.9301893 | 22.9560416 | 8.080590e+01 | 5.795736e+01 | 1.001293e+02 | 8.670157e+01 | 8.568179e+01 | 7.929251e+01 |
| LILRB5 | 2.905046e+01 | 37.4401319 | 4.548331e+01 | 59.3448566 | 4.873754e+01 | 46.6528102 | 21.3669392 | 27.6954417 | 33.0868456 | 43.3265838 | 32.0866750 | 30.6571983 | 3.949695e+01 | 5.061351e+01 | 6.252428e+01 | 8.128525e+01 | 7.402910e+01 | 7.099425e+01 |
| LILRP1 | 1.261715e-01 | 0.0993942 | 9.106570e-02 | 0.0995384 | 7.219090e-02 | 0.1239019 | 0.0295097 | 0.0200254 | 0.0156192 | 0.0182160 | 0.0053705 | 0.0156382 | 5.394587e-01 | 4.933327e-01 | 5.309470e-01 | 5.439122e-01 | 9.704014e-01 | 9.816779e-01 |
| LTA | 1.265584e+00 | 0.7856210 | 1.430851e+00 | 0.7349406 | 6.021643e-01 | 0.9086569 | 0.6910922 | 0.3960690 | 0.7663322 | 0.3503717 | 0.2106031 | 0.3585776 | 2.317639e+00 | 1.558315e+00 | 2.671603e+00 | 1.541613e+00 | 1.721731e+00 | 2.302590e+00 |
| LY6E | 1.823022e+02 | 185.5070076 | 1.940469e+02 | 218.7995034 | 1.689755e+02 | 157.1506329 | 136.1505049 | 137.2060701 | 142.6265998 | 159.7760266 | 112.2904135 | 104.4707371 | 2.440981e+02 | 2.508114e+02 | 2.640055e+02 | 2.996271e+02 | 2.542758e+02 | 2.363946e+02 |
| MILR1 | 1.394310e+01 | 10.8248745 | 1.567869e+01 | 13.9822909 | 1.372737e+01 | 12.9389610 | 10.3035232 | 7.9477089 | 11.4793711 | 10.2166687 | 9.0334577 | 8.4726222 | 1.886831e+01 | 1.474361e+01 | 2.141418e+01 | 1.913583e+01 | 2.086031e+01 | 1.975973e+01 |
| MMP10 | 1.767799e-01 | 0.2710490 | 1.983864e-01 | 0.1769912 | 5.423609e-01 | 0.2428900 | 0.0457837 | 0.0828363 | 0.0498926 | 0.0422558 | 0.1308050 | 0.0430585 | 6.825819e-01 | 8.869006e-01 | 7.888371e-01 | 7.413389e-01 | 2.248807e+00 | 1.370125e+00 |
| MS4A1 | 9.002418e+00 | 9.8298156 | 1.611937e+01 | 6.1099131 | 4.368496e+00 | 3.9815255 | 8.6932421 | 9.3554203 | 6.9390350 | 2.5614388 | 4.1578457 | 3.7123624 | 9.322589e+00 | 1.032827e+01 | 3.744528e+01 | 1.457425e+01 | 4.589819e+00 | 4.270204e+00 |
| NEIL1 | 1.649605e+01 | 20.1920239 | 1.941997e+01 | 18.5783957 | 2.357363e+01 | 21.5752728 | 12.8694016 | 15.8981126 | 14.9898368 | 14.3935713 | 16.8668611 | 15.3823767 | 2.114470e+01 | 2.564568e+01 | 2.515938e+01 | 2.397993e+01 | 3.294721e+01 | 3.026141e+01 |
| NEIL2 | 7.474717e+00 | 7.3219541 | 7.330086e+00 | 7.6234509 | 7.949963e+00 | 8.7525985 | 6.0032023 | 5.8725541 | 5.8013834 | 6.0499419 | 5.8631074 | 6.5081711 | 9.306930e+00 | 9.129079e+00 | 9.261611e+00 | 9.606209e+00 | 1.077959e+01 | 1.177105e+01 |
| NEIL3 | 2.776811e-01 | 0.1304970 | 2.198992e-01 | 0.1410913 | 1.880464e-01 | 0.2942676 | 0.1062645 | 0.0342479 | 0.0714052 | 0.0358766 | 0.0377533 | 0.0781283 | 7.256119e-01 | 4.972417e-01 | 6.772011e-01 | 5.548676e-01 | 9.366444e-01 | 1.108349e+00 |
| NFIL3 | 1.293897e+01 | 9.2818456 | 1.239795e+01 | 9.6421481 | 1.357190e+01 | 11.4018653 | 9.6861646 | 6.9079279 | 9.1715522 | 7.0691779 | 9.0877556 | 7.5647988 | 1.728414e+01 | 1.247156e+01 | 1.675934e+01 | 1.315160e+01 | 2.026866e+01 | 1.718519e+01 |
| NFKBIL1 | 1.226301e+01 | 15.2664779 | 1.092593e+01 | 15.8720302 | 1.573046e+01 | 15.4863287 | 9.6411800 | 12.0895499 | 8.4262386 | 12.4075185 | 11.3236060 | 11.1406224 | 1.559781e+01 | 1.927825e+01 | 1.416717e+01 | 2.030393e+01 | 2.185235e+01 | 2.152720e+01 |
| NKILA | 6.424251e-01 | 0.6829111 | 5.697697e-01 | 0.6650491 | 7.218376e-01 | 0.6551292 | 0.3493494 | 0.3775007 | 0.2880742 | 0.3520047 | 0.3185615 | 0.2788951 | 1.181367e+00 | 1.235408e+00 | 1.126923e+00 | 1.256490e+00 | 1.635632e+00 | 1.538910e+00 |
| OASL | 4.285754e+00 | 3.7658360 | 3.920467e+00 | 4.7160024 | 2.144945e+00 | 2.6562836 | 2.8273214 | 2.3763610 | 2.5189480 | 3.0494360 | 1.1095545 | 1.4089864 | 6.496499e+00 | 5.967747e+00 | 6.101778e+00 | 7.293374e+00 | 4.146518e+00 | 5.007744e+00 |
| ODC1 | 2.509651e+01 | 22.8584776 | 2.550342e+01 | 22.2389145 | 2.264886e+01 | 23.5197895 | 20.7063699 | 18.8263569 | 20.8382745 | 18.1136946 | 17.2100681 | 17.8752450 | 3.041745e+01 | 2.775417e+01 | 3.121298e+01 | 2.730361e+01 | 2.980644e+01 | 3.094674e+01 |
| PADI1 | 1.665612e-01 | 0.2595531 | 1.117590e-01 | 0.0882609 | 2.279290e-01 | 0.1256204 | 0.0256910 | 0.0454619 | 0.0129728 | 0.0090057 | 0.0185316 | 0.0076621 | 1.079858e+00 | 1.481853e+00 | 9.627928e-01 | 8.650022e-01 | 2.803403e+00 | 2.059540e+00 |
| PADI2 | 1.493051e+00 | 0.7361604 | 1.216697e+00 | 0.5845184 | 1.811927e+00 | 0.8204981 | 1.4674514 | 0.7183546 | 0.6247351 | 0.2651219 | 0.7837796 | 0.3081209 | 1.519097e+00 | 7.544075e-01 | 2.369566e+00 | 1.288697e+00 | 4.188779e+00 | 2.184912e+00 |
| PADI4 | 9.769857e-01 | 1.3202375 | 1.947235e+00 | 0.9443531 | 2.230587e+00 | 1.3176012 | 0.4911450 | 0.6925959 | 1.0267273 | 0.4527105 | 0.9659524 | 0.5289407 | 1.943420e+00 | 2.516658e+00 | 3.693021e+00 | 1.969919e+00 | 5.150893e+00 | 3.282169e+00 |
| PAX5 | 7.689978e-01 | 0.5302605 | 6.902880e-01 | 0.2339320 | 3.450524e-01 | 0.4300829 | 0.3522498 | 0.2250510 | 0.2952368 | 0.0716544 | 0.0869115 | 0.1187373 | 1.678802e+00 | 1.249389e+00 | 1.613951e+00 | 7.637241e-01 | 1.369913e+00 | 1.557820e+00 |
| PDCD1 | 3.813046e+00 | 1.8372135 | 3.966694e+00 | 1.8884010 | 2.035045e+00 | 1.5263744 | 2.2509516 | 1.0272338 | 2.2729346 | 1.0222064 | 0.9068055 | 0.6520805 | 6.459189e+00 | 3.285867e+00 | 6.922620e+00 | 3.488589e+00 | 4.567029e+00 | 3.572901e+00 |
| PFKFB1 | 7.041439e-01 | 0.3407562 | 1.278982e+00 | 0.4886508 | 1.498501e+00 | 1.3192798 | 0.6914587 | 0.3319566 | 1.2465404 | 0.4720709 | 1.4604278 | 0.4246625 | 7.170618e-01 | 3.497892e-01 | 1.312268e+00 | 5.058131e-01 | 1.537566e+00 | 4.098547e+00 |
| PHOSPHO1 | 4.538713e+00 | 4.2975285 | 5.031549e+00 | 3.2193940 | 5.685680e+00 | 4.4336074 | 2.8272491 | 2.7128514 | 2.9245096 | 1.9208488 | 2.9421381 | 2.3164539 | 7.286204e+00 | 6.807874e+00 | 8.656659e+00 | 5.395791e+00 | 1.098757e+01 | 8.485761e+00 |
| PI16 | 1.478399e+01 | 4.5285233 | 1.763832e+01 | 8.0388292 | 3.138371e+01 | 15.9011307 | 6.9341825 | 2.2135073 | 7.9535110 | 3.4710618 | 12.1486878 | 5.6046802 | 3.152014e+01 | 9.264719e+00 | 3.911609e+01 | 1.861758e+01 | 8.107354e+01 | 4.511336e+01 |
| PIGH | 1.779300e+01 | 20.8989160 | 1.766015e+01 | 24.5878910 | 1.997420e+01 | 21.7550635 | 14.8630972 | 17.5428271 | 14.5877386 | 20.5197006 | 15.5573948 | 17.0123766 | 2.130046e+01 | 2.489705e+01 | 2.137967e+01 | 2.946263e+01 | 2.564495e+01 | 2.781991e+01 |
| PILRA | 2.233919e+01 | 18.0496101 | 2.461136e+01 | 20.1320688 | 2.262301e+01 | 21.9302487 | 16.4627445 | 13.3301245 | 18.0613641 | 14.6673420 | 14.9949837 | 14.0549613 | 3.031327e+01 | 2.444001e+01 | 3.353674e+01 | 2.763283e+01 | 3.413145e+01 | 3.421822e+01 |
| PILRB | 2.132563e+01 | 23.6031655 | 2.657277e+01 | 23.2408056 | 3.503725e+01 | 25.3746047 | 16.0688339 | 17.8368430 | 19.7412023 | 17.2540833 | 23.6497069 | 17.0416519 | 2.830213e+01 | 3.123363e+01 | 3.576845e+01 | 3.130477e+01 | 5.190800e+01 | 3.778217e+01 |
| PIWIL2 | 3.131844e-01 | 0.4409517 | 3.635525e-01 | 0.5259716 | 4.727809e-01 | 0.7893503 | 0.1329689 | 0.2119848 | 0.1556701 | 0.2565384 | 0.1732584 | 0.3534357 | 7.376497e-01 | 9.172278e-01 | 8.490418e-01 | 1.078381e+00 | 1.290107e+00 | 1.762906e+00 |
| PIWIL4 | 3.650395e+00 | 4.5286226 | 3.770709e+00 | 6.0027662 | 4.782375e+00 | 4.8559891 | 2.5710041 | 3.2416263 | 2.6060031 | 4.2793733 | 2.9939443 | 3.0396680 | 5.182948e+00 | 6.326584e+00 | 5.455959e+00 | 8.420205e+00 | 7.639125e+00 | 7.757633e+00 |
| PPIL1 | 1.178760e+01 | 9.9231053 | 1.223121e+01 | 10.3460556 | 1.159874e+01 | 10.9857556 | 9.4979057 | 7.9339578 | 9.7428213 | 8.1777288 | 8.5377286 | 8.0596144 | 1.462928e+01 | 1.241096e+01 | 1.535514e+01 | 1.308931e+01 | 1.575720e+01 | 1.497427e+01 |
| PPIL2 | 1.422528e+01 | 14.6776180 | 1.647644e+01 | 15.3892718 | 1.878587e+01 | 17.8168563 | 11.6999124 | 12.0814216 | 13.4536752 | 12.5296242 | 14.4500298 | 13.6669360 | 1.729573e+01 | 1.783172e+01 | 2.017837e+01 | 1.890158e+01 | 2.442271e+01 | 2.322689e+01 |
| PPIL3 | 2.264593e+01 | 25.6412074 | 2.503949e+01 | 27.0361445 | 2.855892e+01 | 30.4408390 | 17.7793479 | 20.1975735 | 19.4376070 | 21.0063899 | 20.3970694 | 21.7723796 | 2.884460e+01 | 3.255201e+01 | 3.225584e+01 | 3.479670e+01 | 3.998671e+01 | 4.256056e+01 |
| PPIL4 | 9.072116e+00 | 9.0314871 | 9.608585e+00 | 10.9184321 | 8.915754e+00 | 10.6392796 | 6.8981408 | 6.8660256 | 7.2079189 | 8.2241349 | 6.0399224 | 7.2757346 | 1.193123e+01 | 1.187991e+01 | 1.280881e+01 | 1.449540e+01 | 1.316088e+01 | 1.555778e+01 |
| PPIL6 | 1.144527e+00 | 2.3194979 | 1.407659e+00 | 2.9429638 | 2.413566e+00 | 2.7290736 | 0.6802263 | 1.5242469 | 0.8409651 | 1.9337127 | 1.3410032 | 1.5433193 | 1.925744e+00 | 3.529658e+00 | 2.356225e+00 | 4.478967e+00 | 4.343986e+00 | 4.825860e+00 |
| RAB3IL1 | 1.781250e+01 | 20.8537220 | 1.839060e+01 | 26.5430117 | 2.417340e+01 | 22.9172431 | 13.9732028 | 16.4126311 | 14.2542355 | 20.7569716 | 17.3702123 | 16.4492819 | 2.270670e+01 | 2.649653e+01 | 2.372726e+01 | 3.394192e+01 | 3.364112e+01 | 3.192845e+01 |
| RADIL | 1.725084e+00 | 2.3810872 | 1.931271e+00 | 2.7626926 | 2.590174e+00 | 2.7684884 | 1.0643466 | 1.5251198 | 1.1444005 | 1.7405645 | 1.4067194 | 1.5161937 | 2.796002e+00 | 3.717463e+00 | 3.259179e+00 | 4.385055e+00 | 4.769253e+00 | 5.055111e+00 |
| RALA | 1.489112e+01 | 15.0474446 | 1.615292e+01 | 17.0180633 | 1.436258e+01 | 18.0569164 | 12.2829074 | 12.4399744 | 13.2179538 | 13.9611050 | 10.9522163 | 13.9031574 | 1.805318e+01 | 1.820145e+01 | 1.973957e+01 | 2.074438e+01 | 1.883487e+01 | 2.345167e+01 |
| RGS4 | 1.777273e+00 | 1.4447091 | 1.389774e+00 | 0.8571862 | 1.923104e+00 | 3.7644977 | 1.7479761 | 1.4111253 | 1.3575052 | 0.8291745 | 1.8784049 | 3.6411572 | 1.807062e+00 | 1.479092e+00 | 1.422810e+00 | 8.861442e-01 | 1.968867e+00 | 3.892016e+00 |
| RILP | 1.801890e+01 | 19.5161631 | 1.827094e+01 | 20.2840540 | 1.926533e+01 | 20.3633862 | 14.2637561 | 15.4791765 | 14.2649718 | 15.8787075 | 13.8756138 | 14.6932677 | 2.276265e+01 | 2.460600e+01 | 2.340189e+01 | 2.591161e+01 | 2.674859e+01 | 2.822160e+01 |
| RILPL1 | 9.404314e+00 | 9.6017321 | 8.649595e+00 | 9.1939979 | 1.133570e+01 | 10.2019376 | 7.3486132 | 7.5306723 | 6.6544612 | 7.0865579 | 8.1324415 | 7.2763686 | 1.203508e+01 | 1.224237e+01 | 1.124291e+01 | 1.192816e+01 | 1.580068e+01 | 1.430377e+01 |
| RILPL2 | 4.682971e+00 | 6.4821506 | 5.074151e+00 | 6.3930025 | 5.561177e+00 | 5.8279800 | 3.6281740 | 5.1550093 | 3.8996144 | 5.0086368 | 3.9567474 | 4.1681997 | 6.044422e+00 | 8.150960e+00 | 6.602450e+00 | 8.160001e+00 | 7.816189e+00 | 8.148686e+00 |
| RSAD2 | 5.029960e+00 | 6.1392998 | 5.134058e+00 | 8.5618641 | 3.124377e+00 | 4.3094875 | 3.3935342 | 4.0134351 | 3.3975008 | 5.7155865 | 1.7186462 | 2.4494694 | 7.455501e+00 | 9.391208e+00 | 7.758218e+00 | 1.282555e+01 | 5.679895e+00 | 7.581921e+00 |
| S100B | 1.152722e+01 | 11.0952624 | 1.938020e+01 | 10.8417865 | 1.721517e+01 | 26.0695521 | 10.9670937 | 10.3439825 | 18.2339220 | 9.9511805 | 7.8799957 | 11.5075509 | 1.211595e+01 | 1.190111e+01 | 2.059853e+01 | 1.181210e+01 | 3.760940e+01 | 5.905875e+01 |
| SAA1 | 6.676082e+00 | 3.0247273 | 3.037971e+00 | 0.6893072 | 1.135659e+01 | 14.3430531 | 2.5982396 | 1.1492104 | 1.0933006 | 0.2182713 | 3.0292405 | 3.8388418 | 1.715395e+01 | 7.961097e+00 | 8.441654e+00 | 2.176852e+00 | 4.257575e+01 | 5.358991e+01 |
| SAA2 | 1.910433e+00 | 0.9490289 | 8.473825e-01 | 0.2275547 | 1.436605e+00 | 1.5944926 | 0.7976090 | 0.3705237 | 0.3134613 | 0.0622948 | 0.4107106 | 0.4611602 | 4.575870e+00 | 2.430765e+00 | 2.290736e+00 | 8.312272e-01 | 5.025035e+00 | 5.513066e+00 |
| SDK2 | 9.275273e-01 | 1.2764099 | 6.455905e-01 | 1.1260358 | 7.939445e-01 | 1.1080502 | 0.5053932 | 0.7342369 | 0.3122059 | 0.6133297 | 0.3219397 | 0.4910245 | 1.702253e+00 | 2.218933e+00 | 1.334975e+00 | 2.067333e+00 | 1.957968e+00 | 2.500436e+00 |
| SIL1 | 3.592841e+01 | 35.2092605 | 4.071806e+01 | 35.3001892 | 4.530728e+01 | 47.9268384 | 27.0369978 | 26.4901676 | 30.1567427 | 26.1048672 | 30.4000941 | 32.1785155 | 4.774385e+01 | 4.679819e+01 | 5.497811e+01 | 4.773452e+01 | 6.752446e+01 | 7.138247e+01 |
| SKIL | 5.973789e+00 | 6.6370790 | 6.476428e+00 | 9.4145740 | 7.053848e+00 | 7.6369106 | 4.6361256 | 5.1923337 | 4.9789457 | 7.3919182 | 5.0166152 | 5.4679552 | 7.697409e+00 | 8.483819e+00 | 8.424298e+00 | 1.199069e+01 | 9.918395e+00 | 1.066622e+01 |
| STAG3L5P-PVRIG2P-PILRB | 6.598598e+00 | 6.6970657 | 8.021877e+00 | 7.1464390 | 8.478071e+00 | 6.9303993 | 4.7345161 | 4.8050692 | 5.6900196 | 5.0383587 | 5.3636176 | 4.3453518 | 9.196610e+00 | 9.334036e+00 | 1.130937e+01 | 1.013655e+01 | 1.340097e+01 | 1.105329e+01 |
| STIL | 7.830046e-01 | 0.6089885 | 7.795424e-01 | 0.6353165 | 7.004732e-01 | 0.9086205 | 0.4522066 | 0.3289605 | 0.4349525 | 0.3347994 | 0.3095246 | 0.4395184 | 1.355788e+00 | 1.127391e+00 | 1.397133e+00 | 1.205579e+00 | 1.585214e+00 | 1.878400e+00 |
| SVIL | 1.016479e+01 | 12.1552139 | 8.009582e+00 | 12.4536609 | 1.103030e+01 | 11.6281179 | 7.4713948 | 8.9959992 | 5.7390601 | 9.0598324 | 7.1793828 | 7.5729220 | 1.382914e+01 | 1.642388e+01 | 1.117838e+01 | 1.711882e+01 | 1.694680e+01 | 1.785482e+01 |
| SVIL-AS1 | 1.848888e+01 | 20.7669603 | 2.102043e+01 | 23.6495989 | 1.958927e+01 | 26.8656251 | 15.1381053 | 17.0630742 | 17.0771334 | 19.2678175 | 14.7991162 | 20.5153815 | 2.258133e+01 | 2.527485e+01 | 2.587427e+01 | 2.902786e+01 | 2.592989e+01 | 3.518150e+01 |
| SVILP1 | 2.349001e-01 | 0.2280990 | 2.037960e-01 | 0.2382573 | 2.138812e-01 | 0.2988665 | 0.0862627 | 0.0826476 | 0.0655985 | 0.0828989 | 0.0487659 | 0.0837585 | 6.396518e-01 | 6.295304e-01 | 6.331361e-01 | 6.847688e-01 | 9.380564e-01 | 1.066414e+00 |
| TIGIT | 3.925485e+00 | 3.0155547 | 4.385816e+00 | 2.2533273 | 1.660806e+00 | 1.4068681 | 2.1615211 | 1.5471642 | 2.3948947 | 1.1460992 | 0.6880979 | 0.5179250 | 7.128977e+00 | 5.877573e+00 | 8.031828e+00 | 4.430231e+00 | 4.008552e+00 | 3.821553e+00 |
| TRIL | 1.402709e+00 | 1.8207061 | 1.566002e+00 | 1.9348643 | 2.122822e+00 | 2.1537932 | 0.8489065 | 1.1410232 | 0.9400106 | 1.1939327 | 1.1204860 | 1.1307290 | 2.317796e+00 | 2.905261e+00 | 2.608865e+00 | 3.135604e+00 | 4.021802e+00 | 4.102508e+00 |
| UBFD1 | 8.406039e+00 | 6.9230618 | 8.007660e+00 | 7.5988008 | 8.277994e+00 | 8.7763811 | 6.6236697 | 5.3944382 | 6.2018834 | 5.8663064 | 5.9044410 | 6.2829038 | 1.066803e+01 | 8.884852e+00 | 1.033922e+01 | 9.842952e+00 | 1.160570e+01 | 1.225944e+01 |
| USP18 | 3.502181e+00 | 4.3453945 | 3.940899e+00 | 4.4694981 | 2.720912e+00 | 3.0776942 | 2.4715262 | 3.1204089 | 2.7516095 | 3.1525973 | 1.6059867 | 1.8487140 | 4.962630e+00 | 6.051275e+00 | 5.644218e+00 | 6.336494e+00 | 4.609851e+00 | 5.123671e+00 |
| USP9Y | 3.611526e-01 | 1.4408979 | 3.156332e+00 | 4.7602203 | 4.053741e+00 | 0.2713043 | 0.0799096 | 0.3721661 | 0.7753121 | 1.1800427 | 0.6286297 | 0.0293763 | 1.632235e+00 | 5.578656e+00 | 1.284958e+01 | 1.920244e+01 | 2.614069e+01 | 2.505630e+00 |
| VIL1 | 2.877140e-01 | 0.4940834 | 2.866187e-01 | 0.3895768 | 4.199510e-01 | 0.2737427 | 0.1002034 | 0.2016967 | 0.0935016 | 0.1409627 | 0.1115278 | 0.0600605 | 8.261137e-01 | 1.210324e+00 | 8.785981e-01 | 1.076668e+00 | 1.581300e+00 | 1.247660e+00 |
| VILL | 6.212449e+00 | 6.7092718 | 6.763039e+00 | 6.4456901 | 7.924241e+00 | 7.2099303 | 4.8507215 | 5.2659304 | 5.2336037 | 4.9711585 | 5.7082012 | 5.1520798 | 7.956451e+00 | 8.548220e+00 | 8.739427e+00 | 8.357593e+00 | 1.100059e+01 | 1.008973e+01 |
| XBP1 | 1.744531e+02 | 125.6412109 | 2.318871e+02 | 112.9167156 | 1.433170e+02 | 92.8226464 | 119.4843495 | 85.9554396 | 157.5397551 | 77.4005966 | 85.7629227 | 55.9612136 | 2.547104e+02 | 1.836500e+02 | 3.413211e+02 | 1.647298e+02 | 2.394945e+02 | 1.539646e+02 |
| XCR1 | 8.558504e-01 | 0.4412318 | 1.300740e+00 | 0.9914319 | 5.530547e-01 | 0.4993068 | 0.4360302 | 0.1923731 | 0.6826263 | 0.4982976 | 0.1864124 | 0.1620938 | 1.679884e+00 | 1.012020e+00 | 2.478552e+00 | 1.972591e+00 | 1.640822e+00 | 1.538043e+00 |
| ZWILCH | 3.823946e+00 | 3.5572915 | 4.130910e+00 | 4.6766732 | 3.819816e+00 | 4.8296336 | 2.8916771 | 2.6720017 | 3.0957909 | 3.5423517 | 2.5770418 | 3.3578092 | 5.056776e+00 | 4.735896e+00 | 5.512136e+00 | 6.174224e+00 | 5.661917e+00 | 6.946601e+00 |
Finally the qvalues from each of the pvalues can be calculated. This will output a significance table based on the cut-off (default p=0.05):
resultTable <- glmmQvals(resultTable, pi0=1)##
## q_Timepoint
## -----------
## Not Significant Significant
## 266 76
##
## q_EULAR_bin
## -----------
## Not Significant Significant
## 323 19
##
## q_Timepoint:EULAR_bin
## ---------------------
## Not Significant Significant
## 322 20
For variables which are paired according to an ID, we can view the model using paired plots. In this case the samples can be paired over time.
Plots can be viewed either in base graphics:
plotColours <- c("skyblue", "goldenrod1", "mediumvioletred")
modColours <- rep(c("dodgerblue3", "goldenrod3", "deeppink4"), each=2)
pairedPlot(glmmResult=resultTable,
geneName = "MS4A1",
x1Label = "Timepoint",
x2Label="EULAR_bin",
IDColumn = "PATID",
graphics = "ggplot",
colours = plotColours,
modColour = modColours,
modLineColour = modColours,
fontSize=8,
logTransform=TRUE,
addViolin = TRUE,
pairedOnly = TRUE)Or using ggplot, with or without the model fit overlaid:
library(ggpubr)## Loading required package: ggplot2
p1 = pairedPlot(glmmResult=resultTable,
geneName = "ADAM12",
x1Label = "Timepoint",
x2Label="EULAR_bin",
IDColumn = "PATID",
graphics="ggplot",
addViolins=FALSE,
fontSize=8,
colours=plotColours,
modSize = 1)
p2 = pairedPlot(glmmResult=resultTable,
geneName = "ADAM12",
x1Label = "Timepoint",
x2Label="EULAR_bin",
IDColumn = "PATID",
addModel=FALSE,
graphics="ggplot",
fontSize=8,
colours=plotColours)
ggarrange(p1, p2, ncol=2)Alternatively to plot the model fits alone you can use the modelPlot function:
p1 <- modelPlot(resultTable,
"ADAM12",
x1Label="Timepoint",
x2Label="EULAR_bin",
xTitle="Time",
fontSize=8,
overlap=FALSE,
colours = plotColours)
p2 <- modelPlot(resultTable,
"ADAM12",
x1Label="Timepoint",
x2Label="EULAR_bin",
xTitle="Time",
fontSize=8,
addErrorbars = FALSE,
overlap=TRUE,
colours = plotColours)
ggarrange(p1, p2, ncol=2, common.legend = T, legend="bottom")The fold change all genes can be plotted on fold change plots to highlight significance. Genes on the x-y plane are associated in the same direction. Genes on the x=-y axis have association in opposite directions.
This can be plotted with plotly or ggplot:
labels = c("IGHV7-4-1", "IGHV3-49", "IGHV3-23", "ADAM12", "FGFRL1", "IL36G",
"BLK", "SAA1", "CILP", "EMILIN3", "EMILIN2", "IGHJ6", "CXCL9")
fcPlot(glmmResult=resultTable,
x1Label="Timepoint",
x2Label="EULAR_bin",
x2Values=c("Good responder", "Non responder"),
pCutoff=0.05,
labels=labels,
useAdjusted = FALSE,
plotCutoff = 1,
graphics="plotly")Or flipping the x1 and x2 labels we can look at the fold change between response at different timepoints. This might be interesting to see if there are differences at certain timepoints which to not present at others.
fcPlot(glmmResult=resultTable,
x2Label="Timepoint",
x1Label="EULAR_bin",
x1Values=c("Good responder", "Non responder"),
labels=labels,
pCutoff=0.05,
useAdjusted = F,
plotCutoff = 1,
graphics="plotly")This has a allowed us to pick out genes of potential interest we can then have another closer look at:
p1 <- pairedPlot(glmmResult=resultTable,
geneName = "ADAM12",
x1Label = "Timepoint",
x2Label="EULAR_bin",
IDColumn = "PATID",
graphics="ggplot",
colours = "grey60",
modColour = rep(plotColours, each=2),
modLineColour =rep(plotColours, each=2),
addViolins=FALSE,
fontSize=8,
logTransform=T) + theme(plot.subtitle=element_text(size=9))
p2 <- pairedPlot(glmmResult=resultTable,
geneName = "CXCL9",
x1Label = "Timepoint",
x2Label="EULAR_bin",
IDColumn = "PATID",
graphics="ggplot",
addViolins = FALSE,
colours = c("blue"),
fontSize=8,
logTransform=T) + theme(plot.subtitle=element_text(size=9))
ggarrange(p1, p2, ncol=2)An MA plot is an application of a Bland–Altman plot. The plot visualizes the differences between measurements taken in two samples, by transforming the data onto M (log ratio) and A (mean average) scales, then plotting these values.
maPlots <- maPlot(resultTable,
x1Label="Timepoint",
x2Label="EULAR_bin",
x2Values=c("Good responder", "Non responder"),
labels=labels)
maPlots$combinedmaPlots <- maPlot(resultTable,
x2Label="Timepoint",
x1Label="EULAR_bin",
x1Values=c("Good responder", "Non responder"),
labels=labels)
maPlots$combined